MX2012007783A - Compuestos sulfona que actuan como ligandos del receptor 5-ht6. - Google Patents
Compuestos sulfona que actuan como ligandos del receptor 5-ht6.Info
- Publication number
- MX2012007783A MX2012007783A MX2012007783A MX2012007783A MX2012007783A MX 2012007783 A MX2012007783 A MX 2012007783A MX 2012007783 A MX2012007783 A MX 2012007783A MX 2012007783 A MX2012007783 A MX 2012007783A MX 2012007783 A MX2012007783 A MX 2012007783A
- Authority
- MX
- Mexico
- Prior art keywords
- receptor ligands
- compounds
- sulfone compounds
- polymorphs
- tautomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
La presente invención se relaciona con nuevos compuestos sulfona que actúan como ligandos del receptor 5-HT6 y que tienen la fórmula (I) y con sus derivados, profármacos, tautómeros, estereoisómeros, polimorfos, solvatos, hidratos, metabolitos, N-óxidos, sales farmacéuticamente aceptables y composiciones que las contienen. La presente invención también se relaciona con un proceso para la preparación de los nuevos compuestos mencionados y de sus derivados, profármacos, tautómeros, estereoisómeros, polimorfos, solvatos, hidratos, metabolitos, N-óxidos, sales farmacéuticamente aceptables y composiciones que las contienen. Estos compuestos son útiles en el tratamiento/ prevención de varios trastornos que están relacionados con las funciones del receptor 5-HT6.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN18CH2010 | 2010-01-05 | ||
PCT/IN2010/000176 WO2011083487A1 (en) | 2010-01-05 | 2010-03-24 | Sulfone compounds as 5-ht6 receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012007783A true MX2012007783A (es) | 2012-10-03 |
Family
ID=42941911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012007783A MX2012007783A (es) | 2010-01-05 | 2010-03-24 | Compuestos sulfona que actuan como ligandos del receptor 5-ht6. |
Country Status (18)
Country | Link |
---|---|
US (1) | US9018231B2 (es) |
EP (1) | EP2521714B1 (es) |
JP (1) | JP5628937B2 (es) |
KR (1) | KR101463190B1 (es) |
CN (1) | CN102869647B (es) |
AU (1) | AU2010340745B2 (es) |
BR (1) | BR112012016526A2 (es) |
CA (1) | CA2786072C (es) |
DK (1) | DK2521714T3 (es) |
EA (1) | EA022043B1 (es) |
ES (1) | ES2552463T3 (es) |
HK (1) | HK1176619A1 (es) |
IL (1) | IL220709A (es) |
MX (1) | MX2012007783A (es) |
NZ (1) | NZ601284A (es) |
SG (1) | SG181992A1 (es) |
WO (1) | WO2011083487A1 (es) |
ZA (1) | ZA201205253B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3718547A1 (en) | 2011-10-03 | 2020-10-07 | The University of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
TWI623520B (zh) * | 2012-12-12 | 2018-05-11 | 德商拜耳作物科學股份有限公司 | 製備雙(3-胺基苯基)二硫化物及3-胺基硫醇之方法 |
US20160038484A1 (en) * | 2013-04-03 | 2016-02-11 | The University Of Utah Research Foundation | Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome |
CN105541693B (zh) | 2014-07-08 | 2018-10-16 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
MA45002B1 (fr) | 2016-05-18 | 2020-10-28 | Suven Life Sciences Ltd | Triple combinaison d'antagonistes purs du récepteurs 5-ht6, d'inhibiteurs de l'acétylcholinestérase et d'antagonistes du récepteur nmda |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
US6316450B1 (en) | 1997-07-11 | 2001-11-13 | Smithkline Beecham P.L.C. | Compounds |
GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
JP4597386B2 (ja) | 1999-04-21 | 2010-12-15 | エヌピーエス ファーマシューティカルス,インコーポレーテッド | 5−ht6親和性を有するピペリジン−インドール化合物 |
GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
JP2004517058A (ja) * | 2000-10-30 | 2004-06-10 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | アミノアルキルピロリジンセロトニン受容体リガンドおよび組成物、その医薬的使用およびその合成方法 |
AU2002236730B2 (en) | 2001-01-30 | 2006-06-15 | Eli Lilly And Company | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5-HT6 receptor |
WO2002098878A1 (en) | 2001-02-08 | 2002-12-12 | Memory Pharmaceuticals Corporation | Trifluoromethylpurines as phosphodiesterase 4 inhibitors |
