MX2010003155A - Derivados de ciclopropil aril amida y uso de los mismos. - Google Patents
Derivados de ciclopropil aril amida y uso de los mismos.Info
- Publication number
- MX2010003155A MX2010003155A MX2010003155A MX2010003155A MX2010003155A MX 2010003155 A MX2010003155 A MX 2010003155A MX 2010003155 A MX2010003155 A MX 2010003155A MX 2010003155 A MX2010003155 A MX 2010003155A MX 2010003155 A MX2010003155 A MX 2010003155A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- amide derivatives
- aryl amide
- cyclopropyl aryl
- cyclopropyl
- Prior art date
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
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- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C07C233/74—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
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- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/62—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
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Abstract
La presente invenci?n se refiere a compuestos de la f?rmula (I) en donde Ar1, Ar2, R1 y R2 son como se definieron aqu?. Tambi?n se proporcionan composiciones farmac?uticas, m?todos de uso, y m?todos de preparaci?n de los compuestos objetivo. (ver f?rmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99758107P | 2007-10-04 | 2007-10-04 | |
PCT/EP2008/062813 WO2009043784A1 (en) | 2007-10-04 | 2008-09-25 | Cyclopropyl aryl amide derivatives and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010003155A true MX2010003155A (es) | 2010-04-01 |
Family
ID=40130956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010003155A MX2010003155A (es) | 2007-10-04 | 2008-09-25 | Derivados de ciclopropil aril amida y uso de los mismos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US7723391B2 (es) |
EP (1) | EP2207540B1 (es) |
JP (1) | JP5362729B2 (es) |
KR (1) | KR101178674B1 (es) |
CN (1) | CN101815512B (es) |
AU (1) | AU2008307195B2 (es) |
CA (1) | CA2699625C (es) |
ES (1) | ES2460897T3 (es) |
IL (1) | IL204437A (es) |
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WO (1) | WO2009043784A1 (es) |
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JP2016512225A (ja) | 2013-03-13 | 2016-04-25 | ルピン・リミテッドLupin Limited | アルファー7nachrモジュレータとしてのピロール誘導体 |
KR20160009667A (ko) | 2013-05-21 | 2016-01-26 | 버지니아 커먼웰스 유니버시티 | 염증의 예방 및 치료를 위한 크리오피린 억제제 |
TW201446243A (zh) | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
WO2014203150A1 (en) | 2013-06-17 | 2014-12-24 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
PL3019476T3 (pl) | 2013-07-08 | 2018-05-30 | Syngenta Participations Ag | Związki karboksyamidowe o 4-członowym pierścieniu jako nematocydy |
WO2015040141A1 (en) | 2013-09-23 | 2015-03-26 | Syngenta Participations Ag | Cyclobutylcarboxamides as nematicides |
BR112016022785B8 (pt) | 2014-04-04 | 2020-09-15 | Iomet Pharma Ltd | composto inibidor de triptofano-2,3-dioxigenase (tdo) e/ou indoleamina-2,3-dioxigenase (ido), composição farmacêutica, e, uso de composto inibidor de triptofano-2,3-dioxigenase (tdo) e/ou indoleamina-2,3dioxigenase (ido) ou de um sal farmaceuticamente aceitável do mesmo para fabricação de um medicamento |
CN104030930B (zh) * | 2014-06-20 | 2016-02-24 | 河北序能生物技术有限公司 | 一种反式-(1r,2s)-2-(3,4-二氟苯基)环丙胺盐酸盐的合成方法 |
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CN108586221B (zh) * | 2018-06-26 | 2021-03-02 | 常州制药厂有限公司 | 用于制备替卡格雷的中间体及其制备方法 |
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- 2008-09-25 WO PCT/EP2008/062813 patent/WO2009043784A1/en active Application Filing
- 2008-09-25 CN CN2008801100940A patent/CN101815512B/zh not_active Expired - Fee Related
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AU2008307195A1 (en) | 2009-04-09 |
CN101815512A (zh) | 2010-08-25 |
US7723391B2 (en) | 2010-05-25 |
CA2699625A1 (en) | 2009-04-09 |
KR20100053677A (ko) | 2010-05-20 |
JP2010540586A (ja) | 2010-12-24 |
CN101815512B (zh) | 2013-04-24 |
AU2008307195B2 (en) | 2012-11-22 |
US20090093525A1 (en) | 2009-04-09 |
JP5362729B2 (ja) | 2013-12-11 |
KR101178674B1 (ko) | 2012-08-30 |
EP2207540B1 (en) | 2014-02-26 |
WO2009043784A1 (en) | 2009-04-09 |
CA2699625C (en) | 2016-02-02 |
EP2207540A1 (en) | 2010-07-21 |
IL204437A (en) | 2013-09-30 |
ES2460897T3 (es) | 2014-05-14 |
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