MX2009004765A - Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf). - Google Patents
Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf).Info
- Publication number
- MX2009004765A MX2009004765A MX2009004765A MX2009004765A MX2009004765A MX 2009004765 A MX2009004765 A MX 2009004765A MX 2009004765 A MX2009004765 A MX 2009004765A MX 2009004765 A MX2009004765 A MX 2009004765A MX 2009004765 A MX2009004765 A MX 2009004765A
- Authority
- MX
- Mexico
- Prior art keywords
- vegf
- human
- molecules
- growth factor
- vascular endothelial
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
La invención se refiere a moléculas polipeptídicas recombinantes relacionadas con anticuerpos, que reconocen específicamente el factor de crecimiento de endotelio vascular-A (VEGF-A) humano, e interfieren con sus efectos estimulatorios in vitro, y pro-angiogénicos in vivo; dichas moléculas polipeptídicas recombinantes son capaces de afectar la proliferación de células endoteliales humanas in vitro, la angiogénesis subcutánea en ratones inducida por tapones de matrigel que contienen VEGF-A, y el crecimiento de tumores humanos transplantados a ratones desnudos; varias de estas moléculas previenen la neovascularización coroidea en un modelo experimental en primates no humanos; estas moléculas pueden emplearse para la inmunoterapia pasiva de entidades patológicas cuyo curso se asocia al aumento de la vasculatura, tales como la degeneración macular asociada a la edad (variante húmeda), el cáncer y sus metástasis, los glaucomas neovasculares, la retinopatía diabética y del recién nacido, los procesos inflamatorios agudos y crónicos, enfermedades infecciosas, enfermedades autoinmunes, el rechazo al transplante de órganos, los hemangiomas y los angiofibromas, entre otros.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060208A CU23636A1 (es) | 2006-11-01 | 2006-11-01 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) |
PCT/CU2007/000019 WO2008052489A1 (es) | 2006-11-01 | 2007-10-30 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009004765A true MX2009004765A (es) | 2009-06-05 |
Family
ID=39148565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009004765A MX2009004765A (es) | 2006-11-01 | 2007-10-30 | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf). |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100151566A1 (es) |
EP (1) | EP2093236A1 (es) |
JP (1) | JP2010508033A (es) |
KR (1) | KR20090078363A (es) |
CN (1) | CN101573379A (es) |
AR (1) | AR063448A1 (es) |
AU (1) | AU2007315484A1 (es) |
BR (1) | BRPI0717971A2 (es) |
CA (1) | CA2667594A1 (es) |
CO (1) | CO6341480A2 (es) |
CU (1) | CU23636A1 (es) |
MX (1) | MX2009004765A (es) |
RU (1) | RU2009120536A (es) |
WO (1) | WO2008052489A1 (es) |
ZA (1) | ZA200903017B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101093717B1 (ko) * | 2008-11-26 | 2011-12-19 | 한국생명공학연구원 | Vegf―특이적인 인간항체 |
CU23895B1 (es) * | 2010-12-28 | 2013-05-31 | Biorec Sa | Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagénesis de regiones variables |
CN103012588A (zh) * | 2011-09-23 | 2013-04-03 | 武汉吉天朋生物科技发展有限公司 | 利用具有中和VEGFA生物学活性的McAb应用于肿瘤的靶向治疗 |
CN104073502B (zh) * | 2013-03-26 | 2016-08-24 | 华东师范大学 | 人脑钠肽的中和性基因工程抗体3c1及其制备方法和应用 |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
CL2014002941A1 (es) * | 2014-10-30 | 2015-04-06 | Univ Concepcion | Moléculas polipeptídicas contra el factor de crecimiento del endotelio vascular (vegf) |
KR20180104635A (ko) | 2015-12-30 | 2018-09-21 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
CU20210101A7 (es) | 2021-12-15 | 2023-07-12 | Ct Ingenieria Genetica Biotecnologia | Polipéptidos que se unen a factores de crecimiento proangiogénicos |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
DK0438200T3 (da) | 1990-01-16 | 2002-11-11 | Ct Ingenieria Genetica Biotech | Fremgangsmåde til ekspression af heterologe gener i gæren Pichia pastoris, ekspressionsvektorer og transformerede mikroorganismer |
CA2150262C (en) | 1992-12-04 | 2008-07-08 | Kaspar-Philipp Holliger | Multivalent and multispecific binding proteins, their manufacture and use |
US5730977A (en) | 1995-08-21 | 1998-03-24 | Mitsui Toatsu Chemicals, Inc. | Anti-VEGF human monoclonal antibody |
US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2006
- 2006-11-01 CU CU20060208A patent/CU23636A1/es unknown
-
2007
- 2007-10-30 BR BRPI0717971-5A2A patent/BRPI0717971A2/pt not_active IP Right Cessation
- 2007-10-30 EP EP07817383A patent/EP2093236A1/en not_active Withdrawn
- 2007-10-30 RU RU2009120536/10A patent/RU2009120536A/ru not_active Application Discontinuation
- 2007-10-30 AU AU2007315484A patent/AU2007315484A1/en not_active Abandoned
- 2007-10-30 JP JP2009534978A patent/JP2010508033A/ja not_active Abandoned
- 2007-10-30 KR KR1020097011229A patent/KR20090078363A/ko not_active Application Discontinuation
- 2007-10-30 MX MX2009004765A patent/MX2009004765A/es unknown
- 2007-10-30 CA CA002667594A patent/CA2667594A1/en not_active Abandoned
- 2007-10-30 WO PCT/CU2007/000019 patent/WO2008052489A1/es active Search and Examination
- 2007-10-30 CN CNA2007800437331A patent/CN101573379A/zh active Pending
- 2007-10-30 US US12/447,711 patent/US20100151566A1/en not_active Abandoned
- 2007-11-01 AR ARP070104873A patent/AR063448A1/es not_active Application Discontinuation
-
2009
- 2009-04-30 ZA ZA200903017A patent/ZA200903017B/xx unknown
- 2009-06-01 CO CO09056360A patent/CO6341480A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU2009120536A (ru) | 2010-12-10 |
BRPI0717971A2 (pt) | 2013-11-12 |
CN101573379A (zh) | 2009-11-04 |
CO6341480A2 (es) | 2011-11-21 |
JP2010508033A (ja) | 2010-03-18 |
WO2008052489A1 (es) | 2008-05-08 |
KR20090078363A (ko) | 2009-07-17 |
AR063448A1 (es) | 2009-01-28 |
US20100151566A1 (en) | 2010-06-17 |
ZA200903017B (en) | 2010-03-31 |
AU2007315484A1 (en) | 2008-05-08 |
WO2008052489A8 (es) | 2009-07-23 |
CU23636A1 (es) | 2011-03-21 |
EP2093236A1 (en) | 2009-08-26 |
CA2667594A1 (en) | 2008-05-08 |
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