MA35419B1 - Inhibiteurs de la tyrosine kinase de bruton - Google Patents
Inhibiteurs de la tyrosine kinase de brutonInfo
- Publication number
- MA35419B1 MA35419B1 MA36783A MA36783A MA35419B1 MA 35419 B1 MA35419 B1 MA 35419B1 MA 36783 A MA36783 A MA 36783A MA 36783 A MA36783 A MA 36783A MA 35419 B1 MA35419 B1 MA 35419B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- inhibitors
- tyrosine kinase
- diseases associated
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
La présente invention concerne des composés selon la formule générique i : dans laquelle les variables sont telles que définies dans la description, et qui inhibent btk. Les composés décrits présentement sont utiles pour moduler l'activité de btk et traiter des maladies associées à une activité btk excessive. Les composés sont en outre utiles pour traiter des maladies inflammatoires et auto-immunes associées à une prolifération aberrante de lymphocytes b, telles que la polyarthrite rhumatoïde. La présente invention concerne en outre des compositions contenant des composés de formule i et au moins un véhicule, diluant ou excipient.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161524374P | 2011-08-17 | 2011-08-17 | |
US201261649991P | 2012-05-22 | 2012-05-22 | |
PCT/EP2012/065844 WO2013024078A1 (fr) | 2011-08-17 | 2012-08-14 | Inhibiteurs de la tyrosine kinase de bruton |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35419B1 true MA35419B1 (fr) | 2014-09-01 |
Family
ID=46690498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36783A MA35419B1 (fr) | 2011-08-17 | 2014-02-26 | Inhibiteurs de la tyrosine kinase de bruton |
Country Status (22)
Country | Link |
---|---|
US (1) | US8889682B2 (fr) |
EP (1) | EP2744804B1 (fr) |
JP (1) | JP5823616B2 (fr) |
KR (1) | KR20140052032A (fr) |
CN (1) | CN103748088A (fr) |
AR (1) | AR087543A1 (fr) |
AU (1) | AU2012296888A1 (fr) |
BR (1) | BR112014003582A2 (fr) |
CA (1) | CA2841801A1 (fr) |
CL (1) | CL2014000350A1 (fr) |
CO (1) | CO6842020A2 (fr) |
CR (1) | CR20140027A (fr) |
EA (1) | EA024689B1 (fr) |
EC (1) | ECSP14013212A (fr) |
HK (1) | HK1197060A1 (fr) |
IL (1) | IL230561A0 (fr) |
MA (1) | MA35419B1 (fr) |
MX (1) | MX349372B (fr) |
PE (1) | PE20140865A1 (fr) |
TW (1) | TW201311669A (fr) |
WO (1) | WO2013024078A1 (fr) |
ZA (1) | ZA201400739B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5976828B2 (ja) | 2011-11-03 | 2016-08-24 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Btk活性阻害剤としてのアルキル化ピペラジン化合物 |
JP5808869B2 (ja) | 2011-11-03 | 2015-11-10 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二環式ピペラジン化合物 |
US8669251B2 (en) * | 2011-11-03 | 2014-03-11 | Genentech, Inc. | 8-fluorophthalazin-1(2H)-one compounds |
UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
JP6182593B2 (ja) | 2012-04-20 | 2017-08-16 | アドヴィーナス セラピューティクス リミテッド | 置換ヘテロ二環化合物、組成物及び医薬並びにそれらの用途 |
WO2013157021A1 (fr) | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Composés bicycliques, compositions et applications médicinales de ceux-ci |
KR20150032340A (ko) | 2012-07-24 | 2015-03-25 | 파마시클릭스, 인코포레이티드 | 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이 |
EP2882741B1 (fr) | 2012-08-10 | 2018-10-24 | Boehringer Ingelheim International GmbH | Composés hétéroromatiques en tant qu'inhibiteurs de la tyrosine kinase de bruton (btk) |
RU2015120216A (ru) * | 2012-11-16 | 2017-01-10 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы тирозинкиназы брутона |
KR20150075115A (ko) * | 2012-11-30 | 2015-07-02 | 에프. 호프만-라 로슈 아게 | 브루톤 티로신 키나제의 억제제 |
CN105051028B (zh) * | 2013-03-05 | 2017-06-09 | 豪夫迈·罗氏有限公司 | 布鲁顿氏酪氨酸激酶抑制剂 |
CN104177338B (zh) * | 2013-05-22 | 2018-04-03 | 南京勇山生物科技有限公司 | 一类布鲁顿激酶抑制剂 |
KR101815360B1 (ko) * | 2013-07-03 | 2018-01-04 | 에프. 호프만-라 로슈 아게 | 헤테로아릴 피리돈 및 아자-피리돈 아마이드 화합물 |
DK3026050T3 (en) | 2013-07-26 | 2019-02-18 | Carna Biosciences Inc | NEW TRIAZINE DERIVATIVE |
AU2014322239A1 (en) * | 2013-09-20 | 2016-04-14 | Carna Biosciences, Inc. | Novel triazine derivative |
EP3077384B1 (fr) | 2013-12-05 | 2017-09-06 | F. Hoffmann-La Roche AG | Composés de pyridone hétéroarylique et d'aza-pyridone à fonctionnalité électrophile |
