MD3692039T2 - Enantiomerii tiazolilor substituiți ca compuși antivirali - Google Patents
Enantiomerii tiazolilor substituiți ca compuși antiviraliInfo
- Publication number
- MD3692039T2 MD3692039T2 MDE20200816T MDE20200816T MD3692039T2 MD 3692039 T2 MD3692039 T2 MD 3692039T2 MD E20200816 T MDE20200816 T MD E20200816T MD E20200816 T MDE20200816 T MD E20200816T MD 3692039 T2 MD3692039 T2 MD 3692039T2
- Authority
- MD
- Moldova
- Prior art keywords
- enantiomers
- antiviral compounds
- substituted thiazoles
- antiviral
- drugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
Abstract
Invenţia de faţă se referă la compuşi noi antivirali cu stereoconfiguraţie specifică, în special la enantiomeri specifici noi, la un procedeu pentru prepararea acestora şi la utilizările lor ca medicamente, în particular ca medicamente antivirale.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17195047 | 2017-10-05 | ||
PCT/EP2018/077022 WO2019068817A1 (en) | 2017-10-05 | 2018-10-04 | SUBSTITUTED THIAZOLEAN ENANTIOMERS AS ANTIVIRAL COMPOUNDS |
Publications (1)
Publication Number | Publication Date |
---|---|
MD3692039T2 true MD3692039T2 (ro) | 2023-05-31 |
Family
ID=60022026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20200816T MD3692039T2 (ro) | 2017-10-05 | 2018-10-04 | Enantiomerii tiazolilor substituiți ca compuși antivirali |
Country Status (36)
Country | Link |
---|---|
US (2) | US11278534B2 (ro) |
EP (2) | EP4209491A1 (ro) |
JP (1) | JP7215689B2 (ro) |
KR (1) | KR20200066619A (ro) |
CN (1) | CN111433203B (ro) |
AR (1) | AR113344A1 (ro) |
AU (1) | AU2018344471B2 (ro) |
BR (1) | BR112020006710A2 (ro) |
CA (1) | CA3077397A1 (ro) |
CL (1) | CL2020000869A1 (ro) |
CR (1) | CR20200154A (ro) |
DK (1) | DK3692039T3 (ro) |
EA (1) | EA202090620A1 (ro) |
EC (1) | ECSP20021132A (ro) |
ES (1) | ES2939652T3 (ro) |
FI (1) | FI3692039T3 (ro) |
HR (1) | HRP20230158T1 (ro) |
HU (1) | HUE061307T2 (ro) |
IL (1) | IL273681A (ro) |
JO (1) | JOP20200110A1 (ro) |
LT (1) | LT3692039T (ro) |
MA (1) | MA50609B1 (ro) |
MD (1) | MD3692039T2 (ro) |
MX (1) | MX2020003369A (ro) |
NI (1) | NI202000025A (ro) |
PH (1) | PH12020550132A1 (ro) |
PL (1) | PL3692039T3 (ro) |
PT (1) | PT3692039T (ro) |
RS (1) | RS64000B1 (ro) |
SG (1) | SG11202002420SA (ro) |
SI (1) | SI3692039T1 (ro) |
TW (1) | TWI706941B (ro) |
UA (1) | UA126163C2 (ro) |
UY (1) | UY37917A (ro) |
WO (1) | WO2019068817A1 (ro) |
ZA (1) | ZA202002150B (ro) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019068817A1 (en) * | 2017-10-05 | 2019-04-11 | Innovative Molecules Gmbh | SUBSTITUTED THIAZOLEAN ENANTIOMERS AS ANTIVIRAL COMPOUNDS |
US11760701B2 (en) | 2018-02-27 | 2023-09-19 | The Research Foundation For The State University Of New Yrok | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
CN116783171A (zh) | 2020-10-29 | 2023-09-19 | 创新分子股份有限公司 | 作为抗病毒化合物的氘化氨基噻唑化合物 |
TW202337444A (zh) | 2022-01-17 | 2023-10-01 | 德商創新分子有限責任公司 | 解旋酶引子酶抑制劑的固體結晶形式及其製備方法 |
WO2024049760A1 (en) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | Cyclic urea thiazolyl compounds for treatment of hsv |
WO2024047508A1 (en) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | Pharmaceutical compositions for herpes virus |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7100497A (ro) | 1970-01-16 | 1971-07-20 | ||
