DE69808017D1 - D-Prolinderivate - Google Patents

D-Prolinderivate

Info

Publication number
DE69808017D1
DE69808017D1 DE69808017T DE69808017T DE69808017D1 DE 69808017 D1 DE69808017 D1 DE 69808017D1 DE 69808017 T DE69808017 T DE 69808017T DE 69808017 T DE69808017 T DE 69808017T DE 69808017 D1 DE69808017 D1 DE 69808017D1
Authority
DE
Germany
Prior art keywords
proline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69808017T
Other languages
English (en)
Other versions
DE69808017T2 (de
Inventor
Cornelia Hertel
Torsten Hoffmann
Roland Jakob-Roetne
Roger David Norcross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pentraxin Therapeutics Ltd
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69808017D1 publication Critical patent/DE69808017D1/de
Publication of DE69808017T2 publication Critical patent/DE69808017T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
DE69808017T 1997-10-31 1998-10-22 D-Prolinderivate Expired - Lifetime DE69808017T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97119031 1997-10-31
EP98113851 1998-07-24

Publications (2)

Publication Number Publication Date
DE69808017D1 true DE69808017D1 (de) 2002-10-24
DE69808017T2 DE69808017T2 (de) 2003-04-30

Family

ID=26145860

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69808017T Expired - Lifetime DE69808017T2 (de) 1997-10-31 1998-10-22 D-Prolinderivate

Country Status (35)

Country Link
US (4) US6103910A (de)
EP (1) EP0915088B1 (de)
JP (1) JP3048558B2 (de)
KR (2) KR100313637B1 (de)
CN (1) CN100357270C (de)
AR (1) AR015473A1 (de)
AT (1) ATE224366T1 (de)
AU (1) AU750734B2 (de)
BR (1) BR9804378B1 (de)
CA (1) CA2252163C (de)
CO (1) CO5011076A1 (de)
CZ (1) CZ296252B6 (de)
DE (1) DE69808017T2 (de)
DK (1) DK0915088T3 (de)
EG (1) EG23756A (de)
ES (1) ES2182203T3 (de)
HK (1) HK1019875A1 (de)
HR (1) HRP980572B1 (de)
HU (1) HUP9802465A1 (de)
ID (1) ID21194A (de)
IL (1) IL126787A (de)
MA (1) MA26559A1 (de)
MY (1) MY142803A (de)
NO (1) NO312064B1 (de)
PE (1) PE123499A1 (de)
PL (1) PL196967B1 (de)
PT (1) PT915088E (de)
RS (1) RS49589B (de)
RU (1) RU2201937C2 (de)
SA (1) SA98190749B1 (de)
SG (1) SG74094A1 (de)
SI (1) SI0915088T1 (de)
TR (1) TR199802197A3 (de)
TW (1) TW585854B (de)
UY (1) UY25230A1 (de)

