MEP11608A - Heparin-derived oligosaccharide mixtures, preparation thereof and pharmaceutical compositions containing said mixtures - Google Patents
Heparin-derived oligosaccharide mixtures, preparation thereof and pharmaceutical compositions containing said mixturesInfo
- Publication number
- MEP11608A MEP11608A MEP-116/08A MEP11608A MEP11608A ME P11608 A MEP11608 A ME P11608A ME P11608 A MEP11608 A ME P11608A ME P11608 A MEP11608 A ME P11608A
- Authority
- ME
- Montenegro
- Prior art keywords
- mixtures
- heparin
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Predmetni pronalazak se odnosi na smješe oligosaharida dobijenih iz heparina, molekulske mase od 1,800 do 2,400 daltona, okarakterisane visokom aXa aktivnošću i bez alla aktivnosti. Predmetni pronalazak se takođe odnosi na njihov metod dobijanja i na farmaceutske preparate koji sadrže ove smješe.The present invention relates to mixtures of oligosaccharides derived from heparin, molecular weight from 1,800 to 2,400 daltons, characterized by high aXa activity and no alla activity. The present invention also relates to a process for their preparation and to pharmaceutical compositions containing these compositions.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0309041A FR2857971B1 (en) | 2003-07-24 | 2003-07-24 | MIXTURES OF HEPARIN DERIVED OLIGOSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
PCT/FR2004/001943 WO2005010051A2 (en) | 2003-07-24 | 2004-07-22 | Heparin-derived oligosaccharide mixtures, preparation thereof and pharmaceutical compositions containing said mixtures |
YUP-2006/0044A RS20060044A (en) | 2003-07-24 | 2004-07-22 | Heparin-derived oligosaccharide mixtures, preparation thereof and pharmaceutical compositions containing said mixtures |
Publications (1)
Publication Number | Publication Date |
---|---|
MEP11608A true MEP11608A (en) | 2010-06-10 |
Family
ID=33561051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-116/08A MEP11608A (en) | 2003-07-24 | 2004-07-22 | Heparin-derived oligosaccharide mixtures, preparation thereof and pharmaceutical compositions containing said mixtures |
Country Status (40)
Country | Link |
---|---|
EP (1) | EP1651677B1 (en) |
JP (1) | JP4865552B2 (en) |
KR (1) | KR101125517B1 (en) |
CN (1) | CN1852926B (en) |
AR (1) | AR045917A1 (en) |
AT (1) | ATE487741T1 (en) |
AU (1) | AU2004259111B2 (en) |
BR (1) | BRPI0412850A (en) |
CA (1) | CA2533555A1 (en) |
CR (1) | CR8201A (en) |
CY (1) | CY1111165T1 (en) |
DE (1) | DE602004030015D1 (en) |
DK (1) | DK1651677T3 (en) |
EC (1) | ECSP066305A (en) |
ES (1) | ES2355827T3 (en) |
FR (1) | FR2857971B1 (en) |
GT (1) | GT200400145A (en) |
HK (1) | HK1094806A1 (en) |
HN (1) | HN2004000250A (en) |
IL (1) | IL173206A (en) |
MA (1) | MA27928A1 (en) |
ME (1) | MEP11608A (en) |
MX (1) | MXPA06000336A (en) |
MY (1) | MY136769A (en) |
NO (1) | NO20060821L (en) |
NZ (1) | NZ544717A (en) |
OA (1) | OA13197A (en) |
PA (1) | PA8606801A1 (en) |
PE (1) | PE20050246A1 (en) |
PL (1) | PL1651677T3 (en) |
PT (1) | PT1651677E (en) |
RS (1) | RS20060044A (en) |
RU (1) | RU2346005C2 (en) |
SI (1) | SI1651677T1 (en) |
TN (1) | TNSN06025A1 (en) |
TW (1) | TWI369208B (en) |
UA (1) | UA89356C2 (en) |
UY (1) | UY28435A1 (en) |
WO (1) | WO2005010051A2 (en) |
ZA (1) | ZA200600657B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7589145B2 (en) | 2004-04-15 | 2009-09-15 | Exxonmobil Chemical Patents Inc. | Syndiotactic rich polyolefins |
WO2007140231A2 (en) * | 2006-05-25 | 2007-12-06 | Momenta Pharmaceutical, Inc. | Low molecular weight heparin composition and uses thereof |
CN101711771B (en) * | 2008-10-07 | 2015-12-09 | 上海喜恩医药科技发展有限公司 | A kind of polysaccharide mixture of heparin derivative and method for making thereof and pharmaceutical composition |
WO2012036152A1 (en) * | 2010-09-14 | 2012-03-22 | 国立大学法人 宮崎大学 | High purity heparin and production method therefor |
WO2012072799A1 (en) | 2010-12-02 | 2012-06-07 | Aventis Pharma S.A. | New methods for the in vitro measurement of the biological activity of an ultra low molecular weight heparin sample |
