MA26559A1 - Derives de d-proline, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation - Google Patents

Derives de d-proline, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation

Info

Publication number: MA26559A1
Authority: MA; Morocco
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; proline derivatives; proline
Prior art date: 1997-10-31

Application number

MA25327A

Other languages

English (en)

Inventor

Hertel Cornelia

Jakob-Roetne Roland

David Norcross Roger

Hoffmann Torsten

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-31

Filing date

1998-10-30

Publication date

2004-12-20

1998-10-30 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-20 Publication of MA26559A1 publication Critical patent/MA26559A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings

MA25327A 1997-10-31 1998-10-30 Derives de d-proline, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation MA26559A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97119031		1997-10-31
EP98113851		1998-07-24

Publications (1)

Publication Number	Publication Date
MA26559A1 true MA26559A1 (fr)	2004-12-20

Family

ID=26145860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA25327A MA26559A1 (fr)	1997-10-31	1998-10-30	Derives de d-proline, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation

Country Status (35)

Country	Link
US (4)	US6103910A (fr)
EP (1)	EP0915088B1 (fr)
JP (1)	JP3048558B2 (fr)
KR (2)	KR100313637B1 (fr)
CN (1)	CN100357270C (fr)
AR (1)	AR015473A1 (fr)
AT (1)	ATE224366T1 (fr)
AU (1)	AU750734B2 (fr)
BR (1)	BR9804378B1 (fr)
CA (1)	CA2252163C (fr)
CO (1)	CO5011076A1 (fr)
CZ (1)	CZ296252B6 (fr)
DE (1)	DE69808017T2 (fr)
DK (1)	DK0915088T3 (fr)
EG (1)	EG23756A (fr)
ES (1)	ES2182203T3 (fr)
HK (1)	HK1019875A1 (fr)
HR (1)	HRP980572B1 (fr)
HU (1)	HUP9802465A1 (fr)
ID (1)	ID21194A (fr)
IL (1)	IL126787A (fr)
MA (1)	MA26559A1 (fr)
MY (1)	MY142803A (fr)
NO (1)	NO312064B1 (fr)
PE (1)	PE123499A1 (fr)
PL (1)	PL196967B1 (fr)
PT (1)	PT915088E (fr)
RS (1)	RS49589B (fr)
RU (1)	RU2201937C2 (fr)
SA (1)	SA98190749B1 (fr)
SG (1)	SG74094A1 (fr)
SI (1)	SI0915088T1 (fr)
TR (1)	TR199802197A3 (fr)
TW (1)	TW585854B (fr)
UY (1)	UY25230A1 (fr)

