MA38273A1 - Thérapie de combinaison avec des anticorps anti-her3 - Google Patents

Thérapie de combinaison avec des anticorps anti-her3

Info

Publication number
MA38273A1
MA38273A1 MA38273A MA38273A MA38273A1 MA 38273 A1 MA38273 A1 MA 38273A1 MA 38273 A MA38273 A MA 38273A MA 38273 A MA38273 A MA 38273A MA 38273 A1 MA38273 A1 MA 38273A1
Authority
MA
Morocco
Prior art keywords
combination therapy
her3 antibodies
antibodies
her3
relates
Prior art date
Application number
MA38273A
Other languages
English (en)
Inventor
Birgit Bossenmaier
Frieder Bauss
Thomas Friess
Christian Gerdes
Max Hasmann
Marlene Thomas
Martin Weisser
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA38273A1 publication Critical patent/MA38273A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

La présente invention concerne la thérapie de combinaison d'anticorps anti-her3 avec certains anticorps anti-her.
MA38273A 2013-01-11 2014-01-10 Thérapie de combinaison avec des anticorps anti-her3 MA38273A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13151076 2013-01-11
PCT/EP2014/050344 WO2014108484A2 (fr) 2013-01-11 2014-01-10 Thérapie de combinaison avec des anticorps anti-her3

Publications (1)

Publication Number Publication Date
MA38273A1 true MA38273A1 (fr) 2017-05-31

Family

ID=47504772

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38273A MA38273A1 (fr) 2013-01-11 2014-01-10 Thérapie de combinaison avec des anticorps anti-her3

Country Status (19)

Country Link
US (2) US9180185B2 (fr)
EP (1) EP2943508B1 (fr)
JP (1) JP6257646B2 (fr)
KR (1) KR20150093231A (fr)
CN (1) CN104797602A (fr)
AR (1) AR094403A1 (fr)
AU (1) AU2014204795A1 (fr)
CA (1) CA2887508A1 (fr)
CL (1) CL2015001049A1 (fr)
CR (1) CR20150284A (fr)
EA (1) EA201500744A1 (fr)
HK (1) HK1211950A1 (fr)
IL (1) IL238393A0 (fr)
MA (1) MA38273A1 (fr)
MX (1) MX2015008313A (fr)
PH (1) PH12015501071A1 (fr)
SG (1) SG11201503802UA (fr)
TW (1) TW201431559A (fr)
WO (1) WO2014108484A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
US9180185B2 (en) * 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
EP3800204A1 (fr) 2013-04-16 2021-04-07 F. Hoffmann-La Roche AG Variants de pertuzumab et leur évaluation
WO2015173248A1 (fr) 2014-05-14 2015-11-19 F. Hoffmann-La Roche Ag Anticorps bispécifiques anti her3/her2 se liant à l'épingle à cheveux bêta de her3 et du domaine ii de her2
EP3091033A1 (fr) * 2015-05-06 2016-11-09 Gamamabs Pharma Anticorps anti-her3 humains et leurs utilisations
CN108602890A (zh) 2015-12-11 2018-09-28 瑞泽恩制药公司 用于减少或预防对egfr和/或erbb3阻滞剂具有抗性的肿瘤生长的方法
WO2017102789A1 (fr) * 2015-12-17 2017-06-22 F. Hoffmann-La Roche Ag Polythérapie à base d'anticorps anti-her3 et d'anticorps anti-her2
UA123292C2 (uk) 2017-01-17 2021-03-10 Дженентек, Інк. Рідка фармацевтична композиція, яка містить пертузумаб та трастузумаб
SG11201907050PA (en) 2017-02-28 2019-09-27 Univ Kinki Method for treating egfr-tki-resistant non-small cell lung cancer by administration of anti-her3 antibody-drug conjugate
US11077189B2 (en) 2017-03-02 2021-08-03 Genentech Inc. Adjuvant treatment of HER2-positive breast cancer
FI3645553T3 (fi) * 2017-06-27 2023-05-22 Regeneron Pharma Tropismilla muokattuja rekombinantteja viruspartikkeleita ja niiden käyttöjä geneettisen materiaalin viemiseksi kohdennetusti ihmissoluihin
CA3105750A1 (fr) * 2018-07-09 2020-01-16 Precigen, Inc. Constructions de fusion et leurs methodes d'utilisation
US20220072144A1 (en) 2018-09-20 2022-03-10 Daiichi Sankyo Company, Limited Treatment of her3-mutated cancer by administration of anti-her3 antibody-drug conjugate
WO2023031435A1 (fr) * 2021-09-03 2023-03-09 Cancer Research Technology Limited Traitement et prévention du cancer à l'aide de molécules de liaison à l'antigène her3

