MA32035B1 - Composes tricycliques servant de modulateurs de synthese de tnf-alpha et d'inhibiteurs de pde4 - Google Patents
Composes tricycliques servant de modulateurs de synthese de tnf-alpha et d'inhibiteurs de pde4Info
- Publication number
- MA32035B1 MA32035B1 MA33045A MA33045A MA32035B1 MA 32035 B1 MA32035 B1 MA 32035B1 MA 33045 A MA33045 A MA 33045A MA 33045 A MA33045 A MA 33045A MA 32035 B1 MA32035 B1 MA 32035B1
- Authority
- MA
- Morocco
- Prior art keywords
- pde4
- tnf
- alpha
- modulators
- inhibitors
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
Abstract
La présente invention concerne des composés chimiques de formule (i) qui sont tels que définis ici, des compositions pharmaceutiques et des procédés d'utilisation dans le traitement d'affections ou de troubles médiés par tnf-alpha ou par pde4, notamment, de manière non limitative, la polyarthrite rhumatoïde.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2361708P | 2008-01-25 | 2008-01-25 | |
PCT/US2009/031819 WO2009094528A1 (fr) | 2008-01-25 | 2009-01-23 | Composés tricycliques utilisés en tant qu'inhibiteurs de la synthèse de tnf-α et en tant qu'inhibiteurs de pde4 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32035B1 true MA32035B1 (fr) | 2011-01-03 |
Family
ID=40901439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33045A MA32035B1 (fr) | 2008-01-25 | 2010-07-23 | Composes tricycliques servant de modulateurs de synthese de tnf-alpha et d'inhibiteurs de pde4 |
Country Status (17)
Country | Link |
---|---|
US (10) | US7964608B2 (fr) |
EP (1) | EP2244574B1 (fr) |
JP (1) | JP5406215B2 (fr) |
KR (1) | KR101709141B1 (fr) |
CN (1) | CN101925301B (fr) |
AU (1) | AU2009206368B2 (fr) |
BR (1) | BRPI0906809A2 (fr) |
CA (1) | CA2711576C (fr) |
EA (1) | EA018462B1 (fr) |
ES (1) | ES2523169T3 (fr) |
HK (1) | HK1147913A1 (fr) |
IL (1) | IL206854A (fr) |
MA (1) | MA32035B1 (fr) |
MX (1) | MX2010007768A (fr) |
NZ (1) | NZ586695A (fr) |
WO (1) | WO2009094528A1 (fr) |
ZA (1) | ZA201004818B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2711576C (fr) | 2008-01-25 | 2016-06-21 | High Point Pharmaceuticals, Llc | Composes tricycliques utilises comme inhibiteurs de la synthese de tnf-.alpha. et inhibiteurs de pde4 |
US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
AR090100A1 (es) * | 2012-02-21 | 2014-10-22 | Celgene Corp | Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina |
EA036592B1 (ru) | 2012-06-13 | 2020-11-26 | Инсайт Холдингс Корпорейшн | Замещенные трициклические соединения как ингибиторы fgfr |
WO2014026125A1 (fr) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Dérivés de pyrazine en tant qu'inhibiteurs de fgfr |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
EP3632426A1 (fr) | 2013-02-01 | 2020-04-08 | Wellstat Therapeutics Corporation | Composés d'amine présentant une activité anti-inflammatoire, antifongique, antiparasitaire et anticancéreuse |
WO2014172644A2 (fr) | 2013-04-19 | 2014-10-23 | Incyte Corporation | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
ES2895769T3 (es) | 2015-02-20 | 2022-02-22 | Incyte Corp | Heterociclos bicíclicos como inhibidores de FGFR |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
WO2016134294A1 (fr) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
HUE059372T2 (hu) * | 2015-06-17 | 2022-11-28 | Pfizer | Triciklusos vegyületek és azok alkalmazása foszfodiészteráz inhibitorként |
WO2017089347A1 (fr) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Procédés et compositions pharmaceutiques pour le traitement de mélanomes résistant aux inhibiteurs de braf |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
US11174257B2 (en) | 2018-05-04 | 2021-11-16 | Incyte Corporation | Salts of an FGFR inhibitor |
CA3099287A1 (fr) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Formes solides d'un inhibiteur de fgfr et leurs procedes de preparation |
CN109705037A (zh) * | 2019-01-24 | 2019-05-03 | 广西师范大学 | 4-氨基喹啉-3-甲酸酯衍生物及其制备方法和应用 |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2021007269A1 (fr) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
KR20210017842A (ko) | 2019-08-09 | 2021-02-17 | 주식회사 엘지화학 | 연쇄발화 방지를 위한 에너지 드레인 저항체를 구비한 배터리 팩 |
CR20220169A (es) | 2019-10-14 | 2022-10-27 | Incyte Corp | Heterociclos bicíclicos como inhibidores de fgfr |
WO2021076728A1 (fr) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr |
EP4069696A1 (fr) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr |
BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