CN102558392A (en) * | 2010-12-14 | 2012-07-11 | 王芃 | Preparation method of high-FXa-resistant low-FIIa-resistant low-molecular heparin sodium |
CN102816255B (en) * | 2011-06-10 | 2015-11-25 | 王芃 | A kind of preparation method of ultra-low molecular heparin sodium |
US9896517B2 (en) | 2013-03-26 | 2018-02-20 | Jiuzhitang Co., Ltd. | Low molecular weight glycosaminoglycan derivative, pharmaceutical composition thereof, preparation method therefor and use thereof |
CN103864959A (en) * | 2014-04-03 | 2014-06-18 | 中国药科大学 | Application of heparin oligosaccharide dp12 in atherosclerosis resistance |
RU2639574C2 (en) * | 2016-05-23 | 2017-12-21 | Алексей Георгиевич Александров | Process for low molecular weight heparin preparation |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL61201A (en) * | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
FR2504928A1 (en) * | 1981-04-29 | 1982-11-05 | Choay Sa | SHORT CHAIN OLIGOSACCHARIDES HAVING BIOLOGICAL PROPERTIES, PREPARATION THEREOF AND APPLICATIONS THEREOF AS MEDICAMENTS |
EP0986581A1 (en) * | 1997-06-06 | 2000-03-22 | Hamilton Civic Hospitals Research Development, Inc. | Modified low molecular weight heparin that inhibits clot associated coagulation factors |
JP4897991B2 (en) * | 1999-07-23 | 2012-03-14 | ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ | Ultra low molecular weight heparin composition |
ES2161615B1 (en) * | 1999-07-23 | 2003-03-16 | Rovi Lab Farmaceut Sa | COMPOSITIONS OF HEPARINS OF VERY LOW MOLECULAR WEIGHT. |
FR2800074B1 (en) * | 1999-10-22 | 2001-12-21 | Aventis Pharma Sa | NOVEL OLIGOSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
JP4585072B2 (en) * | 2000-02-29 | 2010-11-24 | 扶桑薬品工業株式会社 | Heparin depolymerization method, depolymerized heparin, derivatives thereof and pharmaceutical composition |
FR2807043B1 (en) * | 2000-03-28 | 2002-11-22 | Aventis Pharma Sa | PHARMACEUTICAL COMPOSITION CONTAINING OLIGOSACCHARIDES, NEW OLIGOSACCHARIDES AND THEIR PREPARATION |
FR2811992B1 (en) * | 2000-07-21 | 2003-07-04 | Aventis Pharma Sa | MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US6969705B2 (en) * | 2000-07-21 | 2005-11-29 | Aventis Pharma S.A. | Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
JP2005505537A (en) * | 2001-08-28 | 2005-02-24 | レオ・ファーマ・アクティーゼルスカブ | Antithrombotic composition comprising low molecular weight heparin and low molecular weight dermatan sulfate |
FR2845686B1 (en) * | 2002-10-10 | 2013-08-30 | Aventis Pharma Sa | MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
2003
- 2003-07-24 FR FR0309041A patent/FR2857971B1/en not_active Expired - Fee Related
-
2004
- 2004-07-01 PE PE2004000632A patent/PE20050246A1/en not_active Application Discontinuation
- 2004-07-14 PA PA20048606801A patent/PA8606801A1/en unknown
- 2004-07-19 AR ARP040102549A patent/AR045917A1/en not_active Application Discontinuation
- 2004-07-21 HN HN2004000250A patent/HN2004000250A/en unknown
- 2004-07-22 CA CA002533555A patent/CA2533555A1/en not_active Abandoned
- 2004-07-22 WO PCT/FR2004/001943 patent/WO2005010051A2/en active Application Filing
- 2004-07-22 AU AU2004259111A patent/AU2004259111B2/en not_active Ceased
- 2004-07-22 DE DE602004030015T patent/DE602004030015D1/en not_active Expired - Lifetime
- 2004-07-22 JP JP2006520862A patent/JP4865552B2/en not_active Expired - Fee Related
- 2004-07-22 DK DK04785991.3T patent/DK1651677T3/en active
- 2004-07-22 ES ES04785991T patent/ES2355827T3/en not_active Expired - Lifetime
- 2004-07-22 EP EP04785991A patent/EP1651677B1/en not_active Expired - Lifetime
- 2004-07-22 PT PT04785991T patent/PT1651677E/en unknown
- 2004-07-22 UA UAA200601969A patent/UA89356C2/en unknown
- 2004-07-22 NZ NZ544717A patent/NZ544717A/en unknown
- 2004-07-22 AT AT04785991T patent/ATE487741T1/en active
- 2004-07-22 RS YUP-2006/0044A patent/RS20060044A/en unknown
- 2004-07-22 OA OA1200600025A patent/OA13197A/en unknown
- 2004-07-22 BR BRPI0412850-8A patent/BRPI0412850A/en active Search and Examination
- 2004-07-22 ME MEP-116/08A patent/MEP11608A/en unknown
- 2004-07-22 MX MXPA06000336A patent/MXPA06000336A/en active IP Right Grant
