AR070487A1 - Derivados de 3- metil- imidazo -( 1,2-b)- piridazina - Google Patents

Derivados de 3- metil- imidazo -( 1,2-b)- piridazina

Info

Publication number
AR070487A1
AR070487A1 ARP090100659A ARP090100659A AR070487A1 AR 070487 A1 AR070487 A1 AR 070487A1 AR P090100659 A ARP090100659 A AR P090100659A AR P090100659 A ARP090100659 A AR P090100659A AR 070487 A1 AR070487 A1 AR 070487A1
Authority
AR
Argentina
Prior art keywords
unsubstituted
formula
substituted
compound
halogen
Prior art date
Application number
ARP090100659A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39672115&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR070487(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR070487A1 publication Critical patent/AR070487A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un proceso para el tratamiento del cuerpo humano o animal, en particular con respecto una enfermedad mediada por la cinasa de tirosina c-Met; al uso de un compuesto de la formula (1) para la fabricacion de un medicamento para el tratamiento de estas enfermedades; a composiciones farmacéuticas que comprenden un compuesto de la formula (1), opcionalmente en la presencia de un componente de combinacion; y a procesos para la preparacion de un compuesto de la formula (1). Reivindicacion 1: Un compuesto de la formula (1) en donde: R1 representa heterociclilo insustituido o sustituido, arilo insustituido o sustituido, cicloalquilo insustituido o sustituido, alquilo insustituido o sustituido, alcoxilo insustituido o sustituido, ciano, carboxamida, o halogeno; R2 representa heterociclilo insustituido o sustituido, arilo insustituido o sustituido; R3 representa H, deuterio, alquilo inferior, y R3' representa H, deuterio, alquilo inferior, halogeno, hidroxilo, o R3 representa halogeno, y R3' representa halogeno, o R3 y R3' representan, junto con el átomo de carbono con el que están unidos, cicloalquilo o vinilo; A1 representa ya sea un enlace directo, un grupo -SO2-, o bien un grupo de formula (2) en donde el enlace marcado * está unido a R1; n representa 0 o 1; m representa 0, 1, 2, 3, 4 o 5; R4 representa H o alquilo insustituido; R5 representa H o alquilo insustituido; R5' representa H o alquilo insustituido; A2 representa O o NR4; o una sal del mismo.
ARP090100659A 2008-02-28 2009-02-26 Derivados de 3- metil- imidazo -( 1,2-b)- piridazina AR070487A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08152068 2008-02-28

Publications (1)

Publication Number Publication Date
AR070487A1 true AR070487A1 (es) 2010-04-07

Family

ID=39672115

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100659A AR070487A1 (es) 2008-02-28 2009-02-26 Derivados de 3- metil- imidazo -( 1,2-b)- piridazina

Country Status (25)

Country Link
US (1) US8822468B2 (es)
EP (1) EP2265614A1 (es)
JP (1) JP5576802B2 (es)
KR (1) KR20100128305A (es)
CN (1) CN102015716B (es)
AR (1) AR070487A1 (es)
AU (1) AU2009218459A1 (es)
BR (1) BRPI0908504A2 (es)
CA (1) CA2717034A1 (es)
CL (1) CL2009000443A1 (es)
CO (1) CO6300957A2 (es)
CR (1) CR11620A (es)
DO (1) DOP2010000263A (es)
EA (1) EA201001365A1 (es)
EC (1) ECSP10010427A (es)
IL (1) IL207434A0 (es)
MA (1) MA32167B1 (es)
MX (1) MX2010009414A (es)
NI (1) NI201000145A (es)
PE (1) PE20091468A1 (es)
SM (1) SMAP201000112A (es)
TW (1) TW200940545A (es)
UY (1) UY31676A1 (es)
WO (1) WO2009106577A1 (es)
ZA (1) ZA201005602B (es)

