BR112022011838A2 - Derivados de benzimidazol - Google Patents
Derivados de benzimidazolInfo
- Publication number
- BR112022011838A2 BR112022011838A2 BR112022011838A BR112022011838A BR112022011838A2 BR 112022011838 A2 BR112022011838 A2 BR 112022011838A2 BR 112022011838 A BR112022011838 A BR 112022011838A BR 112022011838 A BR112022011838 A BR 112022011838A BR 112022011838 A2 BR112022011838 A2 BR 112022011838A2
- Authority
- BR
- Brazil
- Prior art keywords
- benzimidazole derivatives
- benzimidazoles
- processes
- formula
- same
- Prior art date
Links
- 150000001556 benzimidazoles Chemical class 0.000 title abstract 4
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
DERIVADOS DE BENZIMIDAZOL. A presente invenção refere-se a benzimidazóis de Fórmula (I) e sais farmaceuticamente aceitáveis dos mesmos, em que R1 a R6 são como definidos no relatório descritivo; ao seu uso em medicina; a composições contendo os mesmos, a processos para a preparação dos mesmos; e a intermediários usados em tais processos. Os benzimidazóis de Fórmula (I) são inibidores de ITK e são, portanto, potencialmente úteis no tratamento de uma ampla gama de distúrbios, incluindo dermatite atópica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962951030P | 2019-12-20 | 2019-12-20 | |
US202063108602P | 2020-11-02 | 2020-11-02 | |
PCT/IB2020/062036 WO2021124155A1 (en) | 2019-12-20 | 2020-12-16 | Benzimidazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022011838A2 true BR112022011838A2 (pt) | 2022-08-30 |
Family
ID=73856233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022011838A BR112022011838A2 (pt) | 2019-12-20 | 2020-12-16 | Derivados de benzimidazol |
Country Status (19)
Country | Link |
---|---|
US (1) | US11661419B2 (pt) |
EP (1) | EP4077316A1 (pt) |
JP (1) | JP2023507138A (pt) |
KR (1) | KR20220118525A (pt) |
CN (1) | CN115087655A (pt) |
AU (1) | AU2020405536B2 (pt) |
BR (1) | BR112022011838A2 (pt) |
CA (1) | CA3103120A1 (pt) |
CL (1) | CL2022001675A1 (pt) |
CO (1) | CO2022008313A2 (pt) |
CR (1) | CR20220299A (pt) |
DO (1) | DOP2022000130A (pt) |
EC (1) | ECSP22049160A (pt) |
IL (1) | IL293831B2 (pt) |
MX (1) | MX2022007518A (pt) |
PE (1) | PE20221916A1 (pt) |
TW (1) | TWI766484B (pt) |
UY (1) | UY38998A (pt) |
WO (1) | WO2021124155A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3205020A1 (en) * | 2020-12-15 | 2022-06-23 | Pfizer Inc. | Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease |
CN114624358A (zh) * | 2022-03-11 | 2022-06-14 | 哈尔滨圣泰生物制药有限公司 | 一种地氯雷他定口服液的质量检测方法 |
WO2023249992A2 (en) * | 2022-06-21 | 2023-12-28 | Jjr&D, Llc | Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0901786B1 (en) | 1997-08-11 | 2007-06-13 | Pfizer Products Inc. | Solid pharmaceutical dispersions with enhanced bioavailability |
GB9911053D0 (en) | 1999-05-12 | 1999-07-14 | Pharmacia & Upjohn Spa | 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents |
AU2002334217B2 (en) * | 2001-10-26 | 2008-07-03 | Aventis Pharmaceuticals Inc. | Benzimidazoles and analogues and their use as protein kinases inhibitors |
FR2831536A1 (fr) | 2001-10-26 | 2003-05-02 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr |
JP2003231687A (ja) | 2002-02-04 | 2003-08-19 | Japan Tobacco Inc | ピラゾリル縮合環化合物及びその医薬用途 |
JP2007533753A (ja) | 2004-04-23 | 2007-11-22 | タケダ サン ディエゴ インコーポレイテッド | インドール誘導体及びキナーゼ阻害剤としてのその使用 |
TW200719899A (en) | 2005-04-14 | 2007-06-01 | Hoffmann La Roche | Tricyclic azole derivatives, their manufacture and use as pharmaceutical agents |
GB0602178D0 (en) | 2006-02-03 | 2006-03-15 | Merck Sharp & Dohme | Therapeutic treatment |
US20080070933A1 (en) | 2006-08-24 | 2008-03-20 | Huang Kenneth H | Purine, Pyrimidine, and Azaindole Derivatives |
CN101952294B (zh) | 2008-02-25 | 2014-11-26 | 霍夫曼-拉罗奇有限公司 | 吡咯并吡嗪激酶抑制剂 |
EP2245033B1 (en) | 2008-02-25 | 2011-08-31 | F. Hoffmann-La Roche AG | Pyrrolopyrazine kinase inhibitors |
BRPI0907928A2 (pt) | 2008-02-25 | 2015-07-28 | Hoffmann La Roche | Inibidores de pirrolopirazina quinase. |
WO2009106445A1 (en) | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
EP2247592B1 (en) | 2008-02-25 | 2011-08-31 | F. Hoffmann-La Roche AG | Pyrrolopyrazine kinase inhibitors |
EP2196458A1 (en) | 2008-12-10 | 2010-06-16 | Laboratorios Del. Dr. Esteve, S.A. | Process for obtaining enantiomerically enriched pyrazole derivatives |
EP2202232A1 (en) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | 1,2,4-oxadiazole derivatives and their therapeutic use |
EP2292237A1 (en) | 2009-08-14 | 2011-03-09 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention or treatment of pain induced by chemotherapy |
US8299070B2 (en) | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
EP2366702A1 (en) | 2010-03-18 | 2011-09-21 | Almirall, S.A. | New oxadiazole derivatives |
US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
CA2798970A1 (en) | 2010-05-20 | 2011-11-24 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine derivatives as syk and jak inhibitors |
AU2011269989B2 (en) * | 2010-06-23 | 2014-12-11 | Hanmi Science Co., Ltd. | Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
EP2455081A1 (en) | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of crohn's disease |
EP2455080A1 (en) | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of multiple sclerosis |
PL2672967T3 (pl) | 2011-02-07 | 2019-04-30 | Plexxikon Inc | Związki i sposoby modulacji kinaz i wskazania ku temu |
CA2843499A1 (en) | 2011-08-12 | 2013-02-21 | F. Hoffmann-La Roche Ag | Indazole compounds, compositions and methods of use |
RU2673064C2 (ru) | 2011-09-01 | 2018-11-22 | Ф. Хоффманн-Ля Рош Аг | Пирролопиразиновые ингибиторы киназы |
WO2014023258A1 (en) | 2012-08-10 | 2014-02-13 | F.Hoffmann-La Roche Ag | Pyrazole carboxamide compounds, compositions and methods of use |
WO2014041518A1 (en) | 2012-09-14 | 2014-03-20 | Glenmark Pharmaceuticals S.A. | Thienopyrrole derivatives as itk inhibitors |
CN104640858B (zh) | 2012-09-26 | 2018-11-06 | 霍夫曼-拉罗奇有限公司 | 环醚吡唑-4-基-杂环基-甲酰胺化合物及使用方法 |
CN103804364A (zh) | 2012-11-06 | 2014-05-21 | 韩冰 | 一类治疗缺血性脑损伤的化合物及其用途 |
CN103804361A (zh) | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103800328A (zh) | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103804291A (zh) | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103800337A (zh) | 2012-11-07 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
CN103800327A (zh) | 2012-11-09 | 2014-05-21 | 韩冰 | 一类治疗青光眼的化合物及其用途 |
