MX2021007271A - Nuevas moleculas de acido nucleico conjugado y sus usos. - Google Patents
Nuevas moleculas de acido nucleico conjugado y sus usos.Info
- Publication number
- MX2021007271A MX2021007271A MX2021007271A MX2021007271A MX2021007271A MX 2021007271 A MX2021007271 A MX 2021007271A MX 2021007271 A MX2021007271 A MX 2021007271A MX 2021007271 A MX2021007271 A MX 2021007271A MX 2021007271 A MX2021007271 A MX 2021007271A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- acid molecules
- conjugated nucleic
- new conjugated
- new
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a nuevas moléculas de ácido nucleico de interés terapéutico, en particular para uso en el tratamiento del cáncer.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18306826 | 2018-12-21 | ||
EP18306829 | 2018-12-21 | ||
EP19202834 | 2019-10-11 | ||
EP19202837 | 2019-10-11 | ||
PCT/EP2019/086672 WO2020127965A1 (en) | 2018-12-21 | 2019-12-20 | New conjugated nucleic acid molecules and their uses |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021007271A true MX2021007271A (es) | 2021-07-15 |
Family
ID=69005729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007271A MX2021007271A (es) | 2018-12-21 | 2019-12-20 | Nuevas moleculas de acido nucleico conjugado y sus usos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220054524A1 (es) |
EP (1) | EP3898974A1 (es) |
JP (2) | JP7450622B2 (es) |
KR (1) | KR20210109564A (es) |
CN (1) | CN113166762A (es) |
AU (1) | AU2019408408A1 (es) |
BR (1) | BR112021012066A2 (es) |
CA (1) | CA3118182A1 (es) |
IL (1) | IL282838A (es) |
MX (1) | MX2021007271A (es) |
WO (1) | WO2020127965A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019175132A1 (en) * | 2018-03-13 | 2019-09-19 | Onxeo | A dbait molecule against acquired resistance in the treatment of cancer |
WO2023111203A1 (en) | 2021-12-16 | 2023-06-22 | Onxeo | New conjugated nucleic acid molecules and their uses |
Family Cites Families (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2392477A1 (en) | 1999-11-30 | 2001-06-07 | Mayo Foundation For Medical Education And Research | B7-h1, a novel immunoregulatory molecule |
US7875612B2 (en) | 2001-04-24 | 2011-01-25 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
CA2465129A1 (en) * | 2001-10-29 | 2003-05-08 | Mcgill University | Acyclic linker-containing oligonucleotides and uses thereof |
ATE481985T1 (de) | 2002-07-03 | 2010-10-15 | Ono Pharmaceutical Co | Immunpotenzierende zusammensetzungen |
CA2508660C (en) | 2002-12-23 | 2013-08-20 | Wyeth | Antibodies against pd-1 and uses therefor |
RU2404993C2 (ru) | 2003-07-02 | 2010-11-27 | Иннейт Фарма | Композиции и способы регуляции клеточной активности nk |
CA2532547C (en) | 2003-07-24 | 2020-02-25 | Innate Pharma | Methods and compositions for increasing the efficiency of therapeutic antibodies using nk cell potentiating compounds |
EP1526177A1 (en) | 2003-10-24 | 2005-04-27 | Institut Curie | Nucleic acids useful for triggering tumor cell lethality |
US7476729B2 (en) | 2003-10-24 | 2009-01-13 | Institut Curie | Dbait and uses thereof |
WO2007040469A2 (en) | 2005-09-15 | 2007-04-12 | Kosak Ken M | Chloroquine coupled compositions and methods for their synthesis |
US20090196850A1 (en) | 2005-01-06 | 2009-08-06 | Novo Nordisk A/S | Anti-Kir Combination Treatments and Methods |
JP5295568B2 (ja) | 2005-01-06 | 2013-09-18 | ノヴォ ノルディスク アー/エス | Kir結合剤およびその使用方法 |
SI2439273T1 (sl) | 2005-05-09 | 2019-05-31 | Ono Pharmaceutical Co., Ltd. | Človeška monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka z uporabo protiteles proti PD-1 samostojno ali v kombinaciji z ostalimi imunoterapevtiki |
CN101248089A (zh) | 2005-07-01 | 2008-08-20 | 米德列斯公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
