CY1121545T1 - Ποντικοι που εκφραζουν περιορισμενο ρεπερτοριο ελαφριων αλυσιδων ανοσοσφαιρινης - Google Patents
Ποντικοι που εκφραζουν περιορισμενο ρεπερτοριο ελαφριων αλυσιδων ανοσοσφαιρινηςInfo
- Publication number
- CY1121545T1 CY1121545T1 CY20191100383T CY191100383T CY1121545T1 CY 1121545 T1 CY1121545 T1 CY 1121545T1 CY 20191100383 T CY20191100383 T CY 20191100383T CY 191100383 T CY191100383 T CY 191100383T CY 1121545 T1 CY1121545 T1 CY 1121545T1
- Authority
- CY
- Cyprus
- Prior art keywords
- light chain
- light chains
- spherin
- reporter
- immune
- Prior art date
Links
- 241000699670 Mus sp. Species 0.000 title abstract 3
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 3
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 abstract 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Παρέχεται ένας γενετικά τροποποιημένος ποντικός, όπου ο ποντικός εκφράζει ένα ρεπερτόριο ελαφριών αλυσίδων ανοσοσφαιρίνης που χαρακτηρίζονται από περιορισμένο αριθμό μεταβλητών τομέων ελαφριάς αλυσίδας. Παρέχονται ποντικοί που παρουσιάζουν μια επιλογή από δύο ανθρώπινα γονιδιακά τμήματα μεταβλητής περιοχής ελαφριάς αλυσίδας, έτσι ώστε οι ελαφριές αλυσίδες της ανοσοσφαιρίνης που εκφράζονται από τον ποντικό να περιλαμβάνουν ένα από τα δύο ανθρώπινα γονιδιακά τμήματα μεταβλητής περιοχής ελαφριάς αλυσίδας. Παρέχονται μέθοδοι για τη δημιουργία αμφιειδικών αντισωμάτων που έχουν καθολικές ελαφριές αλυσίδες χρησιμοποιώντας ποντικούς που περιγράφονται στο παρόν, που συμπεριλαμβάνουν τις ανθρώπινες μεταβλητές περιοχές ελαφριάς αλυσίδας. Παρέχονται μέθοδοι για τη δημιουργία ανθρώπινων μεταβλητών περιοχών κατάλληλων για χρήση σε πολυειδικές πρωτεΐνες δέσμευσης, π.χ. αμφιειδικά αντισώματα, καθώς και κύτταρα ξενιστές.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/798,455 US9796788B2 (en) | 2010-02-08 | 2013-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
| PCT/US2014/026040 WO2014160202A1 (en) | 2013-03-13 | 2014-03-13 | Mice expressing a limited immunoglobulin light chain repertoire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121545T1 true CY1121545T1 (el) | 2020-05-29 |
Family
ID=50483561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100383T CY1121545T1 (el) | 2013-03-13 | 2019-04-05 | Ποντικοι που εκφραζουν περιορισμενο ρεπερτοριο ελαφριων αλυσιδων ανοσοσφαιρινης |
Country Status (26)
| Country | Link |
|---|---|
| EP (3) | EP3501272B1 (el) |
| JP (4) | JP6529957B2 (el) |
| KR (2) | KR102295842B1 (el) |
| CN (2) | CN105188357B (el) |
| AU (3) | AU2014244020B2 (el) |
| BR (1) | BR112015022034B1 (el) |
| CA (1) | CA2903698C (el) |
| CY (1) | CY1121545T1 (el) |
| DK (2) | DK2967013T3 (el) |
| ES (2) | ES2712207T3 (el) |
| FI (1) | FI3501272T3 (el) |
| HK (1) | HK1218493A1 (el) |
| HR (2) | HRP20230490T1 (el) |
| HU (2) | HUE061977T2 (el) |
| IL (2) | IL240563B (el) |
| LT (2) | LT3501272T (el) |
| MX (2) | MX357308B (el) |
| PL (2) | PL2967013T3 (el) |
| PT (2) | PT2967013T (el) |
| RS (2) | RS64185B1 (el) |
| RU (1) | RU2689664C2 (el) |
| SG (2) | SG11201506278RA (el) |
| SI (2) | SI3501272T1 (el) |
| TR (1) | TR201901668T4 (el) |
