MX2016009013A - Derivados de heterociclilo biciclicos como inhibores de cinasa-4 asociada al receptor de interleucina-1 (irak4). - Google Patents
Derivados de heterociclilo biciclicos como inhibores de cinasa-4 asociada al receptor de interleucina-1 (irak4).Info
- Publication number
- MX2016009013A MX2016009013A MX2016009013A MX2016009013A MX2016009013A MX 2016009013 A MX2016009013 A MX 2016009013A MX 2016009013 A MX2016009013 A MX 2016009013A MX 2016009013 A MX2016009013 A MX 2016009013A MX 2016009013 A MX2016009013 A MX 2016009013A
- Authority
- MX
- Mexico
- Prior art keywords
- bicyclic heterocyclyl
- inhibitors
- irak4 inhibitors
- diseases
- pharmaceutically acceptable
- Prior art date
Links
- 229940127590 IRAK4 inhibitor Drugs 0.000 title abstract 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 101000977771 Homo sapiens Interleukin-1 receptor-associated kinase 4 Proteins 0.000 abstract 1
- 102100023533 Interleukin-1 receptor-associated kinase 4 Human genes 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 229940125532 enzyme inhibitor Drugs 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Abstract
La presente invención proporciona compuestos biciclicos inhibidores de enzimas heterociclil cinasa de la formula (I), los cuales son terapéuticamente útiles como inhibidores de cinasa, particularmente inhibidores de IRAK4, en donde A, Y, Z, X1, X2, X3, R1, R3, "m", "n", y "p" tienen los significados proporcionados en la especificación y una sal o estereoisómero farmacéuticamente aceptable de los mismos que son útiles en el tratamiento y prevención de enfermedades o trastornos, en particular su uso en enfermedades o trastornos mediados por una enzima cinasa, particularmente la enzima IRAK4. La presente invención también proporciona una composición farmacéutica que comprende por lo menos uno de los compuestos de la formula (I) junto con un portador, diluyente o excipiente farmacéuticamente aceptable para los mismos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN158CH2014 | 2014-01-13 | ||
| IN3000CH2014 | 2014-06-20 | ||
| PCT/IB2015/050217 WO2015104688A1 (en) | 2014-01-13 | 2015-01-12 | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016009013A true MX2016009013A (es) | 2017-01-23 |
| MX359909B MX359909B (es) | 2018-10-16 |
Family
ID=53523587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016009013A MX359909B (es) | 2014-01-13 | 2015-01-12 | Derivados de heterociclilo biciclicos como inhibores de cinasa-4 asociada al receptor de interleucina-1 (irak4). |
Country Status (31)
| Country | Link |
|---|---|
| US (5) | US9732095B2 (es) |
| EP (4) | EP4353324A2 (es) |
| JP (5) | JP6479850B2 (es) |
| KR (3) | KR20230129622A (es) |
| CN (2) | CN106456619B (es) |
| AU (5) | AU2015205374B2 (es) |
| BR (1) | BR112016016158B1 (es) |
| CA (1) | CA2935887A1 (es) |
| CU (1) | CU24389B1 (es) |
| CY (2) | CY1121433T1 (es) |
| DK (3) | DK3094329T3 (es) |
| EA (2) | EA031913B1 (es) |
| ES (2) | ES2692852T3 (es) |
| FI (1) | FI3805233T3 (es) |
| HK (1) | HK1231410A1 (es) |
| HR (2) | HRP20181795T1 (es) |
| HU (2) | HUE052252T2 (es) |
| IL (5) | IL284952B (es) |
| LT (2) | LT3466955T (es) |
| MX (1) | MX359909B (es) |
| MY (1) | MY197116A (es) |
| NZ (2) | NZ760657A (es) |
| PH (2) | PH12016501344A1 (es) |
| PL (2) | PL3094329T3 (es) |
| PT (3) | PT3466955T (es) |
| RS (2) | RS58024B1 (es) |
| SG (2) | SG10201811204RA (es) |
| SI (2) | SI3094329T1 (es) |
| TR (1) | TR201815683T4 (es) |
| WO (1) | WO2015104688A1 (es) |
| ZA (2) | ZA202007273B (es) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| SG11201605408RA (en) | 2014-01-10 | 2016-07-28 | Aurigene Discovery Tech Ltd | Indazole compounds as irak4 inhibitors |
| AU2015205374B2 (en) * | 2014-01-13 | 2018-08-23 | Aurigene Oncology Limited | Bicyclic heterocyclyl derivatives as IRAK4 inhibitors |
| EP3322409A4 (en) * | 2015-07-15 | 2019-07-24 | Aurigene Discovery Technologies Limited | AZA COMPOUNDS SUBSTITUTED AS INHIBITORS OF IRAQ-4 |
| CA2993661A1 (en) | 2015-08-04 | 2017-02-09 | Rigel Pharmaceuticals, Inc. | Benzazole compounds and methods for making and using the compounds |
| CA3016364A1 (en) | 2016-03-03 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | New 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
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