BRPI0717656A2 - Derivados de diaril oxadiazol - Google Patents
Derivados de diaril oxadiazolInfo
- Publication number
- BRPI0717656A2 BRPI0717656A2 BRPI0717656-2A2A BRPI0717656A BRPI0717656A2 BR PI0717656 A2 BRPI0717656 A2 BR PI0717656A2 BR PI0717656 A BRPI0717656 A BR PI0717656A BR PI0717656 A2 BRPI0717656 A2 BR PI0717656A2
- Authority
- BR
- Brazil
- Prior art keywords
- oxadiazol
- diaryl derivatives
- diaryl
- derivatives
- oxadiazol diaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06121495 | 2006-09-29 | ||
PCT/EP2007/008431 WO2008037476A1 (en) | 2006-09-29 | 2007-09-27 | Oxadiazole derivatives with anti-inflammatory and immunosuppressive properties |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0717656A2 true BRPI0717656A2 (pt) | 2014-04-29 |
Family
ID=37771076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0717656-2A2A BRPI0717656A2 (pt) | 2006-09-29 | 2007-09-27 | Derivados de diaril oxadiazol |
Country Status (11)
Country | Link |
---|---|
US (1) | US20100087491A1 (pt) |
EP (1) | EP2081916A1 (pt) |
JP (1) | JP2010504932A (pt) |
KR (1) | KR20090057070A (pt) |
CN (1) | CN101522646A (pt) |
AU (1) | AU2007302262A1 (pt) |
BR (1) | BRPI0717656A2 (pt) |
CA (1) | CA2664268A1 (pt) |
MX (1) | MX2009003129A (pt) |
RU (1) | RU2009115963A (pt) |
WO (1) | WO2008037476A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5253401B2 (ja) | 2006-09-07 | 2013-07-31 | アクテリオン ファーマシューティカルズ リミテッド | 免疫調節薬としてのピリジン−4−イル誘導体 |
PT2069335E (pt) | 2006-09-08 | 2013-03-04 | Actelion Pharmaceuticals Ltd | Derivados de piridin-3-ilo como agentes imunomoduladores |
US8044076B2 (en) | 2006-09-21 | 2011-10-25 | Actelion Pharmaceuticals Ltd. | Phenyl derivatives and their use as immunomodulators |
NZ577111A (en) | 2006-12-15 | 2012-05-25 | Abbott Lab | Novel oxadiazole compounds |
EP2125797B1 (en) | 2007-03-16 | 2014-01-15 | Actelion Pharmaceuticals Ltd. | Amino- pyridine derivatives as s1p1 /edg1 receptor agonists |
KR20100083814A (ko) | 2007-10-04 | 2010-07-22 | 메르크 세로노 에스. 에이. | 옥사디아졸 디아릴 화합물 |
KR20100075608A (ko) | 2007-10-04 | 2010-07-02 | 메르크 세로노 에스. 에이. | 옥사다이졸 유도체 |
MY183039A (en) * | 2008-03-07 | 2021-02-08 | Idorsia Pharmaceuticals Ltd | Pyridin-2-yl derivatives as immunomodulating agents |
KR20100125380A (ko) * | 2008-03-07 | 2010-11-30 | 액테리온 파마슈티칼 리미티드 | 신규한 아미노메틸 벤젠 유도체 |
EP2913326B1 (en) | 2008-05-14 | 2020-07-15 | The Scripps Research Institute | Novel modulators of sphingosine phosphate receptors |
EP2241558A1 (en) * | 2009-04-03 | 2010-10-20 | Merck Serono SA | Oxadiazole derivatives |
WO2011007324A1 (en) | 2009-07-16 | 2011-01-20 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
JP2013510092A (ja) * | 2009-11-05 | 2013-03-21 | レクシコン ファーマシューティカルズ インコーポレイテッド | がんの治療のためのトリプトファンヒドロキシラーゼ阻害剤 |
EP2560969B1 (en) | 2010-04-23 | 2015-08-12 | Bristol-Myers Squibb Company | 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists |
WO2011136927A1 (en) | 2010-04-27 | 2011-11-03 | Allergan, Inc. | 3-(4-((1h-imidazol-1-yl)methyl)phenyl)-5-aryl-1,2,4-oxadiazole derivatives as sphingosine-1 phosphate receptors modulators |
TW201206429A (en) * | 2010-07-08 | 2012-02-16 | Merck Serono Sa | Substituted oxadiazole derivatives |
JP5869579B2 (ja) | 2010-09-24 | 2016-02-24 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 置換オキサジアゾール化合物およびそれらのs1p1アゴニストとしての使用 |
KR101317492B1 (ko) * | 2010-09-29 | 2013-10-15 | 가톨릭대학교 산학협력단 | Ag490을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물 |
AU2012208325B2 (en) | 2011-01-19 | 2016-12-22 | Idorsia Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl derivatives |
CN107667104B (zh) | 2015-05-20 | 2022-03-22 | 爱杜西亚药品有限公司 | (s)-3-{4-[5-(2-环戊基-6-甲氧基-吡啶-4-基)-[1,2,4]噁二唑-3-基]-2-乙基-6-甲基-苯氧基}-丙烷-1,2-二醇的结晶形式 |
JP7086945B2 (ja) | 2016-09-29 | 2022-06-20 | レセプトス・リミテッド・ライアビリティ・カンパニー | 狼瘡を処置するための化合物および方法 |
US10676467B2 (en) * | 2017-06-30 | 2020-06-09 | Washington University | Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof |
CN107827837B (zh) * | 2017-11-21 | 2021-09-24 | 苏州朗科生物技术股份有限公司 | 鞘氨醇-1-磷酸受体调节剂化合物及其制备方法与应用 |
KR20220100795A (ko) * | 2021-01-08 | 2022-07-18 | 광주과학기술원 | 신규한 트립토판 수산화효소 저해제 및 이의 용도 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1172361A4 (en) * | 1999-04-19 | 2002-05-08 | Shionogi & Co | SULFONAMIDE DERIVATIVES HAVING OXADIAZOLE CORES |
