MX2020010837A - Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. - Google Patents
Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina.Info
- Publication number
- MX2020010837A MX2020010837A MX2020010837A MX2020010837A MX2020010837A MX 2020010837 A MX2020010837 A MX 2020010837A MX 2020010837 A MX2020010837 A MX 2020010837A MX 2020010837 A MX2020010837 A MX 2020010837A MX 2020010837 A MX2020010837 A MX 2020010837A
- Authority
- MX
- Mexico
- Prior art keywords
- light chain
- chain variable
- immunoglobulin light
- mice expressing
- mice
- Prior art date
Links
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 title abstract 3
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 title abstract 3
- 241000699670 Mus sp. Species 0.000 title abstract 3
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un ratón genéticamente modificado, en donde el ratón expresa un repertorio de cadena ligera de inmunoglobulina caracterizado por un número limitado de dominios variables de cadena ligera. Se proporcionan ratones que presentan una elección de dos segmentos genéticos variables de cadena ligera humanos, de tal manera que las cadenas ligeras de inmunoglobulina expresadas por el ratón comprenden uno de los dos segmentos genéticos variables de cadena ligera humanos. Se proporcionan métodos para la elaboración de anticuerpos biespecíficos que tienen cadenas ligeras universales utilizando ratones, como se describen en la presente, incluyendo las regiones variables de cadena ligera humanas. Se proporcionan métodos para la elaboración de regiones variables humanas adecuadas para utilizarse en las proteínas de enlace multiespecíficas, por ejemplo, los anticuerpos biespecíficos, y células huésped.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,455 US9796788B2 (en) | 2010-02-08 | 2013-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
| PCT/US2014/026040 WO2014160202A1 (en) | 2013-03-13 | 2014-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020010837A true MX2020010837A (es) | 2022-03-28 |
Family
ID=50483561
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015012539A MX357308B (es) | 2013-03-13 | 2014-03-13 | Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. |
| MX2020010837A MX2020010837A (es) | 2013-03-13 | 2014-03-13 | Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015012539A MX357308B (es) | 2013-03-13 | 2014-03-13 | Ratones que expresan un repertorio limitado de cadena ligera de inmunoglobulina. |
Country Status (26)
| Country | Link |
|---|---|
| EP (3) | EP2967013B1 (es) |
| JP (4) | JP6529957B2 (es) |
| KR (2) | KR102295842B1 (es) |
| CN (2) | CN105188357B (es) |
| AU (3) | AU2014244020B2 (es) |
| BR (1) | BR112015022034B1 (es) |
| CA (1) | CA2903698C (es) |
| CY (1) | CY1121545T1 (es) |
| DK (2) | DK2967013T3 (es) |
| ES (2) | ES2712207T3 (es) |
| FI (1) | FI3501272T3 (es) |
| HK (1) | HK1218493A1 (es) |
| HR (2) | HRP20230490T1 (es) |
| HU (2) | HUE061977T2 (es) |
| IL (2) | IL240563B (es) |
| LT (2) | LT2967013T (es) |
| MX (2) | MX357308B (es) |
| PL (2) | PL2967013T3 (es) |
| PT (2) | PT3501272T (es) |
| RS (2) | RS58669B1 (es) |
| RU (1) | RU2689664C2 (es) |
| SG (2) | SG11201506278RA (es) |
| SI (2) | SI3501272T1 (es) |
| TR (1) | TR201901668T4 (es) |
| WO (1) | WO2014160202A1 (es) |
| ZA (2) | ZA201505835B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| EP2501817B2 (en) | 2010-02-08 | 2021-04-21 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| NZ781020A (en) | 2011-08-05 | 2023-01-27 | Regeneron Pharma | Humanized universal light chain mice |
