MX2015015845A - Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos. - Google Patents

Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos.

Info

Publication number
MX2015015845A
MX2015015845A MX2015015845A MX2015015845A MX2015015845A MX 2015015845 A MX2015015845 A MX 2015015845A MX 2015015845 A MX2015015845 A MX 2015015845A MX 2015015845 A MX2015015845 A MX 2015015845A MX 2015015845 A MX2015015845 A MX 2015015845A
Authority
MX
Mexico
Prior art keywords
pyrimidin
indole
oxy
carboxamide derivatives
methyl
Prior art date
Application number
MX2015015845A
Other languages
English (en)
Inventor
Ulrike Glaenzel
Robert Nufer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2015015845A publication Critical patent/MX2015015845A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a ciertos metabolitos de la N-(1-metil-5-(trifluoro-metil)-1H-pirazol-3-il)-5-((6-((metil-ami no)-metil)-pirimidin-4-il)-oxi)-1H-indol-1-carboxamida; en particular, la presente invención se refiere a composiciones farmacéuticas que comprenden estos metabolitos, así como a los procesos para su preparación, y a su uso en el tratamiento de enfermedades.
MX2015015845A 2013-05-17 2014-05-16 Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos. MX2015015845A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824464P 2013-05-17 2013-05-17
PCT/IB2014/061484 WO2014184778A1 (en) 2013-05-17 2014-05-16 Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof

Publications (1)

Publication Number Publication Date
MX2015015845A true MX2015015845A (es) 2016-06-29

Family

ID=50896374

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015845A MX2015015845A (es) 2013-05-17 2014-05-16 Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos.

Country Status (13)

Country Link
US (2) US20150018376A1 (es)
EP (1) EP2997022B1 (es)
JP (1) JP2016518443A (es)
KR (1) KR20160010522A (es)
CN (1) CN105452241B (es)
AR (1) AR096322A1 (es)
AU (1) AU2014266867B2 (es)
BR (1) BR112015028551A2 (es)
CA (1) CA2912130A1 (es)
EA (1) EA201592190A1 (es)
ES (1) ES2699776T3 (es)
MX (1) MX2015015845A (es)
WO (1) WO2014184778A1 (es)

Family Cites Families (38)

* Cited by examiner, † Cited by third party
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GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
TW225528B (es) 1992-04-03 1994-06-21 Ciba Geigy Ag
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PT817775E (pt) 1995-03-30 2002-01-30 Pfizer Derivados de quinazolina
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GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
JP3370340B2 (ja) 1996-04-12 2003-01-27 ワーナー―ランバート・コンパニー チロシンキナーゼの不可逆的阻害剤
BR9709959A (pt) 1996-06-24 2000-05-09 Pfizer Derivados tricìclicos de fenilamino substituìdo para o tratamento de doenças hiperproliferativas
AU716610B2 (en) 1996-08-30 2000-03-02 Novartis Ag Method for producing epothilones, and intermediate products obtained during the production process
DE938597T1 (de) 1996-09-06 2000-03-09 Obducat Ab Verfahren für das anisotrope ätzen von strukturen in leitende materialien
WO1998010767A2 (en) 1996-09-13 1998-03-19 Sugen, Inc. Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
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BR9713363B1 (pt) 1996-11-18 2011-02-08 processo para preparação de epotilona d.
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
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ES2342240T3 (es) 1998-08-11 2010-07-02 Novartis Ag Derivados de isoquinolina con actividad que inhibe la angiogenia.
WO2000031247A2 (en) 1998-11-20 2000-06-02 Kosan Biosciences, Inc. Recombinant methods and materials for producing epothilone and epothilone derivatives
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
KR100371449B1 (ko) 1999-07-20 2003-02-07 주식회사 아이디어파크 무선 이어폰/마이크를 갖는 착탈형 무선전환장치
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TWI238824B (en) 2001-05-14 2005-09-01 Novartis Ag 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives
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JO3265B1 (ar) * 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض

Also Published As

Publication number Publication date
AU2014266867A1 (en) 2015-12-03
JP2016518443A (ja) 2016-06-23
CN105452241B (zh) 2018-01-05
ES2699776T3 (es) 2019-02-12
WO2014184778A1 (en) 2014-11-20
EP2997022B1 (en) 2018-08-29
EA201592190A1 (ru) 2016-04-29
CA2912130A1 (en) 2014-11-20
US9604969B2 (en) 2017-03-28
US20150018376A1 (en) 2015-01-15
AR096322A1 (es) 2015-12-23
EP2997022A1 (en) 2016-03-23
AU2014266867B2 (en) 2017-07-13
BR112015028551A2 (pt) 2017-07-25
KR20160010522A (ko) 2016-01-27
US20160115156A1 (en) 2016-04-28
CN105452241A (zh) 2016-03-30

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