- 2004-07-22 CN CN2004800265420A patent/CN1852926B/en not_active Expired - Fee Related
- 2004-07-22 PL PL04785991T patent/PL1651677T3/en unknown
- 2004-07-22 SI SI200431594T patent/SI1651677T1/en unknown
- 2004-07-22 MY MYPI20042944A patent/MY136769A/en unknown
- 2004-07-22 RU RU2006105384/04A patent/RU2346005C2/en not_active IP Right Cessation
- 2004-07-22 KR KR1020067001609A patent/KR101125517B1/en not_active IP Right Cessation
- 2004-07-23 GT GT200400145A patent/GT200400145A/en unknown
- 2004-07-23 UY UY28435A patent/UY28435A1/en unknown
- 2004-07-23 TW TW093121979A patent/TWI369208B/en not_active IP Right Cessation
-
2006
- 2006-01-17 IL IL173206A patent/IL173206A/en not_active IP Right Cessation
- 2006-01-18 CR CR8201A patent/CR8201A/en unknown
- 2006-01-20 MA MA28745A patent/MA27928A1/en unknown
- 2006-01-23 ZA ZA200600657A patent/ZA200600657B/en unknown
- 2006-01-23 EC EC2006006305A patent/ECSP066305A/en unknown
- 2006-01-23 TN TNP2006000025A patent/TNSN06025A1/en unknown
- 2006-02-20 NO NO20060821A patent/NO20060821L/en not_active Application Discontinuation
-
2007
- 2007-01-10 HK HK07100324.0A patent/HK1094806A1/en not_active IP Right Cessation
-
2011
- 2011-02-04 CY CY20111100132T patent/CY1111165T1/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MEP9309A (en) | Novel oligosaccharides, preparation method and pharmaceutical compositions containing the same | |
CR8201A (en) | MIXTURES OF OLIGOSACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
BRPI0411670A (en) | method for preparing galactomannan hydrocolloids, galactomannan hydrocolloid, composition, use of galactomannan hydrocolloid, personal care product, health care product or topical health care product, household care product, institutional and industrial product, and, method to purify galactomannan hichrocolloids | |
MEP35808A (en) | New pharmaceutical compositions comprising 4-(4-(3-(4-chloro-3-trifluoromethyl-phenyl)-ureido)-3-fluoro-phenoxy)-pyridine-2-carboxylic acid for the treatment of hyper-proliferative disorders | |
MEP10408A (en) | Platinum derivative pharmaceutical formulations | |
HRP20050690A2 (en) | Hiv inhibiting 1,2,4-triazines | |
RS50035B (en) | PHARMACEUTICAL COMPOSITION CONTAINING PHENOFIBRATE AND PROCEDURE FOR ITS PRODUCTION | |
ATE319480T1 (en) | ACYLATED CYCLODEXTRIN GUEST INCLUSION COMPLEXES | |
BRPI0415449A (en) | Synergistic fungicidal active compound combinations | |
BR0208741A (en) | Piperidine Derivatives | |
BRPI0519620A2 (en) | compounds, process for their manufacture, pharmaceutical compositions comprising them, method for the therapeutic and / or prophylactic treatment of diseases that are modulated by alpha-1xr and / or beta-1xr agonists and use of such compounds | |
TW200714598A (en) | Urea derivatives, methods for their manufacture, and uses therefor | |
DK1965809T3 (en) | Compositions for improving animal health and animal performance including Beta-glucans and Alpha-Fucans | |
ECSP034442A (en) | MIXTURES OF POLYACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
GEP20043366B (en) | Benzothiophene Derivative Compounds Process of Preparation and Use Thereof | |
NO20090459L (en) | 18-methyl-19-nor-androst-4-ene-17,17-spiro ether (18-methyl-19-nor-20-spirox-4-en-3-one) and pharmaceutical compositions containing these | |
RU2008135718A (en) | COMPOSITIONS OF BISULPHATE CLOPIDOGEL | |
NO20010940D0 (en) | TAN-1057 derivatives | |
BRPI0501769A (en) | Pyrrolidine and thiazolidine compounds, process for their preparation and pharmaceutical compositions containing them | |
BR0109054A (en) | Substituted benzoylcyclohexenones | |
MX2009003459A (en) | 2, 3, 3 -trimethylcyclopent-3 -enecarbaldehyde derivatives useful as odorants. | |
NO20023251L (en) | New tetrahydropyridines, processes for their preparation and pharmaceutical compositions containing the same | |
ATE539045T1 (en) | WOODY TYPE PERFUME INGREDIENTS | |
BRPI0406804A (en) | Trussubstituted 4-ketolactam and 3-phenyl substituted lactone | |
BRPI0412554A (en) | pyrazolines as par-1 antagonists for the treatment of cardiovascular disorders |