PE20110854A1 - DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1 - Google Patents
DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1Info
- Publication number
- PE20110854A1 PE20110854A1 PE2011000789A PE2011000789A PE20110854A1 PE 20110854 A1 PE20110854 A1 PE 20110854A1 PE 2011000789 A PE2011000789 A PE 2011000789A PE 2011000789 A PE2011000789 A PE 2011000789A PE 20110854 A1 PE20110854 A1 PE 20110854A1
- Authority
- PE
- Peru
- Prior art keywords
- pyrazolo
- pyridine
- alkyl
- antagonists
- carbonylamine
- Prior art date
Links
- -1 OF 1-PHENYL-1H-PYRAZOLO [3,4-c] PYRIDINE-4-CARBONYLAMINE Chemical class 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000004500 CCR1 Receptors Human genes 0.000 title 1
- 108010017319 CCR1 Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- MFSMJCXBRIYZJH-UHFFFAOYSA-N 1-[4-(aminomethyl)phenyl]-n-propan-2-ylmethanesulfonamide Chemical compound CC(C)NS(=O)(=O)CC1=CC=C(CN)C=C1 MFSMJCXBRIYZJH-UHFFFAOYSA-N 0.000 abstract 1
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 abstract 1
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- YKNZTUQUXUXTLE-UHFFFAOYSA-N [3-(trifluoromethyl)phenyl]methanamine Chemical compound NCC1=CC=CC(C(F)(F)F)=C1 YKNZTUQUXUXTLE-UHFFFAOYSA-N 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 230000006020 chronic inflammation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE W, Y SON CADA UNO C, N, DONDE W, Y NO PUEDEN SER IGUALES; Ar1 Y Ar2 SON CADA UNO CARBOCICLO, HETEROARILO, HETEROCICLILO SUSTITUIDO O NO, ENTRE OTROS; R1 ES H, ALQUILO C1-C6, (ALCOXI C1-C6)-(ALQUILO C1-C6); R2 Y R3 SON CADA UNO H, ALQUILO C1-C6 Y ALQUENILO C1-C6 SUSTITUIDO O NO PARCIAL O COMPLETAMENTE POR 1-3 GRUPOS CIANO, HIDROXILO, ALCOXI C1-C6, ENTRE 0TROS. SON COMPUESTSO PREFERIDOS: 3-TRIFLUOROMETIL-BENCILAMIDA DEL ACIDO 1-(4-FLUOROFENIL)-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBOXILICO; 4-(ISOPROPILSULFAMOIL-METIL)BENCILAMIDA DEL ACIDO 1-(4-FLUOROFENIL)-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBOXILICO; ESTER METILICO DEL ACIDO 3-[5-({[1-(4-FLUOROFENIL)-1H-PIRAZOLO[3,4-c]PIRIDINA4-CARBONIL]-AMINO}-METIL)-PIRIDINA-2-SULFONIL]-PROPIONICO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LA ACTIVIDAD DE CCR1, UTILES EN EL TRATAMIENTO DE INFLAMACION CRONICA, ALERGIAS, PSORIASIS, ARTRITIS REUMATOIDE, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10040108P | 2008-09-26 | 2008-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20110854A1 true PE20110854A1 (es) | 2011-12-23 |
Family
ID=41349302
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011000789A PE20110854A1 (es) | 2008-09-26 | 2009-09-22 | DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1 |
Country Status (24)
Country | Link |
---|---|
US (4) | US7879873B2 (es) |
EP (1) | EP2346868B1 (es) |
JP (1) | JP5507567B2 (es) |
KR (1) | KR20110060904A (es) |
CN (1) | CN102227425A (es) |
AP (1) | AP2739A (es) |
AR (1) | AR073689A1 (es) |
AU (1) | AU2009296839A1 (es) |
BR (1) | BRPI0919844A2 (es) |
CA (1) | CA2737472A1 (es) |
CL (1) | CL2011000668A1 (es) |
CO (1) | CO6351735A2 (es) |
EA (1) | EA201100524A1 (es) |
EC (1) | ECSP11010932A (es) |
IL (1) | IL210857A0 (es) |
MA (1) | MA32655B1 (es) |
MX (1) | MX2011002951A (es) |
NZ (1) | NZ591115A (es) |
PE (1) | PE20110854A1 (es) |
TW (1) | TW201018683A (es) |
UA (1) | UA103634C2 (es) |
UY (1) | UY32140A (es) |
WO (1) | WO2010036632A1 (es) |
ZA (1) | ZA201100625B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009134666A1 (en) | 2008-04-29 | 2009-11-05 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
JP5411927B2 (ja) | 2008-05-06 | 2014-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1アンタゴニストとしてのピラゾール化合物 |