| WO (1) | WO2014160202A1 (el) |
| ZA (2) | ZA201505835B (el) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2603559T5 (es) | 2010-02-08 | 2021-02-22 | Regeneron Pharma | Cadena ligera común de ratón |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| SI3572517T1 (sl) | 2011-08-05 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Humanizirana miš z univerzalno lahko verigo |
| DK2627773T3 (en) | 2011-10-17 | 2017-10-02 | Regeneron Pharma | MOUSE WITH LIMITED IMMUNOGLOBULIN HEAVY CHAIN |
| HUE047266T2 (hu) | 2012-06-12 | 2020-04-28 | Regeneron Pharma | Korlátozott immunglobulin nehézlánc lókuszokkal rendelkezõ, humanizált, nem humán élõlények |
| SI2840892T1 (en) * | 2013-02-20 | 2018-08-31 | Regeneron Pharmaceuticals, Inc. | Animals other than humans with modified immunoglobulin heavy chain sequences |
| CA2942697A1 (en) | 2014-03-21 | 2015-09-24 | Lynn Macdonald | Non-human animals that make single domain binding proteins |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| EP4257599A3 (en) | 2016-01-13 | 2024-01-17 | Regeneron Pharmaceuticals, Inc. | Rodents having an engineered heavy chain diversity region |
| KR20200058525A (ko) * | 2017-09-29 | 2020-05-27 | 리제너론 파아마슈티컬스, 인크. | 스타필로코커스 표적 항원 및 보체 성분에 결합하는 이특이적 항원-결합 분자 및 이의 용도 |
| US20190380316A1 (en) | 2018-06-14 | 2019-12-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of engineered dh-dh rearrangement and uses thereof |
| EP3897117A1 (en) * | 2018-12-21 | 2021-10-27 | Compass Therapeutics LLC | Transgenic mouse expressing common human light chain |
| CA3125380A1 (en) | 2019-02-18 | 2020-08-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| WO2020172505A1 (en) | 2019-02-22 | 2020-08-27 | Regeneron Pharmaceuticals, Inc. | Rodents having genetically modified sodium channels and methods of use thereof |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| CN116635413A (zh) | 2020-12-23 | 2023-08-22 | 再生元制药公司 | 用于获得结合跨膜蛋白的抗体的方法和生产所述抗体的细胞 |
| EP4051700A1 (en) | 2020-12-23 | 2022-09-07 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
| CN114736927A (zh) * | 2022-05-19 | 2022-07-12 | 东北大学 | 一种单抗克隆与表达载体的构建及应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| WO2005007696A2 (en) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
| EP2767161B1 (en) | 2004-10-19 | 2018-02-07 | Regeneron Pharmaceuticals, Inc. | Method for generating an non-human animal homozygous for a genetic modification |
| EP2505058A1 (en) * | 2006-03-31 | 2012-10-03 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| ITMI20071522A1 (it) | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
| CN105191863B (zh) | 2008-06-27 | 2020-12-22 | 莫鲁斯股份有限公司 | 产生抗体的非人哺乳动物 |
| CN112715482B (zh) * | 2008-12-18 | 2022-11-11 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| EP2975051B1 (en) | 2009-06-26 | 2021-04-14 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
| ES2603559T5 (es) * | 2010-02-08 | 2021-02-22 | Regeneron Pharma | Cadena ligera común de ratón |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) * | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| SI2480676T1 (sl) * | 2010-06-22 | 2016-10-28 | Regeneron Pharmaceuticals, Inc. | Hibridna mišja lahka veriga |
