MX2017016619A - Derivados de pirimidina como inhibidores de tirosina cinasa de bruton (btk) y usos de los mismos. - Google Patents

Derivados de pirimidina como inhibidores de tirosina cinasa de bruton (btk) y usos de los mismos.

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Publication number
MX2017016619A
MX2017016619A MX2017016619A MX2017016619A MX2017016619A MX 2017016619 A MX2017016619 A MX 2017016619A MX 2017016619 A MX2017016619 A MX 2017016619A MX 2017016619 A MX2017016619 A MX 2017016619A MX 2017016619 A MX2017016619 A MX 2017016619A
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MX
Mexico
Prior art keywords
btk inhibitors
pyrimidine derivatives
btk
inhibitors
useful
Prior art date
Application number
MX2017016619A
Other languages
English (en)
Inventor
Liu-Bujalski Lesley
Qiu Hui
D Caldwell Richard
Original Assignee
Merck Patent Gmbh
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Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2017016619A publication Critical patent/MX2017016619A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

La presente invención se relaciona a compuestos de pirimidina y composiciones farmacéuticamente aceptables de los mismos, útiles como inhibidores de BTK. (ver Fórmula).
MX2017016619A 2015-07-09 2016-07-08 Derivados de pirimidina como inhibidores de tirosina cinasa de bruton (btk) y usos de los mismos. MX2017016619A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562190350P 2015-07-09 2015-07-09
PCT/US2016/041438 WO2017007987A1 (en) 2015-07-09 2016-07-08 Pyrimidine derivatives as btk inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
MX2017016619A true MX2017016619A (es) 2018-05-15

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MX2017016619A MX2017016619A (es) 2015-07-09 2016-07-08 Derivados de pirimidina como inhibidores de tirosina cinasa de bruton (btk) y usos de los mismos.

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US (2) US10045985B2 (es)
EP (1) EP3319960B1 (es)
JP (1) JP6853234B2 (es)
KR (1) KR20180041119A (es)
CN (1) CN108137559B (es)
AU (2) AU2016290950A1 (es)
BR (1) BR112017028549A2 (es)
CA (1) CA2989651A1 (es)
ES (1) ES2854703T3 (es)
IL (1) IL256610B (es)
MX (1) MX2017016619A (es)
RU (1) RU2743040C2 (es)
WO (1) WO2017007987A1 (es)
ZA (1) ZA201708568B (es)

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