MX2022007518A - Derivados bencimidazol. - Google Patents
Derivados bencimidazol.Info
- Publication number
- MX2022007518A MX2022007518A MX2022007518A MX2022007518A MX2022007518A MX 2022007518 A MX2022007518 A MX 2022007518A MX 2022007518 A MX2022007518 A MX 2022007518A MX 2022007518 A MX2022007518 A MX 2022007518A MX 2022007518 A MX2022007518 A MX 2022007518A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- benzimidazoles
- processes
- formula
- benzimidazole derivatives
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a bencimidazoles de la Fórmula (I) y sales de estos aceptables desde el punto de vista farmacéutico, en donde R1 a R6 son como se definen en la descripción; a su uso en la medicina; a composiciones que los contienen; a procesos para su preparación; y a intermediarios usados en dichos procesos; los bencimidazoles de la Fórmula (I) son inhibidores de ITK y, por lo tanto, son potencialmente útiles en el tratamiento de diversos trastornos, que incluyen dermatitis atópica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962951030P | 2019-12-20 | 2019-12-20 | |
US202063108602P | 2020-11-02 | 2020-11-02 | |
PCT/IB2020/062036 WO2021124155A1 (en) | 2019-12-20 | 2020-12-16 | Benzimidazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022007518A true MX2022007518A (es) | 2022-09-19 |
Family
ID=73856233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022007518A MX2022007518A (es) | 2019-12-20 | 2020-12-16 | Derivados bencimidazol. |
Country Status (19)
Country | Link |
---|---|
US (1) | US11661419B2 (es) |
EP (1) | EP4077316A1 (es) |
JP (1) | JP2023507138A (es) |
KR (1) | KR20220118525A (es) |
CN (1) | CN115087655A (es) |
AU (1) | AU2020405536B2 (es) |
BR (1) | BR112022011838A2 (es) |
CA (1) | CA3103120A1 (es) |
CL (1) | CL2022001675A1 (es) |
CO (1) | CO2022008313A2 (es) |
CR (1) | CR20220299A (es) |
DO (1) | DOP2022000130A (es) |
EC (1) | ECSP22049160A (es) |
IL (1) | IL293831B2 (es) |
MX (1) | MX2022007518A (es) |
PE (1) | PE20221916A1 (es) |
TW (1) | TWI766484B (es) |
UY (1) | UY38998A (es) |
WO (1) | WO2021124155A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3205020A1 (en) * | 2020-12-15 | 2022-06-23 | Pfizer Inc. | Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease |
CN114624358A (zh) * | 2022-03-11 | 2022-06-14 | 哈尔滨圣泰生物制药有限公司 | 一种地氯雷他定口服液的质量检测方法 |
WO2023249992A2 (en) * | 2022-06-21 | 2023-12-28 | Jjr&D, Llc | Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses |
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ES2287971T3 (es) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | Dispersiones farmaceuticas solidas con biodisponibilidad incrementada. |
GB9911053D0 (en) | 1999-05-12 | 1999-07-14 | Pharmacia & Upjohn Spa | 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents |
FR2831536A1 (fr) | 2001-10-26 | 2003-05-02 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr |
WO2003035065A1 (en) * | 2001-10-26 | 2003-05-01 | Aventis Pharmaceuticals Inc | Benzimidazoles and analogues and their use as protein kinases inhibitors |
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BRPI0907928A2 (pt) | 2008-02-25 | 2015-07-28 | Hoffmann La Roche | Inibidores de pirrolopirazina quinase. |
ATE517107T1 (de) | 2008-02-25 | 2011-08-15 | Hoffmann La Roche | Pyrrolopyrazinkinaseinhibitoren |
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ATE522534T1 (de) | 2008-02-25 | 2011-09-15 | Hoffmann La Roche | Pyrrolopyrazin-kinasehemmer |
PL2250172T3 (pl) | 2008-02-25 | 2012-01-31 | Hoffmann La Roche | Pirolopirazynowe inhibitory kinazy |
EP2196458A1 (en) | 2008-12-10 | 2010-06-16 | Laboratorios Del. Dr. Esteve, S.A. | Process for obtaining enantiomerically enriched pyrazole derivatives |
EP2202232A1 (en) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | 1,2,4-oxadiazole derivatives and their therapeutic use |
EP2292237A1 (en) | 2009-08-14 | 2011-03-09 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
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TWI496785B (zh) | 2010-05-20 | 2015-08-21 | Hoffmann La Roche | 吡咯并吡激酶抑制劑 |