UA103634C2 (en) | 2008-09-26 | 2013-11-11 | Берингер Ингельхайм Интернациональ Гмбх | Azaindazole compounds as ccr1 receptor antagonists |
WO2010106333A1 (en) * | 2009-03-19 | 2010-09-23 | Medical Research Council Technology | Compounds |
IN2012DN03449A (es) | 2009-10-21 | 2015-10-23 | Boehringer Ingelheim Int | |
JP5542214B2 (ja) * | 2009-10-27 | 2014-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1受容体アンタゴニストとしての複素環化合物 |
BR112012013582A2 (pt) * | 2009-12-08 | 2016-07-05 | Boehringer Ingelheim Int | processo para síntese de intermediários úteis para a produção de compostos de indazol e azaindazol substituídos |
US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
EP2388260A1 (de) * | 2010-05-21 | 2011-11-23 | Archimica GmbH | Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors |
RU2617988C2 (ru) | 2010-09-03 | 2017-05-02 | ФОРМА ТиЭм, ЭлЭлСИ | Новые соединения и композиции для ингибирования nampt |
EP2655371B1 (en) | 2010-12-23 | 2015-02-25 | Boehringer Ingelheim International GmbH | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
EP2681216B1 (en) | 2011-02-28 | 2017-09-27 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
CN102775365A (zh) * | 2011-05-10 | 2012-11-14 | 无锡立诺康医药科技有限公司 | 5-氨基取代基-异噁唑类化合物或其酸式盐的合成工艺 |
WO2012163848A1 (en) | 2011-05-27 | 2012-12-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of crohn's disease |
EP2771011A4 (en) * | 2011-10-24 | 2015-04-15 | Glaxosmithkline Ip No 2 Ltd | CHEMICAL COMPOUNDS |
EP2771484A1 (en) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
AU2013225531A1 (en) * | 2012-03-02 | 2014-09-25 | Forma Tm, Llc. | Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives |
AR091858A1 (es) | 2012-07-25 | 2015-03-04 | Sova Pharmaceuticals Inc | INHIBIDORES DE CISTATIONIN-g-LIASA (CSE) |
US9045477B2 (en) * | 2013-03-15 | 2015-06-02 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
WO2014144747A1 (en) * | 2013-03-15 | 2014-09-18 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
FR3016879A1 (fr) * | 2014-01-29 | 2015-07-31 | Guillaume Laconde | Procede de preparation de benzotriazole n-acyles |
EA032356B1 (ru) | 2014-03-17 | 2019-05-31 | Пфайзер Инк. | Ингибиторы диацилглицеринацилтрансферазы 2 для применения в лечении метаболических и связанных с метаболизмом расстройств |
US9242989B2 (en) | 2014-04-14 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Compounds as modulators of RORγ |
AU2016342310B2 (en) | 2015-10-23 | 2020-08-27 | Vifor (International) Ag | Novel ferroportin inhibitors |
EP3373733A1 (en) | 2015-11-13 | 2018-09-19 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
EP3373732A1 (en) | 2015-11-13 | 2018-09-19 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
CN109069514B (zh) | 2016-03-07 | 2023-12-29 | 结核病药物开发全球联盟公司 | 抗菌化合物及其用途 |
JOP20180036A1 (ar) | 2017-04-18 | 2019-01-30 | Vifor Int Ag | أملاح لمثبطات فروبورتين جديدة |
CN111393376B (zh) * | 2020-05-11 | 2022-05-13 | 安徽赛迪生物科技有限公司 | 一种2-氯嘧啶-4-甲酸的合成方法 |
WO2021262878A1 (en) * | 2020-06-24 | 2021-12-30 | Oregon Health & Science University | Novel molecule for modulation of innate immune responses controlled by sting protein |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5242931A (en) | 1988-06-09 | 1993-09-07 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds as TXA2 antagonists |
US4999363A (en) | 1988-06-09 | 1991-03-12 | Kyowa Hakko Kogyo Co., Ltd. | Tricyclic compounds |
US5750542A (en) | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
ES2188584T3 (es) | 1991-03-28 | 2003-07-01 | Eisai Co Ltd | Derivados heterociclicos de amina. |
US5612360A (en) | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
