MX2018002402A - Compuestos de heteroarilo o arilo biciclicos fusionados como moduladores de la quinasa 4 asociada al receptor de la interleucina 1 (irak4). - Google Patents

Compuestos de heteroarilo o arilo biciclicos fusionados como moduladores de la quinasa 4 asociada al receptor de la interleucina 1 (irak4).

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Publication number
MX2018002402A
MX2018002402A MX2018002402A MX2018002402A MX2018002402A MX 2018002402 A MX2018002402 A MX 2018002402A MX 2018002402 A MX2018002402 A MX 2018002402A MX 2018002402 A MX2018002402 A MX 2018002402A MX 2018002402 A MX2018002402 A MX 2018002402A
Authority
MX
Mexico
Prior art keywords
bicyclic
fused heteroaryl
aryl compounds
compounds
irak4
Prior art date
Application number
MX2018002402A
Other languages
English (en)
Inventor
David Hepworth
John Paul Mathias
Seungil Han
Christoph Martin Dehnhardt
Saiah Eddine
Wolfgang Zapf Christoph
John David Trzupek
Krim Gavrin Lori
Lee Arthur
Lin Lee Katherine
Eldridge Lovering Frank
Papaioannou Nikolaos
Philippe Allais Christophe
Rhys Owen Dafydd
Wayne Wright Stephen
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2018002402A publication Critical patent/MX2018002402A/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • C07D491/18—Bridged systems

Abstract

Compuestos, tautómeros y sales de estos aceptables desde el punto de vista farmacéutico, en donde los compuestos tienen la estructura de la Fórmula Ia, (ver Fórmula) como se definieron en la memoria descriptiva; también composiciones farmacéuticas, métodos de tratamiento, métodos de síntesis e intermediarios correspondientes.
MX2018002402A 2015-08-27 2016-08-16 Compuestos de heteroarilo o arilo biciclicos fusionados como moduladores de la quinasa 4 asociada al receptor de la interleucina 1 (irak4). MX2018002402A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562210573P 2015-08-27 2015-08-27
PCT/IB2016/054906 WO2017033093A1 (en) 2015-08-27 2016-08-16 Bicyclic-fused heteroaryl or aryl compounds as irak4 modulators

Publications (1)

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MX2018002402A true MX2018002402A (es) 2018-04-11

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MX2018002402A MX2018002402A (es) 2015-08-27 2016-08-16 Compuestos de heteroarilo o arilo biciclicos fusionados como moduladores de la quinasa 4 asociada al receptor de la interleucina 1 (irak4).

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