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007089A1 (fr) 1987-03-18 1988-09-22 Medical Research Council Anticorps alteres
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
US6750334B1 (en) 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
EP1728802A3 (fr) 1996-03-27 2006-12-13 Genentech, Inc. Anticorps de la protèine ErbB3
AU2710597A (en) 1996-06-27 1998-01-14 Pfizer Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
JPH11236333A (ja) 1997-12-30 1999-08-31 Pfizer Prod Inc 抗ガン剤として有用なイミダゾリン−４−オン誘導体
EP2261229A3 (fr) 1998-04-20 2011-03-23 GlycArt Biotechnology AG Modification par glycosylation d'anticorps aux fins d'amélioration de la cytotoxicité cellulaire dépendant des anticorps
WO1999060023A1 (fr) 1998-05-15 1999-11-25 Imclone Systems Incorporated Traitement de tumeurs humaines a l'aide d'un rayonnement et d'inhibiteurs de tyrosine kinases de recepteurs du facteur de croissance
EE200100118A (et) 1998-08-27 2002-06-17 Pfizer Products Inc. Vähivastaste vahenditena kasulikud alkünüül-asendatud kinoliin-2-ooni derivaadid
CA2341739C (fr) 1998-08-27 2005-07-12 Pfizer Products Inc. Derives de quinolin-2-one utiles en tant qu'agents anticancereux
EP1006113A1 (fr) 1998-12-02 2000-06-07 Pfizer Products Inc. Dérivés de 2-(2-oxo-éthylidène)-imidazolidin-4-one et leur utilisation pour inhiber la croissance anormale des cellules
EP1150973B1 (fr) 1999-02-11 2005-06-15 Pfizer Products Inc. Derives de quinolin-2-one a substitution heteroaryle convenant comme anti-cancereux
US6586447B1 (en) 1999-04-01 2003-07-01 Pfizer Inc 3,3-disubstituted-oxindole derivatives useful as anticancer agents
EP2270148A3 (fr) 1999-04-09 2011-06-08 Kyowa Hakko Kirin Co., Ltd. Méthode de régulation de l'activité d'une molécule immunologiquement fonctionnelle
AUPQ105799A0 (en) 1999-06-18 1999-07-08 Victor Chang Cardiac Research Institute, The Cell growth inhibition
CN100340575C (zh) 1999-06-25 2007-10-03 杰南技术公司 人源化抗ErbB2抗体及其在制备药物中的应用
ATE259365T1 (de) 1999-11-30 2004-02-15 Pfizer Prod Inc Chinolinderivate verwendbar zur hemmung der farnesyl-protein transferase
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
HN2000000266A (es) 2000-01-21 2001-05-21 Pfizer Prod Inc Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
FR2807767B1 (fr) 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
EP1228766A1 (fr) 2001-01-31 2002-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Phosphorylation de PYK2 par HER3 induit l'invasion de tumeurs
US7744882B2 (en) 2001-05-31 2010-06-29 Tumor Biology Investment Group, Inc. Soluble ErbB3 methods of detection and antibodies
EP1283053A1 (fr) 2001-08-09 2003-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibiteurs de l'activité de HER3
HUP0600342A3 (en) 2001-10-25 2011-03-28 Genentech Inc Glycoprotein compositions
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
EP1495123B1 (fr) 2002-03-26 2013-10-30 Zensun (Shanghai) Science and Technology Limited Procedes fondes sur l'utilisation de erbb3 et compositions associees de traitement des neoplasmes
ATE475708T1 (de) 2003-01-22 2010-08-15 Glycart Biotechnology Ag Fusionskonstrukte und deren verwendung zur produktion von antikörpern mit erhöhter fc rezeptor bindungsaffinität und effektorfunktion
CA2534077A1 (fr) 2003-07-29 2005-02-10 Morphotek Inc. Anticorps et procedes permettant de produire des anticorps genetiquement modifies presentant une fonction effectrice amelioree
