MX2016016538A - Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa. - Google Patents

Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa.

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Publication number
MX2016016538A
MX2016016538A MX2016016538A MX2016016538A MX2016016538A MX 2016016538 A MX2016016538 A MX 2016016538A MX 2016016538 A MX2016016538 A MX 2016016538A MX 2016016538 A MX2016016538 A MX 2016016538A MX 2016016538 A MX2016016538 A MX 2016016538A
Authority
MX
Mexico
Prior art keywords
phosphatidylinositol
compounds
kinase inhibitors
quinazolinone derivatives
tautomer
Prior art date
Application number
MX2016016538A
Other languages
English (en)
Inventor
Phillips Gary
W Phillips Barton
Evarts Jerry
Kaplan Joshua
Patel Leena
Perreault Stephane
A Treiberg Jennifer
Chung Yeung Suet
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2016016538A publication Critical patent/MX2016016538A/es

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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

La presente solicitud provee los compuestos de la fórmula (J), o sales farmacéuticamente aceptables, isómeros, tautómero, o una mezcla de los mismos, en la cual X, Y, Z, n, m', A', R1, R2 y R3 se describen en la presente solicitud. Los compuestos son inhibidores para las actividades de fosfatidilinositol 3-cinasa (PI3K) y son útiles para tratar condiciones mediadas por una o más isoformas de PI3K. La presente solicitud también provee composiciones farmacéuticas que incluyen un compuesto de la fórmula (1), o sales farmacéuticamente aceptables, isómeros, tautómero o mezcla de los mismos, y métodos para utilizar estos compuestos y composiciones para tratar condiciones mediadas por una o más isoformas de PI3K.
MX2016016538A 2014-06-13 2015-06-10 Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa. MX2016016538A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462011775P 2014-06-13 2014-06-13
PCT/US2015/035145 WO2015191743A1 (en) 2014-06-13 2015-06-10 Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2016016538A true MX2016016538A (es) 2017-05-01

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MX2016016538A MX2016016538A (es) 2014-06-13 2015-06-10 Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa.

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Country Link
US (1) US10308639B2 (es)
EP (1) EP3154961B1 (es)
JP (1) JP6383810B2 (es)
KR (1) KR20170015508A (es)
CN (1) CN106459012A (es)
AR (1) AR100806A1 (es)
AU (1) AU2015274626C1 (es)
BR (1) BR112016028876A2 (es)
CA (1) CA2952018A1 (es)
EA (1) EA201692266A1 (es)
ES (1) ES2763104T3 (es)
IL (1) IL248789A0 (es)
MX (1) MX2016016538A (es)
NZ (1) NZ726055A (es)
SG (1) SG11201609527PA (es)
TW (1) TW201625590A (es)
WO (1) WO2015191743A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2016016516A (es) 2014-06-13 2017-05-01 Gilead Sciences Inc Inhibidores de fosfatidilinositol 3-cinasa.
NZ726360A (en) 2014-06-13 2018-04-27 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
KR20170010063A (ko) 2014-06-13 2017-01-25 길리애드 사이언시즈, 인코포레이티드 포스파티딜이노시톨 3-키나제 억제제
CA2952018A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
US9499523B2 (en) 2014-06-13 2016-11-22 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
CA2972259A1 (en) 2014-12-26 2016-06-30 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
KR101932146B1 (ko) 2016-07-14 2018-12-24 주식회사 바이오웨이 Pi3k를 억제하는 신규한 퀴나졸리논 유도체 및 이를 포함하는 약학적 조성물
RU2020116571A (ru) 2017-12-07 2021-11-22 Эмори Юниверсити N4-гидроксицитидин и производные и связанные с этим противовирусные применения
AU2019209960B2 (en) 2018-01-20 2023-11-23 Sunshine Lake Pharma Co., Ltd. Substituted aminopyrimidine compounds and methods of use
CN108546268B (zh) * 2018-05-28 2019-04-09 西安培华学院 用于治疗动脉粥样硬化的化合物及其应用
CN110013483B (zh) * 2019-05-10 2022-04-15 江苏师范大学 噻唑并[3,2-a]嘧啶-6-甲腈衍生物用于抗菌的用途
CN113512042A (zh) * 2020-04-09 2021-10-19 成都赜灵生物医药科技有限公司 取代喹唑啉-4-酮类化合物及其制备方法和用途
CN117222413A (zh) * 2021-02-10 2023-12-12 同润生物医药(上海)有限公司 ***的方法和组合