ATE353318T1 (de) | 2001-06-07 | 2007-02-15 | Hoffmann La Roche | Neue indolderivate mit affinität zum 5-ht6- rezeptor |
JP2005528587A (ja) | 2002-02-01 | 2005-09-22 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 新規ヒト5−ht6受容体に関連する疾患のための診断用および治療用物質 |
EP1471912A1 (en) | 2002-02-05 | 2004-11-03 | Glaxo Group Limited | Method of promoting neuronal growth |
WO2003080580A2 (en) | 2002-03-27 | 2003-10-02 | Glaxo Group Limited | Quinoline derivatives and their use as 5-ht6 ligands |
CA2507505C (en) | 2002-11-28 | 2011-10-04 | Suven Life Sciences Limited | N-arylsulfonyl-3-aminoalkoxyindoles |
AU2003237599B2 (en) | 2002-11-28 | 2009-06-18 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
WO2004048331A1 (en) | 2002-11-28 | 2004-06-10 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
WO2004108671A1 (en) | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
WO2005066157A1 (en) | 2004-01-02 | 2005-07-21 | Suven Life Sciences | 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators |
WO2007020653A1 (en) * | 2005-08-12 | 2007-02-22 | Suven Life Sciences Limited | Thioether derivatives as functional 5-ht6 ligands |
SI1919896T1 (sl) * | 2005-08-12 | 2010-04-30 | Suven Life Sciences Ltd | Aminoaril sulfonamidni derivati kot funkcionalni 5-HT6 ligandi |
WO2007046112A1 (en) | 2005-10-19 | 2007-04-26 | Suven Life Sciences Inc. | Arylthioether tryptamine derivatives as functional 5-ht6 ligands |
WO2007138611A1 (en) * | 2006-05-30 | 2007-12-06 | Suven Life Sciences Limited | 3-(heterocyclyl)-n-(arylsulfonyl)indole derivatives as functional 5-ht6 ligands |
-
2010
- 2010-03-24 BR BR112012016526A patent/BR112012016526A2/pt not_active Application Discontinuation
- 2010-03-24 NZ NZ601284A patent/NZ601284A/en not_active IP Right Cessation
- 2010-03-24 JP JP2012547589A patent/JP5628937B2/ja not_active Expired - Fee Related
- 2010-03-24 ES ES10725883.2T patent/ES2552463T3/es active Active
- 2010-03-24 KR KR1020127020442A patent/KR101463190B1/ko active IP Right Grant
- 2010-03-24 MX MX2012007783A patent/MX2012007783A/es active IP Right Grant
- 2010-03-24 US US13/520,136 patent/US9018231B2/en not_active Expired - Fee Related
- 2010-03-24 WO PCT/IN2010/000176 patent/WO2011083487A1/en active Application Filing
- 2010-03-24 CA CA2786072A patent/CA2786072C/en not_active Expired - Fee Related
- 2010-03-24 AU AU2010340745A patent/AU2010340745B2/en not_active Ceased
- 2010-03-24 EA EA201290610A patent/EA022043B1/ru not_active IP Right Cessation
- 2010-03-24 CN CN201080065143.0A patent/CN102869647B/zh not_active Expired - Fee Related
- 2010-03-24 DK DK10725883.2T patent/DK2521714T3/en active
- 2010-03-24 EP EP10725883.2A patent/EP2521714B1/en active Active
- 2010-03-24 SG SG2012048542A patent/SG181992A1/en unknown
-
2012
- 2012-07-01 IL IL220709A patent/IL220709A/en active IP Right Grant
- 2012-07-13 ZA ZA2012/05253A patent/ZA201205253B/en unknown
-
2013
- 2013-04-08 HK HK13104217.4A patent/HK1176619A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2786072A1 (en) | 2011-07-14 |
ZA201205253B (en) | 2013-05-29 |
WO2011083487A1 (en) | 2011-07-14 |
ES2552463T3 (es) | 2015-11-30 |
EA201290610A1 (ru) | 2013-02-28 |
CN102869647B (zh) | 2015-06-24 |
CA2786072C (en) | 2014-10-28 |
DK2521714T3 (en) | 2015-10-19 |
KR101463190B1 (ko) | 2014-11-18 |
EP2521714A1 (en) | 2012-11-14 |
BR112012016526A2 (pt) | 2018-11-06 |
HK1176619A1 (en) | 2013-08-02 |
IL220709A (en) | 2015-03-31 |
NZ601284A (en) | 2014-03-28 |
US20130005709A1 (en) | 2013-01-03 |
EP2521714B1 (en) | 2015-08-12 |
US9018231B2 (en) | 2015-04-28 |
JP2013516458A (ja) | 2013-05-13 |
SG181992A1 (en) | 2012-08-30 |
AU2010340745A1 (en) | 2012-08-09 |
KR20120112726A (ko) | 2012-10-11 |
CN102869647A (zh) | 2013-01-09 |
AU2010340745B2 (en) | 2014-11-20 |
EA022043B1 (ru) | 2015-10-30 |
IL220709A0 (en) | 2012-08-30 |
JP5628937B2 (ja) | 2014-11-19 |
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Legal Events
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FG | Grant or registration |