US5616537A (en) | 1992-07-03 | 1997-04-01 | Kumiai Chemical Industry Co., Ltd. | Condensed heterocyclic derivatives and herbicides |
DE69413183T2 (de) | 1993-06-25 | 1999-02-11 | Kumiai Chemical Industry Co | Indazolsulfonylharnstoff-derivat, verwendung und zwischenprodukte zur herstellung |
EP0796258A1 (en) | 1994-12-06 | 1997-09-24 | MERCK SHARP & DOHME LTD. | Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists |
GB9519563D0 (en) | 1995-09-26 | 1995-11-29 | Merck Sharp & Dohme | Therapeutic agents |
GB9523583D0 (en) | 1995-11-17 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
US5760028A (en) | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
EP0939757A1 (en) | 1995-12-22 | 1999-09-08 | Dupont Pharmaceuticals Company | Novel integrin receptor antagonists |
JPH101478A (ja) | 1996-06-11 | 1998-01-06 | Kumiai Chem Ind Co Ltd | インダゾールスルホニル尿素誘導体及び除草剤 |
GB9615449D0 (en) | 1996-07-23 | 1996-09-04 | Merck Sharp & Dohme | Therapeutic agents |
CA2309175A1 (en) | 1997-11-04 | 1999-05-14 | Pfizer Products Inc. | Therapeutically active compounds based on indazole bioisostere replacement of catechol in pde4 inhibitors |
US6331640B1 (en) | 1998-10-13 | 2001-12-18 | Hoffmann-La Roche Inc. | Diaminopropionic acid derivatives |
EP1192135A2 (en) | 1999-06-14 | 2002-04-03 | Eli Lilly And Company | Serine protease inhibitors |
AU5414000A (en) | 1999-06-14 | 2001-01-02 | Eli Lilly And Company | Compounds |
AU5895500A (en) | 1999-06-29 | 2001-01-31 | Cor Therapeutics, Inc. | Novel indazole peptidomimetics as thrombin receptor antagonists |
GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
GB0030304D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
US20050009876A1 (en) | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
US7058826B2 (en) * | 2000-09-27 | 2006-06-06 | Amphus, Inc. | System, architecture, and method for logical server and other network devices in a dynamically configurable multi-server network environment |
US20020052373A1 (en) | 2000-10-26 | 2002-05-02 | Zorn Stevin H. | Combination treatment for dementia or cognitive deficits associated with alzheimer's disease and parkinson's disease |
CA2465207C (en) | 2001-11-01 | 2011-01-04 | Icagen, Inc. | Pyrazole-amides and -sulfonamides |
US20090286791A1 (en) | 2001-11-27 | 2009-11-19 | Takeda Pharmaceutical Company Limited | Amide Compounds |
US7294624B2 (en) * | 2001-12-20 | 2007-11-13 | Bristol Myers Squibb Company | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases |
AU2003224923A1 (en) | 2002-04-11 | 2003-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic amide derivatives as cytokine inhibitors |
JP4414881B2 (ja) | 2002-05-31 | 2010-02-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾール化合物およびこれを含んでなる医薬組成物 |
AU2003236500B9 (en) | 2002-06-12 | 2009-07-02 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazine derivatives for use as CCR1 antagonists for the treatment of inflammation and immune disorders |
TW200500341A (en) | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
SE0203825D0 (sv) | 2002-12-20 | 2002-12-20 | Astrazeneca Ab | Novel fused heterocycles and uses thereof |
US7129264B2 (en) | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
US20040220170A1 (en) | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
JP2007502307A (ja) | 2003-08-15 | 2007-02-08 | アストラゼネカ アクチボラグ | グルタミン酸ラセマーゼ(muri)の阻害剤としての縮合複素環 |
US7960417B2 (en) | 2005-02-24 | 2011-06-14 | Merck Sharp & Dohme Corp. | Benzazole potentiators of metabotropic glutamate receptors |
GB0504828D0 (en) * | 2005-03-09 | 2005-04-13 | Merck Sharp & Dohme | Therapeutic agents |
