SI2252609T1 - Derivati piridin-2-ila kot imunomodulacijska sredstva - Google Patents

Derivati piridin-2-ila kot imunomodulacijska sredstva

Info

Publication number
SI2252609T1
SI2252609T1 SI200930611T SI200930611T SI2252609T1 SI 2252609 T1 SI2252609 T1 SI 2252609T1 SI 200930611 T SI200930611 T SI 200930611T SI 200930611 T SI200930611 T SI 200930611T SI 2252609 T1 SI2252609 T1 SI 2252609T1
Authority
SI
Slovenia
Prior art keywords
pyridin
derivatives
immunomodulating agents
immunomodulating
agents
Prior art date
Application number
SI200930611T
Other languages
English (en)
Inventor
Martin Bolli
Cyrille Lescop
Boris Mathys
Claus Mueller
Oliver Nayler
Beat Steiner
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40584746&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2252609(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of SI2252609T1 publication Critical patent/SI2252609T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
SI200930611T 2008-03-07 2009-02-25 Derivati piridin-2-ila kot imunomodulacijska sredstva SI2252609T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2008050848 2008-03-07
EP09716943.7A EP2252609B1 (en) 2008-03-07 2009-02-25 Pyridin-2-yl derivatives as immunomodulating agents
PCT/IB2009/050749 WO2009109872A1 (en) 2008-03-07 2009-02-25 Pyridin-2-yl derivatives as immunomodulating agents

Publications (1)

Publication Number Publication Date
SI2252609T1 true SI2252609T1 (sl) 2013-07-31

Family

ID=40584746

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200930611T SI2252609T1 (sl) 2008-03-07 2009-02-25 Derivati piridin-2-ila kot imunomodulacijska sredstva

Country Status (27)

Country Link
US (1) US8575200B2 (sl)
EP (1) EP2252609B1 (sl)
JP (1) JP5435745B2 (sl)
KR (1) KR101615779B1 (sl)
CN (1) CN102015695B (sl)
AR (1) AR070858A1 (sl)
AU (1) AU2009220861B2 (sl)
BR (1) BRPI0909055A2 (sl)
CA (1) CA2715437C (sl)
CL (1) CL2009000532A1 (sl)
CY (1) CY1114096T1 (sl)
DK (1) DK2252609T3 (sl)
ES (1) ES2414533T3 (sl)
HK (1) HK1150601A1 (sl)
HR (1) HRP20130641T1 (sl)
IL (1) IL207972A (sl)
MA (1) MA32173B1 (sl)
MX (1) MX2010009644A (sl)
MY (1) MY183039A (sl)
NZ (1) NZ588438A (sl)
PL (1) PL2252609T3 (sl)
PT (1) PT2252609E (sl)
RU (1) RU2494099C2 (sl)
SI (1) SI2252609T1 (sl)
TW (1) TWI444377B (sl)
WO (1) WO2009109872A1 (sl)
ZA (1) ZA201007136B (sl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI392671B (zh) * 2006-09-07 2013-04-11 Actelion Pharmaceuticals Ltd 吡啶-４-基衍生物
WO2008029370A1 (en) * 2006-09-08 2008-03-13 Actelion Pharmaceuticals Ltd Pyridin-3-yl derivatives as immunomodulating agents
EP2069318B1 (en) * 2006-09-21 2012-09-12 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
SI2125797T1 (sl) * 2007-03-16 2014-03-31 Actelion Pharmaceuticals Ltd. Derivati amino-piridina kot agonisti receptorja s1p1/edg1
AU2008290233B2 (en) * 2007-08-17 2013-10-10 Actelion Pharmaceuticals Ltd Pyridine derivatives as S1P1/EDG1 receptor modulators
RU2010121969A (ru) * 2007-11-01 2011-12-10 Актелион Фармасьютиклз Лтд (Ch) Новые производные пиримидина
MY153617A (en) 2009-07-16 2015-02-27 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives
JP5778755B2 (ja) * 2010-04-15 2015-09-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ヒドロキノンの製造方法
WO2012098505A1 (en) 2011-01-19 2012-07-26 Actelion Pharmaceuticals Ltd 2-methoxy-pyridin-4-yl derivatives
BR112015023161B1 (pt) 2013-03-15 2022-11-16 Idorsia Pharmaceuticals Ltd Derivados de piridin-4-ila
RS59788B1 (sr) 2015-05-20 2020-02-28 Idorsia Pharmaceuticals Ltd Kristalni oblik jedinjenja (s)-3-{4-[5-(2-ciklopentil-6-metoksi-piridin-4-il)-[1,2,4]oksadiazol-3-il]-2-etil-6-metil-fenoksi}-propan-1,2-diola