NZ331104A (en) | 1995-12-29 | 2000-03-27 | Boehringer Ingelheim Ca Ltd | Phenyl thiazole derivatives that inhibit herpes replication by inhibiting the herpes helicase primase enzyme complex |
US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
AU3289299A (en) | 1998-02-19 | 1999-09-06 | Tularik Inc. | Antiviral agents |
JP2002506858A (ja) | 1998-03-19 | 2002-03-05 | ファルマシア・アンド・アップジョン・カンパニー | Cmv感染症の治療に有用な1,3,4−チアジアゾール |
WO2000053591A1 (de) | 1999-03-08 | 2000-09-14 | Bayer Aktiengesellschaft | Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel |
DE19959958A1 (de) | 1999-12-13 | 2001-08-30 | Bayer Ag | Thiazolylharnstoff-Derivate |
DE19927415A1 (de) | 1999-06-16 | 2000-12-21 | Bayer Ag | Indolinylharnstoffderivate |
DOP2000000109A (es) | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
DE10039265A1 (de) | 2000-08-11 | 2002-02-21 | Bayer Ag | Thiazolylamid-Derivate |
WO2001096874A1 (en) | 2000-06-15 | 2001-12-20 | Bayer Aktiengesellschaft | Method for identifying compounds with anti-herpes activity |
DE10038022A1 (de) | 2000-08-04 | 2002-02-14 | Bayer Ag | Inverse Thiazolylamid-Derivate |
DE10044328A1 (de) | 2000-09-07 | 2002-03-21 | Bayer Ag | Thiazolylcarbonyl-Derivate |
DE10044353A1 (de) | 2000-09-07 | 2002-04-04 | Bayer Ag | Unkompetitive Inhibitoren der Helikase-Primase |
DE10044358A1 (de) | 2000-09-07 | 2002-03-21 | Bayer Ag | Thiazolylcarbonylheterocyclyl-Derivate |
DE10129714A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Topische Anwendung von Thiazolylamiden |
DE10129715A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Thiazolylamide |
DE10129716A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Kombinationspräparate zur Herpes-Behandlung |
DE10129717A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Kombinationspräparate zur Herpes-Behandlung |
DE10131128A1 (de) | 2001-06-28 | 2003-01-16 | Bayer Ag | Sekundäre Sulfonamide |
DE10210319A1 (de) | 2002-03-08 | 2003-09-18 | Bayer Ag | Thiazolylcarbonyl-Derivate |
DE10235967B4 (de) | 2002-08-06 | 2005-09-08 | Bayer Healthcare Ag | Methode zum Identifizieren von Substanzen mit antimikrobieller Wirkung |
DE10300109A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Methode zur Inhibition der Replikation von Herpesviren |
AU2005210474B2 (en) | 2004-01-30 | 2011-07-07 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding cassette transporters |
DE102005014248A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
US8548554B2 (en) | 2006-12-08 | 2013-10-01 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Dry electrode cap for electro-encephalography |
DE102010046720A1 (de) | 2010-09-23 | 2012-03-29 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von pan-CDK-Inhibitoren der Formel (l), sowie Intermediate der Herstellung |
AU2011323682B2 (en) * | 2010-11-01 | 2016-06-23 | Romark Laboratories L.C. | Alkylsulfinyl-substituted thiazolide compounds |
TW201636330A (zh) | 2011-05-24 | 2016-10-16 | 拜耳知識產權公司 | 含有硫醯亞胺基團之4-芳基-n-苯基-1,3,5-三氮雜苯-2-胺 |
EP2573086A1 (en) | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate |
TWI706940B (zh) * | 2016-04-06 | 2020-10-11 | 德商創新分子有限責任公司 | 新穎之抗病毒化合物 |
AR110251A1 (es) | 2016-11-28 | 2019-03-13 | Aicuris Anti Infective Cures Gmbh | Una sal maleato de la base libre de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida, formulaciones farmacéuticas, métodos de fabricación y usos de la misma |
