MA25746A1 - Derives d'imidazopyrimidine et derive de triazolopyrimidine. - Google Patents

Derives d'imidazopyrimidine et derive de triazolopyrimidine.

Info

Publication number
MA25746A1
MA25746A1 MA26885A MA26885A MA25746A1 MA 25746 A1 MA25746 A1 MA 25746A1 MA 26885 A MA26885 A MA 26885A MA 26885 A MA26885 A MA 26885A MA 25746 A1 MA25746 A1 MA 25746A1
Authority
MA
Morocco
Prior art keywords
sup
sub
optionally substituted
alkoxy
triazolopyrimidine derivative
Prior art date
Application number
MA26885A
Other languages
English (en)
Inventor
Takeshi Yura
Arnel B Concepcion
Gyoonhee Han
Makiko Marumo
Hiroko Katsumata
Norihiro Kawamura
Toshio Kokubo
Hiroshi Komura
Yingfu Li
Timothy B Lowinger
Muneto Mogi
Noriyuki Yamamoto
Nagahiro Yoshida
Scott Miller
Margaret A Popp
Aniko M Redmann
Martha E Rodriguez
Wiliam J Scott
Ming Wang
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MA25746A1 publication Critical patent/MA25746A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
MA26885A 2000-04-28 2002-10-28 Derives d'imidazopyrimidine et derive de triazolopyrimidine. MA25746A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000128870A JP2001302667A (ja) 2000-04-28 2000-04-28 イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体

Publications (1)

Publication Number Publication Date
MA25746A1 true MA25746A1 (fr) 2003-04-01

Family

ID=18638240

Family Applications (1)

Application Number Title Priority Date Filing Date
MA26885A MA25746A1 (fr) 2000-04-28 2002-10-28 Derives d'imidazopyrimidine et derive de triazolopyrimidine.

Country Status (38)