CA2536408A1 (fr) 2003-08-22 2005-03-03 Biogen Idec Ma Inc. Anticorps ameliores possedant une fonction d'effecteur modifiee et procedes de fabrication associes
CA2534959A1 (fr) 2003-09-05 2005-03-31 Genentech, Inc. Anticorps aux fonctions d'effecteur modifiees
PL1692182T3 (pl) 2003-11-05 2010-09-30 Roche Glycart Ag Przeciwciała CD20 o zwiększonym powinowactwie wiązania z receptorem Fc oraz zwiększonej funkcji efektorowej
ES2537631T3 (es) 2004-05-27 2015-06-10 The Regents Of The University Of Colorado Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer
SV2006002143A (es) 2004-06-16 2006-01-26 Genentech Inc Uso de un anticuerpo para el tratamiento del cancer resistente al platino
BRPI0515604A (pt) 2004-09-08 2008-07-29 Genentech Inc método para o tratamento de células de cáncer e método de tratamento de uma doença imune relacionada
AU2005335714B2 (en) 2004-11-10 2012-07-26 Macrogenics, Inc. Engineering Fc antibody regions to confer effector function
KR20070085855A (ko) 2004-12-07 2007-08-27 제넨테크, 인크. Ｈｅｒ 억제제를 이용한 치료를 위한 환자 선택 방법
US7722867B2 (en) 2005-02-07 2010-05-25 Glycart Biotechnology Ag Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
DK1850874T3 (da) * 2005-02-23 2013-11-11 Genentech Inc Forlængelse af tid til sygdomsprogression eller overlevelse for ovariecancer ved anvendelse af pertuzumab
WO2006096861A2 (fr) * 2005-03-08 2006-09-14 Genentech, Inc. Methodes permettant d'identifier des tumeurs sensibles au traitement par des inhibiteurs de dimerisation her (hdi)
TW200720289A (en) 2005-04-01 2007-06-01 Hoffmann La Roche Antibodies against CCR5 and uses thereof
AU2006239851B2 (en) 2005-04-26 2011-06-16 Medimmune, Llc Modulation of antibody effector function by hinge domain engineering
EP1877441A2 (fr) 2005-04-26 2008-01-16 Bioren, Inc. Procede de production d'anticorps igg humains a fonctions effectrices renforcees
PE20070207A1 (es) 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her
EP2395024B1 (fr) 2005-08-26 2018-12-19 Roche Glycart AG Molécules de liaison d'antigène modifiées avec activité de signalisation des cellules altérée
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
WO2008064884A1 (fr) 2006-11-28 2008-06-05 U3 Pharma Gmbh Her3 activé servant de marqueur pour prédire l'efficacité thérapeutique
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
KR101598229B1 (ko) 2007-02-16 2016-02-26 메리맥 파마슈티컬즈, 인크. Ｅｒｂｂ3에 대한 항체 및 이의 용도
PL2162149T3 (pl) 2007-06-01 2014-04-30 Henry M Jackson Found Advancement Military Medicine Inc Szczepionka do zapobiegania nawrotowi raka sutka
CA2687819A1 (fr) 2007-06-06 2008-12-11 F.Hoffmann-La Roche Ag Composition d'un premier anticorps monoclonal non marque se liant a un antigene tumoral et d'un second anticorps monoclonal reactif non croise marque par un marqueur a fluorescence nir
EP2138511A1 (fr) 2008-06-27 2009-12-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. HER3 en tant que déterminant pour le pronostic de mélanome
KR20110044905A (ko) 2008-08-15 2011-05-02 메리맥 파마슈티컬즈, 인크. 치료제에 대한 세포의 반응을 예측하는 방법 및 시스템
WO2010052225A1 (fr) 2008-11-04 2010-05-14 F. Hoffmann-La Roche Ag Modulateurs de la signalisation her2 dans des paramètres d'expression de her2 normaux
US8349574B2 (en) 2009-01-15 2013-01-08 Laboratory Corporation Of America Holdings Methods of determining patient response by measurement of Her-3
TWI461211B (zh) * 2009-03-20 2014-11-21 Genentech Inc 抗－ｈｅｒ抗體
JP5587975B2 (ja) 2009-04-07 2014-09-10 ロシュ グリクアート アクチェンゲゼルシャフト 二重特異的抗−ＥｒｂＢ−３／抗−ｃ−Ｍｅｔ抗体
