ECSP20021132A - Enantiómeros de tiazoles sustituidos compuestos antivirales - Google Patents

Enantiómeros de tiazoles sustituidos compuestos antivirales

Info

Publication number
ECSP20021132A
ECSP20021132A ECSENADI202021132A ECDI202021132A ECSP20021132A EC SP20021132 A ECSP20021132 A EC SP20021132A EC SENADI202021132 A ECSENADI202021132 A EC SENADI202021132A EC DI202021132 A ECDI202021132 A EC DI202021132A EC SP20021132 A ECSP20021132 A EC SP20021132A
Authority
EC
Ecuador
Prior art keywords
enanthomers
antiviral compounds
thiazoles substituted
thiazoles
substituted
Prior art date
Application number
ECSENADI202021132A
Other languages
English (en)
Inventor
Christian Gege
Gerald Kleymann
Original Assignee
Innovative Molecules Gmbh [De/De]
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovative Molecules Gmbh [De/De] filed Critical Innovative Molecules Gmbh [De/De]
Publication of ECSP20021132A publication Critical patent/ECSP20021132A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms

Abstract

La presente invención se refiere a nuevos compuestos antivirales con estereoconfiguración específica, especialmente a nuevos enantiómeros específicos, a un proceso para su preparación y a su uso como medicamentos, en particular como medicamentos antivirales.
ECSENADI202021132A 2017-10-05 2020-04-03 Enantiómeros de tiazoles sustituidos compuestos antivirales ECSP20021132A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17195047 2017-10-05

Publications (1)

Publication Number Publication Date
ECSP20021132A true ECSP20021132A (es) 2020-07-31

Family

ID=60022026

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202021132A ECSP20021132A (es) 2017-10-05 2020-04-03 Enantiómeros de tiazoles sustituidos compuestos antivirales

Country Status (36)

Country Link
US (2) US11278534B2 (es)
EP (2) EP4209491A1 (es)
JP (1) JP7215689B2 (es)
KR (1) KR20200066619A (es)
CN (1) CN111433203B (es)
AR (1) AR113344A1 (es)
AU (1) AU2018344471B2 (es)
BR (1) BR112020006710A2 (es)
CA (1) CA3077397A1 (es)
CL (1) CL2020000869A1 (es)
CR (1) CR20200154A (es)
DK (1) DK3692039T3 (es)
EA (1) EA202090620A1 (es)
EC (1) ECSP20021132A (es)
ES (1) ES2939652T3 (es)
FI (1) FI3692039T3 (es)
HR (1) HRP20230158T1 (es)
HU (1) HUE061307T2 (es)
IL (1) IL273681A (es)
JO (1) JOP20200110A1 (es)
LT (1) LT3692039T (es)
MA (1) MA50609B1 (es)
MD (1) MD3692039T2 (es)
MX (1) MX2020003369A (es)
NI (1) NI202000025A (es)
PH (1) PH12020550132A1 (es)
PL (1) PL3692039T3 (es)
PT (1) PT3692039T (es)
RS (1) RS64000B1 (es)
SG (1) SG11202002420SA (es)
SI (1) SI3692039T1 (es)
TW (1) TWI706941B (es)
UA (1) UA126163C2 (es)
UY (1) UY37917A (es)
WO (1) WO2019068817A1 (es)
ZA (1) ZA202002150B (es)

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AR113344A1 (es) * 2017-10-05 2020-04-22 Innovative Molecules Gmbh Enantiómeros de una serie de compuestos antivirales
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑
CA3196645A1 (en) 2020-10-29 2022-05-05 Innovative Molecules Gmbh Deuterated aminothiazole compounds as antiviral compounds
WO2023135303A1 (en) 2022-01-17 2023-07-20 Innovative Molecules Gmbh Solid crystalline forms of helicase-primase inhibitors and process of preparation thereof
WO2024047508A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. Pharmaceutical compositions for herpes virus
WO2024049760A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. Cyclic urea thiazolyl compounds for treatment of hsv

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US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
WO1999042455A1 (en) 1998-02-19 1999-08-26 Tularik Inc. Antiviral agents
DK1064273T3 (da) 1998-03-19 2003-03-31 Upjohn Co 1,3,4-Thiadiazoler, som er nyttige til behandling af CMV-infektioner
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Also Published As

Publication number Publication date
HRP20230158T1 (hr) 2023-03-31
LT3692039T (lt) 2023-03-27
JOP20200110A1 (ar) 2020-05-07
AU2018344471A1 (en) 2020-04-09
RS64000B1 (sr) 2023-03-31
FI3692039T3 (fi) 2023-03-23
UA126163C2 (uk) 2022-08-25
SI3692039T1 (sl) 2023-04-28
CN111433203B (zh) 2024-02-13
PL3692039T3 (pl) 2023-04-17
DK3692039T3 (da) 2023-03-13
CL2020000869A1 (es) 2020-09-21
PH12020550132A1 (en) 2021-02-08
CR20200154A (es) 2020-05-24
UY37917A (es) 2019-04-30
MA50609A (fr) 2020-08-12
CA3077397A1 (en) 2019-04-11
IL273681A (en) 2020-05-31
ZA202002150B (en) 2022-10-26
EP3692039A1 (en) 2020-08-12
EP4209491A1 (en) 2023-07-12
WO2019068817A1 (en) 2019-04-11
BR112020006710A2 (pt) 2022-11-08
HUE061307T2 (hu) 2023-06-28
US11278534B2 (en) 2022-03-22
EA202090620A1 (ru) 2020-07-10
KR20200066619A (ko) 2020-06-10
AR113344A1 (es) 2020-04-22
US20200289486A1 (en) 2020-09-17
CN111433203A (zh) 2020-07-17
NI202000025A (es) 2020-07-31
AU2018344471B2 (en) 2022-09-29
SG11202002420SA (en) 2020-04-29
TWI706941B (zh) 2020-10-11
JP2020536108A (ja) 2020-12-10
US20220152008A1 (en) 2022-05-19
JP7215689B2 (ja) 2023-01-31
MA50609B1 (fr) 2023-03-31
TW201927758A (zh) 2019-07-16
MD3692039T2 (ro) 2023-05-31
MX2020003369A (es) 2020-07-29
PT3692039T (pt) 2023-03-07
ES2939652T3 (es) 2023-04-25
EP3692039B1 (en) 2022-12-14

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