MX2018008436A - Metodo para activar celulas t auxiliares. - Google Patents
Metodo para activar celulas t auxiliares.Info
- Publication number
- MX2018008436A MX2018008436A MX2018008436A MX2018008436A MX2018008436A MX 2018008436 A MX2018008436 A MX 2018008436A MX 2018008436 A MX2018008436 A MX 2018008436A MX 2018008436 A MX2018008436 A MX 2018008436A MX 2018008436 A MX2018008436 A MX 2018008436A
- Authority
- MX
- Mexico
- Prior art keywords
- molecule
- hla
- drb1
- cell
- helper
- Prior art date
Links
- 210000002443 helper t lymphocyte Anatomy 0.000 title abstract 3
- 230000003213 activating effect Effects 0.000 title abstract 2
- 102100040485 HLA class II histocompatibility antigen, DRB1 beta chain Human genes 0.000 abstract 4
- 108010039343 HLA-DRB1 Chains Proteins 0.000 abstract 4
- 102100031618 HLA class II histocompatibility antigen, DP beta 1 chain Human genes 0.000 abstract 2
- 108010045483 HLA-DPB1 antigen Proteins 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102100040482 HLA class II histocompatibility antigen, DR beta 3 chain Human genes 0.000 abstract 1
- 102100028636 HLA class II histocompatibility antigen, DR beta 4 chain Human genes 0.000 abstract 1
- 108010029657 HLA-DRB1*04:01 antigen Proteins 0.000 abstract 1
- 108010053362 HLA-DRB1*04:06 antigen Proteins 0.000 abstract 1
- 102210010945 HLA-DRB1*0901 Human genes 0.000 abstract 1
- 108010061311 HLA-DRB3 Chains Proteins 0.000 abstract 1
- 108010040960 HLA-DRB4 Chains Proteins 0.000 abstract 1
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 abstract 1
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001152—Transcription factors, e.g. SOX or c-MYC
- A61K39/001153—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464452—Transcription factors, e.g. SOX or c-MYC
- A61K39/464453—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Developmental Biology & Embryology (AREA)
Abstract
La presente invención se refiere a un método para activar las células T auxiliares, que comprende el paso de activar las células T auxiliares agregando un péptido WT1 a las células que presentan antígenos, en donde el péptido WT1 tiene la capacidad de unirse a cualquier moléculas MHC Clase II de una molécula HLA-DRB1*0101, una molécula HLA-DRB1*0401, una molécula HLA-DRB1*0403, una molécula HLA-DRB1*0406, una molécula HLA-DRB1*0803, una molécula HLA-DRB1*0901, una molécula HLA-DRB1* 1101, una molécula HLA-DRB3*0202, una molécula HLA-DRB4*0101, una molécula HLA-DPB1*0201, o una molécula HLA-DPB1*0301.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010225806 | 2010-10-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018008436A true MX2018008436A (es) | 2021-12-08 |
Family
ID=45927725
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013003884A MX361299B (es) | 2010-10-05 | 2011-10-04 | Metodo para activar celulas auxiliares. |
MX2018008436A MX2018008436A (es) | 2010-10-05 | 2013-04-05 | Metodo para activar celulas t auxiliares. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013003884A MX361299B (es) | 2010-10-05 | 2011-10-04 | Metodo para activar celulas auxiliares. |
Country Status (20)
Country | Link |
---|---|
US (2) | US10654892B2 (es) |
EP (1) | EP2626418B8 (es) |
JP (3) | JP6134139B2 (es) |
KR (3) | KR102171794B1 (es) |
CN (2) | CN105802910A (es) |
AR (1) | AR083295A1 (es) |
AU (1) | AU2011313327B2 (es) |
BR (1) | BR112013008230A2 (es) |
CA (1) | CA2813557C (es) |
CO (1) | CO6710946A2 (es) |
EA (1) | EA037547B1 (es) |
ES (1) | ES2849187T3 (es) |
IL (2) | IL225536B (es) |
MX (2) | MX361299B (es) |
MY (1) | MY170306A (es) |
NZ (2) | NZ609460A (es) |
SG (3) | SG189287A1 (es) |
TW (2) | TW201623616A (es) |
WO (1) | WO2012046730A1 (es) |
ZA (1) | ZA201303056B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130062368A (ko) | 2003-11-05 | 2013-06-12 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | Wt1 유래의 hla-dr 결합성 항원 펩티드 |
CA2626238C (en) | 2005-10-17 | 2015-10-06 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
EP3834836A1 (en) | 2006-04-10 | 2021-06-16 | Memorial Sloan Kettering Cancer Center | Immunogenic wt-1 peptides and uses thereof |
NZ599161A (en) | 2007-02-27 | 2012-07-27 | Int Inst Cancer Immunology Inc | Method for activation of helper t cell and composition for use in the method |
AR076349A1 (es) | 2009-04-23 | 2011-06-01 | Int Inst Cancer Immunology Inc | Peptido auxiliar del antigeno del cancer |
TW201623616A (zh) * | 2010-10-05 | 2016-07-01 | 癌免疫研究所股份有限公司 | 用於活化細胞毒性t細胞的方法及組成物,及用於細胞毒性t細胞之活化誘導物 |