CN103800340A (zh) | 2012-11-09 | 2014-05-21 | 韩冰 | 一类治疗青光眼的化合物及其用途 |
CN103804302A (zh) | 2012-11-14 | 2014-05-21 | 杨育新 | 一类治疗创伤性脑损伤疾病的化合物及其用途 |
CN103804351A (zh) | 2012-11-14 | 2014-05-21 | 韩冰 | 一类具有神经保护作用的化合物及其用途 |
CN103804363A (zh) | 2012-11-14 | 2014-05-21 | 韩冰 | 一类具有神经保护作用的化合物及其用途 |
CN103804272A (zh) | 2012-11-14 | 2014-05-21 | 韩冰 | 一类具有神经保护作用的化合物及其用途 |
CN104628657A (zh) | 2013-11-06 | 2015-05-20 | 韩冰 | 一类治疗缺血性脑损伤的化合物及其用途 |
WO2016001341A1 (en) | 2014-07-03 | 2016-01-07 | F. Hoffmann-La Roche Ag | Sulfonylaminopyridine compounds, compositions and methods of use |
CN110845482B (zh) | 2014-07-04 | 2024-01-19 | 日本烟草产业株式会社 | 制备吲哚化合物的方法 |
WO2016010108A1 (ja) | 2014-07-18 | 2016-01-21 | 塩野義製薬株式会社 | 含窒素複素環誘導体およびそれらを含有する医薬組成物 |
CN105524067A (zh) | 2014-09-28 | 2016-04-27 | 江苏柯菲平医药股份有限公司 | 4-取代吡咯并[2,3-d]嘧啶化合物及其用途 |
WO2016091916A1 (en) | 2014-12-10 | 2016-06-16 | F. Hoffmann-La Roche Ag | Pyrazolylaminopurines as itk inhibitors |
US10618914B2 (en) | 2015-01-15 | 2020-04-14 | University of Pittsburgh—of the Commonwealth System of Higher Education | 6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity |
CA2988601C (en) | 2015-07-02 | 2021-12-07 | F. Hoffmann-La Roche Ag | Bicyclic lactams and methods of use thereof |
WO2019225740A1 (ja) | 2018-05-25 | 2019-11-28 | 日本たばこ産業株式会社 | インドール化合物を含む多発性硬化症の治療又は予防剤 |
EP3804727B1 (en) | 2018-05-25 | 2023-10-11 | Japan Tobacco Inc. | Indol-containing compound for use in the treatment of the nephrotic syndrome |
EP3801546A1 (en) | 2018-05-25 | 2021-04-14 | Japan Tobacco Inc. | Method of treating pain or interstitial cystitis using indole compound |
CA3205020A1 (en) * | 2020-12-15 | 2022-06-23 | Pfizer Inc. | Benzimidazole derivatives and their use as inhibitors of itk for the treatment of skin disease |
-
2020
- 2020-12-16 BR BR112022011838A patent/BR112022011838A2/pt not_active Application Discontinuation
- 2020-12-16 KR KR1020227025150A patent/KR20220118525A/ko not_active Application Discontinuation
- 2020-12-16 EP EP20828341.6A patent/EP4077316A1/en active Pending
- 2020-12-16 JP JP2022537036A patent/JP2023507138A/ja active Pending
- 2020-12-16 AU AU2020405536A patent/AU2020405536B2/en active Active
- 2020-12-16 MX MX2022007518A patent/MX2022007518A/es unknown
- 2020-12-16 CN CN202080096751.1A patent/CN115087655A/zh active Pending
- 2020-12-16 CR CR20220299A patent/CR20220299A/es unknown
- 2020-12-16 PE PE2022001143A patent/PE20221916A1/es unknown
- 2020-12-16 WO PCT/IB2020/062036 patent/WO2021124155A1/en active Application Filing
- 2020-12-16 IL IL293831A patent/IL293831B2/en unknown
- 2020-12-17 CA CA3103120A patent/CA3103120A1/en active Pending
- 2020-12-18 US US17/126,358 patent/US11661419B2/en active Active
- 2020-12-18 TW TW109144868A patent/TWI766484B/zh active
- 2020-12-21 UY UY0001038998A patent/UY38998A/es unknown
-
2022
- 2022-06-14 CO CONC2022/0008313A patent/CO2022008313A2/es unknown
- 2022-06-17 CL CL2022001675A patent/CL2022001675A1/es unknown
- 2022-06-17 DO DO2022000130A patent/DOP2022000130A/es unknown
- 2022-06-20 EC ECSENADI202249160A patent/ECSP22049160A/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20210188829A1 (en) | 2021-06-24 |
IL293831B1 (en) | 2023-10-01 |
