MX2017009154A - Sintesis de un inhibidor de tirosina quinasa de bruton. - Google Patents

Sintesis de un inhibidor de tirosina quinasa de bruton.

Info

Publication number
MX2017009154A
MX2017009154A MX2017009154A MX2017009154A MX2017009154A MX 2017009154 A MX2017009154 A MX 2017009154A MX 2017009154 A MX2017009154 A MX 2017009154A MX 2017009154 A MX2017009154 A MX 2017009154A MX 2017009154 A MX2017009154 A MX 2017009154A
Authority
MX
Mexico
Prior art keywords
bruton
synthesis
tyrosine kinase
kinase inhibitor
inhibitor
Prior art date
Application number
MX2017009154A
Other languages
English (en)
Other versions
MX366827B (es
Inventor
Chen Wei
Goldman Erick
Benhaim Cyril
Horvath Andras
Pye Philip
S Smyth Mark
J Verner Erik
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of MX2017009154A publication Critical patent/MX2017009154A/es
Publication of MX366827B publication Critical patent/MX366827B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Abstract

En la presente memoria se describe la síntesis de inhibidor de tirosina quinasa de Bruton (Btk) de 1-((R)-3-(4-amino-3-(4-fenoxif enil)-1H-pirazol[3,4-d]pirimidin-1-il)piperidin-1-il)prop-2-en-1- ona.
MX2017009154A 2015-01-14 2016-01-14 Sintesis de un inhibidor de tirosina quinasa de bruton. MX366827B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562103507P 2015-01-14 2015-01-14
PCT/US2016/013424 WO2016115356A1 (en) 2015-01-14 2016-01-14 Synthesis of a bruton's tyrosine kinase inhibitor

Publications (2)

Publication Number Publication Date
MX2017009154A true MX2017009154A (es) 2017-10-12
MX366827B MX366827B (es) 2019-07-25

Family

ID=56406389

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017009154A MX366827B (es) 2015-01-14 2016-01-14 Sintesis de un inhibidor de tirosina quinasa de bruton.
MX2019008815A MX2019008815A (es) 2015-01-14 2017-07-12 Sintesis de un inhibidor de tirosina quinasa de bruton.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019008815A MX2019008815A (es) 2015-01-14 2017-07-12 Sintesis de un inhibidor de tirosina quinasa de bruton.

Country Status (16)

Country Link
US (4) US20180009814A1 (es)
EP (1) EP3245208A4 (es)
JP (2) JP2018502077A (es)
KR (1) KR20170102887A (es)
CN (2) CN107108640A (es)
AU (2) AU2016206693A1 (es)
BR (1) BR112017015206B1 (es)
CA (2) CA2971460C (es)
HK (1) HK1246293A1 (es)
IL (3) IL308276A (es)
MA (1) MA41350A (es)
MX (2) MX366827B (es)
RU (1) RU2017128308A (es)
SG (2) SG10201906517VA (es)
WO (1) WO2016115356A1 (es)
ZA (1) ZA201704338B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127915A1 (zh) * 2015-02-12 2016-08-18 上海度德医药科技有限公司 伊布替尼的制备方法
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
CN109206426B (zh) * 2017-07-06 2021-10-08 上海复星星泰医药科技有限公司 吡唑并嘧啶类化合物的制备方法
JP7166331B2 (ja) * 2017-08-01 2022-11-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中間体化合物及び方法
CN107814804A (zh) * 2017-10-27 2018-03-20 广州科锐特生物科技有限公司 依鲁替尼的制备方法
CA3094431C (en) 2018-03-19 2023-06-27 Taiho Pharmaceutical Co., Ltd. Pharmaceutical composition including sodium alkyl sulfate
CA3098497A1 (en) 2018-05-03 2019-11-07 Juno Therapeutics, Inc. Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
JP6944496B2 (ja) * 2018-10-22 2021-10-06 ファイザー・インク ピロロ［２，３−ｄ］ピリミジントシル酸塩、その結晶形態、ならびにその製造方法および中間体
AU2018448845B2 (en) 2018-11-09 2022-03-24 Taiho Pharmaceutical Co., Ltd. Method for producing dimethoxybenzene compound
CN109988175A (zh) * 2019-04-28 2019-07-09 梯尔希（南京）药物研发有限公司 一种依鲁替尼-d5的制备方法
US20220235058A1 (en) 2019-05-21 2022-07-28 Janssen Pharmaceutica Nv Processes and intermediates for preparing a btk inhibitor
CA3135240A1 (en) * 2019-05-21 2020-11-26 Philip James Pye Processes and intermediates for preparing a btk inhibitor
EP4281454A1 (en) 2021-01-21 2023-11-29 Synthon B.V. Process for making ibrutinib
CN114853662B (zh) * 2021-02-05 2024-01-12 四川青木制药有限公司 手性肼基哌啶衍生物的制备方法
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
WO2023242384A1 (en) 2022-06-17 2023-12-21 Krka, D.D., Novo Mesto Crystalline form of ibrutinib