Country Link
US (1) US6911443B2 (fr)
EP (1) EP1278750B1 (fr)
JP (2) JP2001302667A (fr)
KR (1) KR20030009456A (fr)
CN (1) CN1263756C (fr)
AR (1) AR033367A1 (fr)
AT (1) ATE272639T1 (fr)
AU (1) AU783043B2 (fr)
BG (1) BG107166A (fr)
BR (1) BR0110404A (fr)
CA (1) CA2407531A1 (fr)
CZ (1) CZ20023551A3 (fr)
DE (1) DE60104671T2 (fr)
DK (1) DK1278750T3 (fr)
DO (1) DOP2001000151A (fr)
EE (1) EE200200606A (fr)
ES (1) ES2225546T3 (fr)
HK (1) HK1058362A1 (fr)
HR (1) HRP20020943A2 (fr)
HU (1) HUP0300846A2 (fr)
IL (1) IL151919A0 (fr)
MA (1) MA25746A1 (fr)
MX (1) MXPA02010579A (fr)
MY (1) MY141578A (fr)
NO (1) NO20025154L (fr)
NZ (2) NZ526221A (fr)
PE (1) PE20011287A1 (fr)
PL (1) PL358106A1 (fr)
PT (1) PT1278750E (fr)
RU (1) RU2306313C2 (fr)
SI (1) SI1278750T1 (fr)
SK (1) SK15332002A3 (fr)
SV (1) SV2001000416A (fr)
TR (1) TR200402300T4 (fr)
TW (1) TWI222974B (fr)
UA (1) UA72615C2 (fr)
WO (1) WO2001083485A1 (fr)
ZA (1) ZA200207676B (fr)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60216747T2 (de) 2001-04-09 2007-10-04 Novartis Vaccines and Diagnostics, Inc., Emeryville Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten
DK1471057T3 (da) 2003-04-25 2006-05-15 Actimis Pharmaceuticals Inc Pyrimidinyleddikesyrederivater, der er egnede til behandlingen af sygdomme medieret af CRTH2
US20070129383A1 (en) * 2003-10-17 2007-06-07 Hiroshi Kuramochi Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof
WO2005061519A1 (fr) 2003-12-19 2005-07-07 Takeda San Diego, Inc. Inhibiteurs de kinase
ATE433452T1 (de) * 2004-01-31 2009-06-15 Actimis Pharmaceuticals Inc Imidazoä1,2-cüpyrimidinylessigsäurederivate
US20050288502A1 (en) * 2004-06-25 2005-12-29 Andersen Denise L Substituted heterocyclic compounds and methods of use
JP2008510734A (ja) 2004-08-18 2008-04-10 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
MX2007002178A (es) 2004-08-23 2007-04-02 Wyeth Corp Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares.
US7713973B2 (en) * 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
BRPI0607062A2 (pt) 2005-02-28 2009-08-04 Japan Tobacco Inc composto de aminopiridina com atividade inibidora de syk, composição farmacêutica e agente terapêutico compreendendo os mesmos
US7442700B2 (en) * 2005-07-01 2008-10-28 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
EA200800664A1 (ru) * 2005-10-13 2009-02-27 Глаксо Груп Лимитед Производные пирролопиримидина в качестве ингибиторов syk
CL2007002617A1 (es) * 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
EP2223925A1 (fr) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase
JP5572388B2 (ja) * 2006-11-22 2014-08-13 インサイト・コーポレイション キナーゼ阻害剤としてのイミダゾトリアジンおよびイミダゾピリミジン
EP2123654A4 (fr) 2006-12-28 2011-05-11 Taisho Pharmaceutical Co Ltd Composé pyrazolopyridimidine
DE102007012645A1 (de) 2007-03-16 2008-09-18 Bayer Healthcare Ag Substituierte Imidazo- und Triazolopyrimidine
JP5600594B2 (ja) 2007-09-25 2014-10-01 アクチミス ファーマシューティカルズ インコーポレーテッド Ｃｒｔｈ２アンタゴニストとしての２−ｓ−ベンジル置換ピリミジン
ES2383249T3 (es) 2007-09-25 2012-06-19 Actimis Pharmaceuticals, Inc. Alquiltiopirimidinas como antagonistas de CRTH2
DE102008023801A1 (de) 2008-05-15 2009-11-19 Bayer Schering Pharma Aktiengesellschaft Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine
SG10201707798SA (en) 2008-12-08 2017-10-30 Gilead Connecticut Inc Imidazopyrazine syk inhibitors
LT2716157T (lt) * 2008-12-08 2016-09-12 Gilead Connecticut, Inc. Imidazopirazino syk inhibitoriai
US8377945B2 (en) 2009-06-15 2013-02-19 Rigel Pharmaceuticals Inc. Small molecule inhibitors of spleen tyrosine kinase (SYK)
ME02186B (me) 2009-12-23 2016-02-20 Takeda Pharmaceuticals Co Fuzionisani heteroaromatski pirolidinoni kao syk inhibitori
ES2530449T3 (es) * 2010-03-11 2015-03-02 Gilead Connecticut Inc Inhibidores de Syk de imidazopiridinas
KR20130094710A (ko) * 2010-04-14 2013-08-26 어레이 바이오파마 인크. Ｊａｋ 키나아제의 억제제로서 5,7-치환된-이미다조［1,2-ｃ］피리미딘
WO2012154518A1 (fr) 2011-05-10 2012-11-15 Merck Sharp & Dohme Corp. Bipyridylaminopyridines en tant qu'inhibiteurs de syk
US9120785B2 (en) 2011-05-10 2015-09-01 Merck Sharp & Dohme Corp. Pyridyl aminopyridines as Syk inhibitors
CA2834604A1 (fr) 2011-05-10 2012-11-15 Merck Sharp & Dohme Corp. Aminopyrimidines en tant qu'inhibiteurs de syk
WO2012167423A1 (fr) 2011-06-08 2012-12-13 Hutchison Medipharma Limited Pyridopyrazines substituées en tant que nouveaux inhibiteurs de syk
EP2723739B1 (fr) 2011-06-22 2016-08-24 Takeda Pharmaceutical Company Limited Dérivés de 6-aza-isoindolin-1-one substitués
US9199975B2 (en) 2011-09-30 2015-12-01 Asana Biosciences, Llc Biaryl imidazole derivatives for regulating CYP17
EP2763975B1 (fr) 2011-10-05 2016-04-06 Merck Sharp & Dohme Corp. Inhibiteurs de tyrosine kinase de la rate (syk) contenant un 3-pyridyl carboxamide
WO2013052391A1 (fr) 2011-10-05 2013-04-11 Merck Sharp & Dohme Corp. Inhibiteurs de tyrosine kinase de la rate (syk) contenant un phényl carboxamide