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US20060211731A1 (en) *	1999-05-05	2006-09-21	Les Laboratories Servier	New substituted pyridine or piperidine compounds
FR2793245B1 (fr) *	1999-05-05	2002-10-11	Adir	Nouveaux composes pyridiniques ou piperidiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU6611800A (en) *	1999-08-05	2001-03-05	Procter & Gamble Company, The	Method of treating hair loss using multivalent ketoamides and amides
JP2004516237A (ja)	2000-06-21	2004-06-03	ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー	ケモカイン受容体活性調節剤としてのピペリジンアミド類
FI20011466A0 (fi) *	2001-07-04	2001-07-04	Orion Corp	Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä, niiden valmistusmenetelmiä ja käyttö
EP1418905B1 (fr)	2001-08-08	2007-05-02	Pentraxin Therapeutics Limited	Agent therapeutique pour la depletion plasmatique d'une population de proteines indesirables
GB0119370D0 (en)	2001-08-08	2001-10-03	Univ London	Therapeutic agent
US6903129B2 (en) *	2001-12-14	2005-06-07	Hoffman-La Roche Inc.	D-proline prodrugs
US7091357B2 (en) *	2001-12-26	2006-08-15	University Of Kentucky Research Foundation	Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies
AU2003223708A1 (en) *	2002-04-23	2003-11-10	Axys Pharmaceuticals, Inc.	Novel phenyl derivatives as inducers of apoptosis
DE10240026A1 (de) *	2002-08-27	2004-03-11	Merck Patent Gmbh	Verfahren zur Herstellung von Monoalkylaminoketonen
FI20030014A0 (fi) *	2003-01-03	2003-01-03	Orion Corp	Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä
WO2004099173A1 (fr) *	2003-05-12	2004-11-18	Theracarb Inc.	Inhibiteurs polyvalents de la composante p des amyloides seriques
PE20050157A1 (es)	2003-05-20	2005-05-17	Novartis Ag	Derivados de n-acil nitrogeno heterociclicos como ligandos del receptor activador del proliferador de peroxisoma (ppar)
GB0313386D0 (en) *	2003-06-10	2003-07-16	Univ London	Treatment of disease
DE102004010943A1 (de) *	2004-03-03	2005-09-29	Degussa Ag	Verfahren zur Herstellung von N-geschützten 4-Ketprolinderivaten
ITMI20041567A1 (it) *	2004-07-30	2004-10-30	Maycos Italiana Di Comini Miro	"derivati n-acilati di acidi bicarbossilici con amminoacidi e con idrolizzati proteici vegetali e loro applicazione in prodotti cosmetici, dermofarmaceutici e farmaceutici"
CN1834095B (zh) *	2005-03-18	2011-04-20	中国科学院上海药物研究所	一类非核苷类抗病毒抑制剂及其制备方法和用途
EP1928865A1 (fr)	2005-08-17	2008-06-11	Schering Corporation	Ligands de kinase thiophene et furane a haute affinite
WO2008014232A2 (fr) *	2006-07-24	2008-01-31	Emisphere Technologies, Inc.	Formulations pharmaceutiques utilisées dans le traitement de la maladie d'alzheimer
GB0712503D0 (en) *	2007-06-27	2007-08-08	Therapeutics Pentraxin Ltd	Use
AU2008358292B2 (en) *	2008-06-27	2015-05-07	Pentraxin Therapeutics Limited	Use
GB2470187A (en) *	2009-05-11	2010-11-17	Pharmapatents Global Ltd	Captopril polymers
US9434716B2 (en)	2011-03-01	2016-09-06	Glaxo Group Limited	Antigen binding proteins
UA108227C2 (xx) *	2010-03-03	2015-04-10		Антигензв'язуючий білок
CA2868073C (fr) *	2012-03-30	2020-12-29	Givaudan S.A.	Derives de n-acyl proline comme composes d'arome alimentaire
CN103333095B (zh) *	2013-06-26	2015-06-24	中国人民解放军第二军医大学	己二酰二d-羟脯氨酸衍生物及其作为核酸疫苗佐剂的应用
DE102013012622A1 (de) *	2013-07-30	2015-02-05	Clariant lnternational Ltd	Neue sterisch gehinderte cyclische Amine
GB201407506D0 (en) *	2014-04-29	2014-06-11	Glaxosmithkline Ip Dev Ltd	Novel compound
DE102015000124A1 (de) *	2015-01-07	2016-07-07	Clariant International Ltd.	Verfahren zur Stabilisierung von Polyamiden
GB201518950D0 (en) *	2015-10-27	2015-12-09	Glaxosmithkline Ip Dev Ltd	Compound
WO2017072090A1 (fr) *	2015-10-27	2017-05-04	Glaxosmithkline Intellectual Property Development Limited	Polythérapie

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JPH0832704B2 (ja) *	1987-11-30	1996-03-29	キッセイ薬品工業株式会社	プロリルエンドペプチダーゼ阻害剤
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JPH02157262A (ja) *	1988-12-10	1990-06-18	Meiji Seika Kaisha Ltd	生理活性を有する新規なピロリジン誘導体
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FR2712888B1 (fr) *	1993-11-23	1996-02-09	Bioeurope	Utilisation de alpha-D-alkylglucopyranosides et esters de ceux-ci pour la préparation de prodrogues capables de traverser la barrière hématoencéphalique, prodrogues obtenues et précurseurs de celles-ci.
JPH0840896A (ja) *	1994-08-04	1996-02-13	Teisan Seiyaku Kk	カプトプリル類似体からなる医薬製剤
CA2230122A1 (fr) *	1995-09-15	1997-03-20	John Hargreaves Bateson	Derives de pyrrolidine et de thiazole, avec proprietes antibacteriennes et inhibitrices de la metallo-beta-lactamase
JPH09157251A (ja) *	1995-10-06	1997-06-17	Kanegafuchi Chem Ind Co Ltd	Ｎ−（Ｄ−α−メチル−β−メルカプトプロピオニル）−Ｌ−プロリン及び該中間体の製造方法
WO1997021728A1 (fr) *	1995-12-12	1997-06-19	Karolinska Innovations Ab	PEPTIDE FIXANT LA SEQUENCE KLVFF DE L'AMYLOIDE $g(b)