| CN113150121A (zh) * | 2010-08-02 | 2021-07-23 | 瑞泽恩制药公司 | 制造包含vl结构域的结合蛋白的小鼠 |
| RU2460287C1 (ru) * | 2011-03-29 | 2012-09-10 | Государственное образовательное учреждение высшего профессионального образования "Российский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО РГМУ Росздрава) | Трансгенная мышь, предназначенная для моделирования состояний, угрожающих развитием синдрома внезапной сердечной смерти при дистрофин-дефицитной кардиомиопатии |
| SI3572517T1 (sl) * | 2011-08-05 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Humanizirana miš z univerzalno lahko verigo |
| GB201122047D0 (en) * | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
-
2014
- 2014-03-13 EP EP18210518.9A patent/EP3501272B1/en active Active
- 2014-03-13 CN CN201480013894.6A patent/CN105188357B/zh active Active
- 2014-03-13 SI SI201432022T patent/SI3501272T1/sl unknown
- 2014-03-13 FI FIEP18210518.9T patent/FI3501272T3/fi active
- 2014-03-13 JP JP2016502035A patent/JP6529957B2/ja active Active
- 2014-03-13 ES ES14717331T patent/ES2712207T3/es active Active
- 2014-03-13 TR TR2019/01668T patent/TR201901668T4/tr unknown
- 2014-03-13 KR KR1020157026152A patent/KR102295842B1/ko active IP Right Grant
- 2014-03-13 WO PCT/US2014/026040 patent/WO2014160202A1/en active Application Filing
- 2014-03-13 HU HUE18210518A patent/HUE061977T2/hu unknown
- 2014-03-13 SG SG11201506278RA patent/SG11201506278RA/en unknown
- 2014-03-13 DK DK14717331.4T patent/DK2967013T3/en active
- 2014-03-13 SI SI201431079T patent/SI2967013T1/sl unknown
- 2014-03-13 PL PL14717331T patent/PL2967013T3/pl unknown
- 2014-03-13 BR BR112015022034-7A patent/BR112015022034B1/pt active IP Right Grant
- 2014-03-13 KR KR1020217027031A patent/KR102424756B1/ko active IP Right Grant
- 2014-03-13 CA CA2903698A patent/CA2903698C/en active Active
- 2014-03-13 LT LTEP18210518.9T patent/LT3501272T/lt unknown
- 2014-03-13 RU RU2015143110A patent/RU2689664C2/ru active
- 2014-03-13 MX MX2015012539A patent/MX357308B/es active IP Right Grant
- 2014-03-13 RS RS20230350A patent/RS64185B1/sr unknown
- 2014-03-13 PT PT14717331T patent/PT2967013T/pt unknown
- 2014-03-13 EP EP23151398.7A patent/EP4218409A3/en active Pending
- 2014-03-13 PT PT182105189T patent/PT3501272T/pt unknown
- 2014-03-13 LT LTEP14717331.4T patent/LT2967013T/lt unknown
- 2014-03-13 SG SG10201801101QA patent/SG10201801101QA/en unknown
- 2014-03-13 DK DK18210518.9T patent/DK3501272T3/da active
- 2014-03-13 ES ES18210518T patent/ES2942413T3/es active Active
- 2014-03-13 PL PL18210518.9T patent/PL3501272T3/pl unknown
- 2014-03-13 HU HUE14717331A patent/HUE044003T2/hu unknown
- 2014-03-13 MX MX2020010837A patent/MX2020010837A/es unknown
- 2014-03-13 EP EP14717331.4A patent/EP2967013B1/en active Active
- 2014-03-13 AU AU2014244020A patent/AU2014244020B2/en active Active
- 2014-03-13 CN CN201810439928.8A patent/CN108611369B/zh active Active
- 2014-03-13 HR HRP20230490TT patent/HRP20230490T1/hr unknown
