MD3472153T2 - Pirimidin-2-ilamino-1H-pirazoli în calitate de inhibitori L RRK2 pentru utilizare în tratamentul tulburărilor neurodegenerative - Google Patents

Pirimidin-2-ilamino-1H-pirazoli în calitate de inhibitori L RRK2 pentru utilizare în tratamentul tulburărilor neurodegenerative

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Publication number
MD3472153T2
MD3472153T2 MDE20190504T MDE20190504T MD3472153T2 MD 3472153 T2 MD3472153 T2 MD 3472153T2 MD E20190504 T MDE20190504 T MD E20190504T MD E20190504 T MDE20190504 T MD E20190504T MD 3472153 T2 MD3472153 T2 MD 3472153T2
Authority
MD
Moldova
Prior art keywords
pyrazols
ylamino
pyrimidin
treatment
neurodegenerative disorders
Prior art date
Application number
MDE20190504T
Other languages
English (en)
Inventor
Anthony A Estrada
Jianwen A Feng
Joseph P Lyssikatos
Zachary K Sweeney
Vicente Fidalgo Javier De
Original Assignee
Denali Therapeutics Inc
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Filing date
Publication date
Application filed by Denali Therapeutics Inc filed Critical Denali Therapeutics Inc
Publication of MD3472153T2 publication Critical patent/MD3472153T2/ro

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    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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Abstract

Prezenta divulgare se referă în general la inhibitori LRRK2, sau la o sare acdceptabilă farmaceutic, analog deuterat, promedicament, tautomer, stereoizomer, sau la un amestec de de stereoizomeri al acestora, şi metode de fabricare şi utilizare a acestora.
MDE20190504T 2016-06-16 2017-06-15 Pirimidin-2-ilamino-1H-pirazoli în calitate de inhibitori L RRK2 pentru utilizare în tratamentul tulburărilor neurodegenerative MD3472153T2 (ro)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662350876P 2016-06-16 2016-06-16
US201662417151P 2016-11-03 2016-11-03
US201762476581P 2017-03-24 2017-03-24
US201762510711P 2017-05-24 2017-05-24
PCT/US2017/037782 WO2017218843A1 (en) 2016-06-16 2017-06-15 Pyrimidin-2-ylamino-1h-pyrazols as lrrk2 inhibitors for use in the treatment of neurodegenerative disorders

Publications (1)

Publication Number Publication Date
MD3472153T2 true MD3472153T2 (ro) 2022-03-31

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MDE20190504T MD3472153T2 (ro) 2016-06-16 2017-06-15 Pirimidin-2-ilamino-1H-pirazoli în calitate de inhibitori L RRK2 pentru utilizare în tratamentul tulburărilor neurodegenerative

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US (6) US20170362206A1 (ro)
EP (2) EP3472153B1 (ro)
JP (1) JP7004459B2 (ro)
KR (2) KR102553188B1 (ro)
CN (2) CN114315819A (ro)
AU (2) AU2017286653B2 (ro)
BR (1) BR112018075569A2 (ro)
CA (1) CA3025672A1 (ro)
CL (1) CL2018003597A1 (ro)
CO (1) CO2018013585A2 (ro)
CR (2) CR20180592A (ro)
CU (1) CU24605B1 (ro)
CY (1) CY1124789T1 (ro)
DO (2) DOP2018000285A (ro)
EC (1) ECSP18092481A (ro)
ES (1) ES2900368T3 (ro)
HR (1) HRP20211923T1 (ro)
HU (1) HUE056678T2 (ro)
IL (3) IL299412A (ro)
JO (1) JOP20180113B1 (ro)
LT (1) LT3472153T (ro)
MD (1) MD3472153T2 (ro)
MX (3) MX2018015630A (ro)
PE (2) PE20190395A1 (ro)
PH (1) PH12018502427A1 (ro)
PL (1) PL3472153T3 (ro)
PT (1) PT3472153T (ro)
RS (1) RS62868B1 (ro)
SA (2) SA521430638B1 (ro)
SG (2) SG11201810579YA (ro)
SI (1) SI3472153T1 (ro)
TN (1) TN2018000422A1 (ro)
TW (1) TWI786049B (ro)
UA (1) UA126231C2 (ro)
WO (1) WO2017218843A1 (ro)
ZA (1) ZA201900229B (ro)

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