1998
- 1998-10-22 DK DK98119986T patent/DK0915088T3/da active
- 1998-10-22 AT AT98119986T patent/ATE224366T1/de active
- 1998-10-22 ES ES98119986T patent/ES2182203T3/es not_active Expired - Lifetime
- 1998-10-22 SI SI9830254T patent/SI0915088T1/xx unknown
- 1998-10-22 DE DE69808017T patent/DE69808017T2/de not_active Expired - Lifetime
- 1998-10-22 EP EP98119986A patent/EP0915088B1/fr not_active Expired - Lifetime
- 1998-10-22 PT PT98119986T patent/PT915088E/pt unknown
- 1998-10-26 HU HU9802465A patent/HUP9802465A1/hu unknown
- 1998-10-27 US US09/179,652 patent/US6103910A/en not_active Expired - Lifetime
- 1998-10-28 CA CA002252163A patent/CA2252163C/fr not_active Expired - Fee Related
- 1998-10-28 TR TR1998/02197A patent/TR199802197A3/tr unknown
- 1998-10-28 IL IL12678798A patent/IL126787A/xx not_active IP Right Cessation
- 1998-10-28 RS YUP-476/98A patent/RS49589B/sr unknown
- 1998-10-29 ID IDP981417A patent/ID21194A/id unknown
- 1998-10-29 JP JP10307719A patent/JP3048558B2/ja not_active Expired - Fee Related
- 1998-10-29 EG EG132998A patent/EG23756A/xx active
- 1998-10-29 CO CO98063547A patent/CO5011076A1/es unknown
- 1998-10-29 UY UY25230A patent/UY25230A1/es not_active IP Right Cessation
- 1998-10-29 MY MYPI98004942A patent/MY142803A/en unknown
- 1998-10-29 TW TW087117984A patent/TW585854B/zh not_active IP Right Cessation
- 1998-10-29 CZ CZ0346398A patent/CZ296252B6/cs not_active IP Right Cessation
- 1998-10-29 AR ARP980105433A patent/AR015473A1/es active IP Right Grant
- 1998-10-29 AU AU89599/98A patent/AU750734B2/en not_active Ceased
- 1998-10-30 HR HR980572A patent/HRP980572B1/xx not_active IP Right Cessation
- 1998-10-30 PL PL329440A patent/PL196967B1/pl not_active IP Right Cessation
- 1998-10-30 BR BRPI9804378-1A patent/BR9804378B1/pt not_active IP Right Cessation
- 1998-10-30 SG SG1998004381A patent/SG74094A1/en unknown
- 1998-10-30 PE PE1998001027A patent/PE123499A1/es not_active Application Discontinuation
- 1998-10-30 MA MA25327A patent/MA26559A1/fr unknown
- 1998-10-30 CN CNB98123674XA patent/CN100357270C/zh not_active Expired - Fee Related
- 1998-10-30 KR KR1019980046216A patent/KR100313637B1/ko not_active IP Right Cessation
- 1998-10-30 RU RU98120057/04A patent/RU2201937C2/ru not_active IP Right Cessation
- 1998-10-30 NO NO19985059A patent/NO312064B1/no not_active IP Right Cessation
- 1998-11-14 SA SA98190749A patent/SA98190749B1/ar unknown
1999
- 1999-10-17 HK HK99104814A patent/HK1019875A1/xx not_active IP Right Cessation
2000
- 2000-02-16 US US09/505,375 patent/US6262089B1/en not_active Expired - Lifetime
- 2000-08-10 US US09/636,076 patent/US6512001B1/en not_active Expired - Lifetime
2001
- 2001-05-24 KR KR1020010028656A patent/KR100342284B1/ko not_active IP Right Cessation
2002
- 2002-07-01 US US10/186,781 patent/US6740760B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PT915088E (pt)	2003-01-31
EP0915088A1 (fr)	1999-05-12
AR015473A1 (es)	2001-05-02
CZ296252B6 (cs)	2006-02-15
UY25230A1 (es)	2001-01-31
US6103910A (en)	2000-08-15
JPH11209343A (ja)	1999-08-03
BR9804378B1 (pt)	2010-07-13
HU9802465D0 (en)	1998-12-28
KR100342284B1 (ko)	2002-06-29
CA2252163A1 (fr)	1999-04-30
KR100313637B1 (ko)	2002-01-12
ID21194A (id)	1999-05-06
US20030100770A1 (en)	2003-05-29
DE69808017T2 (de)	2003-04-30
SI0915088T1 (en)	2002-12-31
NO985059D0 (no)	1998-10-30
CA2252163C (fr)	2008-09-09
EG23756A (en)	2007-08-08
SA98190749B1 (ar)	2006-05-13
US6740760B2 (en)	2004-05-25
NO985059L (no)	1999-05-03
TR199802197A2 (xx)	1999-05-21
PL196967B1 (pl)	2008-02-29
AU750734B2 (en)	2002-07-25
SG74094A1 (en)	2000-07-18
PE123499A1 (es)	1999-12-13
RU2201937C2 (ru)	2003-04-10
TW585854B (en)	2004-05-01
DE69808017D1 (de)	2002-10-24
CO5011076A1 (es)	2001-02-28
KR20010083247A (ko)	2001-08-31
HRP980572B1 (en)	2004-06-30
JP3048558B2 (ja)	2000-06-05
US6262089B1 (en)	2001-07-17
DK0915088T3 (da)	2003-01-27
IL126787A (en)	2003-12-10
CN1217327A (zh)	1999-05-26
HUP9802465A1 (hu)	2000-12-28
ATE224366T1 (de)	2002-10-15
AU8959998A (en)	1999-05-20
EP0915088B1 (fr)	2002-09-18
IL126787A0 (en)	1999-08-17
KR19990037520A (ko)	1999-05-25
RS49589B (sr)	2007-06-04
CN100357270C (zh)	2007-12-26
BR9804378A (pt)	2000-06-13
PL329440A1 (en)	1999-05-10
HRP980572A2 (en)	1999-08-31
NO312064B1 (no)	2002-03-11
ES2182203T3 (es)	2003-03-01
HK1019875A1 (en)	2000-03-03
CZ346398A3 (cs)	1999-05-12
TR199802197A3 (tr)	1999-05-21
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MY142803A (en)	2011-01-14
US6512001B1 (en)	2003-01-28