EP3042903B1 (fr) | 2015-01-06 | 2019-08-14 | Impetis Biosciences Ltd. | Composés hétéro-bicycliques substitués, compositions et leurs applications médicales |
CN107428678B (zh) | 2015-01-22 | 2021-01-01 | 赛诺菲-安万特德国有限公司 | 用于制备2-[4-(环丙烷羰基)苯基]-2-甲基-丙腈的方法 |
WO2017070708A1 (fr) | 2015-10-23 | 2017-04-27 | Array Biopharma, Inc. | Composés de 2-pyridazin-3(2h)-one à substitution 2-aryle et 2-hétéroaryle utilisés en tant qu'inhibiteurs de fgfr tyrosine kinases |
TW202204350A (zh) | 2020-05-06 | 2022-02-01 | 美商雅捷可斯治療公司 | 作為jak2抑制劑之6-雜芳基氧基苯并咪唑及氮雜苯并咪唑 |
WO2023009709A1 (fr) * | 2021-07-29 | 2023-02-02 | Ajax Therapeutics, Inc. | Pyrazolo pipérazines en tant qu'inhibiteurs de jak2 |
WO2023086319A1 (fr) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-hetero-aryloxy-benzimidazoles et azabenzimidazoles en tant qu'inhibiteurs de jak2 |
CN115073299A (zh) * | 2022-06-14 | 2022-09-20 | 爱斯特(成都)生物制药股份有限公司 | 一种制备2-氟-3-三氟甲基苯胺的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7683064B2 (en) * | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
SI2242749T1 (sl) * | 2008-02-05 | 2013-07-31 | F.Hoffmann-La Roche Ag | Novi piridinoni in piridazinoni |
EP2297142B1 (fr) * | 2008-06-24 | 2015-10-14 | F. Hoffmann-La Roche AG | Nouvelles pyridine-2-ones et pyridazine-3-ones substituées |
US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
AR082590A1 (es) * | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
US8669251B2 (en) * | 2011-11-03 | 2014-03-11 | Genentech, Inc. | 8-fluorophthalazin-1(2H)-one compounds |
CA2853138A1 (fr) * | 2011-12-05 | 2013-06-13 | Immunomedics, Inc. | Utilisation therapeutique d'anticorps anti-cd22 pour induire une trogocytose |
-
2012
- 2012-08-14 PE PE2014000220A patent/PE20140865A1/es not_active Application Discontinuation
- 2012-08-14 CA CA2841801A patent/CA2841801A1/fr active Pending
- 2012-08-14 EP EP12748200.8A patent/EP2744804B1/fr not_active Not-in-force
- 2012-08-14 WO PCT/EP2012/065844 patent/WO2013024078A1/fr active Application Filing
- 2012-08-14 MX MX2014001653A patent/MX349372B/es active IP Right Grant
- 2012-08-14 AU AU2012296888A patent/AU2012296888A1/en not_active Abandoned
- 2012-08-14 EA EA201490452A patent/EA024689B1/ru not_active IP Right Cessation
- 2012-08-14 BR BR112014003582A patent/BR112014003582A2/pt not_active IP Right Cessation
- 2012-08-14 TW TW101129401A patent/TW201311669A/zh unknown
- 2012-08-14 JP JP2014525423A patent/JP5823616B2/ja not_active Expired - Fee Related
- 2012-08-14 CN CN201280038959.3A patent/CN103748088A/zh active Pending
- 2012-08-14 KR KR1020147006816A patent/KR20140052032A/ko not_active Application Discontinuation
- 2012-08-15 AR ARP120102984A patent/AR087543A1/es unknown
- 2012-08-16 US US13/586,958 patent/US8889682B2/en not_active Expired - Fee Related
-
2013
- 2013-12-30 CO CO13303019A patent/CO6842020A2/es not_active Application Discontinuation
-
2014
- 2014-01-20 IL IL230561A patent/IL230561A0/en unknown
- 2014-01-20 CR CR20140027A patent/CR20140027A/es unknown
- 2014-01-30 ZA ZA2014/00739A patent/ZA201400739B/en unknown
- 2014-02-12 CL CL2014000350A patent/CL2014000350A1/es unknown
- 2014-02-17 EC ECSP14013212 patent/ECSP14013212A/es unknown
- 2014-02-26 MA MA36783A patent/MA35419B1/fr unknown
- 2014-10-20 HK HK14110443A patent/HK1197060A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
MX2014001653A (es) | 2014-03-21 |
ZA201400739B (en) | 2016-01-27 |
JP2014521734A (ja) | 2014-08-28 |
EA024689B1 (ru) | 2016-10-31 |
BR112014003582A2 (pt) | 2017-03-14 |
CR20140027A (es) | 2014-03-13 |
IL230561A0 (en) | 2014-03-31 |
US20130045965A1 (en) | 2013-02-21 |
KR20140052032A (ko) | 2014-05-02 |
US8889682B2 (en) | 2014-11-18 |
WO2013024078A1 (fr) | 2013-02-21 |
EA201490452A1 (ru) | 2014-05-30 |
JP5823616B2 (ja) | 2015-11-25 |
AU2012296888A1 (en) | 2014-01-23 |
TW201311669A (zh) | 2013-03-16 |
CO6842020A2 (es) | 2014-01-20 |
AR087543A1 (es) | 2014-04-03 |
PE20140865A1 (es) | 2014-07-19 |
CN103748088A (zh) | 2014-04-23 |
HK1197060A1 (en) | 2015-01-02 |
ECSP14013212A (es) | 2014-03-31 |
CL2014000350A1 (es) | 2014-08-22 |
CA2841801A1 (fr) | 2013-02-21 |
EP2744804B1 (fr) | 2017-05-17 |
MX349372B (es) | 2017-07-26 |
EP2744804A1 (fr) | 2014-06-25 |
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