CU24389B1 - Compuestos de heterociclilo bicíclico como inhibidores de irak4 - Google Patents
Compuestos de heterociclilo bicíclico como inhibidores de irak4Info
- Publication number
- CU24389B1 CU24389B1 CU2016000111A CU20160111A CU24389B1 CU 24389 B1 CU24389 B1 CU 24389B1 CU 2016000111 A CU2016000111 A CU 2016000111A CU 20160111 A CU20160111 A CU 20160111A CU 24389 B1 CU24389 B1 CU 24389B1
- Authority
- CU
- Cuba
- Prior art keywords
- compounds
- heterociclyl
- bicyclic
- irak4
- inhibitors
- Prior art date
Links
- 229940127590 IRAK4 inhibitor Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 101000977771 Homo sapiens Interleukin-1 receptor-associated kinase 4 Proteins 0.000 abstract 1
- 102100023533 Interleukin-1 receptor-associated kinase 4 Human genes 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Abstract
<p>La presente invención proporciona compuestos inhibidores de enzima quinasa de heterociclilo bicíclico de fórmula (1), que son terapéuticamente útiles como inhibidores de quinasa, particularmente inhibidores de IRAK4,</p> <p>ESPACIO PARA FÓRMULA</p> <p>donde A, Y, Z, X1, X2, XJ, R1, RJ, 'm', 'n' y 'p' tienen los significados dados en Ia memoria descriptiva y la sal de clorhidrato de los mismos que son útiles en el tratamiento y Ia prevención de enfermedades o trastornos, en particular su usa en enfermedades o trastornos mediados por enzimas quinasas, particularmente una enzima IRAK4.</p>
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN158CH2014 | 2014-01-13 | ||
| IN3000CH2014 | 2014-06-20 | ||
| PCT/IB2015/050217 WO2015104688A1 (en) | 2014-01-13 | 2015-01-12 | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20160111A7 CU20160111A7 (es) | 2017-03-03 |
| CU24389B1 true CU24389B1 (es) | 2019-04-04 |
Family
ID=53523587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2016000111A CU24389B1 (es) | 2014-01-13 | 2015-01-12 | Compuestos de heterociclilo bicíclico como inhibidores de irak4 |
Country Status (31)
| Country | Link |
|---|---|
| US (5) | US9732095B2 (es) |
| EP (4) | EP3805233B1 (es) |
| JP (5) | JP6479850B2 (es) |
| KR (3) | KR102574390B1 (es) |
| CN (2) | CN106456619B (es) |
| AU (5) | AU2015205374B2 (es) |
| BR (1) | BR112016016158B1 (es) |
| CA (1) | CA2935887A1 (es) |
| CU (1) | CU24389B1 (es) |
| CY (2) | CY1121433T1 (es) |
| DK (3) | DK3805233T3 (es) |
| EA (2) | EA038748B1 (es) |
| ES (2) | ES2692852T3 (es) |
| FI (1) | FI3805233T3 (es) |
| HK (1) | HK1231410A1 (es) |
| HR (2) | HRP20181795T1 (es) |
| HU (2) | HUE052252T2 (es) |
| IL (5) | IL302878A (es) |
| LT (2) | LT3466955T (es) |
| MX (1) | MX359909B (es) |
| MY (1) | MY197116A (es) |
| NZ (2) | NZ760657A (es) |
| PH (2) | PH12016501344A1 (es) |
| PL (2) | PL3094329T3 (es) |
| PT (3) | PT3805233T (es) |
| RS (2) | RS61448B1 (es) |
| SG (2) | SG10201811204RA (es) |
| SI (2) | SI3466955T1 (es) |
| TR (1) | TR201815683T4 (es) |
| WO (1) | WO2015104688A1 (es) |
| ZA (2) | ZA202007274B (es) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| EA201691401A1 (ru) | 2014-01-10 | 2016-11-30 | Ориджин Дискавери Текнолоджиз Лимитед | Индазольные соединения в качестве ингибиторов irak4 |
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