TW202130634A (zh) | 2021-08-16 |
CL2022001675A1 (es) | 2023-03-17 |
EP4077316A1 (en) | 2022-10-26 |
CN115087655A (zh) | 2022-09-20 |
ECSP22049160A (es) | 2022-07-29 |
TWI766484B (zh) | 2022-06-01 |
AU2020405536A1 (en) | 2022-07-14 |
CO2022008313A2 (es) | 2022-07-08 |
IL293831B2 (en) | 2024-02-01 |
AU2020405536B2 (en) | 2023-09-07 |
CR20220299A (es) | 2022-08-05 |
UY38998A (es) | 2021-07-30 |
CA3103120A1 (en) | 2021-06-20 |
KR20220118525A (ko) | 2022-08-25 |
IL293831A (en) | 2022-08-01 |
JP2023507138A (ja) | 2023-02-21 |
US11661419B2 (en) | 2023-05-30 |
WO2021124155A1 (en) | 2021-06-24 |
MX2022007518A (es) | 2022-09-19 |
PE20221916A1 (es) | 2022-12-23 |
DOP2022000130A (es) | 2022-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022011838A2 (pt) | Derivados de benzimidazol | |
BR112016015983A2 (pt) | Compostos de indazol como inibidores de irak4, seus usos, e composição farmacêutica | |
CO2017009891A2 (es) | Inhibidores de inhibidores del factor beta de crecimiento de transformación (tgf-beta) | |
BR112018015273A2 (pt) | derivados de benzimidazol como moduladores de ror-gama | |
BR112016016844A2 (pt) | Compostos heterocíclicos | |
BR112018077015A2 (pt) | derivados de ácido borônico e usos terapêuticos dos mesmos | |
CO7350655A2 (es) | Derivados de 5-fenoxi-3h-pirimidin-4-ona y su uso como inhibidores de la transcriptasa inversa del vih | |
EA201591339A1 (ru) | Тиазолкарбоксамиды и пиридинкарбоксамиды, используемые в качестве ингибиторов pim-киназы | |
EA201891917A1 (ru) | Бициклические гетероциклические производные в качестве ингибиторов irak4 | |
BR112014000713A2 (pt) | derivados de indol substituído como moduladores de gama secretase | |
BR112018076169A2 (pt) | derivados azabenzimidazol como inibidores de pi3k beta | |
BR112017026159A2 (pt) | inibidores heterocíclicos de erk1 e erk2 e seu uso no tratamento de câncer | |
MX2016016530A (es) | Inhibidores de fosfatidilinositol 3-quinasa. | |
NZ726052A (en) | Phosphatidylinositol 3-kinase inhibitors | |
BR112019024830A2 (pt) | inibidores de bcl6 derivados de benzimidazolona | |
BR112017026224A2 (pt) | moduladores de ror gama (rory) | |
DOP2018000035A (es) | Derivados del ácido 5-(n-bencil-tetrahidroisoquinolin-6-il)-piridin-3-il acético como inhibidores de la replicación del virus de la inmunodeficiencia humana | |
UY31865A (es) | Derivados de urea heterocíclicos y métodos para la utilización de los mismos | |
UY32856A (es) | Derivados heterocíclicos de urea y métodos de uso de los mismos | |
CO2023008921A2 (es) | N-(2-(4-cianotiazolidin-3-il)-2-oxoetil)-quinolin-4-carboxamidas | |
ECSP21037191A (es) | Pirazoles como moduladores de la hemoglobina | |
BR112015031846A8 (pt) | derivados de estratrientiazol, seus usos, e composição farmacêutica | |
CO2023017151A2 (es) | Inhibidores de ripk1 de nicotinamida | |
BR112023017040A2 (pt) | Derivados de indolina como inibidores de ddr1 e ddr2 | |
BR112022005723A2 (pt) | Compostos de indol carboxamida e seu uso para o tratamento de infecções micobacterianas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25G | Requested change of headquarter approved |
Owner name: PFIZER INC. (US) |
|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |