MEP23808A - Pyridine[3,4-b]pyrazinones - Google Patents

Pyridine[3,4-b]pyrazinones

Info

Publication number: MEP23808A
Authority: ME; Montenegro
Prior art keywords: compounds; pyrazinones; pyridine; disclosed; intermediates
Prior art date: 2006-04-21

Application number

MEP-238/08A

Other languages

Bosnian (bs)

English (en)

Unknown language (me)

Inventor

Robert O Hughes

Andrew Simon Bell

David Graham Brown

Dafydd Rhys Owen

Michael John Palmer

Christopher Phillips

David Louis Brown

Yvette Marlene Fobian

John Nicholas Freskos

Steven Edward Heasley

Eric Jon Jacobsen

Todd Michael Maddux

Brent Virgil Mischke

John Major Molyneaux

Joseph Blair Moon

Donald Joseph Rogier Jr

Michael Brent Tollefson

John Keith Walker

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-21

Filing date

2007-04-10

Publication date

2010-06-10

2007-04-10 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2010-06-10 Publication of MEP23808A publication Critical patent/MEP23808A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

MEP-238/08A 2006-04-21 2007-04-10 Pyridine[3,4-b]pyrazinones MEP23808A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US79397106P	2006-04-21	2006-04-21
PCT/IB2007/001001 WO2007122466A1 (en)	2006-04-21	2007-04-10	Pyridine[3,4-b]pyrazinones

Publications (1)

Publication Number	Publication Date
MEP23808A true MEP23808A (en)	2010-06-10

Family

ID=38431249

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-238/08A MEP23808A (en)	2006-04-21	2007-04-10	Pyridine[3,4-b]pyrazinones

Country Status (42)

Country	Link
US (1)	US7902195B2 (xx)
EP (1)	EP2013208B1 (xx)
JP (1)	JP4436892B2 (xx)
KR (1)	KR101061328B1 (xx)
CN (1)	CN101454320B (xx)
AP (1)	AP2408A (xx)
AR (1)	AR060525A1 (xx)
AT (1)	ATE513831T1 (xx)
AU (1)	AU2007242555B2 (xx)
BR (1)	BRPI0710658A2 (xx)
CA (1)	CA2649775C (xx)
CR (1)	CR10327A (xx)
CU (1)	CU23777B7 (xx)
CY (1)	CY1111739T1 (xx)
DK (1)	DK2013208T3 (xx)
DO (1)	DOP2007000080A (xx)
EA (1)	EA014919B1 (xx)
EC (1)	ECSP088803A (xx)
ES (1)	ES2366239T3 (xx)
GT (1)	GT200700035A (xx)
HK (1)	HK1133875A1 (xx)
HR (1)	HRP20110539T1 (xx)
IL (1)	IL194591A (xx)
MA (1)	MA30352B1 (xx)
ME (1)	MEP23808A (xx)
MX (1)	MX2008012456A (xx)
MY (1)	MY148583A (xx)
NL (1)	NL2000583C2 (xx)
NO (1)	NO20084129L (xx)
NZ (1)	NZ571540A (xx)
PA (1)	PA8724201A1 (xx)
PE (1)	PE20080192A1 (xx)
PL (1)	PL2013208T3 (xx)
RS (2)	RS20080484A (xx)
SI (1)	SI2013208T1 (xx)
SV (1)	SV2008003074A (xx)
TN (1)	TNSN08408A1 (xx)
TW (1)	TWI337609B (xx)
UA (1)	UA92637C2 (xx)
UY (1)	UY30291A1 (xx)
WO (1)	WO2007122466A1 (xx)
ZA (1)	ZA200808283B (xx)

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BRPI0710658A2 (pt)	2006-04-21	2011-08-16	Pfizer Prod Inc	compostos de piridina[3,4-b] pirazinonas, seus usos na preparação de composições farmacêuticas e composições farmacêuticas compreendendo os mesmos
AU2007333115B2 (en) *	2006-12-12	2013-01-10	Gilead Sciences, Inc.	Composition for treating a pulmonary hypertension
EA020372B1 (ru) *	2008-03-05	2014-10-30	Мерк Патент Гмбх	Стимуляторы секреции инсулина - производные пиридопиразинонов, способы их получения и их применение для лечения диабета
WO2010041711A1 (ja) *	2008-10-09	2010-04-15	杏林製薬株式会社	イソキノリン誘導体及びそれらを有効成分とするｐｄｅ阻害剤
KR101903925B1 (ko) *	2009-10-26	2018-10-02	시그날 파마소티칼 엘엘씨	헤테로아릴 화합물의 합성 및 정제 방법
KR20130069855A (ko)	2010-10-15	2013-06-26	길리애드 사이언시즈, 인코포레이티드	폐 고혈압 치료의 조성물 및 방법
EP2691393B1 (en)	2011-03-31	2016-09-14	Pfizer Inc	Novel bicyclic pyridinones
WO2012172449A1 (en)	2011-06-13	2012-12-20	Pfizer Inc.	Lactams as beta secretase inhibitors
WO2013030713A1 (en)	2011-08-31	2013-03-07	Pfizer Inc.	Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds
EP2852597B1 (en)	2012-05-04	2016-06-08	Pfizer Inc	Heterocyclic substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of app, bace1 and bace 2.
EP2897964A1 (en)	2012-09-20	2015-07-29	Pfizer Inc.	Alkyl-substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
UA110688C2 (uk)	2012-09-21	2016-01-25	Пфайзер Інк.	Біциклічні піридинони
CA2893256A1 (en)	2012-12-11	2014-06-19	Pfizer Inc.	Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
EP2935282A1 (en)	2012-12-19	2015-10-28	Pfizer Inc.	CARBOCYCLIC- AND HETEROCYCLIC-SUBSTITUTED HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS
EP2956458B1 (en)	2013-02-13	2017-08-09	Pfizer Inc	Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en)	2013-02-15	2016-01-12	Pfizer Inc.	Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
EP2958915B1 (en)	2013-02-19	2017-07-05	Pfizer Inc	Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders
CA2925743C (en)	2013-10-04	2018-03-06	Pfizer Inc.	Novel bicyclic pyridinones as gamma-secretase modulators
JO3466B1 (ar) *	2013-12-20	2020-07-05	Takeda Pharmaceuticals Co	مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
KR101886945B1 (ko)	2014-04-01	2018-08-08	화이자 인코포레이티드	감마-세크레타제 조절제로서의 크로멘 및 1,1a,2,7b-테트라히드로시클로프로파[c]크로멘 피리도피라진디온
EA030085B1 (ru)	2014-04-10	2018-06-29	Пфайзер Инк.	2-АМИНО-6-МЕТИЛ-4,4a,5,6-ТЕТРАГИДРОПИРАНО[3,4-d][1,3]ТИАЗИН-8a(8H)-ИЛ-1,3-ТИАЗОЛ-4-ИЛ АМИДЫ
WO2016012896A1 (en)	2014-07-24	2016-01-28	Pfizer Inc.	Pyrazolopyrimidine compounds
JP6506833B2 (ja)	2014-08-06	2019-04-24	ファイザー・インク	イミダゾピリダジン化合物
JP6628805B2 (ja)	2015-02-03	2020-01-15	ファイザー・インク	新規シクロプロパベンゾフラニルピリドピラジンジオン
SG10201912333PA (en)	2015-06-17	2020-02-27	Pfizer	Tricyclic compounds and their use as phosphodiesterase inhibitors
JP2018531924A (ja)	2015-09-24	2018-11-01	ファイザー・インク	テトラヒドロピラノ［３，４−ｄ］［１，３］オキサジン誘導体、およびｂａｃｅ阻害剤としてのその使用
JP2018531923A (ja)	2015-09-24	2018-11-01	ファイザー・インク	Ｎ−［２−（２−アミノ−６，６−二置換−４，４ａ，５，６−テトラヒドロピラノ［３，４−ｄ］［１，３］チアジン−８ａ（８Ｈ）−イル）−１，３−チアゾール−４−イル］アミド
JP2018534251A (ja)	2015-09-24	2018-11-22	ファイザー・インク	Ｂａｃｅ阻害剤として有用なｎ−［２−（３−アミノ−２，５−ジメチル−１，１−ジオキシド−５，６−ジヒドロ−２ｈ−１，２，４−チアジアジン−５−イル）−１，３−チアゾール−４−イル］アミド
CA3015166C (en)	2016-02-23	2021-08-03	Pfizer Inc.	6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
EP3478679B1 (en)	2016-07-01	2021-04-21	Pfizer Inc.	5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases
DK3642202T3 (da)	2017-06-22	2023-01-30	Pfizer	Dihydro-pyrrolo-pyridin-derivater
US11382918B2 (en) *	2017-06-28	2022-07-12	Ptc Therapeutics, Inc.	Methods for treating Huntington's Disease
PT3768669T (pt)	2018-03-23	2023-04-24	Pfizer	Derivados de piperazina azaspiro

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JP2000154139A (ja)	1998-09-16	2000-06-06	Kyowa Hakko Kogyo Co Ltd	縮環ピラジン誘導体
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WO2005040337A2 (en) *	2003-05-20	2005-05-06	The Regents Of The University Of California	METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES
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BRPI0710658A2 (pt)	2006-04-21	2011-08-16	Pfizer Prod Inc	compostos de piridina[3,4-b] pirazinonas, seus usos na preparação de composições farmacêuticas e composições farmacêuticas compreendendo os mesmos

2007
- 2007-04-10 BR BRPI0710658-0A patent/BRPI0710658A2/pt not_active IP Right Cessation
- 2007-04-10 EP EP07734320A patent/EP2013208B1/en active Active
- 2007-04-10 KR KR1020087028465A patent/KR101061328B1/ko not_active IP Right Cessation
- 2007-04-10 EA EA200801998A patent/EA014919B1/ru not_active IP Right Cessation
- 2007-04-10 AP AP2008004640A patent/AP2408A/xx active
- 2007-04-10 MX MX2008012456A patent/MX2008012456A/es active IP Right Grant
- 2007-04-10 AT AT07734320T patent/ATE513831T1/de active
- 2007-04-10 PL PL07734320T patent/PL2013208T3/pl unknown
- 2007-04-10 JP JP2009505983A patent/JP4436892B2/ja not_active Expired - Fee Related
- 2007-04-10 AU AU2007242555A patent/AU2007242555B2/en not_active Ceased
- 2007-04-10 RS RSP-2008/0484A patent/RS20080484A/sr unknown
- 2007-04-10 WO PCT/IB2007/001001 patent/WO2007122466A1/en active Application Filing
- 2007-04-10 ES ES07734320T patent/ES2366239T3/es active Active
- 2007-04-10 CA CA2649775A patent/CA2649775C/en not_active Expired - Fee Related
- 2007-04-10 CN CN2007800198932A patent/CN101454320B/zh not_active Expired - Fee Related
- 2007-04-10 ME MEP-238/08A patent/MEP23808A/xx unknown
- 2007-04-10 RS RS20110363A patent/RS51885B/en unknown
- 2007-04-10 DK DK07734320.0T patent/DK2013208T3/da active
- 2007-04-10 SI SI200730675T patent/SI2013208T1/sl unknown
- 2007-04-10 MY MYPI20084131A patent/MY148583A/en unknown
- 2007-04-10 NZ NZ571540A patent/NZ571540A/en not_active IP Right Cessation
- 2007-04-11 NL NL2000583A patent/NL2000583C2/nl not_active IP Right Cessation
- 2007-04-18 UY UY30291A patent/UY30291A1/es not_active Application Discontinuation
- 2007-04-18 AR ARP070101657A patent/AR060525A1/es not_active Application Discontinuation
- 2007-04-19 PE PE2007000483A patent/PE20080192A1/es not_active Application Discontinuation
- 2007-04-19 GT GT200700035A patent/GT200700035A/es unknown
- 2007-04-20 TW TW096114037A patent/TWI337609B/zh not_active IP Right Cessation
- 2007-04-20 DO DO2007000080A patent/DOP2007000080A/es unknown
- 2007-04-20 US US11/737,966 patent/US7902195B2/en not_active Expired - Fee Related
- 2007-04-20 PA PA20078724201A patent/PA8724201A1/es unknown
- 2007-10-04 UA UAA200812397A patent/UA92637C2/ru unknown
2008
- 2008-09-29 NO NO20084129A patent/NO20084129L/no not_active Application Discontinuation
- 2008-09-29 ZA ZA200808283A patent/ZA200808283B/xx unknown
- 2008-09-30 CR CR10327A patent/CR10327A/es unknown
- 2008-10-07 IL IL194591A patent/IL194591A/en not_active IP Right Cessation
- 2008-10-08 EC EC2008008803A patent/ECSP088803A/es unknown
- 2008-10-17 CU CU20080194A patent/CU23777B7/es active IP Right Grant
- 2008-10-17 TN TNP2008000408A patent/TNSN08408A1/fr unknown
- 2008-10-21 SV SV2008003074A patent/SV2008003074A/es unknown
- 2008-10-21 MA MA31321A patent/MA30352B1/fr unknown
2009
- 2009-11-10 HK HK09110478.1A patent/HK1133875A1/xx not_active IP Right Cessation
2011
- 2011-07-20 HR HR20110539T patent/HRP20110539T1/hr unknown
- 2011-07-25 CY CY20111100731T patent/CY1111739T1/el unknown

Also Published As

Publication number	Publication date
PL2013208T3 (pl)	2011-10-31
GT200700035A (es)	2008-02-05
NZ571540A (en)	2010-10-29
AP2408A (en)	2012-05-30
CN101454320B (zh)	2012-12-19
UY30291A1 (es)	2007-11-30
MA30352B1 (fr)	2009-04-01
CY1111739T1 (el)	2015-10-07
ES2366239T3 (es)	2011-10-18
PA8724201A1 (es)	2009-08-26
TWI337609B (en)	2011-02-21
JP2009534368A (ja)	2009-09-24
NL2000583A1 (nl)	2007-10-23
MX2008012456A (es)	2008-10-10
DK2013208T3 (da)	2011-08-15
ATE513831T1 (de)	2011-07-15
CU20080194A7 (es)	2011-03-21
US20070249615A1 (en)	2007-10-25
US7902195B2 (en)	2011-03-08
RS51885B (en)	2012-02-29
CA2649775C (en)	2011-05-31
AP2008004640A0 (en)	2008-10-31
KR101061328B1 (ko)	2011-08-31
SI2013208T1 (sl)	2011-09-30
AR060525A1 (es)	2008-06-25
CA2649775A1 (en)	2007-11-01
SV2008003074A (es)	2010-01-12
TW200808794A (en)	2008-02-16
DOP2007000080A (es)	2007-11-15
EP2013208B1 (en)	2011-06-22
EA200801998A1 (ru)	2009-04-28
MY148583A (en)	2013-04-30
EP2013208A1 (en)	2009-01-14
TNSN08408A1 (fr)	2010-04-14
JP4436892B2 (ja)	2010-03-24
NO20084129L (no)	2008-10-29
WO2007122466A1 (en)	2007-11-01
AU2007242555B2 (en)	2010-12-16
EA014919B1 (ru)	2011-04-29
AU2007242555A1 (en)	2007-11-01
CR10327A (es)	2008-10-21
ECSP088803A (es)	2008-11-27
PE20080192A1 (es)	2008-03-01
CU23777B7 (es)	2012-02-15
RS20080484A (xx)	2009-07-15
IL194591A (en)	2012-07-31
HRP20110539T1 (hr)	2011-08-31
KR20080110930A (ko)	2008-12-19
HK1133875A1 (en)	2010-04-09
NL2000583C2 (nl)	2007-12-14
UA92637C2 (xx)	2010-11-25
CN101454320A (zh)	2009-06-10
BRPI0710658A2 (pt)	2011-08-16
ZA200808283B (en)	2009-11-25

Publication	Publication Date	Title
MEP23808A (en)	2010-06-10	Pyridine[3,4-b]pyrazinones
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