WO2013052394A1 (fr) 2011-10-05 2013-04-11 Merck Sharp & Dohme Corp. Inhibiteurs de tyrosine kinase de la rate (syk) contenant un 2-pyridyl carboxamide
KR20140076619A (ko) * 2011-10-12 2014-06-20 어레이 바이오파마 인크. 5,7-치환된-이미다조[1,2-c]피리미딘
DK2799431T3 (en) * 2011-12-28 2018-03-26 Fujifilm Corp Hitherto unknown nicotinamide derivatives or salts thereof
WO2013192128A1 (fr) 2012-06-20 2013-12-27 Merck Sharp & Dohme Corp. Analogues d'imidazolyle en tant qu'inhibiteurs de syk
EP2863914B1 (fr) 2012-06-20 2018-10-03 Merck Sharp & Dohme Corp. Dérivés de pyrazolyle en tant qu'inhibiteurs de syk
EP2863915B1 (fr) 2012-06-22 2017-12-06 Merck Sharp & Dohme Corp. Inhibiteurs de tyrosine kinase splénique (syk) diazines et triazines substituées
EP2863916B1 (fr) 2012-06-22 2018-07-18 Merck Sharp & Dohme Corp. Inhibiteurs à pyridine substituée de la tyrosine kinase de la rate (syk)
EP2884982B1 (fr) 2012-08-20 2017-09-20 Merck Sharp & Dohme Corp. Inhibiteurs de la phényle tyrosine kinase de la rate (syk) substitués
WO2014048065A1 (fr) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Dérivés triazolyle en tant qu'inhibiteurs de la syk
WO2014093191A1 (fr) 2012-12-12 2014-06-19 Merck Sharp & Dohme Corp. Inhibiteurs de tyrosine kinase splénique contenant une aminopyridine
EP2934525B1 (fr) 2012-12-21 2019-05-08 Merck Sharp & Dohme Corp. Aminopyridines substituées par thiazole en tant qu'inhibiteurs de la tyrosine kinase de la rate
US9499534B2 (en) 2013-04-26 2016-11-22 Merck Sharp & Dohme Corp. Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
EP2988744A4 (fr) 2013-04-26 2016-11-02 Merck Sharp & Dohme Composés aminohétéroaryle à substitution thiazole inhibiteurs de tyrosine kinase splénique
EP3027171B1 (fr) 2013-07-30 2020-03-25 Gilead Connecticut, Inc. Formulation d'inhibiteurs de syk
US9657023B2 (en) 2013-07-30 2017-05-23 Gilead Connecticut, Inc. Polymorph of Syk inhibitors
KR20180002888A (ko) 2013-12-04 2018-01-08 길리애드 사이언시즈, 인코포레이티드 암을 치료하는 방법
WO2015094997A1 (fr) 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Composés aminohétéroaryle à substitution thiazole utilisés comme inhibiteurs de la tyrosine kinase splénique
EP3083560B1 (fr) 2013-12-20 2021-10-27 Merck Sharp & Dohme Corp. Composés aminohétéroaryle à substitution thiazole utilisés comme inhibiteurs de la tyrosine kinase splénique
US9822107B2 (en) 2013-12-20 2017-11-21 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
UY35898A (es) 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
EP3116506B1 (fr) 2014-03-13 2019-04-17 Merck Sharp & Dohme Corp. Composés 2-pyrazine carboxamide utiles comme inhibiteurs de la tyrosine kinase splénique
LT3119772T (lt) * 2014-03-19 2019-08-26 Boehringer Ingelheim International Gmbh Heteroarilo sik inhibitoriai
NZ726365A (en) 2014-07-14 2018-06-29 Gilead Sciences Inc Combinations for treating cancers
DK3347353T3 (da) 2015-09-11 2019-10-21 Boehringer Ingelheim Int Pyrazolyl-substituerede heteroaryler og deres anvendelse som lægemidler
JP6986624B2 (ja) 2017-08-25 2021-12-22 ギリアード サイエンシーズ， インコーポレイテッド Ｓｙｋ阻害剤の多形体
EP3665171A1 (fr) 2017-10-19 2020-06-17 Bayer Animal Health GmbH Utilisation de pyrrolidones hétéroaromatiques fusionnées pour le traitement et la prévention de maladies chez des animaux
JP7304855B2 (ja) 2017-11-14 2023-07-07 ザ チルドレンズ メディカル センター コーポレーション 新規イミダゾピリミジン化合物およびそれらの使用
US11730810B2 (en) 2017-11-14 2023-08-22 Children's Medical Center Corporation Composition comprising an antigen and a substituted imidazo[1,2-a]pyrimidine for enhancing human immune response
WO2019235572A1 (fr) * 2018-06-06 2019-12-12 富士フイルム株式会社 Agent de traitement et composition médicinale contre le cancer solide
WO2019235571A1 (fr) * 2018-06-06 2019-12-12 富士フイルム株式会社 Agent de traitement et composition pharmaceutique pour le cancer hématologique
JP7370079B2 (ja) 2018-06-06 2023-10-27 国立大学法人北海道大学 グリオーマの処置剤および医薬組成物
CA3117556A1 (fr) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Composes de 6-azabenzimidazole substitues en tant qu'inhibiteurs de hpk1
EP3873608A1 (fr) 2018-10-31 2021-09-08 Gilead Sciences, Inc. Composés 6-azabenzimidazole substitués ayant une activité inhibitrice de hpk1
KR20210131372A (ko) 2019-02-22 2021-11-02 크로노스 바이오, 인코포레이티드 Syk 억제제로서의 축합된 피라진의 고체 형태
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
WO2021173476A1 (fr) * 2020-02-24 2021-09-02 The Trustees Of Columbia University In The City Of New York Composés, formulations pharmaceutiques et méthodes de traitement du cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483987A (en) * 1983-06-20 1984-11-20 G. D. Searle & Co. 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides
EP1017682A4 (fr) * 1997-09-26 2000-11-08 Merck & Co Inc Nouveaux inhibiteurs de l'angiogenese
AU1507199A (en) * 1997-12-15 1999-07-05 Yamanouchi Pharmaceutical Co., Ltd. Novel pyrimidine-5-carboxamide derivatives
US6673564B2 (en) * 1999-10-18 2004-01-06 Millennium Pharmaceuticals, Inc. Methods for using 22045, a human cyclic nucleotide phosphodiesterase