EP2802347B1 (en) | 2012-01-13 | 2019-01-09 | Memorial Sloan Kettering Cancer Center | Immunogenic wt-1 peptides and methods of use thereof |
CN104797711B (zh) * | 2012-09-12 | 2018-09-21 | 株式会社癌免疫研究所 | 抗原特异性辅助性t细胞受体基因 |
NZ708990A (en) * | 2012-12-17 | 2020-03-27 | Int Inst Cancer Immunology Inc | Method for activating helper t cell |
CN116789792A (zh) | 2013-01-15 | 2023-09-22 | 纪念斯隆凯特林癌症中心 | 免疫原性wt-1肽和其使用方法 |
US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
AU2014244860B2 (en) | 2013-03-29 | 2018-07-26 | International Institute Of Cancer Immunology, Inc. | WT1-antigen peptide conjugate vaccine |
CN106029699B (zh) | 2014-02-26 | 2019-07-19 | 泰来有限公司 | Wt1抗原性多肽和含有该多肽的抗肿瘤剂 |
KR102588853B1 (ko) | 2014-12-25 | 2023-10-16 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | T 세포 집단의 개변 방법 |
CN106565836B (zh) * | 2015-10-10 | 2020-08-18 | 中国科学院广州生物医药与健康研究院 | 高亲和力的可溶性pdl-1分子 |
JP6994201B2 (ja) | 2016-11-09 | 2022-02-21 | 国立大学法人大阪大学 | T細胞集団の改変方法 |
US20200016255A1 (en) * | 2016-11-30 | 2020-01-16 | Sumitomo Dainippon Pharma Co., Ltd. | Wt1 helper peptides and combinations of wt1 helper peptide and conjugate of cancer antigen peptides |
WO2019131722A1 (ja) * | 2017-12-27 | 2019-07-04 | 大日本住友製薬株式会社 | Wt1由来ペプチドのコンジュゲート体およびこれを含む組成物 |
EP4043569A1 (en) * | 2018-02-15 | 2022-08-17 | National University Corporation Asahikawa Medical University | Cancer antigen peptide |
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US5726288A (en) | 1989-11-13 | 1998-03-10 | Massachusetts Institute Of Technology | Localization and characterization of the Wilms' tumor gene |
AU4932199A (en) | 1998-07-31 | 2000-02-21 | Haruo Sugiyama | Cancer antigens based on tumor suppressor gene wt1 product |
US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
CZ20011144A3 (cs) | 1998-09-30 | 2002-06-12 | Corixa Corporation | Prostředky a způsoby pro WT1 specifickou imunoterapii |
US7063854B1 (en) | 1998-09-30 | 2006-06-20 | Corixa Corporation | Composition and methods for WTI specific immunotherapy |
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WO2003028757A1 (fr) | 2001-09-28 | 2003-04-10 | Haruo Sugiyama | Nouvelle methode pour induire des lymphocytes t specifiques d'antigenes |
EP1447092A4 (en) | 2001-09-28 | 2007-07-11 | Haruo Sugiyama | METHODS OF INDUCING ANTIGEN-SPECIFIC T CELLS |
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DE60329201D1 (de) | 2002-09-20 | 2009-10-22 | Chugai Pharmaceutical Co Ltd | Substituierte wt1-peptide |
ATE444969T1 (de) | 2003-01-15 | 2009-10-15 | Int Inst Cancer Immunology Inc | Dimerisiertes peptid |
EP2338509B1 (en) | 2003-06-27 | 2014-06-18 | International Institute of Cancer Immunology, Inc. | Method of selecting patients suitable for WT1 vaccine |
KR20130062368A (ko) * | 2003-11-05 | 2013-06-12 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | Wt1 유래의 hla-dr 결합성 항원 펩티드 |
PL1731605T3 (pl) | 2004-03-31 | 2010-08-31 | Int Inst Cancer Immunology Inc | Nowotworowe peptydy antygenowe pochodzące z WT1 |
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JP4719876B2 (ja) | 2005-04-04 | 2011-07-06 | 国立大学法人愛媛大学 | Hlaクラスii拘束性wt1抗原ペプチド |
CA2626238C (en) | 2005-10-17 | 2015-10-06 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
CA2631292C (en) | 2005-11-30 | 2014-05-06 | International Institute Of Cancer Immunology, Inc. | Derivatised wt1 cancer antigen peptides and their use |
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SI1988163T1 (sl) | 2006-02-22 | 2012-09-28 | Int Inst Cancer Immunology Inc | HLA-A*3303-omejen WT1 peptid in farmacevtski sestavek, ki ga vsebuje |
EP3834836A1 (en) | 2006-04-10 | 2021-06-16 | Memorial Sloan Kettering Cancer Center | Immunogenic wt-1 peptides and uses thereof |
NZ592510A (en) | 2006-12-28 | 2012-11-30 | Int Inst Cancer Immunology Inc | HLA-A*1101-restricted WTI peptide and pharmaceutical composition comprising the same |
NZ599161A (en) * | 2007-02-27 | 2012-07-27 | Int Inst Cancer Immunology Inc | Method for activation of helper t cell and composition for use in the method |
EP3173480A3 (en) | 2007-03-05 | 2017-08-16 | International Institute of Cancer Immunology, Inc. | Cancer antigen-specific t-cell receptor gene, peptide encoded by the gene, and use of them |
AR076349A1 (es) | 2009-04-23 | 2011-06-01 | Int Inst Cancer Immunology Inc | Peptido auxiliar del antigeno del cancer |
TW201623616A (zh) * | 2010-10-05 | 2016-07-01 | 癌免疫研究所股份有限公司 | 用於活化細胞毒性t細胞的方法及組成物,及用於細胞毒性t細胞之活化誘導物 |
NZ708990A (en) | 2012-12-17 | 2020-03-27 | Int Inst Cancer Immunology Inc | Method for activating helper t cell |
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