WO2002028853A1 - Compose de benzylamine, son procede de production et produit intermediaire correspondant - Google Patents
Compose de benzylamine, son procede de production et produit intermediaire correspondant Download PDFInfo
- Publication number
- WO2002028853A1 WO2002028853A1 PCT/JP2001/008616 JP0108616W WO0228853A1 WO 2002028853 A1 WO2002028853 A1 WO 2002028853A1 JP 0108616 W JP0108616 W JP 0108616W WO 0228853 A1 WO0228853 A1 WO 0228853A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- producing
- benzylamine compound
- same
- halogeno
- intermediate therefor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
L'invention concerne un composé de benzylamine (ou un sel de celui-ci acceptable sur le plan pharmaceutique) représenté par la formule générale (I), dans laquelle R1 représente un groupe hétérocyclique aromatique condensé qui comporte entre un et quatre hétéroatomes sélectionnés parmi des atomes d'azote, d'oxygène et de soufre, et qui est éventuellement substitué par halogéno, oxo, nitro, cyano, alkyle inférieur, halogénoalkyle inférieur, alcoxy inférieur, pyridyle, etc.; R2 et R3 représentant chacun hydrogène, halogéno, alkyle inférieur, halogénoalkyle inférieur, ou alcoxy inférieur.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001292320A AU2001292320A1 (en) | 2000-10-02 | 2001-10-01 | Benzylamine compound, process for producing the same, and intermediate therefor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000301563 | 2000-10-02 | ||
JP2000-301563 | 2000-10-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002028853A1 true WO2002028853A1 (fr) | 2002-04-11 |
Family
ID=18783085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2001/008616 WO2002028853A1 (fr) | 2000-10-02 | 2001-10-01 | Compose de benzylamine, son procede de production et produit intermediaire correspondant |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2001292320A1 (fr) |
WO (1) | WO2002028853A1 (fr) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004030695A1 (fr) * | 2002-10-04 | 2004-04-15 | The University Of Reading | Traitement de maladies vasculaires |
WO2005016862A1 (fr) * | 2003-08-14 | 2005-02-24 | Asahi Kasei Pharma Corporation | Derive d'acide arylalcanoique substitue et son utilisation |
WO2005034869A3 (fr) * | 2003-10-08 | 2005-07-07 | Irm Llc | Composes et compositions convenant comme inhibiteurs de proteine-kinases |
WO2008090117A1 (fr) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Nouvelles compositions pharmaceutiques |
US7645764B2 (en) | 2006-11-09 | 2010-01-12 | Roche Palo Alto Llc | Kinase inhibitors and methods for using the same |
US7678792B2 (en) | 2006-10-20 | 2010-03-16 | Irm Llc | Compositions and methods for modulating c-kit and PDGFR receptors |
US8158828B2 (en) | 2005-11-28 | 2012-04-17 | Gtx, Inc. | Nuclear receptor binding agents |
JP2012533541A (ja) * | 2009-07-15 | 2012-12-27 | インテリカイン, エルエルシー | 特定の化学物質、組成物および方法 |
US8546451B2 (en) | 2005-11-28 | 2013-10-01 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
AU2011265521B2 (en) * | 2005-07-15 | 2013-10-31 | Merck Serono Sa | JNK inhibitors for the treatment of endometreosis |
US8637706B2 (en) | 2005-11-28 | 2014-01-28 | Gtx, Inc. | Nuclear receptor binding agents |
US9290497B2 (en) | 2011-01-10 | 2016-03-22 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US9409856B2 (en) | 2005-11-28 | 2016-08-09 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
US9427418B2 (en) | 2009-02-23 | 2016-08-30 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
US9527847B2 (en) | 2012-06-25 | 2016-12-27 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
US9624161B2 (en) | 2009-02-23 | 2017-04-18 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
US9822131B2 (en) | 2008-01-04 | 2017-11-21 | Intellikine Llc | Certain chemical entities, compositions and methods |
US11110096B2 (en) | 2014-04-16 | 2021-09-07 | Infinity Pharmaceuticals, Inc. | Combination therapies |
US11147818B2 (en) | 2016-06-24 | 2021-10-19 | Infinity Pharmaceuticals, Inc. | Combination therapies |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991009844A1 (fr) * | 1990-01-04 | 1991-07-11 | Pfizer Inc. | Antagonistes de la substance p |
WO1992017449A1 (fr) * | 1991-03-26 | 1992-10-15 | Pfizer Inc. | Preparation stereoselective de piperidines substituees |
WO1994004496A1 (fr) * | 1992-08-19 | 1994-03-03 | Pfizer Inc. | Benzylamino azote substitue renfermant des heterocycles non aromatiques |
WO1994013663A1 (fr) * | 1992-12-10 | 1994-06-23 | Pfizer Inc. | Heterocycles non aromatiques substitues par aminomethylene et leur utilisation comme antagonistes de substance p |
WO1995008549A1 (fr) * | 1993-09-22 | 1995-03-30 | Glaxo Group Limited | Derives de la 3-(5-tetrazolyl-benzyl)amino-piperidine et antagonistes de tachykinines |
WO1997001554A1 (fr) * | 1995-06-28 | 1997-01-16 | Merck Sharp & Dohme Limited | Derives de piperidine et de morpholine, et leur utilisation comme agents therapeutiques |
WO1997021702A1 (fr) * | 1995-12-11 | 1997-06-19 | Merck Sharp & Dohme Limited | 3-benzylamino-pyrrolidines et piperidines utilisees comme antagonistes des recepteurs des tachykinines |
-
2001
- 2001-10-01 WO PCT/JP2001/008616 patent/WO2002028853A1/fr active Application Filing
- 2001-10-01 AU AU2001292320A patent/AU2001292320A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991009844A1 (fr) * | 1990-01-04 | 1991-07-11 | Pfizer Inc. | Antagonistes de la substance p |
WO1992017449A1 (fr) * | 1991-03-26 | 1992-10-15 | Pfizer Inc. | Preparation stereoselective de piperidines substituees |
WO1994004496A1 (fr) * | 1992-08-19 | 1994-03-03 | Pfizer Inc. | Benzylamino azote substitue renfermant des heterocycles non aromatiques |
WO1994013663A1 (fr) * | 1992-12-10 | 1994-06-23 | Pfizer Inc. | Heterocycles non aromatiques substitues par aminomethylene et leur utilisation comme antagonistes de substance p |
WO1995008549A1 (fr) * | 1993-09-22 | 1995-03-30 | Glaxo Group Limited | Derives de la 3-(5-tetrazolyl-benzyl)amino-piperidine et antagonistes de tachykinines |
WO1997001554A1 (fr) * | 1995-06-28 | 1997-01-16 | Merck Sharp & Dohme Limited | Derives de piperidine et de morpholine, et leur utilisation comme agents therapeutiques |
WO1997021702A1 (fr) * | 1995-12-11 | 1997-06-19 | Merck Sharp & Dohme Limited | 3-benzylamino-pyrrolidines et piperidines utilisees comme antagonistes des recepteurs des tachykinines |
Non-Patent Citations (3)
Title |
---|
CARBONNELLE A.C. ET AL., TETRAHEDRON LETT., vol. 39, no. 25, 1998, pages 4467 - 4470, XP002912910 * |
CHEMICAL ABSTRACTS, vol. 51, Columbus, Ohio, US; abstract no. 8081F-8082C, XP002906375 * |
SCI. PROC. ROY. DUBLIN SOC., vol. 27, 1956, pages 111 - 117 * |
Cited By (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004030695A1 (fr) * | 2002-10-04 | 2004-04-15 | The University Of Reading | Traitement de maladies vasculaires |
US7470807B2 (en) | 2003-08-14 | 2008-12-30 | Asahi Kasei Pharma Corporation | Substituted arylalkanoic acid derivatives and use thereof |
JP2007528362A (ja) * | 2003-08-14 | 2007-10-11 | 旭化成ファーマ株式会社 | 置換アリールアルカン酸誘導体及びその用途 |
WO2005016862A1 (fr) * | 2003-08-14 | 2005-02-24 | Asahi Kasei Pharma Corporation | Derive d'acide arylalcanoique substitue et son utilisation |
US7449582B2 (en) | 2003-10-08 | 2008-11-11 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
JP2007508310A (ja) * | 2003-10-08 | 2007-04-05 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
