MA32167B1 - Dérivés d'imidazo[1,2-b]pyridazine pour le traitement de maladies médiées par la tyrosine kinase c-met - Google Patents
Dérivés d'imidazo[1,2-b]pyridazine pour le traitement de maladies médiées par la tyrosine kinase c-metInfo
- Publication number
- MA32167B1 MA32167B1 MA33198A MA33198A MA32167B1 MA 32167 B1 MA32167 B1 MA 32167B1 MA 33198 A MA33198 A MA 33198A MA 33198 A MA33198 A MA 33198A MA 32167 B1 MA32167 B1 MA 32167B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- tyrosine kinase
- imidazo
- mediated diseases
- kinase mediated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La présente invention concerne des composés de formule (i) et des sels de ceux-ci, formule (i), dans lesquels les substituants sont comme défini dans la spécification, l'application d'un composé de formule (i) dans un procédé pour le traitement du corps humain ou animal, en particulier en ce qui concerne une maladie médiée par la tyrosine kinase c-met; l'utilisation d'un composé de formule (i) pour fabriquer un médicament pour le traitement de telles maladies; des compositions pharmaceutiques comprenant un composé de formule (i), facultativement en présence d'un partenaire de combinaison; des procédés pour la préparation d'un composé de formule (i).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08152068 | 2008-02-28 | ||
PCT/EP2009/052302 WO2009106577A1 (fr) | 2008-02-28 | 2009-02-26 | Dérivés d’imidazo[1,2-b]pyridazine pour le traitement de maladies médiées par la tyrosine kinase c-met |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32167B1 true MA32167B1 (fr) | 2011-03-01 |
Family
ID=39672115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33198A MA32167B1 (fr) | 2008-02-28 | 2010-09-24 | Dérivés d'imidazo[1,2-b]pyridazine pour le traitement de maladies médiées par la tyrosine kinase c-met |
Country Status (25)
Country | Link |
---|---|
US (1) | US8822468B2 (fr) |
EP (1) | EP2265614A1 (fr) |
JP (1) | JP5576802B2 (fr) |
KR (1) | KR20100128305A (fr) |
CN (1) | CN102015716B (fr) |
AR (1) | AR070487A1 (fr) |
AU (1) | AU2009218459A1 (fr) |
BR (1) | BRPI0908504A2 (fr) |
CA (1) | CA2717034A1 (fr) |
CL (1) | CL2009000443A1 (fr) |
CO (1) | CO6300957A2 (fr) |
CR (1) | CR11620A (fr) |
DO (1) | DOP2010000263A (fr) |
EA (1) | EA201001365A1 (fr) |
EC (1) | ECSP10010427A (fr) |
IL (1) | IL207434A0 (fr) |
MA (1) | MA32167B1 (fr) |
MX (1) | MX2010009414A (fr) |
NI (1) | NI201000145A (fr) |
PE (1) | PE20091468A1 (fr) |
SM (1) | SMAP201000112A (fr) |
TW (1) | TW200940545A (fr) |
UY (1) | UY31676A1 (fr) |
WO (1) | WO2009106577A1 (fr) |
ZA (1) | ZA201005602B (fr) |
Families Citing this family (24)
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UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
US20110053968A1 (en) | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
US8389526B2 (en) * | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
EA201200260A1 (ru) | 2009-08-12 | 2012-09-28 | Новартис Аг | Гетероциклические гидразоны и их применение для лечения рака и воспаления |
EA201200318A1 (ru) | 2009-08-20 | 2012-09-28 | Новартис Аг | Гетероциклические оксимы |
CN106432225B (zh) | 2009-12-31 | 2019-02-19 | 和记黄埔医药(上海)有限公司 | 某些***并吡啶化合物和***并吡嗪化合物、其组合物和其使用方法 |
US20110195066A1 (en) * | 2010-02-05 | 2011-08-11 | Auspex Pharmaceuticals, Inc. | Quinoline inhibitors of tyrosine kinase |
WO2012003338A1 (fr) * | 2010-07-01 | 2012-01-05 | Takeda Pharmaceutical Company Limited | Combinaison d'un inhibiteur de cmet et d'un anticorps dirigé contre hgf et/ou cmet |
AR085183A1 (es) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
JP5944497B2 (ja) * | 2011-06-22 | 2016-07-05 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | ヘテロシクリルアミノイミダゾピリダジン |
CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]***并[4,3-a]吡啶化合物 |
MX339302B (es) | 2011-09-15 | 2016-05-19 | Novartis Ag | 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina. |
CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术(太仓)有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
PT2925757T (pt) | 2012-11-19 | 2018-01-09 | Novartis Ag | Compostos e composições para o tratamento de doenças parasitárias |
CN105431148A (zh) | 2013-03-07 | 2016-03-23 | 加利菲亚生物公司 | 混合谱系激酶抑制剂及治疗方法 |
AR097543A1 (es) * | 2013-09-06 | 2016-03-23 | Lexicon Pharmaceuticals Inc | COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO |
