MA35459B1 - Composés et compositions pouvant être utilisés en tant qu'inhibiteurs de la kinase c-kit - Google Patents
Composés et compositions pouvant être utilisés en tant qu'inhibiteurs de la kinase c-kitInfo
- Publication number
- MA35459B1 MA35459B1 MA36863A MA36863A MA35459B1 MA 35459 B1 MA35459 B1 MA 35459B1 MA 36863 A MA36863 A MA 36863A MA 36863 A MA36863 A MA 36863A MA 35459 B1 MA35459 B1 MA 35459B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- compositions
- kinase inhibitors
- kit
- kit kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des composés de formule (i) et (ii) et des compositions pharmaceutiques en contenant, pouvant être utilisés en tant qu'inhibiteurs des protéines kinases, ainsi que des méthodes d'utilisation desdits composés à des fins de traitement, d'amélioration ou de prévention d'une affection associée à une activité anormale ou dérégulée des kinases. Dans certains modes de réalisation, l'invention concerne des méthodes d'utilisation desdits composés à des fins de traitement, d'amélioration ou de prévention des maladies ou affections impliquant une activation anormale des kinases c-kit ou c-kit et pdgfr (pdgfr±, pdgfr²).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161530028P | 2011-09-01 | 2011-09-01 | |
PCT/US2012/052621 WO2013033070A1 (fr) | 2011-09-01 | 2012-08-28 | Composés et compositions pouvant être utilisés en tant qu'inhibiteurs de la kinase c-kit |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35459B1 true MA35459B1 (fr) | 2014-09-01 |
Family
ID=46829898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36863A MA35459B1 (fr) | 2011-09-01 | 2014-03-28 | Composés et compositions pouvant être utilisés en tant qu'inhibiteurs de la kinase c-kit |
Country Status (41)
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
WO2013033167A1 (fr) | 2011-09-01 | 2013-03-07 | Irm Llc | Composés et compositions en tant qu'inhibiteurs de kinase c-kit |
EA028722B1 (ru) * | 2012-07-13 | 2017-12-29 | Юсб Байофарма Спрл | Производные имидазопиридина в качестве модуляторов активности tnf |
US9815815B2 (en) | 2013-01-10 | 2017-11-14 | Pulmokine, Inc. | Non-selective kinase inhibitors |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
CN111743901B (zh) | 2013-10-11 | 2023-09-12 | 普尔莫凯恩股份有限公司 | 喷雾干燥制剂 |
EP3077394A1 (fr) * | 2013-12-05 | 2016-10-12 | Bayer Pharma Aktiengesellschaft | Imidazo[1,2-a]pyridine-3-carboxamides aryl et hétéroaryl substitués et leur utilisation |
CN103965190A (zh) * | 2014-05-20 | 2014-08-06 | 定陶县友帮化工有限公司 | 一种咪唑并[1,2-a]吡啶-3-甲酸的合成方法 |
MA42293A (fr) | 2015-07-02 | 2018-05-09 | Janssen Sciences Ireland Uc | Composés antibactériens |
US10059708B2 (en) * | 2016-04-26 | 2018-08-28 | Northwestern University | Therapeutic targeting of the interleukin 1 receptor-associated kinase 4 (IRAK4) in leukemias characterized by rearrangements in the mixed lineage leukemia gene (MLL-r) |
BR112018075939A2 (pt) | 2016-06-16 | 2019-04-09 | Janssen Sciences Ireland Unlimited Company | compostos heterocíclicos como antibacterianos |
AU2017286368B2 (en) | 2016-06-16 | 2021-02-25 | Janssen Sciences Ireland Unlimited Company | Heterocyclic compounds as antibacterials |
AU2017348354B2 (en) | 2016-10-27 | 2023-06-15 | Pulmokine, Inc. | Combination therapy for treating pulmonary hypertension |
MA47676A (fr) | 2017-03-01 | 2021-06-02 | Janssen Sciences Ireland Unlimited Co | Polythérapie |
CN111039946A (zh) * | 2018-10-15 | 2020-04-21 | 上海轶诺药业有限公司 | 一类咪唑并芳环类化合物的制备和应用 |
BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
CA3139552A1 (fr) * | 2019-05-13 | 2020-11-19 | Novartis Ag | Formes cristallines de n-(5-(5-((1r, 2s)-2-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl) imidazo [1,2-a] pyridine-3-carboxamide |
AU2020346370A1 (en) | 2019-09-13 | 2022-05-05 | Janssen Sciences Ireland Unlimited Company | Antibacterial compounds |
KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
TW202146392A (zh) * | 2020-03-17 | 2021-12-16 | 日商大日本住友製藥股份有限公司 | 㗁二唑衍生物 |
JP2023534963A (ja) * | 2020-07-15 | 2023-08-15 | サード ハーモニック バイオ, インコーポレイテッド | 選択的c-kitキナーゼ阻害剤の結晶質形態 |
US20220175740A1 (en) * | 2020-11-19 | 2022-06-09 | Novartis Ag | Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same |
US11744823B2 (en) | 2020-11-19 | 2023-09-05 | Third Harmonic Bio, Inc. | Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same |
WO2022182982A1 (fr) * | 2021-02-26 | 2022-09-01 | Third Harmonic Bio, Inc. | Méthodes de traitement de maladies et de troubles médiés par la kinase c-kit à l'aide d'un inhibiteur sélectif de kinase c-kit |