JP4219810B2 (ja) * | 2001-10-26 | 2009-02-04 | 塩野義製薬株式会社 | Mmp阻害作用を有するスルホンアミド誘導体 |
AU2003276043A1 (en) * | 2002-06-17 | 2003-12-31 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
AU2004277947A1 (en) * | 2003-10-01 | 2005-04-14 | Merck & Co., Inc. | 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as S1P receptor agonists |
JP5315611B2 (ja) * | 2004-06-23 | 2013-10-16 | 小野薬品工業株式会社 | S1p受容体結合能を有する化合物およびその用途 |
CA2583681A1 (en) * | 2004-10-22 | 2006-05-04 | Merck & Co., Inc. | 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists |
KR101262400B1 (ko) * | 2004-12-13 | 2013-05-08 | 오노 야꾸힝 고교 가부시키가이샤 | 아미노카르복실산 유도체 및 그 의약 용도 |
BRPI0612028A2 (pt) * | 2005-06-08 | 2010-10-13 | Novartis Ag | oxadiazóis ou isodiazóis policìclicos e uso dos mesmos como ligantes de receptor s1p |
JP5222561B2 (ja) * | 2005-10-07 | 2013-06-26 | キッセイ薬品工業株式会社 | 含窒素芳香族複素環化合物およびそれを含有する医薬組成物 |
JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
-
2007
- 2007-09-27 EP EP07818514A patent/EP2081916A1/en not_active Withdrawn
- 2007-09-27 MX MX2009003129A patent/MX2009003129A/es not_active Application Discontinuation
- 2007-09-27 AU AU2007302262A patent/AU2007302262A1/en not_active Abandoned
- 2007-09-27 CA CA002664268A patent/CA2664268A1/en not_active Abandoned
- 2007-09-27 RU RU2009115963/04A patent/RU2009115963A/ru not_active Application Discontinuation
- 2007-09-27 KR KR1020097006364A patent/KR20090057070A/ko not_active Application Discontinuation
- 2007-09-27 BR BRPI0717656-2A2A patent/BRPI0717656A2/pt not_active IP Right Cessation
- 2007-09-27 JP JP2009529611A patent/JP2010504932A/ja active Pending
- 2007-09-27 WO PCT/EP2007/008431 patent/WO2008037476A1/en active Application Filing
- 2007-09-27 US US12/443,233 patent/US20100087491A1/en not_active Abandoned
- 2007-09-27 CN CNA2007800362212A patent/CN101522646A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2081916A1 (en) | 2009-07-29 |
US20100087491A1 (en) | 2010-04-08 |
RU2009115963A (ru) | 2010-11-10 |
MX2009003129A (es) | 2009-04-06 |
KR20090057070A (ko) | 2009-06-03 |
CN101522646A (zh) | 2009-09-02 |
WO2008037476A1 (en) | 2008-04-03 |
JP2010504932A (ja) | 2010-02-18 |
AU2007302262A1 (en) | 2008-04-03 |
CA2664268A1 (en) | 2008-04-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0717656A2 (pt) | Derivados de diaril oxadiazol | |
BRPI0818457A2 (pt) | Derivados de oxadiazol | |
ATE475662T1 (de) | Dihydropyrazolopyrimidinonderivate | |
ATE483711T1 (de) | Spiroindolinonderivate | |
ATE469905T1 (de) | Pyridopyrimidinonderivate | |
ATE512135T1 (de) | Spiroindolinonderivate | |
DK2035394T3 (da) | 2-pyrazincarboxamidderivater | |
CR10831A (es) | INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA | |
CR10841A (es) | Imidazotriazinas imidazopirimidinas inhibidores de cinasa | |
DE602006004717D1 (de) | Kapselperforationsmodul | |
DE602007012130D1 (de) | Modifizierte flavin-adenin-dinucleotid-abhängige glucose-dehydrogenase | |
ATE524477T1 (de) | Aziridinylepothilonverbindungen | |
AT504580A3 (de) | Scan-einrichtung | |
ATE546437T1 (de) | Aminomethyl-4-imidazole | |
DE502007000218D1 (de) | nsetzungen | |
DK2086968T3 (da) | 5-hydroxymethyl-oxazolidin-2-on-derivater | |
DE502007000361D1 (de) | Stanznieteinheit | |
DE502007001629D1 (de) | Rfahren | |
DE602007001593D1 (de) | Aryl-/alkylvinylsulfon-hyaluronsäurederivate | |
DE102006045567A8 (de) | Crimpstabilisierung | |
DE112007003147A5 (de) | Rohr-Biegevorrichtung | |
DE502007001652D1 (de) | Notöltank | |
DE502007005975D1 (de) | Wischblatt | |
FI20065256A0 (fi) | Lävistyspuristin | |
BRPI0719956A2 (pt) | Radiofluoração |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08L | Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette] |
Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 4A, 5A, 6A E 7A ANUIDADES. |
|
B08I | Publication cancelled [chapter 8.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2277 DE 26/08/2014 POR TER SIDO INDEVIDA. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 4A, 5A, 6A, 7A, 8A, 9A, 10A, 11A, 12A E 13A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |