MX2016000220A - Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp. - Google Patents
Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp.Info
- Publication number
- MX2016000220A MX2016000220A MX2016000220A MX2016000220A MX2016000220A MX 2016000220 A MX2016000220 A MX 2016000220A MX 2016000220 A MX2016000220 A MX 2016000220A MX 2016000220 A MX2016000220 A MX 2016000220A MX 2016000220 A MX2016000220 A MX 2016000220A
- Authority
- MX
- Mexico
- Prior art keywords
- regulation
- glucose metabolism
- cgrp antibodies
- optionally
- agent
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Abstract
|La presente descripción proporciona métodos para la prevención o tratamiento de trastornos metabólicos. En modalidades ejemplares, se proporcionan métodos para administrar un anticuerpo anti-CGRP, opcionalmente en combinación con un segundo agente, en donde se incrementa la utilización de glucosa periférica y/o hepática, para de esta manera prevenir o tratar enfermedades y trastornos asociados con la resistencia a insulina. También se proporcionan composiciones que comprenden un anticuerpo anti-CGRP, opcionalmente en combinación con un segundo agente, que son adecuadas para la administración para incrementar la utilización de glucosa periférica y/o hepática y de esta manera prevenir o tratar enfermedades y trastornos asociados con la resistencia a insulina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361842745P | 2013-07-03 | 2013-07-03 | |
US201461982611P | 2014-04-22 | 2014-04-22 | |
PCT/US2014/045389 WO2015003122A2 (en) | 2013-07-03 | 2014-07-03 | Regulation of glucose metabolism using anti-cgrp antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016000220A true MX2016000220A (es) | 2016-08-18 |
Family
ID=52144290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016000220A MX2016000220A (es) | 2013-07-03 | 2014-07-03 | Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20150017166A1 (es) |
EP (1) | EP3016684B1 (es) |
JP (4) | JP6502337B2 (es) |
KR (1) | KR102476907B1 (es) |
CN (1) | CN105492026A (es) |
AU (2) | AU2014285052B2 (es) |
CA (1) | CA2916980C (es) |
ES (1) | ES2911690T3 (es) |
IL (1) | IL243355A0 (es) |
MX (1) | MX2016000220A (es) |
NZ (1) | NZ754427A (es) |
SG (2) | SG10201906172XA (es) |
TW (2) | TWI712419B (es) |
WO (1) | WO2015003122A2 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2916980C (en) * | 2013-07-03 | 2023-02-21 | Alder Biopharmaceuticals, Inc. | Regulation of glucose metabolism using anti-cgrp antibodies |
US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
UA123759C2 (uk) | 2014-03-21 | 2021-06-02 | Тева Фармасьютікалз Інтернешнл Гмбх | Застосування моноклонального антитіла, яке інгібує шлях пов'язаного з геном кальциноніну пептиду (cgrp), для лікування або зниження частоти випадків мігренозного головного болю у суб'єкта |
US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
US10392434B2 (en) | 2016-09-23 | 2019-08-27 | Teva Pharmaceuticals International Gmbh | Treating refractory migraine |
BR102020007149A8 (pt) | 2020-04-06 | 2023-09-26 | H Lundbeck As | Usos de um anticorpo anti-cgrp ou anti-cgrp-r ou um fragmento dos mesmos para melhorar o sintoma mais incômodo (mbs) e a impressão global de mudança (pgic) associados com enxaqueca |
KR20240049275A (ko) | 2021-08-27 | 2024-04-16 | 하. 룬드벡 아크티에셀스카브 | 항-cgrp 항체를 사용한 군발성 두통의 치료 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
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US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
GB8720115D0 (en) | 1987-08-26 | 1987-09-30 | Cooper G J S | Treatment of diabetes mellitus |
GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
US5266561A (en) * | 1988-01-11 | 1993-11-30 | Amylin Pharmaceuticals, Inc. | Treatment of type 2 diabetes mellitus |
AU631112B2 (en) * | 1988-01-11 | 1992-11-19 | Amylin Corporation | Treatment of type 2 diabetes mellitus |
US5364841A (en) * | 1988-01-11 | 1994-11-15 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and essential hypertension and related disorders |
US5175145A (en) | 1988-08-26 | 1992-12-29 | Amylin Pharmaceuticals, Inc. | Treatment of diabetes mellitus with amylin agonists |
EP0401384B1 (en) | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
ATE126395T1 (de) * | 1989-01-03 | 1995-08-15 | Motorola Inc | Verfahren zum herstellen von löthöckern hoher dichte und ein substratsockel für löthöcker hoher dichte. |
US5766883A (en) | 1989-04-29 | 1998-06-16 | Delta Biotechnology Limited | Polypeptides |