EP4308239A1 (fr) | 2021-03-16 | 2024-01-24 | Janssen Sciences Ireland Unlimited Company | Composés antibactériens |
CA3211592A1 (fr) | 2021-03-17 | 2022-09-22 | Jerome Emile Georges Guillemont | Composes antibacteriens |
CA3212074A1 (fr) | 2021-03-17 | 2022-09-22 | Janssen Sciences Ireland Unlimited Company | Composes antibacteriens |
CA3234515A1 (fr) | 2021-10-28 | 2023-05-04 | Jose Manuel Bartolome-Nebreda | Amides d'imidazopyridine et composes apparentes destines a etre utilises dans le traitement d'infections bacteriennes |
WO2024089170A1 (fr) | 2022-10-27 | 2024-05-02 | Janssen Sciences Ireland Unlimited Company | Composés antibactériens |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9518993D0 (en) * | 1995-09-16 | 1995-11-15 | Agrevo Uk Ltd | Fungicides |
US20070072861A1 (en) * | 2000-03-27 | 2007-03-29 | Barbara Roniker | Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders |
AU2003251561A1 (en) | 2002-06-20 | 2004-01-06 | Beacon Looms, Inc. | Knitted electrical conductor fabric |
CA2514733A1 (fr) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Compositions pharmaceutiques a base d'un co-cristal |
US7754717B2 (en) | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
US20100048539A1 (en) | 2006-11-03 | 2010-02-25 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
KR20140009251A (ko) * | 2010-11-15 | 2014-01-22 | 애브비 인코포레이티드 | Nampt 및 rock 억제제 |
WO2013033167A1 (fr) * | 2011-09-01 | 2013-03-07 | Irm Llc | Composés et compositions en tant qu'inhibiteurs de kinase c-kit |
CN103930424A (zh) * | 2011-09-01 | 2014-07-16 | Irm责任有限公司 | 作为c-Kit激酶抑制剂的化合物和组合物 |
EP2751103A1 (fr) * | 2011-09-01 | 2014-07-09 | Irm Llc | Composés et compositions pouvant être utilisés en tant qu'inhibiteurs de la kinase c-kit |
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2012
- 2012-08-27 US US13/595,575 patent/US9199981B2/en active Active
- 2012-08-28 AU AU2012300248A patent/AU2012300248B2/en active Active
- 2012-08-28 PL PL12756879T patent/PL2751102T3/pl unknown
- 2012-08-28 LT LTEP12756879.8T patent/LT2751102T/lt unknown
- 2012-08-28 HU HUE12756879 patent/HUE044373T2/hu unknown
- 2012-08-28 SG SG2014011050A patent/SG2014011050A/en unknown
- 2012-08-28 SI SI201231624T patent/SI2751102T1/sl unknown
- 2012-08-28 UA UAA201401136A patent/UA110841C2/uk unknown
- 2012-08-28 PT PT12756879T patent/PT2751102T/pt unknown
- 2012-08-28 CN CN201280042763.1A patent/CN103764653B/zh active Active
- 2012-08-28 JP JP2014528513A patent/JP6117208B2/ja active Active
- 2012-08-28 CA CA2845159A patent/CA2845159C/fr active Active
- 2012-08-28 BR BR112014004504-6A patent/BR112014004504B1/pt active IP Right Grant
- 2012-08-28 RS RS20190784A patent/RS59025B1/sr unknown
- 2012-08-28 MX MX2014002482A patent/MX342329B/es active IP Right Grant
- 2012-08-28 ES ES12756879T patent/ES2732671T3/es active Active
- 2012-08-28 EA EA201490540A patent/EA024293B1/ru not_active IP Right Cessation
- 2012-08-28 ME MEP-2019-183A patent/ME03395B/fr unknown
- 2012-08-28 MY MYPI2014000347A patent/MY167245A/en unknown
- 2012-08-28 AP AP2014007494A patent/AP2014007494A0/xx unknown
- 2012-08-28 WO PCT/US2012/052621 patent/WO2013033070A1/fr active Application Filing
- 2012-08-28 KR KR1020147008106A patent/KR101959590B1/ko active IP Right Grant
- 2012-08-28 TR TR2019/09189T patent/TR201909189T4/tr unknown
- 2012-08-28 PE PE2014000294A patent/PE20141033A1/es active IP Right Grant
- 2012-08-28 DK DK12756879.8T patent/DK2751102T3/da active
- 2012-08-28 EP EP12756879.8A patent/EP2751102B1/fr active Active
- 2012-08-29 UY UY0001034300A patent/UY34300A/es active IP Right Grant
- 2012-08-30 JO JOP/2012/0246A patent/JOP20120246B1/ar active
- 2012-08-31 TW TW101131940A patent/TWI543981B/zh active
- 2012-08-31 AR ARP120103222A patent/AR087752A1/es active IP Right Grant
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2014
- 2014-02-10 TN TNP2014000061A patent/TN2014000061A1/en unknown
- 2014-02-13 ZA ZA2014/01113A patent/ZA201401113B/en unknown
- 2014-02-27 CL CL2014000494A patent/CL2014000494A1/es unknown
- 2014-02-27 CU CUP2014000023A patent/CU20140023A7/es unknown
- 2014-02-27 IL IL231226A patent/IL231226A/en active IP Right Grant
- 2014-02-27 GT GT201400036A patent/GT201400036A/es unknown
- 2014-02-28 CO CO14043411A patent/CO6900140A2/es active IP Right Grant
- 2014-02-28 CR CR20140106A patent/CR20140106A/es unknown
- 2014-03-28 MA MA36863A patent/MA35459B1/fr unknown
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2019
- 2019-06-21 HR HRP20191140TT patent/HRP20191140T1/hr unknown
- 2019-06-27 CY CY20191100671T patent/CY1121695T1/el unknown
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