JP2012525432A (ja) 2009-04-29 2012-10-22 トレリス バイオサイエンス リミテッド ライアビリティー カンパニー ヘレグリン共役型ｈｅｒ３と免疫反応性の改善された抗体
SG178509A1 (en) 2009-08-21 2012-04-27 Merrimack Pharmaceuticals Inc Antibodies against the ectodomain of erbb3 and uses thereof
WO2011044311A2 (fr) 2009-10-09 2011-04-14 Merck Sharp & Dohme Corp. Génération, caractérisation et utilisations d'anticorps anti-her3
EP2496598B1 (fr) 2009-11-04 2017-08-02 Affibody AB Polypeptides de liaison de her3
PT2719708T (pt) * 2009-11-13 2018-01-16 Daiichi Sankyo Europe Gmbh Material e métodos para tratamento ou prevenção de doenças associadas a her-3
RU2560583C2 (ru) * 2009-12-22 2015-08-20 Рош Гликарт Аг Антитела к her3 и их применения
US9556249B2 (en) 2010-02-18 2017-01-31 Genentech, Inc. Neuregulin antagonists and use thereof in treating cancer
BR112012022802A2 (pt) 2010-03-11 2018-05-15 Merrimack Pharmaceuticals Inc uso de um inibidor de erbb3, e, método de supressão de crescimento de uma célula e de um tumor de câncer de mama
ES2566602T3 (es) 2010-04-09 2016-04-14 Aveo Pharmaceuticals, Inc. Anticuerpos anti-ErbB3
WO2012019024A2 (fr) 2010-08-04 2012-02-09 Immunogen, Inc. Molécules se liant à her3 et leurs immunoconjugués
CA2815154A1 (fr) 2010-08-06 2012-02-09 U3 Pharma Gmbh Utilisation d'agents de liaison her3 dans le traitement de la prostate
CN103080134B (zh) 2010-08-20 2015-11-25 诺华股份有限公司 表皮生长因子受体3(her3)的抗体
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
WO2012044612A1 (fr) 2010-09-30 2012-04-05 Merck Sharp & Dohme Corp. Génération, caractérisation et utilisations d'anticorps anti-her3
ES2632486T3 (es) 2010-10-18 2017-09-13 Mediapharma S.R.L. Anticuerpo de unión a ErbB3
KR101773120B1 (ko) 2010-11-01 2017-08-30 심포젠 에이/에스 항―ｈｅｒ3 항체 및 조성물
US9155802B2 (en) 2010-11-01 2015-10-13 Symphogen A/S Pan-HER antibody composition
ITRM20100577A1 (it) 2010-11-02 2012-05-03 Takis Srl Immunoterapia contro il recettore erbb-3
KR20140023921A (ko) 2011-03-15 2014-02-27 메리맥 파마슈티컬즈, 인크. ＥｒｂＢ 경로 저해제들에 대한 저항성을 극복하는 방법
UA123092C2 (uk) 2011-10-14 2021-02-17 Дженентек, Інк. Спосіб неоад'ювантного лікування her2-позитивного раку молочної залози на ранній стадії у пацієнта
EP2797957B1 (fr) 2011-11-23 2019-06-19 MedImmune, LLC Molécules de liaison propres à her3 et utilisation de celles-ci
JP6243345B2 (ja) * 2011-12-05 2017-12-06 ノバルティス アーゲー 上皮細胞増殖因子受容体３（ｈｅｒ３）に対する抗体
WO2013096812A1 (fr) 2011-12-23 2013-06-27 Genentech, Inc. Articles manufacturés et procédés destinés à la coadministration d'anticorps
US8859797B1 (en) 2012-04-27 2014-10-14 Air Liquide Electronics U.S. Lp Synthesis methods for carbosilanes
CN104428318B (zh) 2012-05-02 2018-09-25 西福根有限公司 人源化泛her抗体组合物
US9180185B2 (en) * 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies

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CR20150284A (es) 2015-06-30
AR094403A1 (es) 2015-07-29
WO2014108484A3 (fr) 2014-09-04
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TW201431559A (zh) 2014-08-16
MX2015008313A (es) 2015-11-11
PH12015501071A1 (en) 2015-08-03
US20140227255A1 (en) 2014-08-14
EP2943508B1 (fr) 2020-07-15
EP2943508A2 (fr) 2015-11-18
JP6257646B2 (ja) 2018-01-10
EA201500744A1 (ru) 2015-12-30
CN104797602A (zh) 2015-07-22
KR20150093231A (ko) 2015-08-17
US20160159912A1 (en) 2016-06-09
HK1211950A1 (en) 2016-06-03
US9180185B2 (en) 2015-11-10
AU2014204795A1 (en) 2015-04-30
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CL2015001049A1 (es) 2015-10-16
CA2887508A1 (fr) 2014-07-17

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