MX2015006856A - Compuestos imidazopiridina. - Google Patents

Compuestos imidazopiridina.

Info

Publication number
MX2015006856A
MX2015006856A MX2015006856A MX2015006856A MX2015006856A MX 2015006856 A MX2015006856 A MX 2015006856A MX 2015006856 A MX2015006856 A MX 2015006856A MX 2015006856 A MX2015006856 A MX 2015006856A MX 2015006856 A MX2015006856 A MX 2015006856A
Authority
MX
Mexico
Prior art keywords
sgc
group
imidazo
prevention
pyridine
Prior art date
Application number
MX2015006856A
Other languages
English (en)
Inventor
Toshio Kurosaki
Eisuke Nozawa
Yuji Koga
Takeshi Hanazawa
Kazuhiko Ohne
Tsubasa Watanabe
Hiroshi Shibata
Shunichiro Hachiya
Hiroki Ishioka
Ryo Mizoguchi
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2015006856A publication Critical patent/MX2015006856A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)

Abstract

Se proporciona una composición farmacéutica para tratar o prevenir enfermedades cardiovasculares, que tienen actividades de sGC sobre la base de la mejora de las señales de cGMP. [Medio para la Solución] Se ha descubierto que compuestos de imidazo[1,2-a]piridina que tienen un grupo carbamoílo en la posición 3 y un grupo cíclico particular en la posición 8 por medio de un grupo metilenoxi, o una sal de este, tienen activación de sGC, y son útiles como ingredientes activos de composiciones farmacéuticas para tratar o prevenir diversas enfermedades cardiovasculares relacionadas con sGC, en particular, enfermedades de las arterias periféricas, claudicación intermitente, isquemia crítica de los miembros inferiores, hipertensión e hipertensión pulmonar, por lo cual se completa la presente invención.
MX2015006856A 2012-11-30 2013-11-28 Compuestos imidazopiridina. MX2015006856A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012262962 2012-11-30
PCT/JP2013/082057 WO2014084312A1 (ja) 2012-11-30 2013-11-28 イミダゾピリジン化合物

Publications (1)

Publication Number Publication Date
MX2015006856A true MX2015006856A (es) 2016-02-17

Family

ID=50827943

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015006856A MX2015006856A (es) 2012-11-30 2013-11-28 Compuestos imidazopiridina.

Country Status (19)

Country Link
US (1) US9278968B2 (es)
EP (1) EP2927231B1 (es)
JP (1) JP6056872B2 (es)
KR (1) KR102093608B1 (es)
CN (1) CN104822680B (es)
AU (1) AU2013353117A1 (es)
BR (1) BR112015012571B1 (es)
CA (1) CA2891976C (es)
EA (1) EA027909B1 (es)
ES (1) ES2644611T3 (es)
HK (1) HK1212984A1 (es)
IL (1) IL238874A0 (es)
MX (1) MX2015006856A (es)
PH (1) PH12015501102B1 (es)
PL (1) PL2927231T3 (es)
PT (1) PT2927231T (es)
TW (1) TW201439090A (es)
WO (1) WO2014084312A1 (es)
ZA (1) ZA201503794B (es)

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Also Published As

Publication number Publication date
EP2927231A4 (en) 2016-04-20
WO2014084312A1 (ja) 2014-06-05
ES2644611T3 (es) 2017-11-29
US20150232464A1 (en) 2015-08-20
JP6056872B2 (ja) 2017-01-11
EP2927231B1 (en) 2017-09-20
KR102093608B1 (ko) 2020-03-26
PH12015501102A1 (en) 2015-07-27
CA2891976A1 (en) 2014-06-05
BR112015012571B1 (pt) 2022-05-24
TW201439090A (zh) 2014-10-16
CN104822680B (zh) 2016-10-12
KR20150090157A (ko) 2015-08-05
US9278968B2 (en) 2016-03-08
EA027909B1 (ru) 2017-09-29
HK1212984A1 (zh) 2016-06-24
PL2927231T3 (pl) 2018-01-31
BR112015012571A2 (pt) 2019-12-17
JPWO2014084312A1 (ja) 2017-01-05
ZA201503794B (en) 2016-11-30
PT2927231T (pt) 2017-10-31
EA201591050A1 (ru) 2016-04-29
AU2013353117A1 (en) 2015-06-04
EP2927231A1 (en) 2015-10-07
PH12015501102B1 (en) 2015-07-27
CA2891976C (en) 2020-07-21
IL238874A0 (en) 2015-07-30
CN104822680A (zh) 2015-08-05

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