MA30888B1 - Compositions et procedes de modulation de recepteurs de c-kit et de facteur de croissance derive de plaquettes (pdgfr) - Google Patents
Compositions et procedes de modulation de recepteurs de c-kit et de facteur de croissance derive de plaquettes (pdgfr)Info
- Publication number
- MA30888B1 MA30888B1 MA31869A MA31869A MA30888B1 MA 30888 B1 MA30888 B1 MA 30888B1 MA 31869 A MA31869 A MA 31869A MA 31869 A MA31869 A MA 31869A MA 30888 B1 MA30888 B1 MA 30888B1
- Authority
- MA
- Morocco
- Prior art keywords
- pdgfr
- methods
- raf
- compounds
- modulating
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Transplantation (AREA)
- Child & Adolescent Psychology (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS ET DES COMPOSITIONS PHARMACEUTIQUES UTILES EN TANT QU'INHIBITEURS DE LA PROTÉINE KINASE, AINSI QUE DES PROCÉDÉS D'UTILISATION DE TELS COMPOSÉS POUR TRAITER, AMÉLIORER OU PRÉVENIR UNE CONDITION ASSOCIÉE À UNE ACTIVITÉ ANORMALE OU DÉRÉGLÉE DES KINASES. SELON CERTAINS MODES DE RÉALISATION, L'INVENTION CONCERNE DES PROCÉDÉS D'UTILISATION DE TELS COMPOSÉS POUR TRAITER, AMÉLIORER OU PRÉVENIR DES MALADIES OU TROUBLES IMPLIQUANT L'ACTIVATION ANORMALE DE C-KIT, PDGFR , PDGFR , CSF1R, ABL, BCR-ABL, CSK, JNK1, JNK2, P38, P70S6K, TGF , SRC, EGFR, TRKB, FGFR3, FLT3, FES, LCK, SYK, RAF, MKK4, MKK6, SAPK2, BRK, KDR, C-RAF OU B-RAF KINASE, OU DES FORMES MUTANTES DE CEUX-CI
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86243006P | 2006-10-20 | 2006-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30888B1 true MA30888B1 (fr) | 2009-11-02 |
Family
ID=39027274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31869A MA30888B1 (fr) | 2006-10-20 | 2009-05-13 | Compositions et procedes de modulation de recepteurs de c-kit et de facteur de croissance derive de plaquettes (pdgfr) |
Country Status (25)
Country | Link |
---|---|
US (2) | US7678792B2 (fr) |
EP (1) | EP2076513A1 (fr) |
JP (1) | JP2010506948A (fr) |
KR (1) | KR101079520B1 (fr) |
CN (1) | CN101528744A (fr) |
AR (1) | AR063343A1 (fr) |
AU (1) | AU2007309279B2 (fr) |
BR (1) | BRPI0718162A2 (fr) |
CA (1) | CA2667010A1 (fr) |
CL (1) | CL2007003005A1 (fr) |
CO (1) | CO6170361A2 (fr) |
CR (1) | CR10717A (fr) |
EA (1) | EA200900573A1 (fr) |
EC (1) | ECSP099353A (fr) |
IL (1) | IL197875A0 (fr) |
MA (1) | MA30888B1 (fr) |
MX (1) | MX2009004141A (fr) |
NI (1) | NI200900061A (fr) |
NO (1) | NO20091949L (fr) |
PE (1) | PE20081262A1 (fr) |
SM (1) | SMP200900027B (fr) |
TN (1) | TN2009000145A1 (fr) |
TW (1) | TW200825081A (fr) |
WO (1) | WO2008051757A1 (fr) |
ZA (1) | ZA200902711B (fr) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7794965B2 (en) | 2002-03-13 | 2010-09-14 | Signum Biosciences, Inc. | Method of identifying modulators of PP2A methylase |
EP1843734A4 (fr) | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | Compositions et procedes pour l'amelioration de la fonction cognitive |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US7897762B2 (en) | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
US8188113B2 (en) * | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
AR063621A1 (es) | 2006-11-09 | 2009-02-04 | Alcon Res Ltd | Matriz polimerica insoluble en agua para la administracion de farmacos |
TWI498115B (zh) * | 2007-12-27 | 2015-09-01 | Daiichi Sankyo Co Ltd | 咪唑羰基化合物 |
CA2714700C (fr) * | 2008-02-22 | 2013-07-30 | Irm Llc | Composes et compositions heterocycliques comme inhibiteurs de c-kit et pdgfr kinase |
CN102014897B (zh) | 2008-04-21 | 2015-08-05 | 西格纳姆生物科学公司 | 化合物、组合物和其制备方法 |
FR2930552B1 (fr) * | 2008-04-24 | 2012-10-12 | Centre Nat Rech Scient | N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog |
CN102089278A (zh) * | 2008-06-11 | 2011-06-08 | Irm责任有限公司 | 用于治疗疟疾的化合物和组合物 |
WO2010017331A1 (fr) * | 2008-08-05 | 2010-02-11 | George Mason Intellectual Properties, Inc. | Altérations de voie de signalisation et élévations de médicament cible dans le cancer colorectal métastasique métachrone primaire comparé à une maladie non métastasique |
MX2011004535A (es) * | 2008-10-29 | 2011-11-18 | Deciphera Pharmaceuticals Llc | Ciclopropanamidas y analogos que exhiben actividades anti-cancer y anti-proliferativas. |