CN105326793A (zh) * | 2014-08-06 | 2016-02-17 | 中美冠科生物技术(太仓)有限公司 | 一种包含c-Met激酶抑制剂的固体分散体及其制备方法和用途 |
AU2015366190B2 (en) * | 2014-12-19 | 2020-01-23 | Janssen Pharmaceutica Nv | Imidazopyridazine derivatives as P13Kbeta inhibitors |
CA2967546A1 (fr) * | 2014-12-19 | 2016-06-23 | Janssen Pharmaceutica Nv | Derives d'imidazopyridazine a liaison heterocyclyle en tant qu'inhibiteurs pi3k.beta. |
CN109715631B (zh) * | 2016-09-16 | 2022-02-18 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) | Traf 6抑制剂 |
WO2018138050A1 (fr) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Dérivés hétérocycliques bicycliques condensés utilisés comme pesticides |
US11584744B2 (en) * | 2017-06-23 | 2023-02-21 | University Of Washington | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them |
EP4077332A4 (fr) * | 2019-12-18 | 2024-05-01 | Univ California | Inhibiteurs de lin28 et leurs méthodes d'utilisation |
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AR064420A1 (es) * | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
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EP2170894A1 (fr) | 2007-06-21 | 2010-04-07 | Janssen Pharmaceutica N.V. | Formes polymorphes et hydratées, sels et procédé de préparation de la 6-{difluoro[6-(1-méthyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]méthyl}quinoléine |
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WO2009088955A2 (fr) | 2007-12-31 | 2009-07-16 | Energenox, Inc. | Turbine à effet de couche limite |
JP2009227599A (ja) | 2008-03-21 | 2009-10-08 | Daiichi Sankyo Co Ltd | イミダゾピリダジン誘導体 |
-
2009
- 2009-02-26 KR KR1020107021426A patent/KR20100128305A/ko not_active Application Discontinuation
- 2009-02-26 AU AU2009218459A patent/AU2009218459A1/en not_active Abandoned
- 2009-02-26 WO PCT/EP2009/052302 patent/WO2009106577A1/fr active Application Filing
- 2009-02-26 JP JP2010548110A patent/JP5576802B2/ja not_active Expired - Fee Related
- 2009-02-26 PE PE2009000287A patent/PE20091468A1/es not_active Application Discontinuation
- 2009-02-26 EA EA201001365A patent/EA201001365A1/ru unknown
- 2009-02-26 EP EP09714429A patent/EP2265614A1/fr not_active Withdrawn
- 2009-02-26 CN CN200980114928.XA patent/CN102015716B/zh not_active Expired - Fee Related
- 2009-02-26 CA CA2717034A patent/CA2717034A1/fr not_active Abandoned
- 2009-02-26 UY UY031676A patent/UY31676A1/es not_active Application Discontinuation
- 2009-02-26 BR BRPI0908504-1A patent/BRPI0908504A2/pt not_active IP Right Cessation
- 2009-02-26 MX MX2010009414A patent/MX2010009414A/es not_active Application Discontinuation
- 2009-02-26 AR ARP090100659A patent/AR070487A1/es unknown
- 2009-02-27 TW TW098106564A patent/TW200940545A/zh unknown
- 2009-02-27 CL CL2009000443A patent/CL2009000443A1/es unknown
- 2009-03-02 US US12/396,137 patent/US8822468B2/en not_active Expired - Fee Related
-
2010
- 2010-08-05 IL IL207434A patent/IL207434A0/en unknown
- 2010-08-05 ZA ZA2010/05602A patent/ZA201005602B/en unknown
- 2010-08-06 CR CR11620A patent/CR11620A/es not_active Application Discontinuation
- 2010-08-27 DO DO2010000263A patent/DOP2010000263A/es unknown
- 2010-08-27 CO CO10106017A patent/CO6300957A2/es not_active Application Discontinuation
- 2010-08-27 NI NI201000145A patent/NI201000145A/es unknown
- 2010-08-27 EC EC2010010427A patent/ECSP10010427A/es unknown
- 2010-09-24 MA MA33198A patent/MA32167B1/fr unknown
- 2010-09-28 SM SM201000112T patent/SMAP201000112A/it unknown
Also Published As
Publication number | Publication date |
---|---|
EA201001365A1 (ru) | 2011-04-29 |
ZA201005602B (en) | 2011-04-28 |
CN102015716A (zh) | 2011-04-13 |
CR11620A (es) | 2010-10-08 |
CO6300957A2 (es) | 2011-07-21 |
MX2010009414A (es) | 2010-09-24 |
DOP2010000263A (es) | 2010-09-30 |
IL207434A0 (en) | 2010-12-30 |
US8822468B2 (en) | 2014-09-02 |
CN102015716B (zh) | 2014-09-17 |
CL2009000443A1 (es) | 2010-09-10 |
ECSP10010427A (es) | 2010-09-30 |
JP5576802B2 (ja) | 2014-08-20 |
PE20091468A1 (es) | 2009-10-22 |
UY31676A1 (es) | 2009-09-30 |
NI201000145A (es) | 2011-03-02 |
SMAP201000112A (it) | 2010-11-12 |
TW200940545A (en) | 2009-10-01 |
KR20100128305A (ko) | 2010-12-07 |
CA2717034A1 (fr) | 2009-09-03 |
US20090264406A1 (en) | 2009-10-22 |
EP2265614A1 (fr) | 2010-12-29 |
JP2011513279A (ja) | 2011-04-28 |
AU2009218459A1 (en) | 2009-09-03 |
BRPI0908504A2 (pt) | 2015-08-11 |
AR070487A1 (es) | 2010-04-07 |
WO2009106577A1 (fr) | 2009-09-03 |
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