- 2014-03-13 RS RS20190467A patent/RS58669B1/sr unknown
-
2015
- 2015-08-13 IL IL240563A patent/IL240563B/en active IP Right Grant
- 2015-08-13 ZA ZA2015/05835A patent/ZA201505835B/en unknown
-
2016
- 2016-06-06 HK HK16106453.9A patent/HK1218493A1/zh unknown
-
2018
- 2018-08-13 ZA ZA2018/05369A patent/ZA201805369B/en unknown
-
2019
- 2019-01-18 JP JP2019006738A patent/JP6790136B2/ja active Active
- 2019-04-05 CY CY20191100383T patent/CY1121545T1/el unknown
- 2019-04-16 HR HRP20190706TT patent/HRP20190706T1/hr unknown
- 2019-08-14 JP JP2019148806A patent/JP7010902B2/ja active Active
-
2020
- 2020-05-19 AU AU2020203238A patent/AU2020203238B2/en active Active
- 2020-07-29 JP JP2020128111A patent/JP2020182490A/ja active Pending
-
2021
- 2021-02-15 IL IL280892A patent/IL280892B2/en unknown
-
2023
- 2023-05-04 AU AU2023202783A patent/AU2023202783A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1121545T1 (el) | Ποντικοι που εκφραζουν περιορισμενο ρεπερτοριο ελαφριων αλυσιδων ανοσοσφαιρινης | |
| CY1122036T1 (el) | Μη ανθρωπινα ζωα που εκφραζουν αντισωματα τα οποια εχουν μια κοινη ελαφρια αλυσιδα | |
| CY1124972T1 (el) | Ποντικοι με περιορισμενη βαρια αλυσιδα ανοσοσφαιρινης | |
| MX2015012540A (es) | Ratón de cadena ligera común. | |
| CY1124341T1 (el) | Ποντικοι me εξανθρωπισμενη καθολικη ελαφρια αλυσιδα | |
| CY1124299T1 (el) | Συνδυαστικες θεραπειες που περιλαμβανουν μορια αντισωματων κατα toy lag-3 | |
| CY1121934T1 (el) | Αντισωματα anti-fcrn | |
| CY1126145T1 (el) | Κατασκευασματα αντισωματων για flt3 και cd3 | |
| CY1124573T1 (el) | Καινοφανης αμφιειδικη μορφη καταλληλη για χρηση σε διερευνητικο ελεγχο υψηλης αποδοσης | |
| CY1122940T1 (el) | Μη ανθρωπινα ζωα που εχουν ενα εξανθρωπισμενο γονιδιο προγραμματισμενου κυτταρικου θανατου 1 | |
| CY1122386T1 (el) | Χιμαιρικος υποδοχεας αντιγονων και μεθοδοι χρησης εξ αυτου | |
| CY1120599T1 (el) | Αντισωματα ελαφριων αλυσιδων τροποποιημενων με ιστιδινη και γενετικα τροποποιημενα τρωκτικα για τη δημιουργια αυτων | |
| CY1124691T1 (el) | Διειδικα αντισωματα ειδικα για pd1 και τιμ3 | |
| CY1118562T1 (el) | Ποντικοι οι οποιοι δημιουργουν πρωτεϊνες δεσμευσης οι οποιες περιλαμβανουν επικρατειες vl | |
| CY1118241T1 (el) | Ποντικος κοινης ελαφριας αλυσου | |
| CY1120770T1 (el) | Ζωα πλην του ανθρωπου με τροποποιημενες αλληλουχιες βαριας αλυσιδας της ανοσοσφαιρινης | |
| EA201991383A1 (ru) | Антитела против ctla-4 и способы их применения | |
| MX353278B (es) | Raton con cadena ligera comun. | |
| BR112017025564B8 (pt) | Anticorpos anti-ctla-4 e métodos de uso dos mesmos | |
| MX2021003549A (es) | Anticuerpos dobles especificos. | |
| BR112017006736A2 (pt) | anticorpos antimiostatina, polipeptídeos contendo regiões fc variantes, e métodos de utilização | |
| PE20210107A1 (es) | Anticuerpos anti-cd3 y metodos de uso | |
| CY1121964T1 (el) | Αντισωματα εναντιον toy csf-1r | |
| CY1121798T1 (el) | Αντισωματα ελαφριων αλυσιδων τροποποιημενων με ιστιδινη και γενετικα τροποποιημενα ζωα πλην του ανθρωπου για τη δημιουργια αυτων | |
| WO2015143414A3 (en) | Non-human animals that make single domain binding proteins |