MA40774A - Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 - Google Patents
Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38Info
- Publication number
- MA40774A MA40774A MA040774A MA40774A MA40774A MA 40774 A MA40774 A MA 40774A MA 040774 A MA040774 A MA 040774A MA 40774 A MA40774 A MA 40774A MA 40774 A MA40774 A MA 40774A
- Authority
- MA
- Morocco
- Prior art keywords
- diaryleurea
- kinase
- inhibitors
- derivatives
- diaryleurea derivatives
- Prior art date
Links
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
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- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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GBGB1417344.7A GB201417344D0 (en) | 2014-10-01 | 2014-10-01 | New compounds |
GBGB1510694.1A GB201510694D0 (en) | 2015-06-18 | 2015-06-18 | New compounds |
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MA40774A true MA40774A (fr) | 2017-08-08 |
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MA040774A MA40774A (fr) | 2014-10-01 | 2015-09-30 | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
MA040775A MA40775A (fr) | 2014-10-01 | 2015-09-30 | Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 |
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MA040775A MA40775A (fr) | 2014-10-01 | 2015-09-30 | Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 |
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US (6) | US9499486B2 (fr) |
EP (2) | EP3201179A1 (fr) |
JP (2) | JP6662863B2 (fr) |
KR (2) | KR20170063783A (fr) |
CN (2) | CN107001274A (fr) |
AU (2) | AU2015326543B2 (fr) |
BR (2) | BR112017005531A2 (fr) |
CA (1) | CA2961870A1 (fr) |
EA (2) | EA035478B1 (fr) |
MA (2) | MA40774A (fr) |
MX (2) | MX2017004128A (fr) |
WO (2) | WO2016051188A1 (fr) |
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JP5511680B2 (ja) | 2007-12-19 | 2014-06-04 | キャンサー・リサーチ・テクノロジー・リミテッド | ピリド[2,3−b]ピラジン−8−置換化合物及びその使用 |
PL2531502T3 (pl) | 2010-02-01 | 2014-08-29 | Cancer Research Tech Ltd | 1-(5-tert-Butylo-2-fenylo-2H-pirazol-3-ilo)-3-[2-fluoro-4-(1-metylo-2-okso-2,3-dihydro-1H-imidazo[4,5-b]pirydyn-7-yloksy)-fenylo]-mocznik i związki pokrewne oraz ich zastosowanie w terapii |
PL2763984T3 (pl) | 2011-10-03 | 2016-10-31 | 1-pirazolilo-3-(4-((2-anilinopirymidyno-4-ilo)oksy)naftaleno-1-ilo)moczniki jako inhibitory kinazy p38 MAP | |
EP2578582A1 (fr) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napthtalèn-1-yl) urées comme inhibiteurs de la p38 MAP kinase |
GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
WO2014033447A2 (fr) | 2012-08-29 | 2014-03-06 | Respivert Limited | Inhibiteurs de kinase |
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MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
JP6995774B2 (ja) * | 2016-04-06 | 2022-02-21 | オクラー アクイジションズ リミテッド | キナーゼ阻害剤 |
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GB0921731D0 (en) | 2009-12-11 | 2010-01-27 | Respivert Ltd | Theraputic uses |
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WO2011124923A2 (fr) | 2010-04-08 | 2011-10-13 | Respivert Limited | Nouveaux composés |
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GB201010193D0 (en) | 2010-06-17 | 2010-07-21 | Respivert Ltd | Medicinal use |
GB201010196D0 (en) | 2010-06-17 | 2010-07-21 | Respivert Ltd | Methods |
WO2011158044A2 (fr) | 2010-06-17 | 2011-12-22 | Respivert Limited | Formulations respiratoires et composés destinés à être utilisés dans ces formulations |
EP2578582A1 (fr) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napthtalèn-1-yl) urées comme inhibiteurs de la p38 MAP kinase |
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SG11201402985VA (en) | 2011-12-09 | 2014-08-28 | Chiesi Farma Spa | Kinase inhibitors |
GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
WO2014033449A1 (fr) | 2012-08-29 | 2014-03-06 | Respivert Limited | Inhibiteurs de kinases |
WO2014033447A2 (fr) | 2012-08-29 | 2014-03-06 | Respivert Limited | Inhibiteurs de kinase |
WO2014033446A1 (fr) | 2012-08-29 | 2014-03-06 | Respivert Limited | Inhibiteurs de kinases |
EP2925742B1 (fr) | 2012-11-16 | 2016-10-26 | Respivert Limited | Inhibiteurs de kinase |
WO2014140582A1 (fr) | 2013-03-14 | 2014-09-18 | Respivert Limited | Inhibiteurs de kinases |
DK2981535T3 (da) | 2013-04-02 | 2021-03-01 | Oxular Acquisitions Ltd | Urinstofderivater, der er anvendelige som kinaseinhibitorer |
WO2014162121A1 (fr) | 2013-04-02 | 2014-10-09 | Topivert Pharma Limited | Inhibiteurs de kinase à base de n-alkyl pyrazoles |
AU2014369449B2 (en) * | 2013-12-20 | 2018-07-05 | Oxular Acquisitions Limited | Urea derivatives useful as kinase inhibitors |
DK3105222T3 (en) | 2014-02-14 | 2018-07-23 | Respivert Ltd | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY COMPOUNDS |
WO2016051186A1 (fr) | 2014-10-01 | 2016-04-07 | Respivert Limited | Dérivés de n-phényl-3-quinazolin-6-yl-benzamide en tant qu'inhibiteurs de kinase p38 |
MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
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2015
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- 2015-10-01 WO PCT/GB2015/052876 patent/WO2016051187A1/fr active Application Filing
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2016
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