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550214A (en) * 1981-01-05 1985-10-29 Polaroid Corporation Blocked vinyl biphenyl compounds
US4874822A (en) * 1988-04-07 1989-10-17 Minnesota Mining And Manufacturing Company Process for the acrylamidoacylation of alcohols
CA2548374C (en) * 2003-12-23 2014-05-27 Astex Therapeutics Limited Pyrazole derivatives as protein kinase modulators
EP2081435B1 (en) * 2006-09-22 2016-05-04 Pharmacyclics LLC Inhibitors of bruton's tyrosine kinase
EP2560007A1 (en) * 2007-03-28 2013-02-20 Pharmacyclics, Inc. Identification of bruton's tyrosine kinase inhibitors
US7741330B1 (en) * 2009-10-12 2010-06-22 Pharmacyclics, Inc. Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
MX2015001246A (es) * 2012-07-30 2015-04-10 Concert Pharmaceuticals Inc Ibrutinib deuterado.
CN103121999A (zh) * 2012-08-29 2013-05-29 苏州迪飞医药科技有限公司 一种酪氨酸激酶抑制剂pci-32765的合成方法
US9156847B2 (en) * 2013-03-15 2015-10-13 Janssen Pharmaceutica Nv Processes and intermediates for preparing a medicament
US8957080B2 (en) * 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
CN103626774B (zh) * 2013-11-20 2015-11-04 苏州明锐医药科技有限公司 伊鲁替尼的制备方法
CN105471823B (zh) * 2014-09-03 2018-10-26 阿里巴巴集团控股有限公司 一种敏感信息处理方法、装置、服务器及安全判定***
US10266535B2 (en) * 2015-01-21 2019-04-23 Hefei Institutes Of Physical Science, Chinese Academy Of Sciences Inhibitor of FLT3 kinase and use thereof

Also Published As

Publication number Publication date
BR112017015206B1 (pt) 2023-04-11
CA2971460C (en) 2023-10-10
US20200347064A1 (en) 2020-11-05
SG11201705678YA (en) 2017-08-30
EP3245208A4 (en) 2018-10-17
WO2016115356A1 (en) 2016-07-21
EP3245208A1 (en) 2017-11-22
JP2018502077A (ja) 2018-01-25
AU2016206693A1 (en) 2017-07-13
US20220098200A1 (en) 2022-03-31
IL253020A0 (en) 2017-08-31
AU2020230323A1 (en) 2020-10-01
CN113816962A (zh) 2021-12-21
IL308276A (en) 2024-01-01
RU2017128308A3 (es) 2019-10-24
ZA201704338B (en) 2023-10-25
BR112017015206A2 (pt) 2018-06-19
MA41350A (fr) 2017-11-21
IL274716A (en) 2020-07-30
US20190367518A1 (en) 2019-12-05
MX366827B (es) 2019-07-25
SG10201906517VA (en) 2019-08-27
RU2017128308A (ru) 2019-02-14
JP2021035947A (ja) 2021-03-04
CN107108640A (zh) 2017-08-29
US20180009814A1 (en) 2018-01-11
MX2019008815A (es) 2019-09-26
CA2971460A1 (en) 2016-07-21
KR20170102887A (ko) 2017-09-12
CA3210320A1 (en) 2016-07-21
HK1246293A1 (zh) 2018-09-07

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