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US8389526B2 (en) * 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
BR112012003262A8 (pt) 2009-08-12 2016-05-17 Novartis Ag compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
WO2011020861A1 (en) 2009-08-20 2011-02-24 Novartis Ag Heterocyclic oxime compounds
PE20160588A1 (es) 2009-12-31 2016-07-09 Hutchison Medipharma Ltd Compuestos de triazolopiridinas y triazolopirazinas inhibidores de c-met y composiciones de los mismos
US20110195066A1 (en) * 2010-02-05 2011-08-11 Auspex Pharmaceuticals, Inc. Quinoline inhibitors of tyrosine kinase
US20130315895A1 (en) * 2010-07-01 2013-11-28 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
AR085183A1 (es) 2010-07-30 2013-09-18 Lilly Co Eli Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer
UY33597A (es) * 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
ES2610366T3 (es) * 2011-06-22 2017-04-27 Bayer Intellectual Property Gmbh Heterociclil-aminoimidazopiridazinas
CN103958509B (zh) * 2011-09-15 2015-12-23 诺华股份有限公司 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]***并[4,3-a]吡啶化合物
CA2848809A1 (en) 2011-09-15 2013-03-21 Novartis Ag 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase
CN103122000B (zh) * 2012-09-03 2013-12-25 中美冠科生物技术（太仓）有限公司 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂
CN105164124B (zh) 2012-11-19 2017-03-15 诺华股份有限公司 用于治疗寄生虫疾病的化合物和组合物
WO2014138692A1 (en) 2013-03-07 2014-09-12 Califia Bio, Inc. Mixed lineage kinase inhibitors and method of treatments
AR097543A1 (es) * 2013-09-06 2016-03-23 Lexicon Pharmaceuticals Inc COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
CN105326793A (zh) * 2014-08-06 2016-02-17 中美冠科生物技术（太仓）有限公司 一种包含c-Met激酶抑制剂的固体分散体及其制备方法和用途
AU2015366202B2 (en) * 2014-12-19 2020-01-02 Janssen Pharmaceutica Nv Heterocyclyl linked imidazopyridazine derivatives as PI3Kbeta inhibitors
MD3233862T2 (ro) * 2014-12-19 2019-11-30 Janssen Pharmaceutica Nv Derivați ai imidazopiridazinei în calitate de inhibitori ai pΙ3Κbeta
EP3512852A1 (en) * 2016-09-16 2019-07-24 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Traf 6 inhibitors
WO2018138050A1 (de) 2017-01-26 2018-08-02 Bayer Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
US11584744B2 (en) * 2017-06-23 2023-02-21 University Of Washington Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them
US20230059009A1 (en) * 2019-12-18 2023-02-23 The Regents Of The University Of California Inhibitors of lin28 and methods of use thereof

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Also Published As

Publication number Publication date
CN102015716B (zh) 2014-09-17
EP2265614A1 (en) 2010-12-29
NI201000145A (es) 2011-03-02
CR11620A (es) 2010-10-08
WO2009106577A1 (en) 2009-09-03
CL2009000443A1 (es) 2010-09-10
TW200940545A (en) 2009-10-01
AU2009218459A1 (en) 2009-09-03
KR20100128305A (ko) 2010-12-07
MA32167B1 (fr) 2011-03-01
CA2717034A1 (en) 2009-09-03
CN102015716A (zh) 2011-04-13
EA201001365A1 (ru) 2011-04-29
BRPI0908504A2 (pt) 2015-08-11
CO6300957A2 (es) 2011-07-21
MX2010009414A (es) 2010-09-24
PE20091468A1 (es) 2009-10-22
ECSP10010427A (es) 2010-09-30
JP5576802B2 (ja) 2014-08-20
DOP2010000263A (es) 2010-09-30
IL207434A0 (en) 2010-12-30
US20090264406A1 (en) 2009-10-22
UY31676A1 (es) 2009-09-30
JP2011513279A (ja) 2011-04-28
ZA201005602B (en) 2011-04-28
US8822468B2 (en) 2014-09-02
SMAP201000112A (it) 2010-11-12

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