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL31990A (en) * 1968-04-26 1974-05-16 Chinoin Gyogyszer Es Vegyeszet Pyridyl 1,2,4-oxadiazole derivatives,process for the preparation thereof and pharmaceutical compositions containing same
CA2051494C (en) 1990-09-20 2006-03-14 Robert J. Dinerstein 1-aryl-3-pyridinyl-2-propene-1-ones as calcium uptake inhibitors
DE4429465A1 (de) 1994-08-19 1996-02-22 Bayer Ag Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
JP2003034684A (ja) * 2001-06-29 2003-02-07 Biofor Inc 新規な種類の抗真菌剤
EP1549640A4 (en) * 2002-06-17 2008-08-06 Merck & Co Inc 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) AZETIDINE-3-CARBOXYLATE AND 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) PYRROLIDIN-3-CARBOXYLATE AS EDG RECEPTOR AGONISTS
DE10237883A1 (de) 2002-08-19 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
WO2004035538A1 (en) * 2002-10-15 2004-04-29 Merck & Co., Inc. Process for making azetidine-3-carboxylic acid
US20070043014A1 (en) * 2003-10-01 2007-02-22 Merck & Co., Inc. 3,5-Aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
CA2547198A1 (en) * 2003-12-17 2005-06-30 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
EP1760071A4 (en) * 2004-06-23 2008-03-05 Ono Pharmaceutical Co COMPOUND WITH S1P RECEPTOR BINDING ABILITY AND USE THEREOF
WO2006010379A1 (en) * 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
ES2519346T3 (es) * 2004-12-13 2014-11-06 Ono Pharmaceutical Co., Ltd. Derivado de ácido azetidinacarboxílico y uso medicinal del mismo
JP5063581B2 (ja) * 2005-03-23 2012-10-31 アクテリオン ファーマシューティカルズ リミテッド 新規チオフェン誘導体
ATE510831T1 (de) * 2005-03-23 2011-06-15 Actelion Pharmaceuticals Ltd Hydrierte benzoäcüthiophenderivate als immunmodulatoren
KR20070116645A (ko) * 2005-03-23 2007-12-10 액테리온 파마슈티칼 리미티드 스핑고신-1-포스페이트-1 수용체 길항제로서의 신규한티오펜 유도체
KR20080013886A (ko) * 2005-04-05 2008-02-13 파마코페이아, 인코포레이티드 면역억제용 퓨린 및 이미다조피리딘 유도체
TW200642683A (en) * 2005-04-22 2006-12-16 Sankyo Co Heterocyclic compound
RU2007147940A (ru) * 2005-06-08 2009-07-20 Новартис АГ (CH) Полициклические оксадиазолы или изоксазолы и их применение в качестве лигандов s1p рецептора
US20080306124A1 (en) * 2005-06-08 2008-12-11 Rainer Albert Polycyclic Oxadiazoles or I Soxazoles and Their Use as Sip Receptor Ligands
US20070043104A1 (en) * 2005-06-10 2007-02-22 Luthman Ingrid K UII-modulating compounds and their use
MX2007016505A (es) * 2005-06-24 2008-03-07 Actelion Pharmaceuticals Ltd Nuevos derivados de tiofeno.
AR057894A1 (es) * 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
TWI404706B (zh) * 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
KR20080092385A (ko) * 2006-01-24 2008-10-15 액테리온 파마슈티칼 리미티드 신규한 피리딘 유도체
EP2021338A1 (en) * 2006-05-09 2009-02-11 Pfizer Products Inc. Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
AR061841A1 (es) * 2006-09-07 2008-09-24 Actelion Pharmaceuticals Ltd Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores.
TWI392671B (zh) * 2006-09-07 2013-04-11 Actelion Pharmaceuticals Ltd 吡啶-４-基衍生物
WO2008029370A1 (en) * 2006-09-08 2008-03-13 Actelion Pharmaceuticals Ltd Pyridin-3-yl derivatives as immunomodulating agents
EP2069318B1 (en) * 2006-09-21 2012-09-12 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
RU2009115963A (ru) * 2006-09-29 2010-11-10 Новартис АГ (CH) Производные оксадиазола, обладающие противовоспалительными и иммунодепрессантными свойствами
JP2008120794A (ja) 2006-10-16 2008-05-29 Daiichi Sankyo Co Ltd ヘテロ環化合物を含有する医薬組成物
SG177221A1 (en) * 2006-12-15 2012-01-30 Abbott Lab Novel oxadiazole compounds
SI2125797T1 (sl) * 2007-03-16 2014-03-31 Actelion Pharmaceuticals Ltd. Derivati amino-piridina kot agonisti receptorja s1p1/edg1
AU2008290233B2 (en) * 2007-08-17 2013-10-10 Actelion Pharmaceuticals Ltd Pyridine derivatives as S1P1/EDG1 receptor modulators
RU2010121969A (ru) * 2007-11-01 2011-12-10 Актелион Фармасьютиклз Лтд (Ch) Новые производные пиримидина
CN101896482B (zh) * 2007-12-10 2013-01-09 埃科特莱茵药品有限公司 作为s1p1/edg1激动剂的噻吩衍生物
EP2262800A1 (en) * 2008-03-06 2010-12-22 Actelion Pharmaceuticals Ltd. Novel pyrimidine-pyridine derivatives
EP2262799B1 (en) * 2008-03-06 2012-07-04 Actelion Pharmaceuticals Ltd. Pyridine compounds
CN102007107B (zh) * 2008-03-07 2014-07-23 埃科特莱茵药品有限公司 氨甲基苯衍生物
MY153617A (en) * 2009-07-16 2015-02-27 Actelion Pharmaceuticals Ltd Pyridin-4-yl derivatives

