MX2009003129A - Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras. - Google Patents
Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras.Info
- Publication number
- MX2009003129A MX2009003129A MX2009003129A MX2009003129A MX2009003129A MX 2009003129 A MX2009003129 A MX 2009003129A MX 2009003129 A MX2009003129 A MX 2009003129A MX 2009003129 A MX2009003129 A MX 2009003129A MX 2009003129 A MX2009003129 A MX 2009003129A
- Authority
- MX
- Mexico
- Prior art keywords
- inflammatory
- oxadiazole derivatives
- immunosuppressive properties
- immunosuppressive
- properties
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Abstract
Se dan a conocer compuestos policíclicos de la siguiente fórmula I: (ver fórmula (I)) y su uso como agentes anti-inflamatorios e inmunosupresores.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06121495 | 2006-09-29 | ||
PCT/EP2007/008431 WO2008037476A1 (en) | 2006-09-29 | 2007-09-27 | Oxadiazole derivatives with anti-inflammatory and immunosuppressive properties |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003129A true MX2009003129A (es) | 2009-04-06 |
Family
ID=37771076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003129A MX2009003129A (es) | 2006-09-29 | 2007-09-27 | Derivados de oxadiazol con propiedades anti-inflamatorias e inmunosupresoras. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20100087491A1 (es) |
EP (1) | EP2081916A1 (es) |
JP (1) | JP2010504932A (es) |
KR (1) | KR20090057070A (es) |
CN (1) | CN101522646A (es) |
AU (1) | AU2007302262A1 (es) |
BR (1) | BRPI0717656A2 (es) |
CA (1) | CA2664268A1 (es) |
MX (1) | MX2009003129A (es) |
RU (1) | RU2009115963A (es) |
WO (1) | WO2008037476A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007292993B2 (en) | 2006-09-07 | 2013-01-24 | Idorsia Pharmaceuticals Ltd | Pyridin-4-yl derivatives as immunomodulating agents |
CA2661315C (en) | 2006-09-08 | 2015-11-24 | Actelion Pharmaceuticals Ltd | Pyridin-3-yl derivatives as immunomodulating agents |
RU2442780C2 (ru) | 2006-09-21 | 2012-02-20 | Актелион Фармасьютиклз Лтд | Фенильные производные и их применение в качестве иммуномодуляторов |
AU2007334436A1 (en) | 2006-12-15 | 2008-06-26 | Abbott Laboratories | Novel oxadiazole compounds |
DK2125797T3 (da) | 2007-03-16 | 2014-02-10 | Actelion Pharmaceuticals Ltd | Aminopyridinderivater som s1p1/edg1-receptoragonister |
AU2008306885B2 (en) | 2007-10-04 | 2013-12-05 | Merck Serono S.A. | Oxadiazole derivatives |
CA2696829C (en) | 2007-10-04 | 2017-07-04 | Merck Serono S.A. | Oxadiazole diaryl compounds |
SI2252609T1 (sl) * | 2008-03-07 | 2013-07-31 | Actelion Pharmaceuticals Ltd. | Derivati piridin-2-ila kot imunomodulacijska sredstva |
US8410151B2 (en) * | 2008-03-07 | 2013-04-02 | Actelion Pharmaceuticals Ltd | Aminomethyl benzene derivatives |
NZ589617A (en) | 2008-05-14 | 2012-06-29 | Scripps Research Inst | 3-(Inden-4-yl)-5-(phenyl)-1,2,4-oxadiazole and 3-(tetralin-5-yl)-5-(phenyl)-1,2,4-oxadiazole derivatives |
EP2241558A1 (en) * | 2009-04-03 | 2010-10-20 | Merck Serono SA | Oxadiazole derivatives |
TWI410421B (zh) | 2009-07-16 | 2013-10-01 | Actelion Pharmaceuticals Ltd | 吡啶-4-基衍生物 |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
WO2011056916A1 (en) * | 2009-11-05 | 2011-05-12 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of cancer |
EP2560969B1 (en) | 2010-04-23 | 2015-08-12 | Bristol-Myers Squibb Company | 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists |
WO2011136927A1 (en) | 2010-04-27 | 2011-11-03 | Allergan, Inc. | 3-(4-((1h-imidazol-1-yl)methyl)phenyl)-5-aryl-1,2,4-oxadiazole derivatives as sphingosine-1 phosphate receptors modulators |
TW201206429A (en) * | 2010-07-08 | 2012-02-16 | Merck Serono Sa | Substituted oxadiazole derivatives |
ES2548258T3 (es) | 2010-09-24 | 2015-10-15 | Bristol-Myers Squibb Company | Compuestos de oxadiazol sustituidos y su uso como agonistas de S1P1 |
KR101317492B1 (ko) * | 2010-09-29 | 2013-10-15 | 가톨릭대학교 산학협력단 | Ag490을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물 |
AU2012208325B2 (en) | 2011-01-19 | 2016-12-22 | Idorsia Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl derivatives |
CN114573574A (zh) | 2015-05-20 | 2022-06-03 | 爱杜西亚药品有限公司 | 一种化合物的结晶形式 |
CA3038106A1 (en) | 2016-09-29 | 2018-04-05 | Celgene International Ii Sarl | Compounds and methods for treating lupus |
US10676467B2 (en) * | 2017-06-30 | 2020-06-09 | Washington University | Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof |
CN107827837B (zh) * | 2017-11-21 | 2021-09-24 | 苏州朗科生物技术股份有限公司 | 鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用 |
WO2022149925A1 (ko) * | 2021-01-08 | 2022-07-14 | 광주과학기술원 | 신규한 트립토판 수산화효소 저해제 및 이의 용도 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU765203B2 (en) * | 1999-04-19 | 2003-09-11 | Shionogi & Co., Ltd. | Sulfonamide derivatives having oxadiazole rings |
JP4219810B2 (ja) * | 2001-10-26 | 2009-02-04 | 塩野義製薬株式会社 | Mmp阻害作用を有するスルホンアミド誘導体 |
CA2488117A1 (en) * | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
CN1859908A (zh) * | 2003-10-01 | 2006-11-08 | 默克公司 | 作为s1p受体激动剂的3,5-芳基、杂芳基或环烷基取代的-1,2,4-噁二唑类化合物 |
EP1760071A4 (en) * | 2004-06-23 | 2008-03-05 | Ono Pharmaceutical Co | COMPOUND WITH S1P RECEPTOR BINDING ABILITY AND USE THEREOF |
WO2006047195A2 (en) * | 2004-10-22 | 2006-05-04 | Merck & Co., Inc. | 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists |
PL1826197T3 (pl) * | 2004-12-13 | 2012-06-29 | Ono Pharmaceutical Co | Pochodna kwasu aminokarboksylowego i jej zastosowanie lecznicze |
AU2006256968A1 (en) * | 2005-06-08 | 2006-12-14 | Novartis Ag | Polycyclic oxadiazoles or I soxazoles and their use as SIP receptor ligands |
CN101282936B (zh) * | 2005-10-07 | 2012-05-16 | 橘生药品工业株式会社 | 氮化杂环化合物及包含其的药物组合物 |
JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
-
2007
- 2007-09-27 BR BRPI0717656-2A2A patent/BRPI0717656A2/pt not_active IP Right Cessation
- 2007-09-27 CN CNA2007800362212A patent/CN101522646A/zh active Pending
- 2007-09-27 MX MX2009003129A patent/MX2009003129A/es not_active Application Discontinuation
- 2007-09-27 US US12/443,233 patent/US20100087491A1/en not_active Abandoned
- 2007-09-27 CA CA002664268A patent/CA2664268A1/en not_active Abandoned
- 2007-09-27 AU AU2007302262A patent/AU2007302262A1/en not_active Abandoned
- 2007-09-27 EP EP07818514A patent/EP2081916A1/en not_active Withdrawn
- 2007-09-27 JP JP2009529611A patent/JP2010504932A/ja active Pending
- 2007-09-27 KR KR1020097006364A patent/KR20090057070A/ko not_active Application Discontinuation
- 2007-09-27 RU RU2009115963/04A patent/RU2009115963A/ru not_active Application Discontinuation
- 2007-09-27 WO PCT/EP2007/008431 patent/WO2008037476A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
RU2009115963A (ru) | 2010-11-10 |
CN101522646A (zh) | 2009-09-02 |
BRPI0717656A2 (pt) | 2014-04-29 |
JP2010504932A (ja) | 2010-02-18 |
US20100087491A1 (en) | 2010-04-08 |
AU2007302262A1 (en) | 2008-04-03 |
EP2081916A1 (en) | 2009-07-29 |
KR20090057070A (ko) | 2009-06-03 |
WO2008037476A1 (en) | 2008-04-03 |
CA2664268A1 (en) | 2008-04-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FA | Abandonment or withdrawal |