MX341474B - Nuevas hidroxi-6-heteroarilfenantridinas y su uso como inhibidores de la fosfodiesterasa tipo 4 ( pde4). - Google Patents

Nuevas hidroxi-6-heteroarilfenantridinas y su uso como inhibidores de la fosfodiesterasa tipo 4 ( pde4).

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Publication number
MX341474B
MX341474B MX2011010146A MX2011010146A MX341474B MX 341474 B MX341474 B MX 341474B MX 2011010146 A MX2011010146 A MX 2011010146A MX 2011010146 A MX2011010146 A MX 2011010146A MX 341474 B MX341474 B MX 341474B
Authority
MX
Mexico
Prior art keywords
alkyl
alkoxy
hydrogen
substituted
completely
Prior art date
Application number
MX2011010146A
Other languages
English (en)
Inventor
Marx Degenhard
Schmidt Beate
Hatzelmann Armin
Kley Hans-Peter
Flockerzi Dieter
Zitt Christof
Barsig Johannes
Kautz Ulrich
Original Assignee
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Gmbh filed Critical Takeda Gmbh
Publication of MX341474B publication Critical patent/MX341474B/es

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    • A61K31/47—Quinolines; Isoquinolines
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Abstract

Se describen compuestos de fórmula I. (ver fórmula (I)) que son nuevos inhibidores de PDE4 efectivos, en donde R1 es hidroxilo, alcoxi C1-4, cicloalcoxi C3-7, cicloalquilmetoxi C3-7, 2,2-difluoroetoxi, o alcoxi C1-4 completa o predominantemente sustituido con flúor, R2 es hidroxilo, alcoxi C1-4, cicloalcoxi C3-7, cicloalquilmetoxi C3-7, 2,2-difluoroetoxi, o alcoxi C1-4 completa o predominantemente sustituido con flúor, o en donde R1 y R2 juntos son un grupo alquilendioxi C1-2, R3 es hidrógeno o alquilo C1-4, R31 es hidrógeno o alquilo 01-4, o, en una primera modalidad (modalidad a) de acuerdo a la presente invención, R4 es -O-R41, en donde R41 es hidrógeno, alquilo C1-4, alcoxi C1-4-alquilo C1-4, hidroxialquilo C2-4, alquilcarbonilo C1-7, o alquilo C1-4 completa o predominantemente sustituido con flúor, y R5 es hidrógeno o alquilo C1-4, o, en una segunda modalidad (modalidad b) de acuerdo a la presente invención, R4 es hidrógeno o alquilo C1-4, y R5 es -O-R51, en donde R51 es hidrógeno, alquilo C1-4, alcoxi C1-4-alquilo C1-4, hidroxi alquilo C2-4, alquilcarbonilo C1-7, o alquilo C1-4 completa o predominantemente sustituido con flúor, Har es opcionalmente sustituido por R6 y/o R7 y/o R8, y es un radical heteroarilo insaturado o parcialmente saturado monocíclico o bicíclico fusionado de 5 a 10 miembros que comprende 1 a 4 heteroátomos seleccionados independientemente del grupo que consiste de oxígeno, nitrógeno y azufre.
MX2011010146A 2004-03-03 2005-03-02 Nuevas hidroxi-6-heteroarilfenantridinas y su uso como inhibidores de la fosfodiesterasa tipo 4 ( pde4). MX341474B (es)

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