AU620727B2 (en) * | 1989-07-10 | 1992-02-20 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and essential hypertension and related disorders |
FR2650598B1 (fr) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | Derives de l'albumine a fonction therapeutique |
EP0542810A1 (en) | 1990-08-02 | 1993-05-26 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
WO1994021293A1 (en) | 1993-03-19 | 1994-09-29 | Duke University | Method of treatment of tumors with an antibody binding to tenascin |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
AU3272695A (en) | 1994-08-12 | 1996-03-07 | Immunomedics Inc. | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
US6653104B2 (en) | 1996-10-17 | 2003-11-25 | Immunomedics, Inc. | Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells |
CN1617737A (zh) * | 2001-11-26 | 2005-05-18 | 普罗特米克斯公司 | 用于使哺乳动物组织中的脂质水平正常化的组合物和方法 |
WO2005040395A1 (en) | 2003-10-22 | 2005-05-06 | Keck Graduate Institute | Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy |
MX2008014692A (es) | 2006-05-19 | 2009-08-18 | Alder Biopharmaceuticals Inc | Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno. |
EP2162469A4 (en) | 2007-05-21 | 2012-08-01 | Alderbio Holdings Llc | NEW METHODS OF HUMANIZING RABBIT ANTIBODIES AND HUMANIZED RABBIT ANTIBODIES |
US9056905B2 (en) | 2007-05-21 | 2015-06-16 | Alderbio Holdings Llc | Antibodies to TNF-α and use thereof |
HUE043782T2 (hu) | 2007-05-21 | 2019-09-30 | Alderbio Holdings Llc | IL-6 elleni antitestek és alkalmazásuk |
AR086515A1 (es) * | 2011-05-20 | 2013-12-18 | Alderbio Holdings Llc | Uso de anticuerpos o fragmentos de anticuerpos anti-cgrp o anti-cgrp-r para tratar o prevenir las formas cronicas y agudas de la diarrea |
SI3495392T1 (sl) * | 2011-05-20 | 2021-11-30 | H. Lundbeck A/S | Sestavki proti CGRP in uporaba le-teh |
CA2916980C (en) * | 2013-07-03 | 2023-02-21 | Alder Biopharmaceuticals, Inc. | Regulation of glucose metabolism using anti-cgrp antibodies |
-
2014
- 2014-07-03 CA CA2916980A patent/CA2916980C/en active Active
- 2014-07-03 AU AU2014285052A patent/AU2014285052B2/en active Active
- 2014-07-03 TW TW103122993A patent/TWI712419B/zh active
- 2014-07-03 US US14/323,028 patent/US20150017166A1/en not_active Abandoned
- 2014-07-03 KR KR1020167002907A patent/KR102476907B1/ko active IP Right Grant
- 2014-07-03 NZ NZ754427A patent/NZ754427A/en unknown
- 2014-07-03 TW TW109121891A patent/TWI753471B/zh active
- 2014-07-03 SG SG10201906172XA patent/SG10201906172XA/en unknown
- 2014-07-03 JP JP2016524371A patent/JP6502337B2/ja active Active
- 2014-07-03 CN CN201480047723.5A patent/CN105492026A/zh active Pending
- 2014-07-03 WO PCT/US2014/045389 patent/WO2015003122A2/en active Application Filing
- 2014-07-03 EP EP14820173.4A patent/EP3016684B1/en active Active
- 2014-07-03 MX MX2016000220A patent/MX2016000220A/es active IP Right Grant
- 2014-07-03 SG SG11201510618YA patent/SG11201510618YA/en unknown
- 2014-07-03 ES ES14820173T patent/ES2911690T3/es active Active
-
2015
- 2015-12-24 IL IL243355A patent/IL243355A0/en unknown
-
2018
- 2018-07-06 JP JP2018128766A patent/JP2018168186A/ja not_active Withdrawn
-
2019
- 2019-03-20 JP JP2019052046A patent/JP2019112455A/ja active Pending
- 2019-12-10 AU AU2019279945A patent/AU2019279945B2/en active Active
-
2020
- 2020-06-17 JP JP2020104177A patent/JP2020158525A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2018168186A (ja) | 2018-11-01 |
JP6502337B2 (ja) | 2019-04-17 |
TWI753471B (zh) | 2022-01-21 |
CA2916980C (en) | 2023-02-21 |
WO2015003122A3 (en) | 2015-03-19 |
AU2014285052A1 (en) | 2016-02-11 |
KR20160029822A (ko) | 2016-03-15 |
NZ754427A (en) | 2021-12-24 |
EP3016684A4 (en) | 2017-06-07 |
NZ715834A (en) | 2021-11-26 |
IL243355A0 (en) | 2016-03-31 |
JP2019112455A (ja) | 2019-07-11 |
SG10201906172XA (en) | 2019-08-27 |
EP3016684A2 (en) | 2016-05-11 |
TW201536316A (zh) | 2015-10-01 |
AU2014285052B2 (en) | 2019-09-12 |
CN105492026A (zh) | 2016-04-13 |
SG11201510618YA (en) | 2016-03-30 |
KR102476907B1 (ko) | 2022-12-13 |
ES2911690T3 (es) | 2022-05-20 |
TWI712419B (zh) | 2020-12-11 |
CA2916980A1 (en) | 2015-01-08 |
JP2016528198A (ja) | 2016-09-15 |
JP2020158525A (ja) | 2020-10-01 |
WO2015003122A2 (en) | 2015-01-08 |
AU2019279945B2 (en) | 2022-01-20 |
TW202106335A (zh) | 2021-02-16 |
AU2019279945A1 (en) | 2020-01-16 |
US20150017166A1 (en) | 2015-01-15 |
EP3016684B1 (en) | 2022-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: H. LUNDBECK A/S.* |