LU79547A1 - Procede de preparation de nouvelles compositions antibiotiques a base d'une tetracycline - Google Patents

Procede de preparation de nouvelles compositions antibiotiques a base d'une tetracycline

Info

Publication number
LU79547A1
LU79547A1 LU79547A LU79547A LU79547A1 LU 79547 A1 LU79547 A1 LU 79547A1 LU 79547 A LU79547 A LU 79547A LU 79547 A LU79547 A LU 79547A LU 79547 A1 LU79547 A1 LU 79547A1
Authority
LU
Luxembourg
Prior art keywords
tetracycline
preparation
compositions based
new antibiotic
antibiotic compositions
Prior art date
Application number
LU79547A
Other languages
English (en)
Inventor
W Armstrong
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of LU79547A1 publication Critical patent/LU79547A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
LU79547A 1977-04-27 1978-04-27 Procede de preparation de nouvelles compositions antibiotiques a base d'une tetracycline LU79547A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions

Publications (1)

Publication Number Publication Date
LU79547A1 true LU79547A1 (fr) 1979-11-07

Family

ID=25154289

Family Applications (1)

Application Number Title Priority Date Filing Date
LU79547A LU79547A1 (fr) 1977-04-27 1978-04-27 Procede de preparation de nouvelles compositions antibiotiques a base d'une tetracycline

Country Status (38)

Country Link
US (1) US4126680A (fr)
JP (1) JPS53136514A (fr)
AR (1) AR217844A1 (fr)
AT (1) AT360148B (fr)
AU (1) AU503139B1 (fr)
BE (1) BE866419A (fr)
BG (1) BG47943A3 (fr)
CA (1) CA1100875A (fr)
CH (1) CH630260A5 (fr)
CS (1) CS199527B2 (fr)
DD (1) DD135445A5 (fr)
DE (1) DE2817335C3 (fr)
DK (1) DK155977C (fr)
EG (1) EG14348A (fr)
ES (1) ES468749A1 (fr)
FI (1) FI781300A (fr)
FR (1) FR2388561A1 (fr)
GB (1) GB1563478A (fr)
GR (1) GR70062B (fr)
HU (1) HU179050B (fr)
IE (1) IE47049B1 (fr)
IL (1) IL54581A0 (fr)
IN (1) IN148197B (fr)
IT (1) IT1094557B (fr)
LU (1) LU79547A1 (fr)
MX (1) MX6087E (fr)
NL (1) NL7804455A (fr)
NO (1) NO148280C (fr)
NZ (1) NZ187046A (fr)
OA (1) OA05949A (fr)
PH (1) PH12962A (fr)
PL (1) PL110459B1 (fr)
PT (1) PT67895B (fr)
RO (2) RO77953A (fr)
SE (1) SE443507B (fr)
YU (1) YU87178A (fr)
ZA (1) ZA782400B (fr)
ZM (1) ZM3878A1 (fr)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
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US4399127A (en) * 1980-04-10 1983-08-16 Diamond Shamrock Corporation Injectable oxytetracycline compositions
US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (fr) * 1993-04-20 1994-10-26 Nostras S.A. Composition antibiotique contenant de l'oxytétracycline et du glycofurol
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
DE60027465T2 (de) 1999-09-14 2007-02-01 The Trustees Of Tufts College, Medford Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
WO2001052858A1 (fr) * 2000-01-24 2001-07-26 Trustees Of Tufts College Composes de tetracycline pour le traitement de troubles afferents au cryptosporidium parvum
MXPA02009482A (es) 2000-03-31 2004-05-14 Tufts College Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino.
AU2001259701A1 (en) 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
AU2001268475A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
US6846939B2 (en) * 2000-07-07 2005-01-25 Paratek Pharmaceuticals, Inc. 9-substituted minocycline compounds
CA2415718C (fr) 2000-07-07 2012-08-28 Trustees Of Tufts College Composes de tetracycline substitues en 7
DE60141994D1 (de) 2000-07-07 2010-06-10 Tufts College 13-substituierte Methacyclinverbindungen
WO2002004404A2 (fr) 2000-07-07 2002-01-17 Trustees Of Tufts College Composes de tetracycline substitues en 7, 8 et 9
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
BR0116935A (pt) 2001-03-13 2005-04-12 Paratek Pharm Innc Composto de tetraciclina, método para tratar um estado responsivo à tetraciclina em um indivìduo, e, composição farmacêutica
WO2002072506A2 (fr) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de 7-pyrollyl tetracycline et procedes d'utilisation associes
WO2002072031A2 (fr) 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de tetracycline substitue utilises en tant qu'antifongiques synergiques
US6841546B2 (en) 2001-03-14 2005-01-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as antifungal agents
ATE455092T1 (de) 2001-04-24 2010-01-15 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2311796A1 (fr) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. Composés de tétracycline 4-dedimethylamino
AU2003220123B2 (en) 2002-03-08 2009-05-07 Paratek Pharmaceuticals, Inc. Amino-methyl substituted tetracycline compounds
WO2003079984A2 (fr) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Composes de tetracycline substituee
WO2004006850A2 (fr) 2002-07-12 2004-01-22 Paratek Pharmaceuticals, Inc Composes de tetracycline substituee en 3, 10, et 12a
EP2277504A1 (fr) 2002-10-24 2011-01-26 Paratek Pharmaceuticals, Inc. Composes tetracycline substituee servant au traitement du paludisme
JP4738333B2 (ja) 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド ９−アミノメチルテトラサイクリン化合物のプロドラッグ
CN101786991A (zh) 2003-07-09 2010-07-28 帕拉特克药品公司 取代的四环素化合物
CN1893956A (zh) * 2003-07-25 2007-01-10 沃纳奇尔科特公司 多西环素金属络合物固体剂型
JP5010284B2 (ja) 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2284150A3 (fr) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Composés de tétracycline substituée
AU2005299294B2 (en) 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US8088755B2 (en) 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
US8252776B2 (en) 2007-04-02 2012-08-28 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080242642A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
US7919483B2 (en) * 2005-06-24 2011-04-05 Medicis Pharmaceutical Corporation Method for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US20080241235A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US7544373B2 (en) * 2007-04-02 2009-06-09 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
WO2007087416A2 (fr) 2006-01-24 2007-08-02 Paratek Pharaceuticals, Inc. Procede permettant d'accroitre la biodisponibilite orale de tetracyclines
WO2007120913A2 (fr) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolement de dérivés de la tétracycline