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FR2793245B1 (fr) * 1999-05-05 2002-10-11 Adir Nouveaux composes pyridiniques ou piperidiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20060211731A1 (en) * 1999-05-05 2006-09-21 Les Laboratories Servier New substituted pyridine or piperidine compounds
AU6611800A (en) * 1999-08-05 2001-03-05 Procter & Gamble Company, The Method of treating hair loss using multivalent ketoamides and amides
US6638950B2 (en) 2000-06-21 2003-10-28 Bristol-Myers Squibb Pharma Company Piperidine amides as modulators of chemokine receptor activity
FI20011466A0 (fi) 2001-07-04 2001-07-04 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä, niiden valmistusmenetelmiä ja käyttö
WO2003013508A1 (en) 2001-08-08 2003-02-20 Pentraxin Therapeutics Limited Therapeutic agent for depletion of an unwanted protein population from plasma
GB0119370D0 (en) 2001-08-08 2001-10-03 Univ London Therapeutic agent
US6903129B2 (en) * 2001-12-14 2005-06-07 Hoffman-La Roche Inc. D-proline prodrugs
US7091357B2 (en) * 2001-12-26 2006-08-15 University Of Kentucky Research Foundation Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies
AU2003223708A1 (en) * 2002-04-23 2003-11-10 Axys Pharmaceuticals, Inc. Novel phenyl derivatives as inducers of apoptosis
DE10240026A1 (de) * 2002-08-27 2004-03-11 Merck Patent Gmbh Verfahren zur Herstellung von Monoalkylaminoketonen
FI20030014A0 (fi) * 2003-01-03 2003-01-03 Orion Corp Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä
WO2004099173A1 (en) * 2003-05-12 2004-11-18 Theracarb Inc. Multivalent inhibitors of serum amyloid p component
CA2525764C (en) * 2003-05-20 2012-07-17 Novartis Ag N-acyl nitrogen heterocycles as ligands of peroxisome proliferator-activated receptors
GB0313386D0 (en) * 2003-06-10 2003-07-16 Univ London Treatment of disease
DE102004010943A1 (de) * 2004-03-03 2005-09-29 Degussa Ag Verfahren zur Herstellung von N-geschützten 4-Ketprolinderivaten
ITMI20041567A1 (it) * 2004-07-30 2004-10-30 Maycos Italiana Di Comini Miro "derivati n-acilati di acidi bicarbossilici con amminoacidi e con idrolizzati proteici vegetali e loro applicazione in prodotti cosmetici, dermofarmaceutici e farmaceutici"
CN1834095B (zh) * 2005-03-18 2011-04-20 中国科学院上海药物研究所 一类非核苷类抗病毒抑制剂及其制备方法和用途
CN101287728A (zh) 2005-08-17 2008-10-15 先灵公司 新的高亲和力噻吩基和呋喃基激酶配体
WO2008014232A2 (en) * 2006-07-24 2008-01-31 Emisphere Technologies, Inc. Pharmaceutical formulations for the treatment of alzheimer's disease
GB0712503D0 (en) * 2007-06-27 2007-08-08 Therapeutics Pentraxin Ltd Use
AU2008358292B2 (en) * 2008-06-27 2015-05-07 Pentraxin Therapeutics Limited Use
GB2470187A (en) * 2009-05-11 2010-11-17 Pharmapatents Global Ltd Captopril polymers
UA108227C2 (xx) * 2010-03-03 2015-04-10 Антигензв'язуючий білок
US9434716B2 (en) 2011-03-01 2016-09-06 Glaxo Group Limited Antigen binding proteins
BR112014024157B1 (pt) * 2012-03-30 2020-12-15 Givaudan Sa Composição comestível, solução de estoque e método para complementar as características de sabor ou paladar de produtos comestíveis
CN103333095B (zh) * 2013-06-26 2015-06-24 中国人民解放军第二军医大学 己二酰二d-羟脯氨酸衍生物及其作为核酸疫苗佐剂的应用
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
GB201407506D0 (en) 2014-04-29 2014-06-11 Glaxosmithkline Ip Dev Ltd Novel compound
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
WO2017072090A1 (en) * 2015-10-27 2017-05-04 Glaxosmithkline Intellectual Property Development Limited Combination therapy
GB201518950D0 (en) * 2015-10-27 2015-12-09 Glaxosmithkline Ip Dev Ltd Compound

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Also Published As

Publication number Publication date
HRP980572A2 (en) 1999-08-31
NO985059L (no) 1999-05-03
JP3048558B2 (ja) 2000-06-05
TR199802197A2 (xx) 1999-05-21
NO985059D0 (no) 1998-10-30
YU47698A (sh) 2001-07-10
TW585854B (en) 2004-05-01
HK1019875A1 (en) 2000-03-03
CA2252163A1 (en) 1999-04-30
US6262089B1 (en) 2001-07-17
PL196967B1 (pl) 2008-02-29
BR9804378B1 (pt) 2010-07-13
CZ346398A3 (cs) 1999-05-12
AU750734B2 (en) 2002-07-25
TR199802197A3 (tr) 1999-05-21
US20030100770A1 (en) 2003-05-29
ATE224366T1 (de) 2002-10-15
CN100357270C (zh) 2007-12-26
MA26559A1 (fr) 2004-12-20
BR9804378A (pt) 2000-06-13
CZ296252B6 (cs) 2006-02-15
RS49589B (sr) 2007-06-04
DE69808017T2 (de) 2003-04-30
SI0915088T1 (en) 2002-12-31
US6103910A (en) 2000-08-15
KR20010083247A (ko) 2001-08-31
DK0915088T3 (da) 2003-01-27
UY25230A1 (es) 2001-01-31
PT915088E (pt) 2003-01-31
HU9802465D0 (en) 1998-12-28
CO5011076A1 (es) 2001-02-28
JPH11209343A (ja) 1999-08-03
AU8959998A (en) 1999-05-20
SA98190749B1 (ar) 2006-05-13
KR19990037520A (ko) 1999-05-25
CA2252163C (en) 2008-09-09
EP0915088B1 (de) 2002-09-18
US6512001B1 (en) 2003-01-28
KR100342284B1 (ko) 2002-06-29
HRP980572B1 (en) 2004-06-30
KR100313637B1 (ko) 2002-01-12
EG23756A (en) 2007-08-08
ES2182203T3 (es) 2003-03-01
IL126787A (en) 2003-12-10
MY142803A (en) 2011-01-14
NO312064B1 (no) 2002-03-11
PL329440A1 (en) 1999-05-10
US6740760B2 (en) 2004-05-25
EP0915088A1 (de) 1999-05-12
HUP9802465A1 (hu) 2000-12-28
PE123499A1 (es) 1999-12-13
AR015473A1 (es) 2001-05-02
IL126787A0 (en) 1999-08-17
CN1217327A (zh) 1999-05-26
SG74094A1 (en) 2000-07-18
ID21194A (id) 1999-05-06
RU2201937C2 (ru) 2003-04-10

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Owner name: PENTRAXIN THERAPEUTICS LTD., LONDON, GB