MA32655B1 - Composés modulant sélectivement le récepteur cb2 - Google Patents

Composés modulant sélectivement le récepteur cb2

Info

Publication number
MA32655B1
MA32655B1 MA33724A MA33724A MA32655B1 MA 32655 B1 MA32655 B1 MA 32655B1 MA 33724 A MA33724 A MA 33724A MA 33724 A MA33724 A MA 33724A MA 32655 B1 MA32655 B1 MA 32655B1
Authority
MA
Morocco
Prior art keywords
receptor
selectively modulating
compounds selectively
compounds
relates
Prior art date
Application number
MA33724A
Other languages
Arabic (ar)
English (en)
Inventor
Brian Nicholas Cook
Darren Disalvo
Daniel Robert Fandrick
Christian Harcken
Daniel Kuzmich
Thomas Wai-Ho Lee
Pingrong Liu
John Lord
Can Mao
Jochen Neu
Brian Christopher Raudenbush
Hossein Razavi
Jonathan Timothy Reeves
Jinhua J Song
Alan David Swinamer
Zhulin Tan
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA32655B1 publication Critical patent/MA32655B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne des composés de formule (i), utiles pour le traitement d'une variété de maladies et de troubles qui sont médiés ou prolongés par l'activité de ccr1 qui comprennent des maladies auto-immunes, telles que la polyarthrite rhumatoïde et la sclérose en plaques. La présente invention concerne également des procédés de fabrication et d'utilisation de ces composés.
MA33724A 2008-09-26 2011-03-24 Composés modulant sélectivement le récepteur cb2 MA32655B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10040108P 2008-09-26 2008-09-26
PCT/US2009/057778 WO2010036632A1 (fr) 2008-09-26 2009-09-22 Composés azaindazole en tant qu’antagonistes des récepteurs ccr1

Publications (1)

Publication Number Publication Date
MA32655B1 true MA32655B1 (fr) 2011-09-01

Family

ID=41349302

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33724A MA32655B1 (fr) 2008-09-26 2011-03-24 Composés modulant sélectivement le récepteur cb2

Country Status (24)

Country Link
US (4) US7879873B2 (fr)
EP (1) EP2346868B1 (fr)
JP (1) JP5507567B2 (fr)
KR (1) KR20110060904A (fr)
CN (1) CN102227425A (fr)
AP (1) AP2739A (fr)
AR (1) AR073689A1 (fr)
AU (1) AU2009296839A1 (fr)
BR (1) BRPI0919844A2 (fr)
CA (1) CA2737472A1 (fr)
CL (1) CL2011000668A1 (fr)
CO (1) CO6351735A2 (fr)
EA (1) EA201100524A1 (fr)
EC (1) ECSP11010932A (fr)
IL (1) IL210857A0 (fr)
MA (1) MA32655B1 (fr)
MX (1) MX2011002951A (fr)
NZ (1) NZ591115A (fr)
PE (1) PE20110854A1 (fr)
TW (1) TW201018683A (fr)
UA (1) UA103634C2 (fr)
UY (1) UY32140A (fr)
WO (1) WO2010036632A1 (fr)
ZA (1) ZA201100625B (fr)

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KR20120087923A (ko) 2009-10-21 2012-08-07 베링거 인겔하임 인터내셔날 게엠베하 Ｃｃｒ１ 수용체 길항제로서의 인다졸 및 피라졸로피리딘 화합물
EP2493875B1 (fr) 2009-10-27 2014-08-06 Boehringer Ingelheim International GmbH Composés hétérocycliques utilisés en tant qu'antagonistes des récepteurs ccr1
CN102596908A (zh) 2009-12-08 2012-07-18 贝林格尔.英格海姆国际有限公司 用于制备取代的吲唑和氮杂吲唑化合物的中间体的合成方法
JP5793182B2 (ja) 2010-04-30 2015-10-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしてのアザインダゾールアミド化合物
EP2655371B1 (fr) 2010-12-23 2015-02-25 Boehringer Ingelheim International GmbH Composés de pyrazolopipéridine en tant qu'antagonistes de récepteur ccr1

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US20110086846A1 (en) 2011-04-14
PE20110854A1 (es) 2011-12-23
US8338610B2 (en) 2012-12-25
IL210857A0 (en) 2011-04-28
BRPI0919844A2 (pt) 2019-09-24
US20120035370A1 (en) 2012-02-09
JP2012503664A (ja) 2012-02-09
EP2346868A1 (fr) 2011-07-27
US7879873B2 (en) 2011-02-01
CN102227425A (zh) 2011-10-26
AR073689A1 (es) 2010-11-24
KR20110060904A (ko) 2011-06-08
UA103634C2 (en) 2013-11-11
WO2010036632A1 (fr) 2010-04-01
CL2011000668A1 (es) 2011-10-28
EP2346868B1 (fr) 2016-01-27
MX2011002951A (es) 2011-04-26
ZA201100625B (en) 2011-09-28
US8163918B2 (en) 2012-04-24
UY32140A (es) 2010-04-30
TW201018683A (en) 2010-05-16
US8063065B2 (en) 2011-11-22
US20100093724A1 (en) 2010-04-15
AU2009296839A1 (en) 2010-04-01
NZ591115A (en) 2012-10-26
CO6351735A2 (es) 2011-12-20
EA201100524A1 (ru) 2011-10-31
CA2737472A1 (fr) 2010-04-01
AP2011005685A0 (en) 2011-04-30
US20120136158A1 (en) 2012-05-31

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