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020062930A (ko) 1999-10-27 2002-07-31 싸이토키네틱스, 인코포레이티드 퀴나졸리논을 사용하는 방법 및 조성물
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
CN1440408B (zh) 2000-04-25 2012-07-18 艾科斯有限公司 人磷脂酰肌醇3-激酶δ的抑制剂
EP1761540B1 (en) 2004-05-13 2016-09-28 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
EP1885356A2 (en) 2005-02-17 2008-02-13 Icos Corporation Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
MX2010007419A (es) 2008-01-04 2010-11-12 Intellikine Inc Ciertas entidades quimicas, composiciones y metodos.
US8399460B2 (en) 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
EP2516417B1 (en) 2009-12-22 2017-10-11 Vertex Pharmaceuticals Incorporated Isoindolinone inhibitors of phosphatidylinositol 3-kinase
US8604032B2 (en) 2010-05-21 2013-12-10 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
TWI642670B (zh) 2010-09-14 2018-12-01 伊塞利克斯公司 Ｐｉ３ｋ-德爾塔抑制劑以及其應用和生產方法
US20130196990A1 (en) 2010-10-06 2013-08-01 Junya Qu Benzimidazole Derivatives As PI3 Kinase Inhibitors
PT2658844T (pt) 2010-12-28 2017-01-24 Sanofi Sa Novos derivados de pirimidinas, sua preparação e utilização farmacêutica como inibidores de fosforilação de akt (pkb)
EP2518070A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Pyrrolotriazinone derivatives as PI3K inhibitors
KR20140075693A (ko) 2011-08-29 2014-06-19 인피니티 파마슈티칼스, 인코포레이티드 헤테로사이클릭 화합물 및 그의 용도
SG10202003090VA (en) 2012-08-08 2020-05-28 Kbp Biosciences Co Ltd PI3K δ INHIBITOR
PT2941426T (pt) 2012-12-21 2018-07-18 Gilead Calistoga Llc Quinazolinonas aminoalquis de pirimidina substituída como inibidores de fosfatidilinositol 3-quinase
JP6207100B2 (ja) 2012-12-21 2017-10-04 ギリアード カリストガ エルエルシー イソキノリノンまたはキナゾリノンホスファチジルイノシトール３−キナーゼ阻害剤
WO2014128612A1 (en) * 2013-02-20 2014-08-28 Novartis Ag Quinazolin-4-one derivatives
EP3008053B1 (en) 2013-06-14 2018-03-21 Gilead Calistoga LLC Phosphatidylinositol 3-kinase inhibitors
UY35675A (es) 2013-07-24 2015-02-27 Novartis Ag Derivados sustituidos de quinazolin-4-ona
US9657007B2 (en) 2013-09-22 2017-05-23 Calitor Sciences, Llc Substituted aminopyrimidine compounds and methods of use
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2014354769A1 (en) 2013-11-26 2016-05-26 Gilead Sciences, Inc. Therapies for treating myeloproliferative disorders
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
NZ726360A (en) 2014-06-13 2018-04-27 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
KR20170010063A (ko) 2014-06-13 2017-01-25 길리애드 사이언시즈, 인코포레이티드 포스파티딜이노시톨 3-키나제 억제제
MX2016016516A (es) 2014-06-13 2017-05-01 Gilead Sciences Inc Inhibidores de fosfatidilinositol 3-cinasa.
CA2952018A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
US9499523B2 (en) 2014-06-13 2016-11-22 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
NZ727185A (en) 2014-06-24 2018-04-27 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors

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