Also Published As

Publication number Publication date
CA2715437C (en) 2016-05-24
ES2414533T3 (es) 2013-07-19
PT2252609E (pt) 2013-06-24
US20100331372A1 (en) 2010-12-30
CA2715437A1 (en) 2009-09-11
CN102015695A (zh) 2011-04-13
MY183039A (en) 2021-02-08
US8575200B2 (en) 2013-11-05
IL207972A0 (en) 2010-12-30
BRPI0909055A2 (pt) 2019-02-26
TWI444377B (zh) 2014-07-11
NZ588438A (en) 2012-05-25
EP2252609A1 (en) 2010-11-24
TW200940532A (en) 2009-10-01
WO2009109872A1 (en) 2009-09-11
CL2009000532A1 (es) 2010-04-09
ZA201007136B (en) 2014-03-26
AU2009220861A1 (en) 2009-09-11
CY1114096T1 (el) 2016-07-27
CN102015695B (zh) 2014-08-27
HRP20130641T1 (en) 2013-08-31
IL207972A (en) 2016-03-31
JP5435745B2 (ja) 2014-03-05
PL2252609T3 (pl) 2013-09-30
AR070858A1 (es) 2010-05-12
DK2252609T3 (da) 2013-06-24
KR101615779B1 (ko) 2016-04-26
MX2010009644A (es) 2010-09-22
KR20100137493A (ko) 2010-12-30
EP2252609B1 (en) 2013-04-17
AU2009220861B2 (en) 2014-05-29
JP2011513381A (ja) 2011-04-28
HK1150601A1 (en) 2012-01-06
MA32173B1 (fr) 2011-03-01
RU2494099C2 (ru) 2013-09-27
RU2010140854A (ru) 2012-04-20

Similar Documents

Publication Publication Date Title
HK1135976A1 (en) Pyridin-3-yl derivatives as immunomodulating agents
HK1133654A1 (en) Pyridin-4-yl derivatives as immunomodulating agents
HK1256310A1 (zh) N-磺酰基吡咯衍生物
IL210548A0 (en) Spiroaminodihydrothiazine derivatives
HRP20130641T1 (en) Pyridin-2-yl derivatives as immunomodulating agents
EP2376494A4 (en) DIHYDROPYRIMIDOPIRYMIDINE DERIVATIVES
ZA201100799B (en) Imidazopyridin-2-one derivatives
IL212285A0 (en) Azaindole derivatives
SG10201506608RA (en) 3-deazaneplanocin derivatives
IL206276A0 (en) Pyridine derivatives
IL210406A0 (en) Pyrrolopyridinylpyrimidin - 2 - ylamine derivatives
EP2291078A4 (en) OXAZOLBENZIMIDAZOLDERIVATE
IL211241A0 (en) 7-azaindole derivatives
EP2279532A4 (en) OXAZOLBENZIMIDAZOLDERIVATE
IL210869A0 (en) Imidazothiadiazoles derivatives
IL208336A0 (en) Pyrisazinone derivatives
IL210164A0 (en) Thiazolylpiperidine derivatives
ZA201008052B (en) 2-phenyl-4-cyclopropyl-pyrimidine derivatives
IL213424A0 (en) Quinazolinamide derivatives
ZA201007615B (en) Aminopyridine derivatives
IL218500A0 (en) Apogossypolone derivatives as anticaner agents
EP2292613A4 (en) DIHYDROINDOLINONDERIVATE
EP2285778A4 (en) NIKOTINAMIDDERIVATE
EP2301922A4 (en) pyridone
IL213051A0 (en) Difluorophenyldiacylhydrazide derivatives