MX2009013334A - Derivados de piperidina/piperazina. - Google Patents

Derivados de piperidina/piperazina.

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Publication number
MX2009013334A
MX2009013334A MX2009013334A MX2009013334A MX2009013334A MX 2009013334 A MX2009013334 A MX 2009013334A MX 2009013334 A MX2009013334 A MX 2009013334A MX 2009013334 A MX2009013334 A MX 2009013334A MX 2009013334 A MX2009013334 A MX 2009013334A
Authority
MX
Mexico
Prior art keywords
sup
compounds
optionally
substituted
naphtalenyl
Prior art date
Application number
MX2009013334A
Other languages
English (en)
Inventor
Lieven Meerpoel
Mirielle Braeken
Erwin Coesemans
Joannes Theodorus Maria Linders
Christophe Francis Robert Nestor Buyck
Peter Walter Maria Roevens
Guy Rosalia Eugeen Van Lommen
Monique Jenny Marie Berwaer
Jean-Pierre Andre Marc Bongartz
Waepenaert Katharina Antonia Germania J M De
Petr Vladimirivich Davidenko
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38616252&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009013334(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2009013334A publication Critical patent/MX2009013334A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Abstract

La invención se refiere a un inhibidor de DGAT de fórmula (I) (ver fórmula I) que incluye cualquier forma estereoquímicamente isomérica del mismo, donde A representa CH o N; la línea punteada representa un enlace opcional en el caso en que A represente un átomo de carbono; X representa -O-C(=O).-; - C(=O)-C(=O)-; NRxC(=O) -Z-C(=O)-; ZNRxC(O) -C(=O)-Z-; NRx C(0)-Z-; -C(=S)-; NRxC(=S) -Z-C(S)-; Z.NRxC(S) -C(=S)--Z-; NRx C(=S)-Z-; Z representa un radical bivalente seleccionado de alcandillo C16, alquendiilo C26 o alquindiilo C26 donde cada alcandiilo C1, alquendiilo C2..6 o alquindillo C2..6 puede estar opcionalmente sustituido; y donde dos átomos de hidrógeno unidos al mismo carbono en el alcandiilo C16 pueden estar opcionalmente reemplazados por alcandiilo C1 Y representa _C(=O)NRx o _NRxC(O) R1 representa adamantanilo, cicloalquilo C36 arilo1 o Het1 R2 representa cicloalquilo C3.6, fenilo, naftalenilo, 2,3-dihidro-1 ,4-benzodioxinilo, 1,3-benzodioxolilo, 2,3-dihidrobenzofuranilo o un heterociclo aromático de 6 miembros que contiene 1 o 2 átomos de N, donde dicho cicloalquilo C3.6, fenilo, naftalenilo, 2, 3-dihidro- 1 ,4-benzodioxinilo, 1, 3-benzodioxolilo, o heterociclo pueden estar opcionalmente sustituidos; R7 representa hidrógeno, halo, alquilo C14, alquilo C1..4 sustituido con hidroxilo; con la salvedad de que se excluyen los siguientes compuestos (ver fórmulas A, B) un N-óxido de los mismos, una sal aceptable farmacéuticamente de los mismos o un solvato de los mismos; además, la invención se refiere además a métodos para preparar tales compuestos, composiciones farmacéuticas que comprenden dichos compuestos así como al uso como medicamento, como inhibidor de DGAT, de dichos compuestos.
MX2009013334A 2007-06-08 2008-06-05 Derivados de piperidina/piperazina. MX2009013334A (es)

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WO2008148849A2 (en) 2008-12-11
RU2009148796A (ru) 2011-07-20
BRPI0812923A2 (pt) 2014-12-09
JO2972B1 (en) 2016-03-15
US20100210618A1 (en) 2010-08-19
US20160081997A1 (en) 2016-03-24
JP5443343B2 (ja) 2014-03-19
EP2155198A2 (en) 2010-02-24
AR066153A1 (es) 2009-07-29
RU2478628C2 (ru) 2013-04-10
CN101678013B (zh) 2014-05-07
CA2687243A1 (en) 2008-12-11
EP2155198B1 (en) 2014-08-13
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WO2008148849A8 (en) 2009-07-09
AU2008258558A1 (en) 2008-12-11
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TW200916449A (en) 2009-04-16
PA8783401A1 (es) 2009-01-23
TWI438197B (zh) 2014-05-21
CN101678013A (zh) 2010-03-24
CA2687243C (en) 2016-07-12
US20150087629A1 (en) 2015-03-26
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US9227935B2 (en) 2016-01-05

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