Also Published As

Publication number Publication date
PT1278750E (pt) 2004-11-30
UA72615C2 (en) 2005-03-15
ATE272639T1 (de) 2004-08-15
SV2001000416A (es) 2001-07-03
TR200402300T4 (tr) 2004-12-21
JP2001302667A (ja) 2001-10-31
SI1278750T1 (en) 2005-02-28
HRP20020943A2 (en) 2005-02-28
CZ20023551A3 (cs) 2003-01-15
WO2001083485A1 (fr) 2001-11-08
US6911443B2 (en) 2005-06-28
PE20011287A1 (es) 2002-02-27
NZ522241A (en) 2004-04-30
TWI222974B (en) 2004-11-01
ES2225546T3 (es) 2005-03-16
EE200200606A (et) 2004-04-15
DE60104671D1 (de) 2004-09-09
JP2003535067A (ja) 2003-11-25
EP1278750B1 (fr) 2004-08-04
RU2306313C2 (ru) 2007-09-20
CN1263756C (zh) 2006-07-12
IL151919A0 (en) 2003-04-10
US20040054179A1 (en) 2004-03-18
AU783043B2 (en) 2005-09-22
BR0110404A (pt) 2003-02-11
EP1278750A1 (fr) 2003-01-29
PL358106A1 (en) 2004-08-09
MXPA02010579A (es) 2003-05-14
AR033367A1 (es) 2003-12-17
NO20025154D0 (no) 2002-10-25
HK1058362A1 (en) 2004-05-14
AU6220401A (en) 2001-11-12
CN1439009A (zh) 2003-08-27
DE60104671T2 (de) 2005-12-29
DK1278750T3 (da) 2004-11-22
ZA200207676B (en) 2003-09-25
HUP0300846A2 (hu) 2003-08-28
SK15332002A3 (sk) 2003-06-03
KR20030009456A (ko) 2003-01-29
MY141578A (en) 2010-05-14
DOP2001000151A (es) 2002-05-15
NZ526221A (en) 2005-01-28
NO20025154L (no) 2002-10-25
BG107166A (bg) 2003-06-30
CA2407531A1 (fr) 2001-10-25

