MX2016013149A - Produccion de celulas t modificadas, mediante transposon bella durmiente, acoplada con seleccion por metotrexato. - Google Patents

Produccion de celulas t modificadas, mediante transposon bella durmiente, acoplada con seleccion por metotrexato.

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Publication number
MX2016013149A
MX2016013149A MX2016013149A MX2016013149A MX2016013149A MX 2016013149 A MX2016013149 A MX 2016013149A MX 2016013149 A MX2016013149 A MX 2016013149A MX 2016013149 A MX2016013149 A MX 2016013149A MX 2016013149 A MX2016013149 A MX 2016013149A
Authority
MX
Mexico
Prior art keywords
cells
engineered
production
sleeping beauty
methotrexate selection
Prior art date
Application number
MX2016013149A
Other languages
English (en)
Inventor
C Jensen Michael
Pun Suzie
Kacherovsky Nataly
Original Assignee
Seattle Children's Hospital (Dba Seattle Children's Res Institute)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Children's Hospital (Dba Seattle Children's Res Institute) filed Critical Seattle Children's Hospital (Dba Seattle Children's Res Institute)
Publication of MX2016013149A publication Critical patent/MX2016013149A/es

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    • C12N2740/00—Reverse transcribing RNA viruses
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    • C12N2820/00—Vectors comprising a special origin of replication system
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Abstract

Los aspectos de la invención descritos en la presente incluyen métodos para tratar, inhibir, mejorar y/o eliminar un virus o células de cáncer en un sujeto utilizando células T genéticamente modificadas que tienen receptores para una molécula presentada por el virus o las células de cáncer, en donde las células T genéticamente modificadas se aíslan utilizando un selección por MTX de dos etapas que emplea concentraciones crecientes de MTX.
MX2016013149A 2014-04-10 2015-04-08 Produccion de celulas t modificadas, mediante transposon bella durmiente, acoplada con seleccion por metotrexato. MX2016013149A (es)

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US201462088363P 2014-12-05 2014-12-05
US201462089730P 2014-12-09 2014-12-09
US201462090845P 2014-12-11 2014-12-11
PCT/US2015/024868 WO2015157386A1 (en) 2014-04-10 2015-04-08 Production of engineered t-cells by sleeping beauty transposon coupled with methotrexate selection

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MX2016013160A MX2016013160A (es) 2014-04-10 2015-04-08 Marcas geneticas de transgenes y metodos de uso.
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US20180009891A1 (en) 2018-01-11
ES2880932T3 (es) 2021-11-26
US11155616B2 (en) 2021-10-26
EP3129053A1 (en) 2017-02-15
EP3129480A1 (en) 2017-02-15
SG10201808833XA (en) 2018-11-29
RU2016143389A (ru) 2018-05-15
AU2015243922A1 (en) 2016-11-03
WO2015157384A1 (en) 2015-10-15
JP2022153456A (ja) 2022-10-12
CN106574246A (zh) 2017-04-19
KR102463529B1 (ko) 2022-11-07
KR20160143762A (ko) 2016-12-14
RU2016143381A3 (es) 2018-11-30
CA2945303C (en) 2024-02-13
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JP6788573B2 (ja) 2020-11-25
BR112016023517A2 (pt) 2017-10-17
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CN106661570A8 (zh) 2017-07-04
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RU2016143381A (ru) 2018-05-11
JP7148580B2 (ja) 2022-10-05
RU2016143389A3 (es) 2018-12-04
KR20160144432A (ko) 2016-12-16
KR102387243B1 (ko) 2022-04-14
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CN112877291A (zh) 2021-06-01
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MX2016013144A (es) 2017-04-27
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NZ758289A (en) 2024-01-26
AU2015243882A1 (en) 2016-11-03
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JP2021000117A (ja) 2021-01-07
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AU2015243920B2 (en) 2020-10-08
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JP2017513520A (ja) 2017-06-01
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BR112016023500A2 (pt) 2017-10-17
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SA516380056B1 (ar) 2021-07-04
SG11201608393TA (en) 2016-11-29
CA2945320A1 (en) 2015-10-15
AU2021201679B2 (en) 2023-05-04
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JP2021036867A (ja) 2021-03-11
EP3943507A1 (en) 2022-01-26
IL248229B2 (en) 2023-05-01
PH12016502010A1 (en) 2017-01-09
US20210371517A1 (en) 2021-12-02
AU2021273652A1 (en) 2021-12-16
CN106661570B (zh) 2020-02-07
WO2015157399A9 (en) 2016-11-24
KR20160138298A (ko) 2016-12-02
AU2021201679A1 (en) 2021-04-08
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MY186846A (en) 2021-08-26
MX2016013158A (es) 2017-04-27
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IL248243A0 (en) 2016-11-30
US10266592B2 (en) 2019-04-23
EP3129480A4 (en) 2017-08-16
KR20160144430A (ko) 2016-12-16
JP7106610B2 (ja) 2022-07-26
RU2016143388A3 (es) 2018-11-30
EP3954708A1 (en) 2022-02-16
EP3129399B1 (en) 2021-05-26
JP2017513470A (ja) 2017-06-01
RU2016143385A (ru) 2018-05-15
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MY185678A (en) 2021-05-30
CA2945305A1 (en) 2015-10-15
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PH12016502011A1 (en) 2017-01-09
SG10201808825XA (en) 2018-11-29
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JP2017512484A (ja) 2017-05-25
EP4056201A1 (en) 2022-09-14
JP7093385B2 (ja) 2022-06-29
AU2015243882B2 (en) 2020-03-12
MY184163A (en) 2021-03-24
SG10201808811QA (en) 2018-11-29
KR20220153100A (ko) 2022-11-17
MX2022010807A (es) 2022-09-27
KR102509481B1 (ko) 2023-03-10
SG11201608396YA (en) 2016-11-29
CN106536558A (zh) 2017-03-22
SG11201608395PA (en) 2016-11-29
NZ725081A (en) 2018-02-23
AU2015243927B2 (en) 2021-09-02
JP2017518037A (ja) 2017-07-06
KR20160144431A (ko) 2016-12-16
BR112016023507A2 (pt) 2017-10-17
US10611837B2 (en) 2020-04-07

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