US9447185B2 (en) | 2005-10-14 | 2016-09-20 | Innate Pharma, S.A. | Compositions and methods for treating proliferative disorders |
AU2007285782B2 (en) | 2006-08-18 | 2010-06-24 | Arrowhead Research Corporation | Polyconjugates for in vivo delivery of polynucleotides |
AU2008204433B2 (en) | 2007-01-11 | 2014-03-13 | Novo Nordisk A/S | Anti-KIR antibodies, formulations, and uses thereof |
EP1944369A1 (en) | 2007-01-12 | 2008-07-16 | The Centre National de la Recherche Scientifique | Dbait and its standalone uses thereof |
EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
US9244059B2 (en) | 2007-04-30 | 2016-01-26 | Immutep Parc Club Orsay | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
KR101586617B1 (ko) | 2007-06-18 | 2016-01-20 | 머크 샤프 앤 도메 비.브이. | 사람 프로그램된 사멸 수용체 pd-1에 대한 항체 |
CN110698561A (zh) | 2007-12-14 | 2020-01-17 | 诺沃—诺迪斯克有限公司 | 抗人nkg2d抗体及其用途 |
WO2009101611A1 (en) | 2008-02-11 | 2009-08-20 | Curetech Ltd. | Monoclonal antibodies for tumor treatment |
EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
WO2009126933A2 (en) | 2008-04-11 | 2009-10-15 | Alnylam Pharmaceuticals, Inc. | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
WO2010017103A2 (en) | 2008-08-04 | 2010-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Fully human anti-human nkg2d monoclonal antibodies |
AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
PE20110435A1 (es) | 2008-08-25 | 2011-07-20 | Amplimmune Inc | Composiciones antagonistas del pd-1 |
JP2012510429A (ja) | 2008-08-25 | 2012-05-10 | アンプリミューン、インコーポレーテッド | Pd−1アンタゴニストおよびその使用方法 |
WO2010029435A1 (en) | 2008-09-12 | 2010-03-18 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
SI2342226T1 (sl) | 2008-09-26 | 2016-11-30 | Dana-Farber Cancer Institute Inc. | Humana protitelesa proti PD-1, PD-L1 in PD-L2 in njihove uporabe |
WO2010065939A1 (en) | 2008-12-05 | 2010-06-10 | Indiana University Research & Technology Corporation | Combination therapy to enhace nk cell mediated cytotoxicty |
US10865233B2 (en) | 2008-12-18 | 2020-12-15 | Dana-Farber Cancer Institute, Inc. | NKG2D-fc for immunotherapy |
US20130017199A1 (en) | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
ES2646863T3 (es) | 2009-11-24 | 2017-12-18 | Medimmune Limited | Agentes de unión específica contra B7-H1 |
US8993731B2 (en) | 2010-03-11 | 2015-03-31 | Ucb Biopharma Sprl | PD-1 antibody |
EP2581113B1 (en) | 2010-06-11 | 2018-05-09 | Kyowa Hakko Kirin Co., Ltd. | Anti-tim-3 antibody |
JP2013532153A (ja) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体 |
PL3135301T3 (pl) * | 2010-06-22 | 2018-11-30 | Onxeo | Zoptymalizowany system dostarczania in vivo z czynnikami andosomolitycznymi koniugatów kwasów nukleinowych |
US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
AR083957A1 (es) | 2010-11-22 | 2013-04-10 | Innate Pharma Sa | Tratamiento para modular las celulas nk y metodos para tratar malignidad hematologica |
DK2699264T3 (en) | 2011-04-20 | 2018-06-25 | Medimmune Llc | ANTIBODIES AND OTHER MOLECULES BINDING B7-H1 AND PD-1 |
CN103717619B (zh) | 2011-05-25 | 2018-11-13 | 因内特制药股份有限公司 | 治疗发炎及自体免疫疾病之抗-kir抗体 |
EP2527440A1 (en) * | 2011-05-27 | 2012-11-28 | Institut Curie | Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia |
US8841418B2 (en) | 2011-07-01 | 2014-09-23 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to TIM3 |
DK2785375T3 (da) | 2011-11-28 | 2020-10-12 | Merck Patent Gmbh | Anti-pd-l1-antistoffer og anvendelser deraf |
KR102410078B1 (ko) | 2012-05-31 | 2022-06-22 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Pd-l1에 결합하는 항원 결합 단백질 |
AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
CN111499755A (zh) | 2012-08-03 | 2020-08-07 | 丹娜法伯癌症研究院 | 抗-pd-l1和pd-l2双结合抗体单一试剂及其使用方法 |
