MX2018003256A - Derivados de indol mono- o disustituidos como inhibidores de la replicacion viral del dengue. - Google Patents

Derivados de indol mono- o disustituidos como inhibidores de la replicacion viral del dengue.

Info

Publication number
MX2018003256A
MX2018003256A MX2018003256A MX2018003256A MX2018003256A MX 2018003256 A MX2018003256 A MX 2018003256A MX 2018003256 A MX2018003256 A MX 2018003256A MX 2018003256 A MX2018003256 A MX 2018003256A MX 2018003256 A MX2018003256 A MX 2018003256A
Authority
MX
Mexico
Prior art keywords
dengue viral
compounds
mono
substituted indole
viral replication
Prior art date
Application number
MX2018003256A
Other languages
English (en)
Inventor
Bart Rudolf Romanie Kesteleyn
Jean-François Bonfanti
Pierre Jean-Marie Bernard Raboisson
Tim Hugo Maria Jonckers
Didier M Marchand Arnaud
Alice Marie- Eve BARDIOT Dorothée
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of MX2018003256A publication Critical patent/MX2018003256A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a compuestos indólicos mono- o disustituidos, a métodos para prevenir o tratar infecciones virales por dengue utilizando dichos compuestos y también se refiere a dichos compuestos para su uso como una medicina, más preferentemente para su uso como una medicina para tratar o prevenir infecciones virales por dengue; la presente invención se refiere además a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como una medicina, más preferentemente para la prevención o el tratamiento de infecciones virales por dengue;la invención también se refiere a procesos para la preparación de los compuestos.
MX2018003256A 2015-09-16 2016-09-15 Derivados de indol mono- o disustituidos como inhibidores de la replicacion viral del dengue. MX2018003256A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15185522 2015-09-16
EP16163465 2016-04-01
PCT/EP2016/071852 WO2017046258A1 (en) 2015-09-16 2016-09-15 Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
MX2018003256A true MX2018003256A (es) 2018-11-09

Family

ID=56958913

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018003256A MX2018003256A (es) 2015-09-16 2016-09-15 Derivados de indol mono- o disustituidos como inhibidores de la replicacion viral del dengue.

Country Status (37)

Country Link
US (1) US10786484B2 (es)
EP (1) EP3350163B1 (es)
JP (2) JP7045984B2 (es)
KR (1) KR20180051563A (es)
CN (1) CN108368044B (es)
AU (1) AU2016323535B2 (es)
CA (1) CA2996856C (es)
CL (1) CL2018000697A1 (es)
CO (1) CO2018003369A2 (es)
CR (1) CR20180214A (es)
CY (1) CY1122792T1 (es)
DK (1) DK3350163T3 (es)
EA (1) EA035679B1 (es)
EC (1) ECSP18020039A (es)
ES (1) ES2778431T3 (es)
HK (1) HK1258320A1 (es)
HR (1) HRP20200408T1 (es)
IL (1) IL258031B (es)
JO (1) JO3633B1 (es)
LT (1) LT3350163T (es)
MA (1) MA42811B1 (es)
MD (1) MD3350163T2 (es)
ME (1) ME03674B (es)
MX (1) MX2018003256A (es)
MY (1) MY188347A (es)
NI (1) NI201800040A (es)
PE (1) PE20181007A1 (es)
PH (1) PH12018500569A1 (es)
PL (1) PL3350163T3 (es)
PT (1) PT3350163T (es)
RS (1) RS60039B1 (es)
SI (1) SI3350163T1 (es)
TW (1) TWI758256B (es)
UA (1) UA123672C2 (es)
UY (1) UY36904A (es)
WO (1) WO2017046258A1 (es)
ZA (1) ZA201801764B (es)

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JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
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Also Published As

Publication number Publication date
LT3350163T (lt) 2020-04-10
ES2778431T3 (es) 2020-08-10
CR20180214A (es) 2018-05-14
CY1122792T1 (el) 2021-05-05
PT3350163T (pt) 2020-03-23
JP7045984B2 (ja) 2022-04-01
JP2018528222A (ja) 2018-09-27
RS60039B1 (sr) 2020-04-30
JP2021193092A (ja) 2021-12-23
JO3633B1 (ar) 2020-08-27
UY36904A (es) 2017-03-31
AU2016323535B2 (en) 2021-02-18
PH12018500569A1 (en) 2018-09-17
KR20180051563A (ko) 2018-05-16
EP3350163B1 (en) 2019-12-25
AU2016323535A1 (en) 2018-03-08
MY188347A (en) 2021-12-02
UA123672C2 (uk) 2021-05-12
ECSP18020039A (es) 2018-04-30
IL258031A (en) 2018-05-31
SI3350163T1 (sl) 2020-07-31
CL2018000697A1 (es) 2018-07-06
EA035679B1 (ru) 2020-07-24
CN108368044B (zh) 2021-06-15
CO2018003369A2 (es) 2018-07-10
TW201722912A (zh) 2017-07-01
PL3350163T3 (pl) 2020-08-24
HK1258320A1 (zh) 2019-11-08
MD3350163T2 (ro) 2020-06-30
HRP20200408T1 (hr) 2020-06-12
TWI758256B (zh) 2022-03-21
MA42811B1 (fr) 2020-03-31
ZA201801764B (en) 2021-04-28
PE20181007A1 (es) 2018-06-26
EP3350163A1 (en) 2018-07-25
IL258031B (en) 2021-03-25
WO2017046258A1 (en) 2017-03-23
ME03674B (me) 2020-10-20
CA2996856A1 (en) 2017-03-23
US10786484B2 (en) 2020-09-29
EA201890723A1 (ru) 2018-08-31
MA42811A (fr) 2018-07-25
DK3350163T3 (da) 2020-03-16
CA2996856C (en) 2023-08-01
US20180256544A1 (en) 2018-09-13
NI201800040A (es) 2018-07-24
CN108368044A (zh) 2018-08-03

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