DK1881823T3 (en) | 2005-05-17 | 2015-03-02 | Sarcode Bioscience Inc | COMPOSITION AND PROCEDURES FOR TREATMENT OF EYE DISORDERS |
EA017278B9 (ru) * | 2005-06-22 | 2013-01-30 | Кемосентрикс, Инк. | Соединения азаиндазола и способы применения |
BRPI0615048A2 (pt) | 2005-09-01 | 2010-03-30 | Lilly Co Eli | composto, composição farmacêutica, e, uso de um composto |
JP2009513677A (ja) | 2005-10-25 | 2009-04-02 | スミスクライン・ビーチャム・コーポレイション | 化合物 |
TW200829578A (en) * | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
EP2167497A2 (en) * | 2007-06-29 | 2010-03-31 | Sunesis Pharmaceuticals, Inc. | Heterocyclic compounds useful as raf kinase inhibitors |
CN101815718A (zh) | 2007-08-10 | 2010-08-25 | 克里斯捷诺米有限公司 | 吡啶衍生物及其用法 |
GB0716292D0 (en) | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
WO2009085256A1 (en) * | 2007-12-27 | 2009-07-09 | Panacos Pharmaceuticals, Inc. | Anti-hiv compounds |
WO2009134666A1 (en) | 2008-04-29 | 2009-11-05 | Boehringer Ingelheim International Gmbh | Indazole compounds as ccr1 receptor antagonists |
JP5411927B2 (ja) | 2008-05-06 | 2014-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1アンタゴニストとしてのピラゾール化合物 |
UA103634C2 (en) | 2008-09-26 | 2013-11-11 | Берингер Ингельхайм Интернациональ Гмбх | Azaindazole compounds as ccr1 receptor antagonists |
IN2012DN03449A (es) | 2009-10-21 | 2015-10-23 | Boehringer Ingelheim Int | |
JP5542214B2 (ja) | 2009-10-27 | 2014-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr1受容体アンタゴニストとしての複素環化合物 |
BR112012013582A2 (pt) | 2009-12-08 | 2016-07-05 | Boehringer Ingelheim Int | processo para síntese de intermediários úteis para a produção de compostos de indazol e azaindazol substituídos |
US8871786B2 (en) | 2010-04-30 | 2014-10-28 | Boehringer Ingelheim International Gmbh | Azaindazole amide compounds as CCR1 receptor antagonists |
EP2655371B1 (en) | 2010-12-23 | 2015-02-25 | Boehringer Ingelheim International GmbH | Pyrazolopiperidine compounds as ccr1 receptor antagonists |
-
2009
- 2009-09-22 UA UAA201105061A patent/UA103634C2/ru unknown
- 2009-09-22 CA CA2737472A patent/CA2737472A1/en not_active Abandoned
- 2009-09-22 PE PE2011000789A patent/PE20110854A1/es not_active Application Discontinuation
- 2009-09-22 EP EP09792818.8A patent/EP2346868B1/en active Active
- 2009-09-22 WO PCT/US2009/057778 patent/WO2010036632A1/en active Application Filing
- 2009-09-22 US US12/564,129 patent/US7879873B2/en active Active
- 2009-09-22 JP JP2011529154A patent/JP5507567B2/ja active Active
- 2009-09-22 EA EA201100524A patent/EA201100524A1/ru unknown
- 2009-09-22 NZ NZ591115A patent/NZ591115A/xx not_active IP Right Cessation
- 2009-09-22 BR BRPI0919844A patent/BRPI0919844A2/pt not_active IP Right Cessation
- 2009-09-22 AU AU2009296839A patent/AU2009296839A1/en not_active Abandoned
- 2009-09-22 AP AP2011005685A patent/AP2739A/xx active
- 2009-09-22 CN CN2009801472064A patent/CN102227425A/zh active Pending
- 2009-09-22 KR KR1020117006720A patent/KR20110060904A/ko not_active Application Discontinuation
- 2009-09-22 MX MX2011002951A patent/MX2011002951A/es active IP Right Grant
- 2009-09-24 UY UY0001032140A patent/UY32140A/es not_active Application Discontinuation
- 2009-09-25 AR ARP090103709A patent/AR073689A1/es unknown
- 2009-09-25 TW TW098132530A patent/TW201018683A/zh unknown
-
2010
- 2010-12-16 US US12/969,753 patent/US8063065B2/en active Active
-
2011
- 2011-01-25 IL IL210857A patent/IL210857A0/en unknown
- 2011-01-25 ZA ZA2011/00625A patent/ZA201100625B/en unknown
- 2011-03-17 CO CO11033549A patent/CO6351735A2/es active IP Right Grant
- 2011-03-24 MA MA33724A patent/MA32655B1/fr unknown
- 2011-03-25 CL CL2011000668A patent/CL2011000668A1/es unknown