SI2904011T1 (sl) | 2012-10-02 | 2017-10-30 | Bristol-Myers Squibb Company | Kombinacija anti-kir protiteles in anti-pd-1 protiteles za zdravljenje raka |
CN107892719B (zh) | 2012-10-04 | 2022-01-14 | 达纳-法伯癌症研究所公司 | 人单克隆抗-pd-l1抗体和使用方法 |
AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
CA2906356A1 (en) | 2013-03-15 | 2014-09-18 | Novelogics Biotechnology, Inc. | Antibodies to mica and micb proteins |
JP6224739B2 (ja) | 2013-03-15 | 2017-11-01 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 抗lag−3結合タンパク質 |
WO2014170441A1 (en) * | 2013-04-19 | 2014-10-23 | Dna Therapeutics | Inhibition of dna damage repair by artificial activation of parp with oligonucleotide molecules |
SG11201508528TA (en) | 2013-05-02 | 2015-11-27 | Anaptysbio Inc | Antibodies directed against programmed death-1 (pd-1) |
US9676853B2 (en) | 2013-05-31 | 2017-06-13 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-1 |
US20160145355A1 (en) | 2013-06-24 | 2016-05-26 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
PL3702373T3 (pl) | 2013-09-13 | 2022-12-05 | Beigene Switzerland Gmbh | Przeciwciała anty-PD1 i ich zastosowanie jako środki terapeutyczne i diagnostyczne |
US10202454B2 (en) | 2013-10-25 | 2019-02-12 | Dana-Farber Cancer Institute, Inc. | Anti-PD-L1 monoclonal antibodies and fragments thereof |
WO2015081158A1 (en) | 2013-11-26 | 2015-06-04 | Bristol-Myers Squibb Company | Method of treating hiv by disrupting pd-1/pd-l1 signaling |
SG10201804945WA (en) | 2013-12-12 | 2018-07-30 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
HUE057917T2 (hu) | 2014-01-15 | 2022-06-28 | Kadmon Corp Llc | Immunmodulátor szerek |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
EP3988572A1 (en) | 2014-01-28 | 2022-04-27 | Bristol-Myers Squibb Company | Anti-lag-3 antibodies to treat hematological malignancies |
EP3149042B1 (en) | 2014-05-29 | 2019-08-28 | Spring Bioscience Corporation | Pd-l1 antibodies and uses thereof |
WO2015195163A1 (en) | 2014-06-20 | 2015-12-23 | R-Pharm Overseas, Inc. | Pd-l1 antagonist fully human antibody |
TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
KR102130600B1 (ko) | 2014-07-03 | 2020-07-08 | 베이진 엘티디 | Pd-l1 항체와 이를 이용한 치료 및 진단 |
JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
MX2017005920A (es) | 2014-11-06 | 2017-06-27 | Hoffmann La Roche | Anticuerpos anti-tim3 y metodos de uso. |
TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
WO2016111947A2 (en) | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof |
CN107922484A (zh) | 2015-03-06 | 2018-04-17 | 索伦托治疗有限公司 | 结合tim3的抗体治疗剂 |
ES2926369T3 (es) | 2015-03-27 | 2022-10-25 | Bonac Corp | Molécula de ácido nucleico monocatenario que tiene función de suministro y capacidad de control de la expresión génica |
MA41867A (fr) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
DK3594343T3 (da) * | 2015-07-23 | 2021-06-28 | Inst Curie | Anvendelse af en kombination af dbait-molekyle og parp-inhibitorer til behandling af kræft |
EP3373952A4 (en) | 2015-11-10 | 2019-05-22 | Fred Hutchinson Cancer Research Center | NKG2D decoys |
WO2017081190A1 (en) | 2015-11-13 | 2017-05-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti- nkg2d single domain antibodies and uses thereof |
CN114853907A (zh) | 2015-11-13 | 2022-08-05 | 达纳-法伯癌症研究所有限公司 | 用于癌症免疫疗法的nkg2d-ig融合蛋白 |
KR102441432B1 (ko) | 2016-03-01 | 2022-09-07 | 옹쎄오 | Dbait 분자의 전신 투여에 의한 암 치료법 |
CA3016765A1 (en) | 2016-03-15 | 2017-09-21 | Innate Pharma | Anti-mica antibodies |
WO2017186882A1 (en) * | 2016-04-29 | 2017-11-02 | Onxeo | A method of predicting a response to an anti-tumor treatment by means of signal interfering dna molecules |
KR20190038919A (ko) | 2016-08-19 | 2019-04-09 | 얀센 바이오테크 인코포레이티드 | 항-nkg2d 항체로 크론병을 치료하는 방법 |