CN113861189A (zh) * | 2020-06-29 | 2021-12-31 | Vtv治疗有限责任公司 | 喹啉衍生物,其药学上可接受的盐及其使用方法 |
WO2022026350A1 (fr) * | 2020-07-28 | 2022-02-03 | Vtv Therapeutics Llc | Forme cristalline de sel chlorhydrate de dérivé quinoléine |
EP4352059A1 (fr) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr |
WO2023109909A1 (fr) * | 2021-12-15 | 2023-06-22 | 上海翊石医药科技有限公司 | Composés hétérocycliques aromatiques, leur procédé de préparation et leurs utilisations |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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NO162019C (no) * | 1983-11-23 | 1989-10-25 | Fujisawa Pharmaceutical Co | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater. |
US4927820A (en) * | 1988-11-25 | 1990-05-22 | Hoechst Roussel Pharmaceuticals Inc. | Fused heterocyclic derivatives of 1,2,3,4-tetrahydroacridine |
JPH0741479A (ja) * | 1993-07-28 | 1995-02-10 | Taisho Pharmaceut Co Ltd | 7−アザプテリジン類およびその製造方法 |
CN1219168A (zh) * | 1996-05-20 | 1999-06-09 | 达尔文发现有限公司 | 作为tnf抑制剂和pdc-iv抑制剂的喹啉磺酰胺类化合物 |
US6930101B1 (en) * | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
US20030207845A1 (en) | 2001-02-08 | 2003-11-06 | Keating Elizabeth T. | Method and compositions for treating an inflammatory disease |
PT1429807E (pt) | 2001-09-19 | 2007-05-31 | Altana Pharma Ag | Combinação de um nsaid e de um inibidor de pde-4 |
TW200306192A (en) | 2002-01-18 | 2003-11-16 | Bristol Myers Squibb Co | Tricyclic 2-pyrimidone compounds useful as HIV reverse transcriptase inhibitors |
PL193012B1 (pl) * | 2003-06-09 | 2007-01-31 | Univ Medyczny | 3-podstawiony 1,2,3,4-tetrahydropirymido[5,4-c]cynnolin-2,4-dion i 3-podstawiony 1,2,3,4-tetrahydropirymido[5,4-c]chinolin-2,4-dion oraz sposób otrzymywania 3-podstawionego 1,2,3,4-tetrahydropirymido[5,4-c]cynnolin-2,4-dionu i 3-podstawionego 1,2,3,4-tetrahydropirymido[5,4-c]chinolin-2,4-dionu |
TW200726767A (en) | 2005-07-04 | 2007-07-16 | Astrazeneca Ab | Chemical compounds 2 |
CA2711576C (fr) * | 2008-01-25 | 2016-06-21 | High Point Pharmaceuticals, Llc | Composes tricycliques utilises comme inhibiteurs de la synthese de tnf-.alpha. et inhibiteurs de pde4 |
CA2753597A1 (fr) | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Combinaisons de medicaments contenant des inhibiteurs de pde4 et des ains |
US9161927B2 (en) | 2009-02-27 | 2015-10-20 | Boehringer Ingelheim International Gmbh | Drug combinations containing PDE4 inhibitors and NSAIDs |
JP2013529184A (ja) | 2010-04-08 | 2013-07-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pde4阻害剤及びep4受容体アンタゴニストを含有する医薬の組み合わせ |
WO2011124525A1 (fr) | 2010-04-08 | 2011-10-13 | Boehringer Ingelheim International Gmbh | Combinaisons de produits pharmaceutiques contenant des inhibiteurs de pde4 et des antagonistes du récepteur ep4 |
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2009
- 2009-01-23 CA CA2711576A patent/CA2711576C/fr active Active
- 2009-01-23 MX MX2010007768A patent/MX2010007768A/es active IP Right Grant
- 2009-01-23 JP JP2010544436A patent/JP5406215B2/ja active Active
- 2009-01-23 ES ES09704760.9T patent/ES2523169T3/es active Active
- 2009-01-23 EP EP09704760.9A patent/EP2244574B1/fr active Active
- 2009-01-23 KR KR1020107017176A patent/KR101709141B1/ko active IP Right Grant
- 2009-01-23 US US12/532,861 patent/US7964608B2/en active Active
- 2009-01-23 CN CN200980102961.0A patent/CN101925301B/zh active Active
- 2009-01-23 BR BRPI0906809-0A patent/BRPI0906809A2/pt not_active Application Discontinuation
- 2009-01-23 AU AU2009206368A patent/AU2009206368B2/en active Active
- 2009-01-23 WO PCT/US2009/031819 patent/WO2009094528A1/fr active Application Filing
- 2009-01-23 EA EA201070884A patent/EA018462B1/ru not_active IP Right Cessation
- 2009-01-23 NZ NZ586695A patent/NZ586695A/en not_active IP Right Cessation
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2010
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- 2010-07-08 ZA ZA2010/04818A patent/ZA201004818B/en unknown
- 2010-07-23 MA MA33045A patent/MA32035B1/fr unknown
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2011
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- 2011-03-04 US US13/040,382 patent/US8853226B2/en active Active
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2012
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2017
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2018
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2019
- 2019-07-10 US US16/507,219 patent/US10568888B2/en active Active
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