| HUE057680T2 (hu) | 2011-10-17 | 2022-06-28 | Regeneron Pharma | Korlátozott immunglobulin-nehézlánccal rendelkezõ egerek |
| RS62121B1 (sr) | 2012-06-12 | 2021-08-31 | Regeneron Pharma | Humanizovane nehumane životinje sa ograničenim lokusima imunoglobulinskog teškog lanca |
| BR112015019350A2 (pt) * | 2013-02-20 | 2017-08-22 | Regeneron Pharma | Animal não humano, locus de imunoglobulina, e, métodos de fabricação de um animal não humano, para a obtenção de uma sequência de ácido nucleico e de fabricação de uma proteína de ligação ao antígeno |
| SG11201607203XA (en) | 2014-03-21 | 2016-09-29 | Regeneron Pharma | Non-human animals that make single domain binding proteins |
| AU2016232715A1 (en) | 2015-03-19 | 2017-09-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| MX2018008701A (es) | 2016-01-13 | 2019-06-06 | Regeneron Pharma | Roedores que tienen una region de diversidad de cadena pesada modificada geneticamente. |
| MX2020002976A (es) * | 2017-09-29 | 2020-07-24 | Regeneron Pharma | Moleculas de union a antigeno biespecificas que se unen a un antigeno objetivo de staphylococcus y a un componente de complemento, y usos de las mismas. |
| CA3103646C (en) | 2018-06-14 | 2023-06-27 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of engineered dh-dh rearrangement and uses thereof |
| US20220090125A1 (en) * | 2018-12-21 | 2022-03-24 | Compass Therapeutics Llc | Transgenic mouse expressing common human light chain |
| JP2022521358A (ja) | 2019-02-18 | 2022-04-06 | バイオサイトジェン ファーマシューティカルズ （ベイジン） カンパニー リミテッド | ヒト化免疫グロブリン遺伝子座を有する遺伝子改変非ヒト動物 |
| US11464217B2 (en) | 2019-02-22 | 2022-10-11 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| MX2023007583A (es) | 2020-12-23 | 2023-07-07 | Regeneron Pharma | Metodos para obtener anticuerpos que se unen a proteinas transmembranarias y celulas que los producen. |
| WO2022140219A1 (en) | 2020-12-23 | 2022-06-30 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN114736927A (zh) * | 2022-05-19 | 2022-07-12 | 东北大学 | 一种单抗克隆与表达载体的构建及应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| JP2007537704A (ja) * | 2003-07-15 | 2007-12-27 | セラピューティック ヒューマン ポリクローナルズ， インコーポレイテッド | ヒト化免疫グロブリン遺伝子座 |
| CA2583750C (en) | 2004-10-19 | 2015-11-24 | Regeneron Pharmaceuticals, Inc. | Methods for generating a rodent having a genetic modification |
| JP5514539B2 (ja) * | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
| US7582298B2 (en) | 2006-06-02 | 2009-09-01 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human IL-6 receptor |
| ITMI20071522A1 (it) * | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| PT2147594E (pt) * | 2008-06-27 | 2014-02-17 | Merus B V | Mamíferos não humanos que produzem anticorpos |
| CN112626117A (zh) * | 2008-12-18 | 2021-04-09 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| EP2445936A1 (en) | 2009-06-26 | 2012-05-02 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
| EP2501817B2 (en) * | 2010-02-08 | 2021-04-21 | Regeneron Pharmaceuticals, Inc. | Common light chain mouse |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| CN103068993B (zh) * | 2010-06-22 | 2016-01-06 | 瑞泽恩制药公司 | 杂交轻链小鼠 |
| ES2612459T3 (es) * | 2010-08-02 | 2017-05-17 | Regeneron Pharmaceuticals, Inc. | Ratones que producen proteínas de unión que comprenden dominios VL |
| RU2460287C1 (ru) * | 2011-03-29 | 2012-09-10 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) | Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии |
| NZ781020A (en) * | 2011-08-05 | 2023-01-27 | Regeneron Pharma | Humanized universal light chain mice |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