WO2018073648A1 (en) | 2016-10-19 | 2018-04-26 | Novelogics Biotechnology, Inc. | Antibodies to mica and micb proteins |
EP3579866A4 (en) | 2017-02-08 | 2020-12-09 | Dragonfly Therapeutics, Inc. | HEAVY CHAIN VARIABLE ANTIBODY DOMAINS WITH NKG2D RECEPTOR AIMING |
WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
-
2019
- 2019-12-20 KR KR1020217023171A patent/KR20210109564A/ko unknown
- 2019-12-20 BR BR112021012066A patent/BR112021012066A2/pt unknown
- 2019-12-20 WO PCT/EP2019/086672 patent/WO2020127965A1/en unknown
- 2019-12-20 JP JP2021534234A patent/JP7450622B2/ja active Active
- 2019-12-20 CA CA3118182A patent/CA3118182A1/en active Pending
- 2019-12-20 AU AU2019408408A patent/AU2019408408A1/en active Pending
- 2019-12-20 US US17/414,342 patent/US20220054524A1/en active Pending
- 2019-12-20 CN CN201980082033.6A patent/CN113166762A/zh active Pending
- 2019-12-20 EP EP19827746.9A patent/EP3898974A1/en active Pending
- 2019-12-20 MX MX2021007271A patent/MX2021007271A/es unknown
-
2021
- 2021-05-02 IL IL282838A patent/IL282838A/en unknown
-
2024
- 2024-02-29 JP JP2024029960A patent/JP2024054419A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112021012066A2 (pt) | 2021-11-03 |
IL282838A (en) | 2021-06-30 |
EP3898974A1 (en) | 2021-10-27 |
US20220054524A1 (en) | 2022-02-24 |
CA3118182A1 (en) | 2020-06-25 |
JP2024054419A (ja) | 2024-04-16 |
JP2022514259A (ja) | 2022-02-10 |
JP7450622B2 (ja) | 2024-03-15 |
WO2020127965A1 (en) | 2020-06-25 |
CN113166762A (zh) | 2021-07-23 |
KR20210109564A (ko) | 2021-09-06 |
AU2019408408A1 (en) | 2021-06-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12018502429A1 (en) | Antibody molecules for cancer treatment | |
MX2021006531A (es) | Composicion que contiene arn para tratamiento de enfermedades tumorales. | |
MX2019001920A (es) | Arn la terapia contra el cancer. | |
PH12019501959A1 (en) | Therapeutic rna | |
MX2019012233A (es) | Anticuerpos anti-sirpa. | |
BR112017024384A2 (pt) | bactérias modificadas para reduzir hiperfenilalaninemia | |
MD4733B1 (ro) | Anticorpi anti-TIGIT | |
BR112018003269A2 (pt) | conjugados de fármaco-anticorpo anti-dll3 e métodos de utilização | |
WO2017079570A3 (en) | Splise-switching oligonucleotides and methods of use | |
AU2018278311A1 (en) | IRE1 small molecule inhibitors | |
TR201901077T4 (tr) | Kanser Veya Enfeksiyon Tedavisine Yönelik Birleşik Preparasyonlar | |
MX2023002076A (es) | Conjugado de polimero util para tratar tumores ocasionados por disfuncion metabolica. | |
EA201591925A1 (ru) | Терапевтические композиции и их применение | |
MX2017011794A (es) | Composiciones y metodos para diagnosticos y tratamiento del cancer. | |
MX2020003219A (es) | Anticuerpos que tienen especificidad para btn2 y usos de los mismos. | |
EP4353320A3 (en) | Blood plasma and plasma fractions as therapy for tumor growth and progression | |
EA201791814A1 (ru) | Имидазолильные трициклические еноны как антиоксидантные модуляторы воспаления | |
MY200161A (en) | Bacteria for targeting tumors and treating cancer | |
PH12020551543A1 (en) | Therapeutic modulators of the reverse mode of atp synthase | |
MX2019008233A (es) | Nanoconjugados de doxorrubicina y oro dirigidos para terapia tumoral. | |
WO2019043176A3 (en) | HISTONE-DEACETYLASE INHIBITOR IN COMBINATION WITH ANTIMETABOLITE AGENT FOR CANCER THERAPY | |
MX2021007271A (es) | Nuevas moleculas de acido nucleico conjugado y sus usos. | |
MX2023007706A (es) | Nanoparticulas para su uso como vacuna terapeutica. | |
WO2015169811A3 (en) | Anti-cxc chemokine receptor-2 binding molecules and uses thereof | |
EP3581653A3 (en) | Methods and compositions for treating cancer using peptide nucleic acid-based agents |