TW201034675A (en) * | 2008-12-18 | 2010-10-01 | Sanofi Aventis | Method for treating macular degeneration |
US8674095B2 (en) | 2008-12-19 | 2014-03-18 | Afraxis Holdings, Inc. | Compounds for treating neuropsychiatric conditions |
KR20110116160A (ko) * | 2009-02-13 | 2011-10-25 | 포비어 파마수티칼스 | 카이네이스 저해제로서의 〔1,2,4〕트리아졸로〔1,5-a〕피리딘 |
AU2010303218A1 (en) | 2009-10-09 | 2012-05-10 | Afraxis Holdings, Inc. | 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8H)-ones for the treatment of CNS disorders |
EP2528915B1 (fr) | 2010-01-29 | 2015-10-28 | Boehringer Ingelheim International GmbH | Naphtyridines substituées et leur utilisation comme inhibiteurs de syk kinase |
EP2531498B1 (fr) | 2010-02-05 | 2016-07-13 | Novartis AG | Composés et compositions comme inhibiteurs de protéine-kinases |
DK2668210T3 (da) * | 2011-01-26 | 2020-08-24 | Celldex Therapeutics Inc | Anti-kit antistoffer og anvendelser deraf |
PL2701510T3 (pl) * | 2011-04-25 | 2017-07-31 | Usher Iii Initiative Inc | Pirazolopirydazyny oraz sposoby leczenia zwyrodnieniowych chorób siatkówki i utraty słuchu związanych z zespołem ushera |
AU2012288969B2 (en) * | 2011-07-26 | 2017-02-23 | Boehringer Ingelheim International Gmbh | Substituted quinolines and their use as medicaments |
WO2013049407A2 (fr) * | 2011-09-30 | 2013-04-04 | Kineta, Inc | Composés anti-viraux |
SI2861579T1 (en) | 2012-05-15 | 2018-05-31 | Novartis Ag | Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 |
MX357305B (es) | 2012-05-15 | 2018-07-04 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de abl-1, abl-2, y bcr-abl1. |
EA201492005A1 (ru) | 2012-05-15 | 2015-04-30 | Новартис Аг | Бензамидные производные для ингибирования активности abl1, abl2 и bcr-abl1 |
CN104302634B (zh) | 2012-05-15 | 2017-02-08 | 诺华股份有限公司 | 用于抑制abl1、abl2和bcr‑abl1的活性的苯甲酰胺衍生物 |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
CN104902895B (zh) * | 2012-06-07 | 2019-03-29 | 德西费拉制药有限责任公司 | 可用作用于治疗增生性疾病的激酶抑制剂的二氢萘啶和相关化合物 |
CN116574185A (zh) | 2012-07-25 | 2023-08-11 | 塞尔德克斯医疗公司 | 抗kit抗体及其用途 |
US9227976B2 (en) | 2012-10-25 | 2016-01-05 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
US20160151335A1 (en) * | 2013-06-26 | 2016-06-02 | Proteostasis Therapeutics, Inc. | Methods of modulating cftr activity |
GB201401886D0 (en) | 2014-02-04 | 2014-03-19 | Lytix Biopharma As | Neurodegenerative therapies |
WO2015138934A1 (fr) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité cftr |
US9790219B2 (en) | 2014-03-13 | 2017-10-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
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WO2002028853A1 (fr) | 2000-10-02 | 2002-04-11 | Tanabe Seiyaku Co., Ltd. | Compose de benzylamine, son procede de production et produit intermediaire correspondant |
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WO2007136465A2 (fr) | 2006-05-15 | 2007-11-29 | Irm Llc | Compositions et procédés utilisés en tant qu'inhibiteurs des kinases réceptrices fgf |
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CL2007003005A1 (es) | 2008-05-23 |
ZA200902711B (en) | 2010-05-26 |
BRPI0718162A2 (pt) | 2013-11-26 |
NI200900061A (es) | 2010-03-10 |
MX2009004141A (es) | 2009-05-01 |
AR063343A1 (es) | 2009-01-21 |
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US20100081656A1 (en) | 2010-04-01 |
JP2010506948A (ja) | 2010-03-04 |
KR20090054477A (ko) | 2009-05-29 |
AU2007309279A1 (en) | 2008-05-02 |
US8106068B2 (en) | 2012-01-31 |
CA2667010A1 (fr) | 2008-05-02 |
SMP200900027B (it) | 2010-01-19 |
EA200900573A1 (ru) | 2009-10-30 |
AU2007309279B2 (en) | 2011-03-24 |
SMAP200900027A (it) | 2009-07-14 |
US7678792B2 (en) | 2010-03-16 |
CR10717A (es) | 2009-07-02 |
KR101079520B1 (ko) | 2011-11-03 |
ECSP099353A (es) | 2009-06-30 |
IL197875A0 (en) | 2009-12-24 |
EP2076513A1 (fr) | 2009-07-08 |
WO2008051757A1 (fr) | 2008-05-02 |
CO6170361A2 (es) | 2010-06-18 |
US20080176846A1 (en) | 2008-07-24 |
CN101528744A (zh) | 2009-09-09 |
TN2009000145A1 (en) | 2010-10-18 |
TW200825081A (en) | 2008-06-16 |
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