MX340971B - Fragmento cristalizable (fc) de anticuerpo monomerico. - Google Patents

Fragmento cristalizable (fc) de anticuerpo monomerico.

Info

Publication number
MX340971B
MX340971B MX2012005731A MX2012005731A MX340971B MX 340971 B MX340971 B MX 340971B MX 2012005731 A MX2012005731 A MX 2012005731A MX 2012005731 A MX2012005731 A MX 2012005731A MX 340971 B MX340971 B MX 340971B
Authority
MX
Mexico
Prior art keywords
polypeptides
monomeric antibody
monomeric
amino acid
region
Prior art date
Application number
MX2012005731A
Other languages
English (en)
Other versions
MX2012005731A (es
Inventor
Zhou Hongxing
Kannan Gunasekaran
Sun Nancy
Original Assignee
Amgen Inc *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc * filed Critical Amgen Inc *
Publication of MX2012005731A publication Critical patent/MX2012005731A/es
Publication of MX340971B publication Critical patent/MX340971B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

Abstract

La presente invención se refiere a polipéptidos Fc monoméricos y métodos para elaborar y utilizar estos polipéptidos. Los polipéptidos comprenden sustitución de uno o más residuos de interfase hidrofóbicos en la región CH3 con un aminoácido polar.
MX2012005731A 2009-11-23 2010-11-22 Fragmento cristalizable (fc) de anticuerpo monomerico. MX340971B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26373009P 2009-11-23 2009-11-23
PCT/US2010/057662 WO2011063348A1 (en) 2009-11-23 2010-11-22 Monomeric antibody fc

Publications (2)

Publication Number Publication Date
MX2012005731A MX2012005731A (es) 2012-06-13
MX340971B true MX340971B (es) 2016-08-02

Family

ID=44060063

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012005731A MX340971B (es) 2009-11-23 2010-11-22 Fragmento cristalizable (fc) de anticuerpo monomerico.

Country Status (8)

Country Link
US (1) US9200060B2 (es)
EP (1) EP2504360B1 (es)
JP (2) JP2013511281A (es)
AU (1) AU2010321720B2 (es)
CA (1) CA2781539C (es)
ES (1) ES2688978T3 (es)
MX (1) MX340971B (es)
WO (1) WO2011063348A1 (es)

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Also Published As

Publication number Publication date
US9200060B2 (en) 2015-12-01
EP2504360B1 (en) 2018-08-15
EP2504360A4 (en) 2013-12-25
JP2013511281A (ja) 2013-04-04
CA2781539C (en) 2021-07-20
US20120244578A1 (en) 2012-09-27
CA2781539A1 (en) 2011-05-26
JP2016190844A (ja) 2016-11-10
AU2010321720B2 (en) 2017-03-02
MX2012005731A (es) 2012-06-13
EP2504360A1 (en) 2012-10-03
WO2011063348A1 (en) 2011-05-26
JP6329585B2 (ja) 2018-05-23
ES2688978T3 (es) 2018-11-07
AU2010321720A1 (en) 2012-05-31

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