TR201901668T4 - Sınırlı bir immünoglobulin hafif zincir repertuvarını eksprese eden fareler. - Google Patents

Sınırlı bir immünoglobulin hafif zincir repertuvarını eksprese eden fareler. Download PDF

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Publication number
TR201901668T4
TR201901668T4 TR2019/01668T TR201901668T TR201901668T4 TR 201901668 T4 TR201901668 T4 TR 201901668T4 TR 2019/01668 T TR2019/01668 T TR 2019/01668T TR 201901668 T TR201901668 T TR 201901668T TR 201901668 T4 TR201901668 T4 TR 201901668T4
Authority
TR
Turkey
Prior art keywords
light chain
chain variable
mouse
immunoglobulin light
human
Prior art date
Application number
TR2019/01668T
Other languages
English (en)
Inventor
Babb Robert
Mcwhirter John
Macdonald Lynn
Stevens Sean
Davis Samuel
R Buckler David
A Meagher Karolina
J Murphy Andrew
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/798,455 external-priority patent/US9796788B2/en
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of TR201901668T4 publication Critical patent/TR201901668T4/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic

Abstract

Genetiği değiştirilmiş bir fare sağlanmaktadır, burada fare, sınırlı sayıdaki hafif zincir değişken alanları ile karakterize edilen bir immünoglobulin hafif zincir repertuvarını eksprese etmektedir. İki insan hafif zincir değişken gen segmentine dair bir tercih sunan fareler sağlanmaktadır, böylelikle fare tarafından eksprese edilen immünoglobulin hafif zincirler, iki insan hafif zincir değişken gen segmentinden birini içermektedir. İnsan hafif zincir değişken bölgeleri de dahil olmak üzere burada açıklanan fare kullanılarak evrensel hafif zincirlere sahip bispesifik antikorların meydana getirilmesine yönelik yöntemler sağlanmaktadır. Multispesifik bağlama proteinleri, örneğin bispesifik antikorlar ve konak hücrelerinde kullanım için uygun olan insan değişken bölgelerinin meydana getirilmesine yönelik yöntemler sağlanmaktadır.
TR2019/01668T 2013-03-13 2014-03-13 Sınırlı bir immünoglobulin hafif zincir repertuvarını eksprese eden fareler. TR201901668T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/798,455 US9796788B2 (en) 2010-02-08 2013-03-13 Mice expressing a limited immunoglobulin light chain repertoire

Publications (1)

Publication Number Publication Date
TR201901668T4 true TR201901668T4 (tr) 2019-02-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/01668T TR201901668T4 (tr) 2013-03-13 2014-03-13 Sınırlı bir immünoglobulin hafif zincir repertuvarını eksprese eden fareler.

Country Status (26)

Country Link
EP (3) EP4218409A3 (tr)
JP (4) JP6529957B2 (tr)
KR (2) KR102295842B1 (tr)
CN (2) CN108611369B (tr)
AU (3) AU2014244020B2 (tr)
BR (1) BR112015022034B1 (tr)
CA (1) CA2903698C (tr)
CY (1) CY1121545T1 (tr)
DK (2) DK2967013T3 (tr)
ES (2) ES2712207T3 (tr)
FI (1) FI3501272T3 (tr)
HK (1) HK1218493A1 (tr)
HR (2) HRP20230490T1 (tr)
HU (2) HUE061977T2 (tr)
IL (2) IL240563B (tr)
LT (2) LT2967013T (tr)
MX (2) MX2020010837A (tr)
PL (2) PL2967013T3 (tr)
PT (2) PT2967013T (tr)
RS (2) RS64185B1 (tr)
RU (1) RU2689664C2 (tr)
SG (2) SG11201506278RA (tr)
SI (2) SI3501272T1 (tr)
TR (1) TR201901668T4 (tr)
WO (1) WO2014160202A1 (tr)
ZA (2) ZA201505835B (tr)

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ES2603559T5 (es) 2010-02-08 2021-02-22 Regeneron Pharma Cadena ligera común de ratón
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JP2020182490A (ja) 2020-11-12
KR20150126871A (ko) 2015-11-13
BR112015022034A2 (pt) 2017-08-29
EP4218409A3 (en) 2023-08-30
ES2712207T3 (es) 2019-05-09
PL2967013T3 (pl) 2019-07-31
MX2020010837A (es) 2022-03-28
IL280892B1 (en) 2023-01-01
HUE044003T2 (hu) 2019-09-30
CN105188357A (zh) 2015-12-23
LT3501272T (lt) 2023-03-27
EP2967013A1 (en) 2016-01-20
JP7010902B2 (ja) 2022-02-10
HUE061977T2 (hu) 2023-09-28
BR112015022034B1 (pt) 2023-02-28
HRP20190706T1 (hr) 2019-10-18
ZA201505835B (en) 2019-09-25
WO2014160202A1 (en) 2014-10-02
KR102295842B1 (ko) 2021-08-31
IL280892A (en) 2021-04-29
SG11201506278RA (en) 2015-09-29
DK2967013T3 (en) 2019-03-11
NZ711776A (en) 2021-09-24
LT2967013T (lt) 2019-04-25
ZA201805369B (en) 2021-08-25
KR102424756B1 (ko) 2022-07-25
JP2019213549A (ja) 2019-12-19
RU2689664C2 (ru) 2019-05-28
PL3501272T3 (pl) 2023-07-03
EP2967013B1 (en) 2019-01-16
RS64185B1 (sr) 2023-05-31
JP6790136B2 (ja) 2020-11-25
KR20210107911A (ko) 2021-09-01
SI3501272T1 (sl) 2023-05-31
PT3501272T (pt) 2023-03-29
JP6529957B2 (ja) 2019-06-12
IL240563A0 (en) 2015-09-24
JP2016512034A (ja) 2016-04-25
ES2942413T3 (es) 2023-06-01
EP3501272B1 (en) 2023-03-01
WO2014160202A4 (en) 2014-11-13
MX357308B (es) 2018-07-04
AU2020203238B2 (en) 2023-04-13
IL280892B2 (en) 2023-05-01
RU2019115237A (ru) 2019-06-11
CA2903698C (en) 2023-02-28
MX2015012539A (es) 2016-06-28
AU2014244020A1 (en) 2015-09-24
IL240563B (en) 2021-03-25
CY1121545T1 (el) 2020-05-29
EP3501272A1 (en) 2019-06-26
FI3501272T3 (fi) 2023-04-06
CA2903698A1 (en) 2014-10-02
PT2967013T (pt) 2019-04-03
EP4218409A2 (en) 2023-08-02
AU2023202783A1 (en) 2023-05-25
SG10201801101QA (en) 2018-04-27
RU2015143110A (ru) 2017-04-18
CN105188357B (zh) 2018-04-24
CN108611369A (zh) 2018-10-02
SI2967013T1 (sl) 2019-03-29
CN108611369B (zh) 2022-08-26
DK3501272T3 (da) 2023-04-03
AU2020203238A1 (en) 2020-06-11
JP2019076109A (ja) 2019-05-23
AU2014244020B2 (en) 2020-06-04
HRP20230490T1 (hr) 2023-08-04
RS58669B1 (sr) 2019-06-28
HK1218493A1 (zh) 2017-02-24

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