WO2005034869A3 (fr) * | 2003-10-08 | 2005-07-07 | Irm Llc | Composes et compositions convenant comme inhibiteurs de proteine-kinases |
AU2004279427B2 (en) * | 2003-10-08 | 2008-07-03 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
JP4758349B2 (ja) * | 2003-10-08 | 2011-08-24 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
AU2011265521B2 (en) * | 2005-07-15 | 2013-10-31 | Merck Serono Sa | JNK inhibitors for the treatment of endometreosis |
US9409856B2 (en) | 2005-11-28 | 2016-08-09 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
US8637706B2 (en) | 2005-11-28 | 2014-01-28 | Gtx, Inc. | Nuclear receptor binding agents |
US8158828B2 (en) | 2005-11-28 | 2012-04-17 | Gtx, Inc. | Nuclear receptor binding agents |
US9051267B2 (en) | 2005-11-28 | 2015-06-09 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
US8546451B2 (en) | 2005-11-28 | 2013-10-01 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
US7678792B2 (en) | 2006-10-20 | 2010-03-16 | Irm Llc | Compositions and methods for modulating c-kit and PDGFR receptors |
US8106068B2 (en) | 2006-10-20 | 2012-01-31 | Irm Llc | Compositions and methods for modulating c-kit and PDGFR receptors |
US7645764B2 (en) | 2006-11-09 | 2010-01-12 | Roche Palo Alto Llc | Kinase inhibitors and methods for using the same |
WO2008090117A1 (fr) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Nouvelles compositions pharmaceutiques |
US9655892B2 (en) | 2008-01-04 | 2017-05-23 | Intellikine Llc | Certain chemical entities, compositions and methods |
US11433065B2 (en) | 2008-01-04 | 2022-09-06 | Intellikine Llc | Certain chemical entities, compositions and methods |
US9216982B2 (en) | 2008-01-04 | 2015-12-22 | Intellikine Llc | Certain chemical entities, compositions and methods |
US9822131B2 (en) | 2008-01-04 | 2017-11-21 | Intellikine Llc | Certain chemical entities, compositions and methods |
US9624161B2 (en) | 2009-02-23 | 2017-04-18 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
US9427418B2 (en) | 2009-02-23 | 2016-08-30 | Gtx, Inc. | Estrogen receptor ligands and methods of use thereof |
US9522146B2 (en) | 2009-07-15 | 2016-12-20 | Intellikine Llc | Substituted Isoquinolin-1(2H)-one compounds, compositions, and methods thereof |
US9206182B2 (en) | 2009-07-15 | 2015-12-08 | Intellikine Llc | Substituted isoquinolin-1(2H)-one compounds, compositions, and methods thereof |
JP2012533541A (ja) * | 2009-07-15 | 2012-12-27 | インテリカイン, エルエルシー | 特定の化学物質、組成物および方法 |
US9840505B2 (en) | 2011-01-10 | 2017-12-12 | Infinity Pharmaceuticals, Inc. | Solid forms of (S)-3-(1-(9H-purin-6-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1 (2H)-one and methods of use thereof |
USRE46621E1 (en) | 2011-01-10 | 2017-12-05 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US9290497B2 (en) | 2011-01-10 | 2016-03-22 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US10550122B2 (en) | 2011-01-10 | 2020-02-04 | Infinity Pharmaceuticals, Inc. | Solid forms of (S)-3-(1-(9H-purin-6-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one and methods of use thereof |
US11312718B2 (en) | 2011-01-10 | 2022-04-26 | Infinity Pharmaceuticals, Inc. | Formulations of (S)-3-(1-(9H-purin-6-ylamino)ethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one |
US9527847B2 (en) | 2012-06-25 | 2016-12-27 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
US11110096B2 (en) | 2014-04-16 | 2021-09-07 | Infinity Pharmaceuticals, Inc. | Combination therapies |
US11944631B2 (en) | 2014-04-16 | 2024-04-02 | Infinity Pharmaceuticals, Inc. | Combination therapies |
US11147818B2 (en) | 2016-06-24 | 2021-10-19 | Infinity Pharmaceuticals, Inc. | Combination therapies |
Also Published As
Publication number | Publication date |
---|---|
AU2001292320A1 (en) | 2002-04-15 |
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