BR112013008230A2 - método para ativar célula t auxiliar - Google Patents

método para ativar célula t auxiliar

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Publication number
BR112013008230A2
BR112013008230A2 BR112013008230A BR112013008230A BR112013008230A2 BR 112013008230 A2 BR112013008230 A2 BR 112013008230A2 BR 112013008230 A BR112013008230 A BR 112013008230A BR 112013008230 A BR112013008230 A BR 112013008230A BR 112013008230 A2 BR112013008230 A2 BR 112013008230A2
Authority
BR
Brazil
Prior art keywords
molecule
hla
drb1
cell
helper
Prior art date
Application number
BR112013008230A
Other languages
English (en)
Inventor
Haruo Sugiyama
Masayoshi Sato
Ryuki Kitamoto
Shinji Sogo
Yoshihiro Goto
Original Assignee
Int Inst Cancer Immunology Inc
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Int Inst Cancer Immunology Inc, Otsuka Pharma Co Ltd filed Critical Int Inst Cancer Immunology Inc
Publication of BR112013008230A2 publication Critical patent/BR112013008230A2/pt

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    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464452—Transcription factors, e.g. SOX or c-MYC
    • A61K39/464453—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2501/20—Cytokines; Chemokines
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Abstract

método para ativar célula t auxiliar. a presente invenção refere-se a um método para ativar células t auxiliares, que inclui a etapa de ativar células t auxiliares adicionando um peptídeo wt1 a células apresentando antígeno, em que o peptídeo wt1 tem a capacidade de se ligar a qualquer molécula classe ii mhc de uma molécula hla-drb1*0101, uma molécula hla-drb1*0401, uma molécula hla-drb1*0403, uma molécula hla-drb1*0406, uma molécula hla-drb1*0803, uma molécula hla-drb1*0901, uma molécula hla-drb1*1101, uma molécula hla-drb3*0202, uma molécula hla-drb4*0101, uma molécula hla-dpb1*0201 ou uma molécula hla-dpb1*0301, e similares.
BR112013008230A 2010-10-05 2011-10-04 método para ativar célula t auxiliar BR112013008230A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010225806 2010-10-05
PCT/JP2011/072874 WO2012046730A1 (ja) 2010-10-05 2011-10-04 ヘルパーｔ細胞の活性化方法

Publications (1)

Publication Number Publication Date
BR112013008230A2 true BR112013008230A2 (pt) 2016-06-14

Family

ID=45927725

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013008230A BR112013008230A2 (pt) 2010-10-05 2011-10-04 método para ativar célula t auxiliar

Country Status (20)

Country Link
US (2) US10654892B2 (pt)
EP (1) EP2626418B8 (pt)
JP (3) JP6134139B2 (pt)
KR (3) KR102171794B1 (pt)
CN (2) CN105802910A (pt)
AR (1) AR083295A1 (pt)
AU (1) AU2011313327B2 (pt)
BR (1) BR112013008230A2 (pt)
CA (1) CA2813557C (pt)
CO (1) CO6710946A2 (pt)
EA (1) EA037547B1 (pt)
ES (1) ES2849187T3 (pt)
IL (2) IL225536B (pt)
MX (2) MX361299B (pt)
MY (1) MY170306A (pt)
NZ (2) NZ609460A (pt)
SG (3) SG189287A1 (pt)
TW (2) TW201623616A (pt)
WO (1) WO2012046730A1 (pt)
ZA (1) ZA201303056B (pt)

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JP6134139B2 (ja) 2017-05-24
NZ703560A (en) 2016-11-25
AU2011313327A1 (en) 2013-05-02
MX2018008436A (es) 2021-12-08
JP2018093870A (ja) 2018-06-21
AR083295A1 (es) 2013-02-13
EP2626418A4 (en) 2014-02-19
KR102171794B1 (ko) 2020-10-29
US20200354405A1 (en) 2020-11-12
CN105802910A (zh) 2016-07-27
SG10202108581TA (en) 2021-09-29
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CA2813557A1 (en) 2012-04-12
TW201623616A (zh) 2016-07-01
KR20190034359A (ko) 2019-04-01
US20130266958A1 (en) 2013-10-10
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ZA201303056B (en) 2013-12-23
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JPWO2012046730A1 (ja) 2014-02-24
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TW201217525A (en) 2012-05-01
ES2849187T3 (es) 2021-08-16
EA201390509A1 (ru) 2013-08-30
JP2017006120A (ja) 2017-01-12
IL245440A0 (en) 2016-06-30
EP2626418A1 (en) 2013-08-14
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KR20140009168A (ko) 2014-01-22
IL225536A0 (en) 2013-06-27
NZ609460A (en) 2015-07-31
IL225536B (en) 2019-03-31
AU2011313327B2 (en) 2015-10-22
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WO2012046730A1 (ja) 2012-04-12
EA037547B1 (ru) 2021-04-12
US10654892B2 (en) 2020-05-19
TWI608099B (zh) 2017-12-11
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JP6298101B2 (ja) 2018-03-20
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CN103298928A (zh) 2013-09-11

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