- 2011-03-29 EC EC2011010932A patent/ECSP11010932A/es unknown
- 2011-10-14 US US13/273,509 patent/US8163918B2/en active Active
-
2012
- 2012-02-08 US US13/368,397 patent/US8338610B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US8063065B2 (en) | 2011-11-22 |
US20120035370A1 (en) | 2012-02-09 |
CL2011000668A1 (es) | 2011-10-28 |
AP2739A (en) | 2013-09-30 |
US20100093724A1 (en) | 2010-04-15 |
US20120136158A1 (en) | 2012-05-31 |
EP2346868B1 (en) | 2016-01-27 |
ZA201100625B (en) | 2011-09-28 |
WO2010036632A1 (en) | 2010-04-01 |
EP2346868A1 (en) | 2011-07-27 |
US20110086846A1 (en) | 2011-04-14 |
CO6351735A2 (es) | 2011-12-20 |
IL210857A0 (en) | 2011-04-28 |
ECSP11010932A (es) | 2011-04-29 |
AR073689A1 (es) | 2010-11-24 |
AU2009296839A1 (en) | 2010-04-01 |
JP2012503664A (ja) | 2012-02-09 |
MA32655B1 (fr) | 2011-09-01 |
CN102227425A (zh) | 2011-10-26 |
AP2011005685A0 (en) | 2011-04-30 |
UA103634C2 (en) | 2013-11-11 |
US7879873B2 (en) | 2011-02-01 |
KR20110060904A (ko) | 2011-06-08 |
CA2737472A1 (en) | 2010-04-01 |
JP5507567B2 (ja) | 2014-05-28 |
BRPI0919844A2 (pt) | 2019-09-24 |
US8163918B2 (en) | 2012-04-24 |
NZ591115A (en) | 2012-10-26 |
EA201100524A1 (ru) | 2011-10-31 |
UY32140A (es) | 2010-04-30 |
TW201018683A (en) | 2010-05-16 |
MX2011002951A (es) | 2011-04-26 |
US8338610B2 (en) | 2012-12-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20110854A1 (es) | DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1 | |
PE20161405A1 (es) | Analogos de cortistatina y sintesis y usos de los mismos | |
PE20121050A1 (es) | Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog | |
PE20100562A1 (es) | Derivados policiclicos de indazol como inhibidores de erk | |
PE20080839A1 (es) | Determinadas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas | |
PE20091523A1 (es) | Derivados de tiazol como inhibidores de la enzima fosfatidilinositol 3-cinasa (pi3k) | |
UA112061C2 (uk) | Активуючі ampk гетероциклічні сполуки і способи їх використання | |
PE20130311A1 (es) | Composiciones y metodos para modular la via de senalizacion de wnt | |
PE20080404A1 (es) | Derivados bencil-amino-piperidina como inhibidores de cetp | |
PE20080538A1 (es) | Derivado heterociclico fusionado y su uso | |
PE20060937A1 (es) | Derivados de sulfonilbencimidazol como agonistas del receptor cannabinoide 2 (cb2) | |
PE20081845A1 (es) | Nuevos derivados de aminopirimidina como inhibidores de plk1 | |
PE20141682A1 (es) | Derivados de (4-fenilimidazol-2-il) etilamina utiles como moduladores de canal de sodio | |
AR059249A1 (es) | Compuesto amina trisustituido | |
PE20120620A1 (es) | Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas | |
PE20090770A1 (es) | Derivados de benzoxazolona | |
PE20080768A1 (es) | Compuestos de isoindolina 5-sustituidos | |
AR074676A1 (es) | Derivados de isooxazol como antagonistas de receptores de acido lisofosfatidico, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por la actividad fisiologica de lpa. | |
PE20141167A1 (es) | Piridopirazinas sustituidas como inhibidores novedosos de ptk | |
EA200901379A1 (ru) | Производные никотиновой кислоты как модуляторы метаботропных глутаматных рецепторов 5 подтипа | |
PE20070212A1 (es) | Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen | |
PE20090892A1 (es) | MODULADORES DUALES DE LOS RECEPTORES 5-HT2a Y D3 | |
ECSP11010830A (es) | Derivados de heteroarilo como inhibidores de dgat1 | |
ATE552246T1 (de) | Substituierte aryloxy-n- bicyclomethylacetamidverbindungen als vr1- antagonisten | |
PE20080405A1 (es) | COMPUESTOS Y COMPOSICIONES COMO INHIBIDORES DE ITPKb |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |