AR091858A1 - INHIBIDORES DE CISTATIONIN-g-LIASA (CSE) - Google Patents
INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)Info
- Publication number
- AR091858A1 AR091858A1 ARP130102599A ARP130102599A AR091858A1 AR 091858 A1 AR091858 A1 AR 091858A1 AR P130102599 A ARP130102599 A AR P130102599A AR P130102599 A ARP130102599 A AR P130102599A AR 091858 A1 AR091858 A1 AR 091858A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- cse
- inhibitors
- compounds
- Prior art date
Links
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A61K31/433—Thidiazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
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- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
Abstract
Compuestos y composiciones farmacéuticas que los contienen que inhiben la cistationin-g-liasa (CSE). También se describen métodos para usar tales inhibidores de CSE, solos o en combinación con otros compuestos, para tratar el tratamiento de enfermedades o condiciones en las que resulta beneficiosa su inhibición. Reivindicación 1: Un compuesto, caracterizado porque es de fórmula (1), donde: A es un isóstero de ácido carboxílico; X es CR¹, o N; R¹ es H, alquilo sustituido o no sustituido, heteroalquilo sustituido o no sustituido, heterocicloalquilo sustituido o no sustituido, arilo sustituido o no sustituido, o heteroarilo sustituido o no sustituido; R² y R³ son en forma independiente entre sí H, alquilo sustituido o no sustituido, o heteroalquilo sustituido o no sustituido; o R² y R³ junto con el carbono al cual están unidos forman un anillo cicloalquilo o heterocicloalquilo; o una sal aceptable farmacéuticamente, solvato, o prodroga del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201261675753P | 2012-07-25 | 2012-07-25 |
Publications (1)
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AR091858A1 true AR091858A1 (es) | 2015-03-04 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP130102599A AR091858A1 (es) | 2012-07-25 | 2013-07-22 | INHIBIDORES DE CISTATIONIN-g-LIASA (CSE) |
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US (2) | US9771339B2 (es) |
EP (1) | EP2877458A4 (es) |
JP (2) | JP6407864B2 (es) |
KR (1) | KR20150041634A (es) |
CN (2) | CN104684901A (es) |
AR (1) | AR091858A1 (es) |
AU (2) | AU2013293089A1 (es) |
CA (1) | CA2879986C (es) |
HK (1) | HK1210615A1 (es) |
IN (1) | IN2015DN01197A (es) |
RU (1) | RU2640418C2 (es) |
TW (1) | TWI606040B (es) |
WO (1) | WO2014018569A1 (es) |
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-
2013
- 2013-07-22 AR ARP130102599A patent/AR091858A1/es unknown
- 2013-07-23 RU RU2015105893A patent/RU2640418C2/ru active
- 2013-07-23 US US14/416,574 patent/US9771339B2/en not_active Expired - Fee Related
- 2013-07-23 JP JP2015524401A patent/JP6407864B2/ja not_active Expired - Fee Related
- 2013-07-23 AU AU2013293089A patent/AU2013293089A1/en not_active Abandoned
- 2013-07-23 EP EP13823562.7A patent/EP2877458A4/en not_active Withdrawn
- 2013-07-23 CN CN201380049533.2A patent/CN104684901A/zh active Pending
- 2013-07-23 WO PCT/US2013/051744 patent/WO2014018569A1/en active Application Filing
- 2013-07-23 CA CA2879986A patent/CA2879986C/en not_active Expired - Fee Related
- 2013-07-23 CN CN201811165284.4A patent/CN109748881A/zh active Pending
- 2013-07-23 KR KR1020157004421A patent/KR20150041634A/ko not_active Application Discontinuation
- 2013-07-24 TW TW102126482A patent/TWI606040B/zh not_active IP Right Cessation
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2015
- 2015-02-13 IN IN1197DEN2015 patent/IN2015DN01197A/en unknown
- 2015-11-18 HK HK15111387.1A patent/HK1210615A1/xx unknown
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2017
- 2017-08-09 US US15/672,511 patent/US10227314B2/en not_active Expired - Fee Related
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2018
- 2018-01-25 AU AU2018200635A patent/AU2018200635B2/en not_active Ceased
- 2018-06-07 JP JP2018109810A patent/JP2018172397A/ja active Pending
Also Published As
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RU2015105893A (ru) | 2016-09-10 |
IN2015DN01197A (es) | 2015-06-26 |
RU2640418C2 (ru) | 2018-01-09 |
CN104684901A (zh) | 2015-06-03 |
JP6407864B2 (ja) | 2018-10-17 |
US9771339B2 (en) | 2017-09-26 |
US10227314B2 (en) | 2019-03-12 |
TWI606040B (zh) | 2017-11-21 |
US20150175561A1 (en) | 2015-06-25 |
JP2015530368A (ja) | 2015-10-15 |
AU2013293089A1 (en) | 2015-02-19 |
AU2018200635A1 (en) | 2018-02-15 |
EP2877458A4 (en) | 2016-08-10 |
CA2879986C (en) | 2020-09-29 |
AU2018200635B2 (en) | 2019-07-04 |
TW201406732A (zh) | 2014-02-16 |
KR20150041634A (ko) | 2015-04-16 |
JP2018172397A (ja) | 2018-11-08 |
HK1210615A1 (en) | 2016-04-29 |
EP2877458A1 (en) | 2015-06-03 |
CN109748881A (zh) | 2019-05-14 |
WO2014018569A1 (en) | 2014-01-30 |
CA2879986A1 (en) | 2014-01-30 |
US20170334866A1 (en) | 2017-11-23 |
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