MX344696B - Derivados de pirrol como moduladores de los receptores de acetilcolina nicotinicos para su uso en el tratamiento de enfermedades neurodegenerativas como el alzheimer y la enfermedad de parkinson. - Google Patents

Derivados de pirrol como moduladores de los receptores de acetilcolina nicotinicos para su uso en el tratamiento de enfermedades neurodegenerativas como el alzheimer y la enfermedad de parkinson.

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Publication number
MX344696B
MX344696B MX2013011290A MX2013011290A MX344696B MX 344696 B MX344696 B MX 344696B MX 2013011290 A MX2013011290 A MX 2013011290A MX 2013011290 A MX2013011290 A MX 2013011290A MX 344696 B MX344696 B MX 344696B
Authority
MX
Mexico
Prior art keywords
alzheimer
disease
nicotinic acetylcholine
parkinson
treatment
Prior art date
Application number
MX2013011290A
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English (en)
Other versions
MX2013011290A (es
Inventor
Sinha Neelima
Jana Gourhari
Ramchandra Tilekar Ajay
Popat Karche Navnath
P Palle Venkata
Kumar Kamboj Rajender
Original Assignee
Lupin Ltd
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Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of MX2013011290A publication Critical patent/MX2013011290A/es
Publication of MX344696B publication Critical patent/MX344696B/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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Abstract

Se describe un compuesto de la fórmula (I) en donde 'a' y R1-R5 son como se describen en el presente, como un modulador de receptores de acetilcolina nicotínica particularmente el subtipo a7, en un sujeto en la necesidad del mismo, así como los análogos, profármacos, análogos de manera isotópica sustituidos, metabolitos, sales farmacéuticamente aceptables, polimorfos, solvatos, isómeros, clatratos y co-cristales de los mismos, para uso ya sea solos o en combinaciones con otros medicamentos adecuados y composiciones farmacéuticas que contienen dichos compuestos y análogos. También se describen procesos de preparación de los compuestos y los usos deseados de los mismos en terapia, particularmente en el profilaxis y terapia de desórdenes como enfermedad Alzheimer, daño cognitivo medio, demencia senil y similares.
MX2013011290A 2011-03-31 2012-03-27 Derivados de pirrol como moduladores de los receptores de acetilcolina nicotinicos para su uso en el tratamiento de enfermedades neurodegenerativas como el alzheimer y la enfermedad de parkinson. MX344696B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN458KO2011 2011-03-31
PCT/IB2012/051451 WO2012131576A1 (en) 2011-03-31 2012-03-27 Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease

Publications (2)

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MX2013011290A MX2013011290A (es) 2013-12-06
MX344696B true MX344696B (es) 2017-01-03

Family

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MX2013011290A MX344696B (es) 2011-03-31 2012-03-27 Derivados de pirrol como moduladores de los receptores de acetilcolina nicotinicos para su uso en el tratamiento de enfermedades neurodegenerativas como el alzheimer y la enfermedad de parkinson.

Country Status (12)

Country Link
US (1) US9187420B2 (es)
EP (1) EP2691368A1 (es)
JP (2) JP2014509641A (es)
KR (1) KR20140025395A (es)
CN (1) CN103443075A (es)
AU (1) AU2012235779B2 (es)
BR (1) BR112013025128A2 (es)
CA (1) CA2829860A1 (es)
MX (1) MX344696B (es)
SG (1) SG193387A1 (es)
WO (1) WO2012131576A1 (es)
ZA (1) ZA201306833B (es)

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BR112013025128A2 (pt) 2017-02-14
KR20140025395A (ko) 2014-03-04
JP2017081986A (ja) 2017-05-18
SG193387A1 (en) 2013-10-30
WO2012131576A1 (en) 2012-10-04
US20140018327A1 (en) 2014-01-16
JP2014509641A (ja) 2014-04-21
NZ615583A (en) 2015-09-25
US9187420B2 (en) 2015-11-17
CA2829860A1 (en) 2012-10-04
AU2012235779A1 (en) 2013-10-03
ZA201306833B (en) 2015-04-29
MX2013011290A (es) 2013-12-06
EP2691368A1 (en) 2014-02-05
AU2012235779B2 (en) 2017-03-02
CN103443075A (zh) 2013-12-11

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