PL2975042T3 (pl) * | 2010-06-23 | 2019-07-31 | Hanmi Science Co., Ltd. | Nowe pochodne skondensowanych pirymidyn do hamowania aktywności kinaz tyrozynowych |
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EP2455080A1 (en) | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of multiple sclerosis |
EP2455081A1 (en) | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of crohn's disease |
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CN103889976A (zh) | 2011-08-12 | 2014-06-25 | 弗·哈夫曼-拉罗切有限公司 | 吲唑化合物、组合物及使用方法 |
MX359032B (es) | 2011-09-01 | 2018-09-12 | Hoffmann La Roche | Inhibidores de pirrolopirazina cinasa. |
MX2015001864A (es) | 2012-08-10 | 2015-05-15 | Hoffmann La Roche | Compuestos de pirazol-carboxamida, composiciones y metodos de uso. |
WO2014041518A1 (en) | 2012-09-14 | 2014-03-20 | Glenmark Pharmaceuticals S.A. | Thienopyrrole derivatives as itk inhibitors |
RS60202B1 (sr) | 2012-09-26 | 2020-06-30 | Hoffmann La Roche | Jedinjenja cikličnog etra pirazol-4-il-heterociklil-karboksamida i postupci primene |
CN103804364A (zh) | 2012-11-06 | 2014-05-21 | 韩冰 | 一类治疗缺血性脑损伤的化合物及其用途 |
CN103804291A (zh) | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103800337A (zh) | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103804361A (zh) | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
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WO2016091916A1 (en) | 2014-12-10 | 2016-06-16 | F. Hoffmann-La Roche Ag | Pyrazolylaminopurines as itk inhibitors |
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KR20210014656A (ko) | 2018-05-25 | 2021-02-09 | 니뽄 다바코 산교 가부시키가이샤 | 인돌 화합물을 사용한 통증 또는 간질성 방광염의 치료 방법 |
JP7407705B2 (ja) | 2018-05-25 | 2024-01-04 | 日本たばこ産業株式会社 | インドール化合物を含む多発性硬化症の治療又は予防剤 |
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CA3205020A1 (en) * | 2020-12-15 | 2022-06-23 | Pfizer Inc. | Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease |
-
2020
- 2020-12-16 MX MX2022007518A patent/MX2022007518A/es unknown
- 2020-12-16 CN CN202080096751.1A patent/CN115087655A/zh active Pending
- 2020-12-16 EP EP20828341.6A patent/EP4077316A1/en active Pending
- 2020-12-16 JP JP2022537036A patent/JP2023507138A/ja active Pending
- 2020-12-16 AU AU2020405536A patent/AU2020405536B2/en active Active
- 2020-12-16 WO PCT/IB2020/062036 patent/WO2021124155A1/en active Application Filing
- 2020-12-16 PE PE2022001143A patent/PE20221916A1/es unknown
- 2020-12-16 BR BR112022011838A patent/BR112022011838A2/pt not_active Application Discontinuation
- 2020-12-16 IL IL293831A patent/IL293831B2/en unknown
- 2020-12-16 KR KR1020227025150A patent/KR20220118525A/ko not_active Application Discontinuation
- 2020-12-16 CR CR20220299A patent/CR20220299A/es unknown
- 2020-12-17 CA CA3103120A patent/CA3103120A1/en active Pending
- 2020-12-18 US US17/126,358 patent/US11661419B2/en active Active
- 2020-12-18 TW TW109144868A patent/TWI766484B/zh active
- 2020-12-21 UY UY0001038998A patent/UY38998A/es unknown
-
2022
- 2022-06-14 CO CONC2022/0008313A patent/CO2022008313A2/es unknown
- 2022-06-17 CL CL2022001675A patent/CL2022001675A1/es unknown
- 2022-06-17 DO DO2022000130A patent/DOP2022000130A/es unknown
- 2022-06-20 EC ECSENADI202249160A patent/ECSP22049160A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CR20220299A (es) | 2022-08-05 |
CL2022001675A1 (es) | 2023-03-17 |
JP2023507138A (ja) | 2023-02-21 |
IL293831B2 (en) | 2024-02-01 |
AU2020405536B2 (en) | 2023-09-07 |
BR112022011838A2 (pt) | 2022-08-30 |
CN115087655A (zh) | 2022-09-20 |
PE20221916A1 (es) | 2022-12-23 |
AU2020405536A1 (en) | 2022-07-14 |
IL293831B1 (en) | 2023-10-01 |
ECSP22049160A (es) | 2022-07-29 |
KR20220118525A (ko) | 2022-08-25 |
WO2021124155A1 (en) | 2021-06-24 |
CO2022008313A2 (es) | 2022-07-08 |
UY38998A (es) | 2021-07-30 |
TWI766484B (zh) | 2022-06-01 |
EP4077316A1 (en) | 2022-10-26 |
US20210188829A1 (en) | 2021-06-24 |
US11661419B2 (en) | 2023-05-30 |
TW202130634A (zh) | 2021-08-16 |
IL293831A (en) | 2022-08-01 |
DOP2022000130A (es) | 2022-07-31 |
CA3103120A1 (en) | 2021-06-20 |
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