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MA26499A1 (fr)	2004-12-20	Derives de tetrazole, procede pour leur preparation et compositions pharmaceutiques les contenant .
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MA26443A1 (fr)	2004-12-20	Aralkyl- et aralkylidene-lactames et -imides heterocycliques, procedes pour leur preparation et compositions pharmaceutiques les contenant
MA26526A1 (fr)	2004-12-20	Derives d'indole inhibiteurs de cyclo-oxygenase, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26630A1 (fr)	2004-12-20	4-phenylpyperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26465A1 (fr)	2004-12-20	Derives de quinoleine et derives de quinazoline nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26622A1 (fr)	2004-12-20	Pyrazolopyrimidinones nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant
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MA26415A1 (fr)	2004-12-20	Composes heterocycliques, procede pour la preparation et compositions pharmaceutiques les contenant
FR2740136B1 (fr)	1998-01-09	Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
MA26558A1 (fr)	2004-12-20	Derives nouveaux de 6-0-methylerythromycine a, procede pour leur preparation et compositions pharmaceutiques les contenant.
MA26505A1 (fr)	2004-12-20	Derives de 6-o-methylerythromycine a, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26686A1 (fr)	2004-12-20	Derives de 4,4-biarylpiperidine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
MA26508A1 (fr)	2004-12-20	Formulations pharmaceutiques contenant du variconazole, et procede pour leur preparation.
MA26490A1 (fr)	2004-12-20	Derives de tetrahydroisoquinoleine nouveaux, procedes pour leur preparation et compositions pharmaceutiques les contenant.
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