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2016045B1 (fr) * 2006-04-24 2014-10-29 Teva Pharmaceutical Industries, Ltd. Forme cristalline de tigecycline et procedes pour sa preparation
EP2026776A2 (fr) * 2006-05-15 2009-02-25 Paratek Pharmaceuticals, Inc. Méthodes de régulation de l'expression de gènes ou de produits géniques à l'aide de composés de tétracycline substituée
ES2315123B1 (es) * 2006-09-25 2009-12-30 Divasa-Farmavic, S.A. Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
ES2463457T3 (es) 2006-12-21 2014-05-28 Paratek Pharmaceuticals, Inc. Derivados de la tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias
PT2120963T (pt) 2006-12-21 2018-12-17 Paratek Pharm Innc Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele
AU2012230089B2 (en) * 2007-03-23 2013-11-21 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
AP2657A (en) * 2007-03-23 2013-05-07 Molecular Res Ct Inc Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
US20080241197A1 (en) * 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline dosage forms for the treatment of acne
EP2144614A1 (fr) * 2007-04-12 2010-01-20 Paratek Pharmaceuticals, Inc. Procédés pour le traitement de l'amyotrophie spinale à l'aide de composés tétracyclines.
CA2688662A1 (fr) 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methodes de synthese et de purification de composes de type aminoalkyle de tetracycline
ES2386926T3 (es) 2007-07-06 2012-09-06 Paratek Pharmaceuticals, Inc. Métodos para sintetizar minociclina9-sustituida
WO2009111064A2 (fr) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Composés de minocycline et procédés d’utilisation de ceux-ci
PT2271348T (pt) 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
US20100022483A1 (en) * 2008-04-14 2010-01-28 Paratek Pharmaceuticals, Inc. Substituted Tetracycline Compounds
TW202332671A (zh) * 2008-05-23 2023-08-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
AP2011005631A0 (en) * 2008-09-19 2011-04-30 Paratek Pharmaceuticals Ind Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment.
AU2010233089B2 (en) 2009-04-10 2016-05-26 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (MMP-1)
CA2835876C (fr) 2011-05-12 2020-04-14 Paratek Pharmaceuticals, Inc. Sels cristallins d'amide de l'acide (4s,4as,5ar,12as)-4-dimethylamino- 3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]- 1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphta cene-2-carboxylique et procedes d'utilisation associes
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
ES2611185T3 (es) * 2013-05-20 2017-05-05 Fundación Comunidad Valenciana Centro De Investigación Principe Felipe Conjugados polímero-fármaco para el tratamiento de la amiloidosis
CN107708665B (zh) 2015-03-23 2022-07-22 贝尔生物制药有限公司 用于皮肤病学用途的药用四环素组合物
SG10201913599RA (en) 2016-11-01 2020-02-27 Paratek Pharm Innc 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (cabp)
EP3654988B1 (fr) 2017-07-21 2023-09-06 Almirall, LLC Sarecycline destinée au traitement des lésions acnéiques non inflammatoires
CN113655052B (zh) * 2021-08-03 2023-12-12 哈尔滨工程大学 基于高活性MgO对四环素类抗生素可视化检测的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) * 1963-01-30 1966-02-02 Chugai Pharmaceutical Co Ltd Hemostatic preparation for injection and process for the production thereof
DK129969B (da) * 1973-01-11 1974-12-09 Rosco Ak Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
OA05949A (fr) 1981-06-30
MX6087E (es) 1984-11-08
CS199527B2 (en) 1980-07-31
CA1100875A (fr) 1981-05-12
DK155977C (da) 1989-10-30
DD135445A5 (de) 1979-05-09
BG47943A3 (en) 1990-10-15
DE2817335B2 (de) 1981-06-11
IL54581A0 (en) 1978-07-31
FR2388561A1 (fr) 1978-11-24
IE47049B1 (en) 1983-12-14
IN148197B (fr) 1980-11-29
FI781300A (fi) 1978-10-28
BE866419A (fr) 1978-10-26
DE2817335A1 (de) 1978-11-16
AU503139B1 (en) 1979-08-23
AR217844A1 (es) 1980-04-30
CH630260A5 (fr) 1982-06-15
RO77953A (fr) 1981-12-25
PH12962A (en) 1979-10-19
ZA782400B (en) 1979-04-25
NO781457L (no) 1978-10-30
ATA300478A (de) 1980-05-15
HU179050B (en) 1982-08-28
ZM3878A1 (en) 1978-11-21
PL206050A1 (pl) 1979-03-26
SE7801816L (sv) 1978-10-28
IT7822720A0 (it) 1978-04-26
SE443507B (sv) 1986-03-03
DE2817335C3 (de) 1982-04-22
IE780828L (en) 1978-10-27
GB1563478A (en) 1980-03-26
GR70062B (fr) 1982-07-26
AT360148B (de) 1980-12-29
EG14348A (en) 1984-09-30
US4126680A (en) 1978-11-21
IT1094557B (it) 1985-08-02
NZ187046A (en) 1980-03-05
JPS53136514A (en) 1978-11-29
NO148280B (no) 1983-06-06
JPS5632290B2 (fr) 1981-07-27
NO148280C (no) 1983-09-21
FR2388561B1 (fr) 1980-07-18
RO75099A (fr) 1980-12-30
PT67895A (en) 1978-05-01
PL110459B1 (en) 1980-07-31
ES468749A1 (es) 1979-01-01
NL7804455A (nl) 1978-10-31
DK155977B (da) 1989-06-12
YU87178A (en) 1984-04-30
PT67895B (en) 1979-11-14
DK182578A (da) 1978-10-28

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