Similar Documents

Publication Publication Date Title
MA25746A1 (fr) Derives d'imidazopyrimidine et derive de triazolopyrimidine.
EA200000334A1 (ru) Производные карбоксамидотиазолов, их получение, содержащие их фармацевтические композиции
NO2015020I2 (no) Ceritinib eller et farmasøytisk akseptabelt salt derav
ATE301640T1 (de) Anellierte 4-carboxyamino-2-methyl-1,2,3,4- tetrahydrochinoline als cetp-hemmer
HUP0004333A2 (hu) Új triazolo [4,5-d] pirimidin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
BR9710780A (pt) Novos compostos de para-terefenila
FI913017A0 (fi) Menetelmä antianginaalisten 5-(2-alkoksi-5-piperidinyyli- ja -piperatsinyylisulfonyylifenyyli)-1,6-dihydro-7H-pyratsolo/4,3-d/pyrimidin-7-onien valmistamiseksi ja välituotteita
HUT40668A (en) Process for preparing new benzoxazole and amine derivatives and pharmaceutical compositions containing such compounds
FI970317A0 (fi) Antiproliferatiivisina aineina ja Garft-inhibiittoreina käyttökelpoisia yhdisteitä
EA200100983A1 (ru) Производные 13-метилэритромицина
PE20020524A1 (es) 7-oxo-piridopirimidinas como inhibidores de quinasas
AU6124699A (en) Aromatic amine derivatives, process for the preparation thereof and agents containing the same
DE60001182T2 (de) Erythromycin-Derivate, ihr Verfahren zur Herstellung und ihre Verwendung als Arzneimittel
DK534381A (da) Fremgangsmaade til fremstilling af 2-oxoazetidinderivater
PT76574A (fr) Procede de preparation de derives d'imidazo <1,2-a> pyridine et de compositions pharmaceutiques les contenant
ATE141606T1 (de) Cephemverbindungen und verfahren zu ihrer herstellung
FI832739A0 (fi) 5-alkyl-1,6-naftyridin-2(1h)-oner, mellanprodukter deras framstaellning och anvaendning som hjaertlaekemedel
HUT41739A (en) Herbicidal and plant growth regulating compositions comprising novel "1-aryl-5-alkoxy-imino-alkyl-aminopyrazoles as active substance and process for preparing the novel active substances
AR035076A1 (es) Procedimiento y derivados ester utiles para la preparacion de cefalosporinas
DK0786459T3 (da) Fremgangsmåde til fremstilling af en heterobicyklisk alkoholenantiomer
FR2751655B1 (fr) Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HUT50474A (en) Process for producing imidazobenzodiazepine derivatives and pharmaceutical compositions comprising such compounds as active ingredient
DK0703237T3 (da) Fremgangsmåde til fremstilling af thio-phospholipider af ether-typen
ATE8633T1 (de) Vinyl-3-cephalosporinverbindungen und ihre herstellung.
HUP0301500A2 (hu) Eljárás imidazo [1,2-c][2,3]benzodiazepin-származékok és köztitermékeik előállítására