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2014
- 2014-03-13 TR TR2019/01668T patent/TR201901668T4/tr unknown
- 2014-03-13 KR KR1020157026152A patent/KR102295842B1/ko active IP Right Grant
- 2014-03-13 WO PCT/US2014/026040 patent/WO2014160202A1/en active Application Filing
- 2014-03-13 PT PT182105189T patent/PT3501272T/pt unknown
- 2014-03-13 SI SI201432022T patent/SI3501272T1/sl unknown
- 2014-03-13 HU HUE18210518A patent/HUE061977T2/hu unknown
- 2014-03-13 JP JP2016502035A patent/JP6529957B2/ja active Active
- 2014-03-13 EP EP14717331.4A patent/EP2967013B1/en active Active
- 2014-03-13 RS RS20190467A patent/RS58669B1/sr unknown
- 2014-03-13 SI SI201431079T patent/SI2967013T1/sl unknown
- 2014-03-13 SG SG11201506278RA patent/SG11201506278RA/en unknown
- 2014-03-13 KR KR1020217027031A patent/KR102424756B1/ko active IP Right Grant
- 2014-03-13 DK DK14717331.4T patent/DK2967013T3/en active
- 2014-03-13 HR HRP20230490TT patent/HRP20230490T1/hr unknown
- 2014-03-13 FI FIEP18210518.9T patent/FI3501272T3/fi active
- 2014-03-13 PT PT14717331T patent/PT2967013T/pt unknown
- 2014-03-13 SG SG10201801101QA patent/SG10201801101QA/en unknown
- 2014-03-13 EP EP23151398.7A patent/EP4218409A3/en active Pending
- 2014-03-13 CN CN201480013894.6A patent/CN105188357B/zh active Active
- 2014-03-13 CN CN201810439928.8A patent/CN108611369B/zh active Active
- 2014-03-13 PL PL14717331T patent/PL2967013T3/pl unknown
- 2014-03-13 ES ES14717331T patent/ES2712207T3/es active Active
- 2014-03-13 ES ES18210518T patent/ES2942413T3/es active Active
- 2014-03-13 MX MX2015012539A patent/MX357308B/es active IP Right Grant
- 2014-03-13 EP EP18210518.9A patent/EP3501272B1/en active Active
- 2014-03-13 RU RU2015143110A patent/RU2689664C2/ru active
- 2014-03-13 LT LTEP14717331.4T patent/LT2967013T/lt unknown
- 2014-03-13 DK DK18210518.9T patent/DK3501272T3/da active
- 2014-03-13 LT LTEP18210518.9T patent/LT3501272T/lt unknown
- 2014-03-13 BR BR112015022034-7A patent/BR112015022034B1/pt active IP Right Grant
- 2014-03-13 HU HUE14717331A patent/HUE044003T2/hu unknown
- 2014-03-13 RS RS20230350A patent/RS64185B1/sr unknown
- 2014-03-13 AU AU2014244020A patent/AU2014244020B2/en active Active
- 2014-03-13 CA CA2903698A patent/CA2903698C/en active Active
- 2014-03-13 MX MX2020010837A patent/MX2020010837A/es unknown
- 2014-03-13 PL PL18210518.9T patent/PL3501272T3/pl unknown
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2015
- 2015-08-13 IL IL240563A patent/IL240563B/en active IP Right Grant
- 2015-08-13 ZA ZA2015/05835A patent/ZA201505835B/en unknown
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2016
- 2016-06-06 HK HK16106453.9A patent/HK1218493A1/zh unknown
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2018
- 2018-08-13 ZA ZA2018/05369A patent/ZA201805369B/en unknown
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2019
- 2019-01-18 JP JP2019006738A patent/JP6790136B2/ja active Active
- 2019-04-05 CY CY20191100383T patent/CY1121545T1/el unknown
- 2019-04-16 HR HRP20190706TT patent/HRP20190706T1/hr unknown
- 2019-08-14 JP JP2019148806A patent/JP7010902B2/ja active Active
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2020
- 2020-05-19 AU AU2020203238A patent/AU2020203238B2/en active Active
- 2020-07-29 JP JP2020128111A patent/JP2020182490A/ja active Pending
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2021
- 2021-02-15 IL IL280892A patent/IL280892B2/en unknown
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2023
- 2023-05-04 AU AU2023202783A patent/AU2023202783A1/en active Pending
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