US11021474B2 (en) | 2016-11-28 | 2021-06-01 | Aicuris Anti-Infective Cures Gmbh | N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide free base hemihydrate, methods of manufacture and uses thereof |
WO2018095576A1 (en) | 2016-11-28 | 2018-05-31 | Aicuris Anti-Infective Cures Gmbh | Topical pharmaceutical formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide |
WO2018127207A1 (zh) | 2017-01-09 | 2018-07-12 | 南京明德新药研发股份有限公司 | 噻唑衍生物及其应用 |
WO2019068817A1 (en) * | 2017-10-05 | 2019-04-11 | Innovative Molecules Gmbh | SUBSTITUTED THIAZOLEAN ENANTIOMERS AS ANTIVIRAL COMPOUNDS |
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2018
- 2018-10-04 WO PCT/EP2018/077022 patent/WO2019068817A1/en active Application Filing
- 2018-10-04 CN CN201880065255.2A patent/CN111433203B/zh active Active
- 2018-10-04 MX MX2020003369A patent/MX2020003369A/es unknown
- 2018-10-04 FI FIEP18779696.6T patent/FI3692039T3/fi active
- 2018-10-04 US US16/753,814 patent/US11278534B2/en active Active
- 2018-10-04 JP JP2020519403A patent/JP7215689B2/ja active Active
- 2018-10-04 AU AU2018344471A patent/AU2018344471B2/en active Active
- 2018-10-04 UA UAA202002635A patent/UA126163C2/uk unknown
- 2018-10-04 MA MA50609A patent/MA50609B1/fr unknown
- 2018-10-04 EP EP22213253.2A patent/EP4209491A1/en active Pending
- 2018-10-04 ES ES18779696T patent/ES2939652T3/es active Active
- 2018-10-04 SI SI201830861T patent/SI3692039T1/sl unknown
- 2018-10-04 HR HRP20230158TT patent/HRP20230158T1/hr unknown
- 2018-10-04 PL PL18779696.6T patent/PL3692039T3/pl unknown
- 2018-10-04 MD MDE20200816T patent/MD3692039T2/ro unknown
- 2018-10-04 DK DK18779696.6T patent/DK3692039T3/da active
- 2018-10-04 UY UY0001037917A patent/UY37917A/es unknown
- 2018-10-04 EP EP18779696.6A patent/EP3692039B1/en active Active
- 2018-10-04 PT PT187796966T patent/PT3692039T/pt unknown
- 2018-10-04 LT LTEPPCT/EP2018/077022T patent/LT3692039T/lt unknown
- 2018-10-04 HU HUE18779696A patent/HUE061307T2/hu unknown
- 2018-10-04 CA CA3077397A patent/CA3077397A1/en active Pending
- 2018-10-04 BR BR112020006710A patent/BR112020006710A2/pt unknown
- 2018-10-04 KR KR1020207009294A patent/KR20200066619A/ko not_active Application Discontinuation
- 2018-10-04 SG SG11202002420SA patent/SG11202002420SA/en unknown
- 2018-10-04 TW TW107135101A patent/TWI706941B/zh active
- 2018-10-04 EA EA202090620A patent/EA202090620A1/ru unknown
- 2018-10-04 RS RS20230156A patent/RS64000B1/sr unknown
- 2018-10-04 JO JOP/2020/0110A patent/JOP20200110A1/ar unknown
- 2018-10-04 CR CR20200154A patent/CR20200154A/es unknown
- 2018-10-04 AR ARP180102864A patent/AR113344A1/es unknown
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2020
- 2020-03-25 PH PH12020550132A patent/PH12020550132A1/en unknown
- 2020-03-29 IL IL273681A patent/IL273681A/en unknown
- 2020-04-01 NI NI202000025A patent/NI202000025A/es unknown
- 2020-04-01 CL CL2020000869A patent/CL2020000869A1/es unknown
- 2020-04-03 EC ECSENADI202021132A patent/ECSP20021132A/es unknown
- 2020-05-04 ZA ZA2020/02150A patent/ZA202002150B/en unknown
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2022
- 2022-01-21 US US17/581,166 patent/US20220152008A1/en active Pending
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